Gut Microbiota and Cancer

Dear Colleagues,

With the continuous iteration of deep sequencing, the profound link between the gut microbiota and cancer has been gradually unveiled. In past studies, the gut microbiota has been suggested to influence the occurrence, progression, proliferation, metastasis, and drug resistance of many different types of cancer, partly because the gut microbiota and its metabolites interact with the host at multiple body sites and are closely linked to the body’s immune system, thereby influencing a variety of physiopathological processes. The gut microbiota can also help with diagnosis and prognosis as well as suggest therapeutic strategies, including cancer immunotherapy. Additionally, the intratumoral microbiota has become one of the hotspots of research today. However, the specific mechanisms by which the gut microbiota influences cancer development have not been elucidated. Currently, the relationship between microbiota-induced non-coding RNAs and cancer is also attracting more attention, offering a possible molecular mechanism by which the gut microbiota impacts cancer development. Therefore, this issue aims to explore the molecular mechanism of intestinal microbiome influencing cancer progression based on different perspectives and aims to contribute to new strategies for cancer treatment. This open access Topic will bring together original research and review articles on the gut microbiome and cancer. Potential submission topics include but are not limited to:

• Gut microbiota and its metabolites;
• Gut-microbiota-induced non-coding RNAs;
• Intratumoral microbiota;
• Tumor microenvironment;
• Molecular mechanisms;
• Therapeutic strategies;
• Cancer immunotherapy;
• Drug design;
• Drug resistance;
• Pharmacokinetics;
• Tumor epidemiology.

Dr. Dong Tang
Prof. Dr. Takeo Fukagawa
Topic Editors