Topic Editors

UNIPRO—Unidade de Investigação em Patologia e Reabilitação Oral, IUCS, CESPU, Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal
Pelotonia Institute for Immuno-Oncology, Arthur G. James Comprehensive Cancer Center, Ohio State University College of Medicine, Columbus, OH 43210, USA

Recent Advances in Anticancer Strategies, 2nd Edition

Abstract submission deadline
31 January 2026
Manuscript submission deadline
31 March 2026
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4240

Topic Information

Dear Colleagues,

The topic "Recent Advances in Anticancer Strategies, 2nd Edition" aims to provide an overview of the latest developments in the field of cancer treatment. Cancer remains one of the leading causes of death worldwide, and researchers have been working to develop more effective and targeted treatments to improve outcomes for patients. The existing cancer therapies suffer from severe side-effects and drug resistance, leading to an increase in cancer incidence and mortality worldwide. Hence, there is a pressing need to develop and discover novel therapeutic strategies that can offer more effective and less-toxic treatment options for cancer patients. Novel anticancer approaches are being developed which can selectively identify and eliminate cancerous cells while minimizing harm to healthy tissues, unlike traditional therapies.

For this topic, we welcome original articles and comprehensive reviews that showcase the latest advances in novel anticancer strategies with reduced toxicity and improved therapeutic indices. These articles can suggest potential prospects for optimizing cancer therapies with significant clinical value in the near future. We encourage submissions that focus on the development and validation of various anticancer approaches, including ligand-/receptor-based targeting, controlled drug delivery, gene therapy, gene delivery, immunotherapy, targeted anticancer prodrugs and conjugates (such as photoactivatable caged prodrugs, ADEPT, ADAPT, and ADCs), magnetic- and ultrasound-mediated drug targeting, and cancer stem cell therapy, as well as strategies that explore the targeting of signaling cascades and the tumor microenvironment.

Overall, this topic aims at providing recent advances in anticancer strategies, highlighting the potential impact of these new approaches on cancer treatment and patient outcomes. We eagerly anticipate your valuable contribution to this exciting topic.

Dr. Hassan Bousbaa
Dr. Zhiwei Hu
Topic Editors

Keywords

  • anticancer strategies
  • cancer treatment
  • chemotherapy
  • radiation therapy
  • immunotherapy
  • targeted therapy
  • gene therapy
  • stem cell therapy
  • precision medicine
  • combination therapy
  • biomarkers
  • drug delivery
  • nanoparticles
  • CAR-T cell therapy
  • checkpoint inhibitors
  • epigenetic therapy
  • oncolytic viruses
  • artificial intelligence in cancer treatment

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Cancers
cancers
4.5 8.0 2009 17.4 Days CHF 2900 Submit
International Journal of Molecular Sciences
ijms
4.9 8.1 2000 16.8 Days CHF 2900 Submit
Pharmaceuticals
pharmaceuticals
4.3 6.1 2004 13.9 Days CHF 2900 Submit
Pharmaceutics
pharmaceutics
4.9 7.9 2009 15.5 Days CHF 2900 Submit
Scientia Pharmaceutica
scipharm
2.3 4.6 1930 26.1 Days CHF 1000 Submit
Current Oncology
curroncol
2.8 3.3 1994 19.8 Days CHF 2200 Submit
Molecules
molecules
4.2 7.4 1996 15.1 Days CHF 2700 Submit

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Published Papers (3 papers)

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32 pages, 6286 KiB  
Article
Synthesis and In Vitro Evaluation of the Anticancer Effect of Novel Phosphonium Vindoline Derivatives
by Mónika Halmai, Viktória Donkó-Tóth, Péter Keglevich, Károly Kánai, Márton Weber, Miklós Dékány, Ejlal A. Abdallah, Noémi Bózsity, István Zupkó, Andrea Nehr-Majoros, Éva Szőke, Zsuzsanna Helyes and László Hazai
Int. J. Mol. Sci. 2025, 26(8), 3775; https://doi.org/10.3390/ijms26083775 - 16 Apr 2025
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Abstract
The Vinca alkaloid vindoline was coupled at position 17 with several trisubstituted phosphine derivatives and their in vitro anticancer activities on 60 human tumor cell lines (NCI60) were investigated. This phosphonium-type ionic side chain is beneficial because it allows therapeutic molecules to pass [...] Read more.
The Vinca alkaloid vindoline was coupled at position 17 with several trisubstituted phosphine derivatives and their in vitro anticancer activities on 60 human tumor cell lines (NCI60) were investigated. This phosphonium-type ionic side chain is beneficial because it allows therapeutic molecules to pass through the cell membrane. Thus, the candidates coupled to it can exert their activities in the mitochondria. The coupling of vindoline with the trisubstituted phosphines was achieved through flexible or rigid linkers. Instead of the ionic phosphonium structural part, a neutral moiety, namely the triphenylmethyl group, was also added to the side chain, being sterically similar but without a charge and phosphorus atom. In addition, the triphenylphosphine element was also built at position 10 of vindoline. Most of the derivatives showed low micromolar growth inhibition (GI50) values against most cell lines. Among them, conjugate 9e was outstanding: it exhibited nanomolar anticancer activity on the RPMI-8226 leukemia cell line (GI50 = 20.0 nM). Compound 9g elicited cell cycle disturbance and apoptosis on A2780 ovary cancer cells and inhibited their migration at subantiproliferative concentrations. The selectivity of the conjugates was determined by their effects on non-tumor Chinese hamster ovary (CHO) cells in the CellTiter-Glo Luminescent Cell Viability Assay. Compound 9e showed an estimated half-maximal inhibitory concentration (IC50) value of 1.36 µM, suggesting good selectivity on cancer cells. These results open new perspectives of novel phosphonium-based vindoline derivatives as anticancer compounds. Full article
(This article belongs to the Topic Recent Advances in Anticancer Strategies, 2nd Edition)
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22 pages, 1121 KiB  
Review
Advancing Cancer Treatment and Diagnosis: A Review on Photodynamic Therapy Using OLED Technology
by Rajesh Kumar Tiwari, Rajesh Mishra, Sanjay Kumar Sharma, Nakshathra Prabhu, Mangey Ram Nagar and Saulius Grigalevicius
Molecules 2025, 30(6), 1305; https://doi.org/10.3390/molecules30061305 - 14 Mar 2025
Viewed by 1048
Abstract
Photodynamic therapy (PDT) is an innovative and non-invasive approach to treating apparent tumours with minimal toxicity. PDT has a long-standing application in antitumor treatment utilizing various photosensitizers (PSs) for different tumours. Historically, light has served as a therapeutic tool in many diseases. PDT [...] Read more.
Photodynamic therapy (PDT) is an innovative and non-invasive approach to treating apparent tumours with minimal toxicity. PDT has a long-standing application in antitumor treatment utilizing various photosensitizers (PSs) for different tumours. Historically, light has served as a therapeutic tool in many diseases. PDT involves a dual treatment process in which light energy and PSs are combined to ablate tumour cells following light activation. In general, PDT exhibits reduced side effects and toxicity compared to chemotherapy and radiotherapy, as it spares the extracellular matrix, facilitating excellent tissue healing and minimizing scarring. In addition, PSs can serve in diagnostic roles in tumour identification, termed photodynamic diagnosis (PDD). Advancements in flexible light sources that produce uniform illumination could significantly enhance the consistency of light delivery. This review outlines the clinical applications of OLEDs in PDT for cancer, addressing both diagnostic and therapeutic methods. Furthermore, we will explore various tumour cases using PDT with OLEDs. In particular, antimicrobial PDT targets antibiotic-resistant strains in diabetic foot ulcers, while metronomic PDT promotes cancer cell apoptosis through prolonged, low-intensity light exposure. Our emphasis is on PDT employing organic light-emitting diodes (OLEDs). Furthermore, the combination of PDT with NIR-OLEDs is examined for its potential to enhance tumour-targeting effectiveness, possibly exceeding the results of standalone treatments. Full article
(This article belongs to the Topic Recent Advances in Anticancer Strategies, 2nd Edition)
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28 pages, 2851 KiB  
Review
Targeting c-MYC G-Quadruplexes for Cancer Treatment with Small Molecules
by Prasanth Thumpati, Sachchida Nand Rai, Chandrabhan Prajapati, Kakarla Ramakrishna and Santosh Kumar Singh
Sci. Pharm. 2025, 93(1), 6; https://doi.org/10.3390/scipharm93010006 - 22 Jan 2025
Cited by 4 | Viewed by 1590
Abstract
Novel therapies are required due to the rising cancer burden. Conventional chemotherapeutics tend to be particularly toxic, but there is a promising alternative for oncogenes, such as c-MYC. Often overexpressed in many cancer types, the potential c-MYC oncogene seems essential to the development [...] Read more.
Novel therapies are required due to the rising cancer burden. Conventional chemotherapeutics tend to be particularly toxic, but there is a promising alternative for oncogenes, such as c-MYC. Often overexpressed in many cancer types, the potential c-MYC oncogene seems essential to the development of cancer. Targeting c-MYC protein directly was limited, but these DNA structures composed of guanine-rich sequences suppress c-MYC transcription. This review discusses recent advances in developing small compounds that selectively bind to and stabilize c-MYC G-quadruplexes (G4). These molecules have also shown promise for the inhibition of c-MYC signaling and inhibition of tumor growth, suggesting that G-quadruplex targeting could be a promising therapeutic for cancer. Full article
(This article belongs to the Topic Recent Advances in Anticancer Strategies, 2nd Edition)
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