Gastric Cancer: New Trends in Endoscopic Diagnosis Staging and Treatment

A special issue of Diseases (ISSN 2079-9721). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: 1 March 2026 | Viewed by 743

Special Issue Editors


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Guest Editor
Gastroenterology and Endoscopy Unit, ASST Rhodense, 20024 Garbagnate Milanese, Italy
Interests: pancreatic diseases; pancreatic cancer; EUS-guided radiofrequency ablation and EUS-guided drainage new endoscopic devices to treat acute/delayed GI bleedings; gastric and colonic emr/esd
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Gastroenterology and Endoscopy Unit, ASST Rhodense, 20024 Garbagnate Milanese, Italy
Interests: hepato-biliary disease; gastric-colonic EMR/ESD; bowel preparation; therapeutic endoscopy

Special Issue Information

Dear Colleagues,

Diseases is launching a Special Issue entitled “Gastric Cancer: New Trends in Endoscopic Diagnosis Staging and Treatment”. Diseases is an international, peer-reviewed, open access, and multidisciplinary journal that focuses on the latest and most outstanding research on diseases and conditions, published quarterly online by MDPI. The first issue was released in 2013.

In 2024, 1.1 million individuals worldwide were diagnosed with gastric cancer and 770,000 died from it, making this neoplasia as the sixth-most common cancer and third-leading cause of cancer death.

Diagnoses of gastric cancer are made daily, and efforts to study the lesions and correctly stage and identify prognostic factors can affect therapy outcomes of patients and determine their chance of healing or survival.

Thus, the aim of this Special Issue is to collect original papers or reviews about the wide and interesting topic of the use of endoscopic in the proper diagnosis, staging and treatment of gastric cancer in its earlier or more advanced forms.

We look forward to receiving your contributions.

Kind regards

Dr. Germana de Nucci
Dr. Gianpiero Manes
Guest Editors

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Keywords

  • gastric cancer
  • endoscopy
  • diagnosis
  • treatment

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Published Papers (1 paper)

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Research

11 pages, 4970 KB  
Article
Pioneering Endoscopic Calcium-Electroporation in Gastric Cancer: A Case Series of an Emerging Therapeutic Approach
by Giuliano Francesco Bonura, Noemi Gualandi, Paola Soriani, Pablo Cortegoso Valdivia, Tommaso Gabbani, Valentina Zadro, Federica Indulti, Gabriella Frassanito, Germana de Nucci and Mauro Manno
Diseases 2025, 13(10), 340; https://doi.org/10.3390/diseases13100340 - 15 Oct 2025
Viewed by 517
Abstract
Background/Objectives: Gastric cancer often presents at advanced stages with complications such as iron-deficiency anemia (IDA) due to chronic bleeding, representing a significant global health burden. Palliative management of bleeding tumors in frail patients remains challenging. This study evaluates the feasibility, safety, and efficacy [...] Read more.
Background/Objectives: Gastric cancer often presents at advanced stages with complications such as iron-deficiency anemia (IDA) due to chronic bleeding, representing a significant global health burden. Palliative management of bleeding tumors in frail patients remains challenging. This study evaluates the feasibility, safety, and efficacy of endoscopic calcium-electroporation (Ca-EP), a novel non-thermal ablation technique, for controlling bleeding in end-stage gastric cancer. Methods: Retrospective case series including consecutive patients with end-stage, bleeding gastric cancer and IDA requiring transfusions. Ca-EP was performed using the EndoVE system, which delivers bipolar electrical pulses (250 kHz) to induce reversible electroporation, enabling calcium influx and tumor cell apoptosis. Primary endpoints were clinical success (hemoglobin stabilization/reduced transfusions) and safety. Secondary endpoints included tumor regression, procedural time, and hospital stay. Results: Five patients (median age 81 years) were included. Clinical success was achieved in 80% (4/5) of patients, with reduced transfusion needs and stable hemoglobin levels. One patient required adjunctive hemostatic radiotherapy. No major or minor adverse events were reported, and all patients were discharged within 24 h. Procedural median time was 38 min (range: 22–65). Endoscopic follow-up in three patients showed mild tumor regression or stability. Three patients required repeat Ca-EP sessions due to recurrent bleeding. Conclusions: Endoscopic Ca-EP is a safe, minimally invasive palliative option for bleeding gastric cancer, offering sustained hemostasis and potential antitumor effects without systemic toxicity. Its feasibility in frail patients underscores its clinical relevance, though larger prospective studies are needed to optimize parameters and validate long-term outcomes. Full article
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