Search Results (13,349)

Polymer–drug conjugates (PDCs) represent an advanced drug delivery strategy designed to address critical limitations of conventional therapeutics, including poor water solubility, rapid systemic clearance, and off-target toxicity. By covalently linking therapeutic agents to polymeric carriers through rationally designed linkers, PDCs enable improved pharmacokinetic profiles, enhanced stability, and controlled drug release. This review provides a comprehensive overview of the key design principles governing PDC systems, with a particular focus on the role of biofunctional polymers. Essential parameters for polymer selection, including biocompatibility, biodegradability, molecular weight, and functional group availability, are discussed in relation to their influence on drug loading, release kinetics, and biological performance. In addition, both natural and synthetic polymers are evaluated for their ability to improve solubility, modulate biodistribution, and reduce systemic toxicity. An overview of stimuli-responsive PDCs is provided, including pH-, redox-, and temperature-sensitive systems, which enable site-specific and spatiotemporally controlled drug release in response to pathological microenvironments. We emphasize the special role of bioactive polymers such as poly-lysine, hyaluronic acid, chitosan, and gelatin for their intrinsic biological activity, including receptor-mediated targeting, antimicrobial activity, and synergistic therapeutic effects. These properties support the development of dual-active conjugates with enhanced specificity and efficacy. Overall, this review underscores the transition of polymers from passive carriers to active therapeutic components and outlines current challenges and future perspectives for the clinical translation of next-generation PDCs. Full article

Magnesium phosphate cement (MPC) is a type of rapid-hardening inorganic cementitious material, which has important application value in rapid road repair, solidification of hazardous and radioactive waste, and other fields. However, it suffers from excessively fast setting and hardening and a short working time retention, which severely restrict its engineering application. Therefore, the development of high-efficiency set retarders is of great significance for optimizing MPC performance, enhancing its construction workability, and expanding its application scope. In this study, the effect of sodium polyacrylate (PAAS) on the setting and hardening of magnesium potassium phosphate cement (MKPC) was investigated by testing the setting time and fluidity at a low water-to-solid ratio (W/S = 0.18). Through pH and electrical conductivity measurements, combined with XRD, TG/DTG, and FTIR characterizations, we elucidated the retarding mechanism of PAAS on MKPC using a high water-to-solid ratio (W/S = 10). The results indicate that the setting time of MKPC is positively correlated with the PAAS dosage, whereas the fluidity and compressive strength exhibited a negative correlation with the PAAS dosage. Additionally, PAAS reduces the total heat release and the heat release rate of MKPC. The addition of PAAS increased the pH of the suspension, thereby reducing the solubility of MgO, but did not inhibit the dissolution of KH₂PO₄  The carboxylate groups in PAAS chemically reacted with Mg²⁺ on the surface of MgO to form magnesium carboxylate complexes (Mg-PAA), which remained as precipitates in the MKPC suspension system, thus reducing the amount of available Mg²⁺ participating in the hydration reaction. Furthermore, PAAS had no effect on the final precipitate composition at the end of hydration, which was composed of MgKPO₄·6H₂O  and Mg₃(PO₄)₂·22H₂O  in all cases. Full article

The beneficial use of mining waste aligns with circular economy thinking: saving primary resources can extend their lifetime and maintain availability, reduce the volume of legacy mining waste and its environmental impacts, and develop a resource beneficiation industry that is less energy and water intensive; mining lower grades at larger scale inevitably requires more beneficial reuse. Existing classifications applicable to different types of mine waste were reviewed. These include factors such as the mode of origin during the mining operation, grain size, chemical composition and stability. The result shows that these factors also largely control their civil engineering applications, suitability for end use sectors and potential hazards. Long-term liabilities related to chemical stability were identified as the most difficult challenge. When developing a reuse project, either by the end users or by the mine operator, it is likely that resource screening covering a comprehensive range of factors will be required, as none of the existing schemes individually cover all of the aspects needed to fully assess suitability for beneficial use. In conclusion, there is a need for a systematic and structured approach to classification of mining waste to facilitate reuse as raw materials, such as that presented in our review. Full article

The adoption of photovoltaic (PV) energy in irrigation is rapidly increasing, supported by a range of available technologies. However, an agronomic perspective that could help overcome inherent limitations of PV systems remains absent. In fact, current irrigation design methods do not explicitly take into account the dynamic nature of PV power generation. While irrigation engineering conceptualises soil as a reservoir for plant-available water, it can also function as an energy reservoir, storing solar-derived energy in the form of soil moisture for subsequent crop use. Building on this concept, this study proposes an integrated framework for designing off-grid PV irrigation systems based on asymmetric irrigation sectors. The framework couples hydrological, agronomic, and energy components to synchronise solar energy generation with crop water requirements, thereby eliminating the need for intermediate energy storage. The methodology was applied to two case studies: a hedgerow olive orchard and an almond orchard in southern Portugal, both with drip irrigation. Results demonstrate that the asymmetric-sector design provides a technically feasible and low-complexity solution for integrating photovoltaic energy into irrigation systems. The conventional irrigation system required 1.42 kW of minimum pumping power for olive orchards and 1.32 kW for almond orchards. The dimensions of the main lines ranged from 97.8 mm for olive and 75 mm for almond orchards, while the flow rate of the emitter was 2.3 L h⁻¹ for olive and 3 L h⁻¹ for almond orchards. Although PV-compatible operation required hydraulic adjustments including increases in design flow rate (226–255%), pump power demand (87.5–241%), and pipe diameters (up to 120% in olive and 75% in almond), these adaptations enable irrigation systems to operate under the variability inherent to solar-based energy supply. This hydraulic oversizing leads to higher initial investment costs; however, this can be mitigated to a certain extent by diminished operating costs and complete energy autonomy from the electricity grid. Full article

Karst ecosystems play an important hydrological role in regulating regional water availability and supporting biodiversity, yet they face increasing threats from deforestation, land-use conversion, and limited scientific data to inform sustainable conservation efforts. This study aims to assess karst geodiversity, aquatic habitat diversity, and freshwater endemism in the Maybrat Karst, and to explain the linkages among these three aspects as a scientific basis for regional karst conservation. The research employed geospatial analysis and descriptive ecological analysis. Data were collected through satellite image interpretation, participatory mapping, field observations, and a comprehensive literature review. Results show that the Maybrat Karst has very high geodiversity, with ±2322.91 km² (41.49%) of the region classified as karst. All seven karst elements were identified, including 40–56 hills/km², 110 water-filled dolines, 334 springs, 178 subterranean rivers, 90 caves, and three major karst lakes. Aquatic habitat diversity is likewise very high, comprising seven habitat types across the full 100–500 m elevational range, accompanied by 17 Cherax morphotypes, indicating strong environmental differentiation. The literature review identified 18 endemic freshwater species, consisting of five Cherax species, ten rainbowfish species of the genus Melanotaenia, and three additional taxa: Pseudomugil reticulatus, Glossogobius hoesei, and Zenarchopterus ornithocephala. These findings confirm that high karst geodiversity and habitat heterogeneity make the Maybrat Karst a key aquatic endemism center, highlighting the urgent national and global imperative for comprehensive karst protection to safeguard long-term biodiversity and ecosystem sustainability. Full article

Background/Objectives: Rezum therapy is a novel, minimally invasive way of treating benign prostatic hyperplasia (BPH) that involves the injection of heated water vapour into the prostate. It was approved by NICE in 2018 and is now available in select centres across the UK. It has been shown to have significant advantages over standard BPH therapies: it can be done under local anaesthetic, making it an option for those unsuitable for general anaesthetic, it is suitable for treating patients who want to maintain ejaculation, and it is cost-effective. It has been recommended as a treatment for smaller prostates (<80cc) and in cases where patients are keen to preserve ejaculatory function. Our unit performs this procedure under local anaesthetic (LA) with a transperineal ultrasound-guided peri-prostatic block and urethral lidocaine gel in the clinic. We aimed to analyse the patients undergoing Rezum in our institution to establish its tolerability under local anaesthetic, its effectiveness and its complication rate. Methods: We analysed all patients who underwent Rezum prostate steam ablation in our institution between May 2023 and September 2025. From individual patient notes, we collected data on patient demographics, prostate size and shape, pre- and post-op IPSS and Qmax, and post-void residual. Patient-reported outcomes such as pain during the procedure and satisfaction of the procedure were also collected and analysed as well as complication rates. Results: The data of 82 patients undergoing LA Rezum in the above time period were collected and analysed. They had a mean prostate size of 53cc (minimum 21cc and maximum of 100cc). The results showed significant improvement in voiding parameters, with Qmax improving by 40.1% (p < 0.05) and PVR by 40.8% (p < 0.05). Patients similarly reported improved symptoms, with IPSS improving by 54.7% (p < 0.05) and QOL scores by 54.1% (p < 0.05). The procedure had a high degree of satisfaction, with 36 of the 49 patients who completed the post-procedure questionnaire recording an overall satisfaction of 9 or 10 out of 10. The mean intraoperative visual analogue (VAS) pain score was 3.5. Conclusions: Rezum is a minimally invasive procedure that has been seen to produce significant and reliable improvements in patients’ lower urinary tract symptoms and voiding dynamics. It has a low complication rate, is tolerated well and is readily performed under local anaesthetic in the ambulatory setting. Full article

The FAO Irrigation and Drainage Paper 56, which was first published in 1998, has been widely recognized as a comprehensive guidebook for estimating crop evapotranspiration and calculating crop water requirements under various conditions, supporting the efficient management of water resources in agriculture. Over the past twenty-eight years, science and technology have significantly evolved in agricultural productivity and water resource mobilization, use, and management, as well as in research advances, data availability and management, and modeling capabilities and uses. However, these improvements have come against a backdrop of increasingly pressing challenges, especially those posed by climate change and water scarcity. Thus, considering all recent advances in knowledge, an updated version (FAO56 Rev.1) of that guidebook was recently released. The current article summarizes and highlights the main features and innovations that the revision has incorporated. Full article

This study evaluated eleven resin cements used as core build-up materials by examining the following properties: (a) push-out force between root dentin and the fiber post; (b) pull-out force between the fiber post and the core build-up material; (c) shear bond strength of the resin cement to root dentin; (d) flexural strength of the resin cement; and (e) flexural modulus of elasticity of the resin cement. The purpose of this investigation was to clarify the relationships between recently available universal adhesives, core build-up materials, resin cements, and fiber posts. All experiments were performed at two evaluation periods: after 1 day of water storage (Base) and after 20,000 thermocycles (TC 20k). For the push-out test, simulated post spaces were prepared in single-rooted human premolars. The specimens were sectioned perpendicular to the long axis into 2 mm-thick slices and then subjected to push-out testing to assess the bond strength of the dentin–resin cement–fiber post complex. No significant differences in bonding performance were found between Base and TC 20k. These findings suggest that universal adhesives used for pretreatment of multiple substrates in fiber post cementation can provide not only strong but also durable adhesion over time. Full article

Groundwater in the coastal industrial cities of the Guangdong–Hong Kong–Macao Greater Bay Area faces rising pressure from saline–tidal intrusion, multi-source contamination, and intensive abstraction. Effective management therefore requires an integrated view of water quality and resource availability. A total of 369 groundwater samples were collected from Quaternary porous and fractured bedrock aquifers during the wet and dry seasons. Major ions and key pollutants were analyzed, and overall quality was assessed using the improved Nemerow pollution index. A 3D transient FEFLOW model calibrated for 2022–2024 was combined with Nemerow quality classes to quantify season-specific exploitable resources by grade. The results indicate that NO₃⁻, Mn, and NO₃–N are the dominant pollutants (0–202.05 mg/L, 0.001–8.91 mg/L, and 0–108 mg/L, respectively). Nemerow grading shows Class IV prevailing (47.4–54.5%), with higher Class V proportions in fractured groundwater (27.3–34.5%) than in porous groundwater (14.0–15.5%); overall quality deteriorates in the dry season. Annual mean sustainable exploitable resources are 2.72 × 10⁸ m³/a (porous aquifers) and 1.25 × 10⁸ m³/a (fractured aquifers). These results provide a quantitative basis for season- and quality-informed groundwater development and protection in coastal industrial cities. Full article

Chieng Hac in northern Vietnam is expanding maize cultivation, intensifying water competition and soil erosion. This study mapped regional water balance and erosion using remote sensing and GISs by coupling the Thornthwaite–Mather (TM) water balance model with the Revised Universal Soil Loss Equation (RUSLE) at 12.5 m resolution. Land cover was classified into maize, tree crops, paddy, forest, and other types using Random Forest. The TM model used 2021 precipitation and temperature measurements to estimate evapotranspiration, surplus, and deficit, while the RUSLE quantified soil loss. Two scenarios were evaluated: a baseline reflecting existing land use and an adjusted case applying strip cropping on 10–20° maize slopes and converting maize to tree crops on slopes > 20°. Tree crop conversion increased evapotranspiration and prolonged seasonal deficits relative to maize, increasing water deficit from 1013.6 to 1022.2 mm/year. In contrast, the interventions reduced mean soil loss from 15.52 to 11.51 t/ha/year, with the largest decline in the 5–25 t/ha/year class. Residual hotspots persisted on steep slopes and near drainage lines. The integrated framework highlights trade-offs between erosion control and seasonal water availability, supporting slope-based land-use planning in upland agricultural systems. These findings offer guidance for slope-based land-use planning by indicating that intervention priorities should vary depending on slope conditions and local water availability. Full article

Phytoecdysteroids have garnered increasing interest due to their broad biological and pharmacological properties. The present study reports on the development and validation of a reliable liquid chromatography–mass spectrometry method for the detection and quantification of 20-hydroxyecdysone, turkesterone, and ponasterone. The optimized procedure improved ionization efficiency and chromatographic resolution through gradient elution using 0.1% formic acid in water and acetonitrile. Data acquisition in selective ion monitoring modes ensured high analytical precision, reproducibility, and sensitivity. The method demonstrated excellent linearity, accuracy, repeatability, and low detection limits, making it suitable for routine phytochemical and quality control applications. Application of the method to extracts from nutrient-rich superfoods, including kaniwa, spinach, quinoa, and asparagus, confirmed these plants as natural sources of phytoecdysteroids. Additionally, thirteen commercially available dietary supplements labeled as containing extracts of Rhaponticum carthamoides, Cyanotis arachnoidea, Ajuga turkestanica, or ecdysteroids were analyzed. Several products standardized to 80–95% ecdysterone contained substantially lower amounts than declared, with measured 20-hydroxyecdysone levels ranging from below the limit of detection to approximately 50 mg per capsule, whereas some non-standardized products exhibited moderate to high levels, reaching up to approximately 105 mg per capsule. Variability in turkesterone content was also observed among products marketed as standardized extracts. The method provides a simple, reliable, and accessible approach for the quantitative analysis of major phytoecdysteroids in complex plant matrices and dietary supplements. Its implementation may support phytochemical research, routine quality control, and anti-doping monitoring of ecdysteroid-containing products. Full article

Lettuce (Lactuca sativa L.) is a leafy herb that contains many useful nutrients, allowing it to easily overcome the threats to food security in countries of the Global South by adding fiber/bulk, folate and other available nutrients. In 2020, almost 220 metric tons of lettuce was produced in Pakistan. This high production needs attention to meet the demand. Southern Pakistan is facing water crises and the hydroponic system is one revolutionary technique which can allow the region to meet its food demand. In this experiment, different treatment combinations were used to study their effects and evaluate the best combination of nutrients to get the maximum production of lettuce. Results are concluded on the basis of last-week (5th week) production of shoot and root mass. Treatment one (T1) performed outstanding overall out of all four treatments across all parameters. Maximum average root and shoot length (RL, SL) was observed in treatment one (T1) at 5.94 cm and 15.50 cm respectively. Shoot length is directly proportional to production of the head of the plant. For root and shoot weight (RW, SW) treatment 1 (T1) is more effective than treatment 2 (T2). For treatment 1, root weight (RW) was recorded at 0.09 g and shoot weight (SW) was 0.22 g. The hydroponic system demands huge capital investment, which can be compensated by high production of crops. To increase the efficiency of the system, there is a dire need to calculate optimum nutrient combinations for application to the crop for a sound food security plan. Full article

The widespread utilization of synthetic dyes within the textile industry, driven by their chemical recalcitrance and diverse chromatic spectra, constitutes a significant global environmental challenge. Improper discharge of these highly stable effluents into natural water bodies leads to severe ecological imbalances, affecting aquatic life and soil integrity while posing indirect risks to human health due to their mutagenic potential. Conventional physicochemical treatment methods are often hindered by prohibitive operational costs and the frequent generation of hazardous secondary pollutants. Consequently, there is an urgent demand for sustainable biotechnological alternatives to mitigate these industrial impacts. Bioremediation, specifically using white-rot fungi, represents a robust and eco-friendly strategy for the degradation of complex aromatic structures. Species such as Trametes versicolor, Pleurotus ostreatus, and Phanerochaete chrysosporium utilize a specialized extracellular enzymatic complex to mineralize toxic compounds effectively. Here we review the ligninolytic capacity of white-rot fungi and their specialized enzymatic systems for environmental sustainability. The primary points are: (i) the biochemical mechanisms of the ligninolytic system of laccases and peroxidases during dye degradation; (ii) the influence of operational parameters such as pH, temperature, and nutrient availability on fungal metabolic efficiency; (iii) the diverse environmental applications of these microorganisms in treating real textile effluents; (iv) the current biotechnological challenges, including maintaining enzymatic stability in non-sterile industrial environments; and (v) the future perspectives for scaling up fungal treatment systems from laboratory research to large-scale industrial implementation. Full article

Water availability represents a major limiting factor for crop production, particularly in Mediterranean agroecosystems. In parallel, water-stressed plants are often more susceptible to diseases, including Grapevine Trunk Diseases (GTDs), such as Botryosphaeria Dieback caused by Botryosphaeriaceae species. In Italy, the increasing prevalence of GTDs in young table grape plants and nursery material highlights the need to better understand the interaction between abiotic stress and pathogen dissemination in woody tissues. This study investigated the relationship between different water regimes (WRs) and infections by Neofusicoccum parvum. Grapevine cuttings (Vitis vinifera ‘Italia’ vines grafted onto the rootstock ‘140 Ruggeri’) were subjected to three WRs (20%, 50%, and 100% of crop evapotranspiration, ET_c) under controlled environmental conditions and, subsequently, inoculated with mycelial plugs of N. parvum at both the scion and rootstock levels. Plant responses were monitored non-destructively using low-cost proximal sensing tools, including leaf temperature (T_leaf) and the Normalized Difference Vegetation Index (NDVI). Disease development was assessed by measuring internal necrotic lesion extension. Reduced irrigation was associated with increased disease severity, while proximal sensing detected differences in plant physiological responses among water regimes. Overall, the results highlight the interplay between water availability, plant physiological status, and disease severity under controlled conditions. Full article

Risk-based management of water quality in drinking water supply systems requires decision-support tools that extend beyond parameter-level hazard assessment and enable prioritization at the level of physical system objects. In this context, hazard assessment refers specifically to drinking water quality parameters and their possible operational and health-related implications, particularly in facilities serving sensitive user groups. This study proposes a class-based extension of the FPOR (Fuzzy Priority of Objects at Risk) framework to support object-level operational prioritization under conditions of limited data availability. Hazard importance is adopted from prior hazard prioritization using the Fuzzy Priority Index (FPI), while priority premises (PP) are represented as object classes reflecting typical functional and operational characteristics. Class-based profiles of local hazard relevance and object vulnerability are defined using expert-informed fuzzy representations and aggregated into FPOR scores to produce a relative ranking of priority premises classes. The results demonstrate how hazard prioritization can be systematically propagated to object-level decision units without reliance on site-specific monitoring data. The proposed framework provides a transparent and scalable basis for early-stage risk-based planning and supports the operational implementation of object-oriented management strategies in drinking water systems, while maintaining a clear conceptual separation from health risk assessment addressed in subsequent studies. Full article