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6 Results Found

  • Article
  • Open Access
4 Citations
1,656 Views
11 Pages

Uveoscleral Outflow Routes after MicroPulse Laser Therapy for Refractory Glaucoma: An Optical Coherence Tomography Study of the Sclera

  • Luca Agnifili,
  • Andrea Palamini,
  • Lorenza Brescia,
  • Annamaria Porreca,
  • Francesco Oddone,
  • Lucia Tanga,
  • Maria Ludovica Ruggeri,
  • Alberto Quarta,
  • Rodolfo Mastropasqua and
  • Marta Di Nicola
  • + 1 author

To analyze in vivo scleral changes induced by MicroPulse transscleral laser therapy (MP-TLT) in refractory glaucoma using anterior segment–optical coherence tomography (AS-OCT). Forty-two candidate patients for MP-TLT were consecutively enrolle...

  • Article
  • Open Access
6 Citations
2,813 Views
10 Pages

27 September 2022

Intraocular pressure (IOP) is regulated primarily through aqueous humor production by ciliary body and drainage through uveoscleral and trabecular meshwork (TM) tissues. The goal of this study was to measure the effect of non-psychotropic cannabidiol...

  • Review
  • Open Access
16 Citations
7,375 Views
14 Pages

Glaucoma is a chronic neurodegenerative disease that poses a significant threat of irreversible blindness worldwide. Current treatments for glaucoma focus on reducing intraocular pressure (IOP), which is the only modifiable risk factor. Traditional a...

  • Review
  • Open Access
9 Citations
3,638 Views
10 Pages

26 July 2022

Latanoprostene bunod (LBN) 0.024%, a newly approved glaucoma eye drop, is metabolized into latanoprost acid and a nitric oxide (NO)-donating moiety, thus increasing the outflow of aqueous humor through the uveoscleral and trabecular routes, respectiv...

  • Review
  • Open Access
3 Citations
2,767 Views
15 Pages

21 April 2023

For decades, trabeculectomy (TE) was considered the gold standard for surgical treatment of open-angle glaucoma owing to its powerful intraocular pressure (IOP)-lowering potency. However, owing to the invasive nature and high-risk profile of TE, this...

  • Article
  • Open Access
26 Citations
4,818 Views
17 Pages

Targeted Lipidomic Analysis of Aqueous Humor Reveals Signaling Lipid-Mediated Pathways in Primary Open-Angle Glaucoma

  • Nadezhda V. Azbukina,
  • Dmitry V. Chistyakov,
  • Sergei V. Goriainov,
  • Vladislav I. Kotelin,
  • Elena V. Fedoseeva,
  • Sergey Yu. Petrov,
  • Marina G. Sergeeva,
  • Elena N. Iomdina and
  • Evgeni Yu. Zernii

13 July 2021

Primary open-angle glaucoma (POAG) is characterized by degeneration of retinal ganglion cells associated with an increase in intraocular pressure (IOP) due to hindered aqueous humor (AH) drainage through the trabecular meshwork and uveoscleral pathwa...