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Search Results (1,746)

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35 pages, 8516 KiB  
Article
Study on Stress Monitoring and Risk Early Warning of Flexible Mattress Deployment in Deep-Water Sharp Bend Reaches
by Chu Zhang, Ping Li, Zebang Cui, Kai Wu, Tianyu Chen, Zhenjia Tian, Jianxin Hao and Sudong Xu
Water 2025, 17(15), 2333; https://doi.org/10.3390/w17152333 - 6 Aug 2025
Abstract
This study addresses the complex challenges associated with flexible mattress (soft mattress) installation in the sharply curved and deep-water sections of the Yangtze River, particularly in the Yaozui revetment reconstruction project. Under extreme hydrodynamic conditions—water depths exceeding 30 m and velocities over 2.5 [...] Read more.
This study addresses the complex challenges associated with flexible mattress (soft mattress) installation in the sharply curved and deep-water sections of the Yangtze River, particularly in the Yaozui revetment reconstruction project. Under extreme hydrodynamic conditions—water depths exceeding 30 m and velocities over 2.5 m/s—the risk of structural failures such as displacement, flipping, or tearing of the mattress becomes significant. To improve construction safety and stability, the study integrates numerical modeling and on-site strain monitoring to analyze the mechanical response of flexible mattresses during deployment. A three-dimensional finite element model based on the catenary theory was developed to simulate stress distributions under varying flow velocities and angles, revealing stress concentrations at the mattress’s upper edge and reinforcement junctions. Concurrently, a real-time monitoring system using high-precision strain sensors was deployed on critical shipboard components, with collected data analyzed through a remote IoT platform. The results demonstrate strong correlations between mattress strain, flow velocity, and water depth, enabling the identification of high-risk operational thresholds. The proposed monitoring and early-warning framework offers a practical solution for managing construction risks in extreme riverine environments and contributes to the advancement of intelligent construction management for underwater revetment works. Full article
(This article belongs to the Section Oceans and Coastal Zones)
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15 pages, 5909 KiB  
Article
Test–Retest Reliability of Task-Oriented Strength and Object Position in a Box Lifting Task Using the Activities of Daily Living Test and Training Device (ADL-TTD) in Children with Unilateral Spastic Cerebral Palsy
by Haowei Guo, Inge Heus, Bart Snijders, Nanne E. Land, Menno van der Holst, Rob. J. E. M. Smeets, Caroline H. G. Bastiaenen and Eugene A. A. Rameckers
Children 2025, 12(8), 1030; https://doi.org/10.3390/children12081030 - 5 Aug 2025
Abstract
Purpose: This study investigates the test–retest reliability of maximal voluntary contraction (MVC) and integrated object positioning during bimanual box lifting tasks in children with unilateral spastic cerebral palsy (USCP), using the Activities of Daily Living Test and Training Device (ADL-TTD). Materials and [...] Read more.
Purpose: This study investigates the test–retest reliability of maximal voluntary contraction (MVC) and integrated object positioning during bimanual box lifting tasks in children with unilateral spastic cerebral palsy (USCP), using the Activities of Daily Living Test and Training Device (ADL-TTD). Materials and Methods: Utilizing an explorative cross-sectional design, the study recruited 47 children with USCP. The ADL-TTD, equipped with an Inertial Measurement Unit (IMU) for precise object positioning, measured MVC, and object position in 3D space in a cross-sectional measurement containing two measurements in a fixed time period. Results: The findings demonstrated good test–retest reliability for MVC, with an ICCagreement of 0.95 for the mean MVC value. Additionally, good reliability was observed for object positioning in different directions measured with an IMU, with ICCagreement ranging from 0.82 to 0.86 degrees. Regarding the standard error of measurement (SEM), the SEMagreement for the mean MVC value was 5.94 kg, while the SEMagreement for object positioning was 1.48, 5.39, and 3.43 degrees, respectively. Conclusions: These results indicate that the ADL-TTD demonstrates good test–retest reliability for both MVC and object positioning, making it a valuable tool for analyzing this population in cross-sectional research by providing reliable measures of task-oriented strength and object manipulation. However, the relatively high SEMagreement, particularly in MVC, suggests that caution is needed when using this tool for repeated testing over time. This pioneering approach could significantly contribute to tailored assessment and training for children with USCP, highlighting the importance of integrating task-specific strength and positional accuracy into therapeutic interventions. Full article
(This article belongs to the Section Pediatric Orthopedics & Sports Medicine)
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17 pages, 2219 KiB  
Article
Assessing Lithium-Ion Battery Safety Under Extreme Transport Conditions: A Comparative Study of Measured and Standardised Parameters
by Yihan Pan, Xingliang Liu, Jinzhong Wu, Haocheng Zhou and Lina Zhu
Energies 2025, 18(15), 4144; https://doi.org/10.3390/en18154144 - 5 Aug 2025
Abstract
The safety of lithium-ion batteries during transportation is critically important. However, current standards exhibit limitations, as their environmental testing parameter thresholds fail to fully encompass actual transportation conditions. To enhance both safety and standard applicability, in this study, we focused on four representative [...] Read more.
The safety of lithium-ion batteries during transportation is critically important. However, current standards exhibit limitations, as their environmental testing parameter thresholds fail to fully encompass actual transportation conditions. To enhance both safety and standard applicability, in this study, we focused on four representative environmental conditions: temperature, vibration, shock, and low atmospheric pressure. Field measurements were conducted across road, rail, and air transport modes using a self-developed data acquisition system based on the NearLink communication technology. The measured data were then compared with the threshold values defined in current international and national standards. The results reveal that certain measured values exceeded the upper limits prescribed by existing standards, indicating limitations in their applicability under extreme transport conditions. Based on these findings, we propose revised testing parameters that better reflect actual transport risks, including a temperature cycling range of 72 ± 2 °C (high) and −40 ± 2 °C (low), a shock acceleration limit of 50 gn, adjusted peak frequencies in the vibration PSD profile, and a minimum pressure threshold of 11.6 kPa. These results provide a scientific basis for optimising safety standards and improving the safety of lithium-ion battery transportation. Full article
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36 pages, 5151 KiB  
Article
Flexibility Resource Planning and Stability Optimization Methods for Power Systems with High Penetration of Renewable Energy
by Haiteng Han, Xiangchen Jiang, Yang Cao, Xuanyao Luo, Sheng Liu and Bei Yang
Energies 2025, 18(15), 4139; https://doi.org/10.3390/en18154139 - 4 Aug 2025
Abstract
With the accelerating global transition toward sustainable energy systems, power grids with a high share of renewable energy face increasing challenges due to volatility and uncertainty, necessitating advanced flexibility resource planning and stability optimization strategies. This paper presents a comprehensive distribution network planning [...] Read more.
With the accelerating global transition toward sustainable energy systems, power grids with a high share of renewable energy face increasing challenges due to volatility and uncertainty, necessitating advanced flexibility resource planning and stability optimization strategies. This paper presents a comprehensive distribution network planning framework that coordinates and integrates multiple types of flexibility resources through joint optimization and network reconfiguration to enhance system adaptability and operational resilience. A novel virtual network coupling modeling approach is proposed to address topological constraints during network reconfiguration, ensuring radial operation while allowing rapid topology adjustments to isolate faults and restore power supply. Furthermore, to mitigate the uncertainty and fault risks associated with extreme weather events, a CVaR-based risk quantification framework is incorporated into a bi-level optimization model, effectively balancing investment costs and operational risks under uncertainty. In this model, the upper-level planning stage optimizes the siting and sizing of flexibility resources, while the lower-level operational stage coordinates real-time dispatch strategies through demand response, energy storage operation, and dynamic network reconfiguration. Finally, a hybrid SA-PSO algorithm combined with conic programming is employed to enhance computational efficiency while ensuring high solution quality for practical system scales. Case study analyses demonstrate that, compared to single-resource configurations, the proposed coordinated planning of multiple flexibility resources can significantly reduce the total system cost and markedly improve system resilience under fault conditions. Full article
(This article belongs to the Special Issue Analysis and Control of Power System Stability)
11 pages, 258 KiB  
Article
Occupational and Nonoccupational Chainsaw Injuries in the United States: 2018–2022
by Judd H. Michael and Serap Gorucu
Safety 2025, 11(3), 75; https://doi.org/10.3390/safety11030075 - 4 Aug 2025
Abstract
Chainsaws are widely used in various occupational settings, including forestry, landscaping, farming, and by homeowners for tasks like tree felling, brush clearing, and firewood cutting. However, the use of chainsaws poses significant risks to operators and bystanders. This research quantified and compared occupational [...] Read more.
Chainsaws are widely used in various occupational settings, including forestry, landscaping, farming, and by homeowners for tasks like tree felling, brush clearing, and firewood cutting. However, the use of chainsaws poses significant risks to operators and bystanders. This research quantified and compared occupational and nonoccupational injuries caused by contact with chainsaws and related objects during the period from 2018 to 2022. The emergency department and OSHA (Occupational Safety and Health Administration) data were used to characterize the cause and nature of the injuries. Results suggest that for this five-year period an estimated 127,944 people were treated in U.S. emergency departments for chainsaw-related injuries. More than 200 non-fatal and 57 fatal occupational chainsaw-involved injuries were found during the same period. Landscaping and forestry were the two industries where most of the occupational victims were employed. Upper and lower extremities were the most likely injured body parts, with open wounds from cuts being the most common injury type. The majority of fatal injuries were caused by falling objects such as trees and tree limbs while using a chainsaw. Our suggestions to reduce injuries include proper training and wearing personal protective equipment, as well as making sure any bystanders are kept in a safety zone away from trees being cut. Full article
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13 pages, 551 KiB  
Article
Classifying Patient Characteristics and Determining a Predictor in Acute Stroke Patients: Application of Latent Class Analysis in Rehabilitation Practice
by Junya Uchida, Moeka Yamada, Hirofumi Nagayama, Kounosuke Tomori, Kohei Ikeda and Keita Yamauchi
J. Clin. Med. 2025, 14(15), 5466; https://doi.org/10.3390/jcm14155466 - 4 Aug 2025
Viewed by 86
Abstract
Background/Objectives: Predicting comprehensive patient characteristics is essential for optimal individualized rehabilitation plans for acute stroke patients. However, current models primarily predict single outcomes. This study aimed to assess the applicability of latent class analysis (LCA) in rehabilitation practice by identifying comprehensive characteristics [...] Read more.
Background/Objectives: Predicting comprehensive patient characteristics is essential for optimal individualized rehabilitation plans for acute stroke patients. However, current models primarily predict single outcomes. This study aimed to assess the applicability of latent class analysis (LCA) in rehabilitation practice by identifying comprehensive characteristics and associated predictors in acute stroke patients. Methods: We conducted a retrospective observational study using the Japan Association of Rehabilitation Database, including 10,270 stroke patients admitted to 37 acute-care hospitals between January 2005 and March 2016. Patients were classified using LCA based on outcomes at discharge, including Functional Independence Measure (FIM), National Institutes of Health Stroke Scale (NIHSS) subscales for upper-extremity function, length of hospitalization, and discharge destination. Predictor variables at admission included age, FIM scores, NIHSS subscales for upper-extremity function, stroke type, and daily rehabilitation volume. Results: 6881 patients were classified into nine distinct classes (class size: 4–29%). Class 1, representing the mildest cases, was noted for independent ambulation and good upper limb function. Class 2 comprised those with the most severe clinical outcome. Other classes exhibited a gradient of severity, commonly encountered in clinical practice. For instance, Class 7 included right-sided paralysis with preserved motor activities of daily living (ADLs) and modified dependence in cognitive functions, such as communication. All predictors at admission were significantly associated with class membership at discharge (p < 0.001). Conclusions: LCA effectively identified unique clinical subgroups among acute stroke patients and demonstrated that key admission variables could predict class membership. This approach offers a promising insight into targeted, personalized rehabilitation practice for acute stroke patients. Full article
(This article belongs to the Section Clinical Rehabilitation)
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25 pages, 3590 KiB  
Article
Effectiveness of Firefighter Training for Indoor Intervention: Analysis of Temperature Profiles and Extinguishing Effectiveness
by Jan Hora
Fire 2025, 8(8), 304; https://doi.org/10.3390/fire8080304 - 1 Aug 2025
Viewed by 194
Abstract
This study assessed the effectiveness of stress-based cognitive-behavioral training compared to standard training in firefighters, emphasizing their ability to distribute extinguishing water and cool environments evenly during enclosure fires. Experiments took place at the Zbiroh training facility with two firefighter teams (Team A [...] Read more.
This study assessed the effectiveness of stress-based cognitive-behavioral training compared to standard training in firefighters, emphasizing their ability to distribute extinguishing water and cool environments evenly during enclosure fires. Experiments took place at the Zbiroh training facility with two firefighter teams (Team A with stress-based training and Team B with standard training) under realistic conditions. Using 58 thermocouples and 4 radiometers, temperature distribution and radiant heat flux were measured to evaluate water distribution efficiency and cooling performance during interventions. Team A consistently achieved temperature reductions of approximately 320 °C in the upper layers and 250–400 °C in the middle layers, maintaining stable conditions, whereas Team B only achieved partial cooling, with upper-layer temperatures remaining at 750–800 °C. Additionally, Team A recorded lower radiant heat flux densities (e.g., 20.74 kW/m2 at 0°) compared to Team B (21.81 kW/m2), indicating more effective water application and adaptability. The findings confirm that stress-based training enhances firefighters’ operational readiness and their ability to distribute water effectively during interventions. This skill is essential for safer and effective management of indoor fires under extreme conditions. This study supports the inclusion of stress-based and scenario-based training in firefighter education to enhance safety and operational performance. Full article
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20 pages, 562 KiB  
Article
Effectiveness of a Post-Acute-Care Rehabilitation Program in Patients with Stroke: A Retrospective Cohort Study
by Yi-Pang Lo, Mei-Chen Wang, Yao-Hsiang Chen, Shang-Lin Chiang and Chia-Huei Lin
Life 2025, 15(8), 1216; https://doi.org/10.3390/life15081216 - 1 Aug 2025
Viewed by 513
Abstract
Early rehabilitation is essential for restoring functional recovery in patients with stroke, particularly during the early phase of post-acute care (PAC), or the subacute stage. We aimed to evaluate the effectiveness of a 7-week PAC rehabilitation program in improving muscle strength, physical performance, [...] Read more.
Early rehabilitation is essential for restoring functional recovery in patients with stroke, particularly during the early phase of post-acute care (PAC), or the subacute stage. We aimed to evaluate the effectiveness of a 7-week PAC rehabilitation program in improving muscle strength, physical performance, and functional recovery. A total of 219 inpatients with stroke in the subacute stage were initially recruited from the PAC ward of a regional teaching hospital in Northern Taiwan, with 79 eligible patients—within 1 month of an acute stroke—included in the analysis. The program was delivered 5 days per week, with 3–4 sessions daily (20–30 min each, up to 120 min daily), comprising physical, occupational, and speech–language therapies. Sociodemographic data, muscle strength, physical performance (Berg Balance Scale [BBS], gait speed, and 6-minute walk test [6MWT]), and functional recovery (modified Rankin Scale [mRS], Barthel Index [BI], Instrumental Activities of Daily Living [IADL], and Fugl–Meyer assessment: sensory and upper extremity) were collected at baseline, 3 weeks, and 7 weeks. Generalized estimating equations analyzed program effectiveness. Among the 56 patients (70.9%) who completed the program, significant improvements were observed in the muscle strength of both the affected upper (B = 0.93, p < 0.001) and lower limbs (B = 0.88, p < 0.001), as well as in their corresponding unaffected limbs; in physical performance, including balance (BBS score: B = 9.70, p = 0.003) and gait speed (B = 0.23, p = 0.024); and in functional recovery, including BI (B = 19.5, p < 0.001), IADL (B = 1.48, p < 0.001), and mRS (B = −0.13, p = 0.028). These findings highlight the 7-week PAC rehabilitation program as an effective strategy during the critical recovery phase for patients with stroke. Full article
(This article belongs to the Special Issue Advances in the Rehabilitation of Stroke)
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19 pages, 1913 KiB  
Systematic Review
Innovative but Difficult to Replicate: A Systematic Review of the Reporting Quality of Robotic and Conventional Upper-Limb Interventions in Stroke Rehabilitation Randomized Controlled Trials Using the TIDieR-Rehab Checklist
by Emeline Gomes, Gemma Alder, Kate Boardsworth, Kate L. Anderson, Sharon Olsen and Nada Signal
Appl. Sci. 2025, 15(15), 8487; https://doi.org/10.3390/app15158487 (registering DOI) - 31 Jul 2025
Viewed by 245
Abstract
Background: Upper-limb impairment is a major cause of post-stroke disability, limiting participation in meaningful activities. Robotic rehabilitation may address this by delivering high-dosage, task-oriented training while reducing clinician workload. However, limited clinical translation of robotic interventions may be partly due to poor reporting [...] Read more.
Background: Upper-limb impairment is a major cause of post-stroke disability, limiting participation in meaningful activities. Robotic rehabilitation may address this by delivering high-dosage, task-oriented training while reducing clinician workload. However, limited clinical translation of robotic interventions may be partly due to poor reporting in the literature. This systematic review evaluated the intervention-reporting quality (completeness and consistency) of randomized controlled trials (RCTs) comparing robotic and conventional upper-limb stroke rehabilitation. Methods: Four databases were searched for RCTs investigating robotic upper-limb interventions compared with dose-matched conventional interventions for people with stroke. Intervention reporting was assessed using the TIDieR-Rehab checklist. Trained reviewers independently extracted and evaluated data, resolving discrepancies through consensus. Completeness and consistency were analyzed descriptively. Results: Among 25 RCTs, the overall reporting completeness was low (43%). Robotic interventions were better described (50%) than conventional interventions (36%). While timing and total dose were commonly reported, critical details on provider expertise, active dose, progressive challenge, personalization, and harms were often omitted. Reporting consistency was moderate (68%), with key information dispersed across article sections. Conclusions: Inadequate reporting limits the transparency, replication, and implementation of robotic upper-limb interventions. Adopting structured reporting frameworks like TIDieR-Rehab is essential for advancing the field. Full article
(This article belongs to the Special Issue Current Advances in Rehabilitation Technology)
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35 pages, 12322 KiB  
Article
Research on the Evaluation Method of Electrical Stress Limit Capability Based on Reliability Enhancement Theory
by Shuai Zhou, Kaixue Ma, Zhihua Cai, Shoufu Liu, Jian Xiang and Chi Ma
Electronics 2025, 14(15), 3056; https://doi.org/10.3390/electronics14153056 - 30 Jul 2025
Viewed by 142
Abstract
This study focuses on the evaluation of electrical stress limit capability for 3D-packaged memory (256 M × 72-bit DDR3 SDRAM) (Shanghai Fudan Microelectronics Group Co., Ltd., Shanghai, China). Guided by Reliability Enhancement Theory, this study presents a meticulously designed comprehensive test profile that [...] Read more.
This study focuses on the evaluation of electrical stress limit capability for 3D-packaged memory (256 M × 72-bit DDR3 SDRAM) (Shanghai Fudan Microelectronics Group Co., Ltd., Shanghai, China). Guided by Reliability Enhancement Theory, this study presents a meticulously designed comprehensive test profile that incorporates critical stress parameters, including supply voltage, input clock frequency, electrostatic discharge (ESD) sensitivity, and electrical endurance. Explicit criteria for stress selection, upper/lower bounds, step increments, and duration are established. A dedicated test platform is constructed, integrating automated test equipment (ATE) and ESD sensitivity analyzers with detailed specifications on device selection criteria and operational principles. The functional performance testing methodology is systematically investigated, covering test platform configuration, initialization protocols, parametric testing procedures, functional verification, and acceptance criteria. Extreme-condition experiments—including supply voltage margining, input clock frequency tolerance, ESD sensitivity characterization, and accelerated electrical endurance testing—are conducted to quantify operational and destructive limits. The findings provide critical theoretical insights and practical guidelines for the design optimization, quality control, and reliability enhancement of 3D-packaged memory devices. Full article
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22 pages, 551 KiB  
Review
Limited Evidence to Review—Is There an Association Between Cognition and Upper Extremity Motor Reaction Time in Older Adults?
by Alexandria Jones, Natalie Weaver, Mardon E. So, Abbis Jaffri and Rosalind L. Heckman
NeuroSci 2025, 6(3), 71; https://doi.org/10.3390/neurosci6030071 - 30 Jul 2025
Viewed by 288
Abstract
Optimal sensorimotor control depends on response timing. With age, it is broadly assumed that reaction time (RT) increases as cognitive function declines. However, it is not clear if the literature supports this assumption. The purpose of this work was to review the association [...] Read more.
Optimal sensorimotor control depends on response timing. With age, it is broadly assumed that reaction time (RT) increases as cognitive function declines. However, it is not clear if the literature supports this assumption. The purpose of this work was to review the association between cognition and upper extremity RT in older adults. We conducted a search using Scopus database with four inclusion criteria: (1) healthy, community-dwelling adults over 60 years old, (2) upper extremity movement, (3) cognitive assessment, and (4) RT measure. Twenty-five of the 1608 articles screened met the inclusion criteria. Only nine studies directly or indirectly assessed the association between cognition and RT. Our interpretation of the literature was further limited by inconsistency in test selection and measurement interdependence that could be addressed by future studies. We present a conceptual framework to guide research assessing the influence of cognition on sensorimotor control with age. Full article
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10 pages, 1969 KiB  
Case Report
A Rare t(3;15;17) in a Patient with Acute Promyelocytic Leukemia: Case Report and Review of the Literature
by Linda Shi, Chu En Chen, Tahmeena Ahmed, Jacob Rocha, Pons Materum, Sashank Cherukuri, Leah Gallagher, Paula Fernicola, Roxana Ponce, Htien Lee, Christina Giordano, Gabriela Evans, Changtai Tian and Carlos A. Tirado
Diagnostics 2025, 15(15), 1901; https://doi.org/10.3390/diagnostics15151901 - 29 Jul 2025
Viewed by 229
Abstract
We present a 48-year-old female with a past medical history of endometrioid adenocarcinoma who presented with symptoms of spontaneous gum bleeding, post-coital bleeding, and upper extremities–lower extremities-abdomen ecchymosis. Initial laboratory findings were significant for cytopenia and disseminated intravascular coagulation (DIC). Due to a [...] Read more.
We present a 48-year-old female with a past medical history of endometrioid adenocarcinoma who presented with symptoms of spontaneous gum bleeding, post-coital bleeding, and upper extremities–lower extremities-abdomen ecchymosis. Initial laboratory findings were significant for cytopenia and disseminated intravascular coagulation (DIC). Due to a suspected case of acute promyelocytic leukemia (APL), conventional karyotyping and fluorescence in situ hybridization (FISH) were performed. FISH analysis confirmed an unusual chromosome rearrangement that affected chromosomes 3, 15, and 17. This t(3;15;17)(q29;q24;q21) was characterized by the presence of PML::RARA fusion on the derivative chromosome 15. Treatment at the hospital with standard APL therapy of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO) was complicated by the development of differentiation syndrome, which necessitated the temporary stoppage of ATO. However, complete remission was achieved despite complications after starting consolidation treatment. Full article
(This article belongs to the Section Pathology and Molecular Diagnostics)
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10 pages, 3042 KiB  
Article
Validity of IMUs in Comparison to a Marker-Based-Motion Capture System for Spatio-Temporal Parameters During Wheelchair Propulsion
by Lukas Karner, Lucas Schreff, Rainer Abel and Roy Müller
Sensors 2025, 25(15), 4676; https://doi.org/10.3390/s25154676 - 29 Jul 2025
Viewed by 159
Abstract
Background: Manual wheelchair propulsion is often associated with pain in the upper extremities. Recording spatio-temporal parameters can optimize movement patterns and prevent injuries. This study compares a marker-based camera system with inertial measurement units to validate their use in wheelchair propulsion on a [...] Read more.
Background: Manual wheelchair propulsion is often associated with pain in the upper extremities. Recording spatio-temporal parameters can optimize movement patterns and prevent injuries. This study compares a marker-based camera system with inertial measurement units to validate their use in wheelchair propulsion on a test stand. Methods: Spatio-temporal parameters of 27 manual wheelchair users propelling at three self-selected speeds (slow, normal, fast) were simultaneously recorded using a marker-based camera system and inertial measurement units, and subsequently compared between both systems. Results: A high correlation was observed among all spatio-temporal parameters (ρ > 0.992). The biases for the start time of hand contact with the pushrim (−0.02 ± 0.02 s), hand release from the pushrim (−0.02 ± 0.01 s), and push length (−0.45 ± 21.45 ms) were slightly overestimated, while recovery length (0.54 ± 21.02 ms), cycle speed (2.37 ± 2.67°/s), and push angle (1.75 ± 4.14°) were slightly underestimated. No bias was found for propulsion frequency. Conclusions: The spatio-temporal parameters recorded using inertial measurement units are suitable for the evaluation of manual wheelchair propulsion and can be used in a clinical context. The low acquisition costs and simple installation process may increase the use of inertial measurement units in the future. Full article
(This article belongs to the Section Physical Sensors)
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16 pages, 1423 KiB  
Article
Measurement of Oxidative Stress Index in 102 Patients with Peyronie’s Disease
by Gianni Paulis, Andrea Paulis, Giovanni De Giorgio and Salvatore Quattrocchi
Metabolites 2025, 15(8), 503; https://doi.org/10.3390/metabo15080503 - 29 Jul 2025
Viewed by 247
Abstract
Background: Peyronie’s disease (PD) is a chronic inflammatory condition that affects the penile albuginea. Oxidative stress (OS) plays a crucial role in the development of the disease, prompting us to investigate OS levels at the site of the disease and in peripheral [...] Read more.
Background: Peyronie’s disease (PD) is a chronic inflammatory condition that affects the penile albuginea. Oxidative stress (OS) plays a crucial role in the development of the disease, prompting us to investigate OS levels at the site of the disease and in peripheral blood. This article presents our second study in which the OS was evaluated by calculating the OS index (OSI) in blood samples taken directly from the penile corpora cavernosa of patients with PD. Our innovative diagnostic method, which focuses on the analysis of oxidative stress (OS) in the corpora cavernosa of the penis, allows us to accurately identify the “chemical” signals (OS levels) of the pathology in the area where it is present. Methods: Our study included 102 PD patients from our Peyronie’s care center and 100 control cases. To conduct a comprehensive OS analysis, we measured both the total oxidant status (TOS) and total antioxidant status (TAS) and calculated the oxidative stress index (OSI) as OSI = TOS/TAS × 100. Blood samples were collected from the penis and a vein in the upper extremity, and OS was measured using d-ROMs and PATs (FRAS kit). Results: Pearson’s analyses revealed a significant statistical correlation between penile OSI values and PD plaque volumes (p = 0.003), while no correlation was found between systemic OSI values and plaque volumes (p = 0.356). Penile OSI values decreased significantly after PD plaque removal (p < 0.0001). A comparison of penile OSI values in PD patients (post plaque removal) and the control group showed no significant differences (p = 0.418). Conclusions: The lack of correlation between systemic OSI values and Peyronie’s plaque volume suggests that direct sampling from the site of the disease is preferable for OS studies. Conducting a penile OSI study could provide a precise oxidative marker dependent on plaque volume. In addition, the penile OSI study can biochemically monitor the therapeutic result, alongside penile ultrasound imaging. Full article
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17 pages, 451 KiB  
Article
Primary and Recurrent Erysipelas—Epidemiological Patterns in a Single-Centre Retrospective Analysis
by Marta Matych, Agata Ciosek, Karol Miler, Marcin Noweta, Karolina Brzezińska, Małgorzata Sarzała, Joanna Narbutt and Aleksandra Lesiak
J. Clin. Med. 2025, 14(15), 5299; https://doi.org/10.3390/jcm14155299 - 27 Jul 2025
Viewed by 378
Abstract
Background/Objectives: Erysipelas is an acute bacterial skin infection, particularly affecting the lower limbs, with a tendency to recur. Despite its clinical importance, data on demographic and epidemiological risk factors, as well as factors influencing hospitalization, remain limited. This study aimed to analyze the [...] Read more.
Background/Objectives: Erysipelas is an acute bacterial skin infection, particularly affecting the lower limbs, with a tendency to recur. Despite its clinical importance, data on demographic and epidemiological risk factors, as well as factors influencing hospitalization, remain limited. This study aimed to analyze the epidemiological and clinical characteristics of patients hospitalized with primary and recurrent erysipelas, focusing on risk factors contributing to disease onset, recurrence, and prolonged hospitalization. Methods: A retrospective single-center analysis was conducted on 239 patients hospitalized for erysipelas at the Department of Dermatology, Pediatric Dermatology, and Oncology at the Medical University of Lodz. Data collected included demographics, lesion location, laboratory markers, comorbidities, and hospitalization outcomes. Statistical analyses were performed to assess associations between risk factors, disease recurrence, and hospitalization duration. Results: The majority of erysipelas cases (85.4%) involved the lower limbs, with a higher prevalence in men. Upper extremities were mostly affected in women, especially those who had undergone breast cancer surgery. Recurrent erysipelas accounted for 75.7% of cases. Most patients (89.1%) had at least one comorbidity, with hypertension, diabetes type 2 (DM2), and obesity being the most common. Higher white blood cell (WBC) count, obesity, atrial fibrillation (AF), and the need for enoxaparin administration were independently associated with prolonged hospitalization. Dyslipidemia was significantly associated with erysipelas recurrence (p < 0.05). Conclusions: Both primary and recurrent erysipelas are associated with specific risk factors. Recurrent erysipelas may be linked to components of metabolic syndrome, particularly obesity and dyslipidemia, which emerged as a significant risk factor in this study. Hospitalization length may be prolonged by inflammation markers (WBC and CRP) and comorbidities such as AF, obesity, or the need for enoxaparin in patients with elevated thrombosis risk. Further multicenter studies with larger cohorts are needed to assess the impact of demographics, biomarkers, metabolic disorders, and treatment strategies on erysipelas recurrence and outcomes. Awareness of these risk factors is essential for effective prevention, management, and recurrence reduction. Full article
(This article belongs to the Special Issue Clinical Epidemiology of Skin Diseases: 3rd Edition)
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