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Article

671 Views

15 Pages

Ocular Troxipide Nanosuspension Enhances Therapeutic Efficacy in an N-Acetylcysteine-Induced Dry Eye Model

Hiroko Otake,
Rie Tanaka,
Fumihiko Ogata,
Yosuke Nakazawa and ,
Manju Misra,
Kazutaka Kanai,
Masanobu Tsubaki,
Naoki Yamamoto,
Naohito Kawasaki and
Noriaki Nagai
+ 5 authors+ 0 author

Pharmaceutics2026, 18(6), 699;https://doi.org/10.3390/pharmaceutics18060699

6 June 2026

Background/Objectives: Dry eye disease (DED) is a multifactorial ocular surface disorder characterized by tear film instability and decreased tear secretion, largely driven by chronic ocular surface inflammation. Although current therapies primarily...

(This article belongs to the Special Issue Non-Invasive Ocular Drug Delivery Science and Technology)

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Article

549 Views

16 Pages

Meibomian Gland-Mediated Drug Delivery via Eyelid Application of Troxipide Nanoparticles Improves an N-Acetylcysteine-Induced Dry Eye

Hiroko Otake,
Rie Tanaka,
Fumihiko Ogata,
Manju Misra and ,
Kazutaka Kanai,
Masanobu Tsubaki,
Naoki Yamamoto,
Naohito Kawasaki and
Noriaki Nagai
+ 4 authors+ 0 author

Pharmaceutics2026, 18(8), 973;https://doi.org/10.3390/pharmaceutics18080973

8 August 2026

Background/Objectives: Dry eye disease (DED) is a multifactorial disorder characterized by tear film instability, inflammation, and ocular surface damage, which significantly impairs visual function and quality of life. Conventional ophthalmic formul...

(This article belongs to the Special Issue Current and Future Perspectives in Dermal and Transdermal Drug Delivery)

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