Search Results (47)

Background/Objectives: Human physiological evidence for functional clothing is limited, and garment changes may reflect ordinary material or measurement effects. We described surface-temperature and heart rate variability (HRV) observations before and after wearing black-silica-containing clothing and quantified paired changes and between-participant dispersion. Methods: Ten adults enrolled as healthy volunteers completed this single-center, non-randomized, unblinded, uncontrolled, fixed-order, single-group before–after pilot protocol. No physically matched control textile was used. No directional hypothesis or single primary outcome was prospectively specified. Exploratory domains comprised abdominal and leg surface temperature and eight RR interval (RRI)-derived HRV indices. All participants were analyzed; a post hoc n = 9 quality-control sensitivity analysis excluded one participant with a short post-wearing RRI segment. Effect estimates, 95% confidence intervals (CIs), and Holm-adjusted p values were reported. Between-participant dispersion was secondary and exploratory. Results: Leg surface temperature showed a modest increase of 0.668 °C (95% CI −0.001 to 1.336; raw p = 0.050; Holm p = 0.100); abdominal temperature changed by 0.007 °C (95% CI −0.447 to 0.462). No paired HRV outcome retained support after correction (all Holm p ≥ 0.797). In the secondary dispersion analysis, total power had an after/before log-scale SD ratio of 0.612 (bootstrap 95% CI 0.347 to 0.861; Holm p = 0.031); no dispersion outcome retained support in the n = 9 sensitivity analysis. Conclusions: This small uncontrolled pilot provides hypothesis-generating observations but cannot isolate an effect attributable specifically to black silica or demonstrate autonomic benefit, therapeutic action, or product efficacy. Confirmation requires an adequately powered, randomized, participant-blinded crossover study using physically matched garments and standardized measurement conditions. Full article

Frankincense, a natural resin obtained from Boswellia species, has been extensively utilized in traditional medicine and has attracted significant attention in biomedical applications owing to its vast therapeutic effects. While many studies and reviews have reported its pharmacological and biomedical applications, its potential in broader engineering domains and material science remains less explored. In biomedical engineering, frankincense-based compounds have been successfully incorporated into several matrices including hydrogels, nanomaterials, scaffolds, coatings for tissue engineering, food preservation and functional textiles. Frankincense has also exhibited significant potential as a functional component in engineering materials and environmental applications including its significant effects as a green corrosion inhibitor, drilling-fluid modifier and adsorbent materials. This review also highlights the economic aspects of frankincense utilization by evaluating and comparing its production, market value and scalability with other natural resin and gums. Additionally, environmental and sustainability factors associated with frankincense production, harvesting practices and resource availability have also been discussed. Overall, this review provides an overview of frankincense’s potential in diverse engineering applications and highlights the transition of frankincense from a traditional medicinal resin to a promising bio-based material for biomedical, material and environmental engineering applications. Full article

The growing demand for natural, safe, and sustainable bioactive compounds has sparked interest in indigenous essential oils (EOs) for their antimicrobial, antioxidant, and therapeutic properties. Their practical applications are often limited by poor solubility, volatility, and susceptibility to degradation when exposed to light, heat, and or oxygen. The literature lacks exploration of the indigenous EOs in nanoencapsulation studies. Using nanosystems and carriers, the oil can be delivered to targeted areas over a longer period. This is useful for various applications, including biopesticides, regenerative medicine, gene therapy, textiles, and antimicrobial coatings. Studies reveal that nanoencapsulated EOs exhibit higher insecticidal and antimicrobial activity than free oil. In this review, we observed that Lippia javanica is the most used EO in nanoencapsulation processes. This may be attributed to its broad spectrum of biological activities and its wide distribution in South Africa. This review examines the applications of selected nanoencapsulated indigenous EOs of the Eastern Cape province in medicine, food, and agriculture. The findings underscore the potential of nanoencapsulation to transform indigenous EOs into multifunctional agents that can support health, food security, and sustainable agricultural practices, while calling for further research on safety, regulatory frameworks, and commercialization pathways. Full article

Children’s skin is uniquely vulnerable, requiring specialised design solutions that transcend traditional aesthetics. This exploratory study investigates the importance of paediatric dermatology in informing functional fashion design through expert medical perspectives. Using a qualitative approach, data were gathered from a purposive cohort of paediatric dermatologists and immunoallergologists and analysed through inductive thematic analysis. Findings identify four core themes: the physiological immaturity of children’s skin (notably the prevalence of atopic dermatitis), clothing’s role as a symptomatic aggravator rather than a primary aetiology, the clinical risks posed by chemical additives in synthetic textile processes, and the therapeutic potential of natural fibres and biofunctional agents. The data also highlights significant diagnostic constraints in paediatric patch testing, emphasising the necessity of proactive material safety. The findings suggest that integrating healthcare expertise into human-centred design may support the development of safer paediatric clothing solutions, ensuring that fashion industry innovation meets the physiological requirements of children. By transitioning from hazardous synthetic processes to biocompatible textiles, such as undyed natural fibres and medicinal plant-derived dyes, the industry can transform apparel from a potential irritant into a secondary protective barrier. This provides initial insights for developing clothing that safeguards the skin barrier and improves the overall wellbeing of vulnerable populations. Full article

Biomedical antennas are essential components in modern healthcare systems, supporting wireless communication, physiological monitoring, diagnostic imaging, and therapeutic energy delivery. Their performance is strongly influenced by proximity to the human body, creating challenges such as impedance detuning, signal absorption, and size constraints that motivate new materials and fabrication approaches. This work reviews recent advances enabling next-generation wearable and implantable antennas, with emphasis on printed electronics, additive manufacturing, flexible hybrid integration, and metamaterial design. Methods discussed include 3D printing and inkjet, aerosol jet, and screen printing for fabricating conductive traces on textiles, elastomers, and biodegradable substrates, as well as multilayer Flexible Hybrid Electronics that co-integrate sensing, power management, and RF components into thin, body-conforming assemblies. Key results highlight how metamaterial and metasurface concepts provide artificial control over dispersion, radiation, and near-field interactions, enabling antenna miniaturization, enhanced gain and focusing, and improved isolation from lossy biological tissue. These approaches reduce SAR, stabilize impedance under deformation, and support more efficient communication and energy transfer. The review concludes that the convergence of novel materials, engineered electromagnetic structures, and AI-assisted optimization is enabling biomedical antennas that are compact, stretchable, personalized, and highly adaptive, supporting future developments in unobtrusive monitoring, wireless implants, point-of-care diagnostics, and continuous clinical interfacing. Full article

Compression garments are widely employed in medical and sports contexts for their ability to promote venous return, manage oedema, support musculoskeletal function, and enhance athletic recovery. Advances in textile-based compression systems have been driven by innovations in fibres, yarn structures, fabric structure engineering, and design methods. This review critically examines the current literature on compression garments, highlighting the influence of raw materials and yarn architectures on performance, durability, and wearer comfort. Attention is given specially to fabric structures and manufacturing methods, where the evolution from traditional cut-and-sew methods to advanced seamless, flatbed, and circular knitting technologies is highlighted, along with their impact on pressure distribution and overall garment efficacy. The integration of 3D body scanning, finite element analysis, and predictive modelling, which enables more personalised and precise garment design, is also speculated upon. Moreover, the review highlights testing and evaluation methodologies, spanning both in vivo and in vitro based assessments, pressure sensor studies for real-time monitoring, and theoretical models mostly based on Laplace’s law. This literature survey provides a foundation for future innovations aimed at optimising compression garment design for both therapeutic and athletic use. Full article

The utilization of agro-byproducts for textile dyeing and finishing is strongly suggested to meet sustainability and cost-efficiency objectives. Despite recently proliferating studies, three major issues hinder the industrialization of such a technique: identifying reasonable bio-resources, ensuring compatibility between agro-byproducts and textile substrates, and achieving satisfactory color depth, functionality, and durability. This research introduces an approach that forms and fixes silver nanoparticles (AgNPs) on silk using three representative flavonoids (FLs)—Quercetin (QUE), Baicalin (BAI), and Rutin (RUT)—through a single-step in situ bio-reduction. Results demonstrate that FLs-synthesized AgNPs@silk generates attractive spectra of hues, varying from pale cream-brown to deep golden-brown. Using an equivalent quantity of FLs, the color intensity of silk descends in QUE-Ag@silk > BAI-Ag@silk > RUR-Ag@silk, due to the decreasing reactivity and binding affinity of FLs to silk. SEM reveals uniformly distributed spherical AgNPs in dimensions between 20 and 40 nm on silk and the dimension inversely correlates with FLs concentration while being directly proportional to silver nitrate. The modified silk exhibits remarkable antimicrobial performance (>98% pathogen elimination) and exceptional wash resistance (>90% reduction both of E. coli and S. aureus after ten cycles of washing). Additionally, the FLs-synthesized AgNPs provide silk with superior UV shielding capability. This study stems from environmental awareness and sustainable production of AgNPs by FLs, ready for developing hygienic and therapeutic textile materials. Full article

Knitted heaters have attracted significant interest due to their flexibility and ease of integration into smart textile applications. However, uneven heat distribution remains a major challenge, leading to comfort issues and inefficient energy usage. This study presents an analytical, physics-based model that links the resistance, power distribution, and surface temperature of knitted heaters to key design parameters such as size, configuration, material properties, and knitting structure to establish guidelines for achieving a desired temperature rise over a specified surface area. The model was validated experimentally across a range of heaters (3–12 lines) arranged in ladder and diagonal configurations. Results showed good agreement between predictions and measurements for higher line counts (10–12), while larger deviations occurred in smaller heaters (3–5 lines) due to contact resistance and current losses. A prototype knitted wristband demonstrated physiologically relevant heating (>33 °C) under safe, low-voltage operation. These findings provide a quantitative design framework for optimizing knitted heaters and highlight their potential for scalable integration into wearable and therapeutic applications. Full article

The search for bioactive compounds with antioxidant properties is critical in combating oxidative stress-related diseases and advancing novel therapeutic agents. Azo dyes, traditionally used in textiles, food, and cosmetics, have recently attracted attention due to their emerging biological activities, including antioxidant potential. In this study, we synthesized and characterized 267 azo dyes derived from natural phenolic cores such as salicylic acid, syringol, and 5,6,7,8-tetrahydro-2-naphthol. Eighteen of these compounds are novel. Structural characterization was performed using NMR, UV-Vis, IR spectroscopy, and mass spectrometry. Antioxidant activity was assessed using in vitro assays with ABTS radical scavenging method. SAR analysis revealed that dyes derived from syringol and 5, 6, 7, 8-tetrahydro-2-naphthol showed the most consistent and potent antioxidant activity. Notably, azo dyes bearing fluoro and nitro substituents in the para position exhibited the lowest IC₅₀ values, highlighting the influence of electron-withdrawing groups and substitution patterns on antioxidant behavior. This work establishes a precedent for SAR-driven evaluation of azo dyes using ABTS and supports their further exploration as functional antioxidant agents in medicinal chemistry. Full article

Wearable computing is evolving from a passive data collection paradigm into an active, precision-guided health orchestration system. This survey synthesizes developments across sensing modalities, wireless protocols, computational frameworks, and AI-driven analytics that collectively define the state of the art in mental and physical health monitoring. A narrative review methodology is used to map the landscape of hardware innovations—including microfluidic sweat sensing, smart textiles, and textile-embedded biosensing ecosystems—alongside advances in on-device AI acceleration, context-aware multimodal fusion, and privacy-preserving learning frameworks. The analysis highlights a shift toward multiplexed biochemical sensing for real-time metabolic profiling, neuromorphic and analog AI processors for ultra–low-power analytics, and closed-loop therapeutic systems capable of adapting interventions dynamically to both physiological and psychological states. These trends are examined in the context of emerging clinical and consumer use cases, with a focus on scalability, personalization, and data security. By grounding these insights in current research trajectories, this work positions wearable computing as a cornerstone of preventive, personalized, and participatory healthcare. Addressing identified technical and ethical challenges will be essential for the next generation of systems to become trusted, equitable, and clinically indispensable tools. Full article

Moringa oleifera (MO), a nutritionally and pharmacologically potent species, is emerging as a sustainable candidate for applications across bioenergy, agriculture, textiles, pharmaceuticals, and biomedicine. This review explores recent advances in MO-based biotechnologies, highlighting novel extraction methods, green nanotechnology, and clinical trial findings. Although MO’s resilience offers promise for climate-smart agriculture and public health, challenges remain in standardizing cultivation and verifying therapeutic claims. This work underscores MO’s translational potential and the need for integrative, interdisciplinary research. MO is used in advanced materials, like electrospun fibers and biopolymers, showing filtration, antibacterial, anti-inflammatory, and antioxidant properties—important for the biomedical industry and environmental remediation. In textiles, it serves as an eco-friendly alternative for wastewater treatment and yarn sizing. Biotechnological advancements, such as genome sequencing and in vitro culture, enhance traits and metabolite production. MO supports green biotechnology through sustainable agriculture, nanomaterials, and biocomposites. MO shows potential for disease management, immune support, metabolic health, and dental care, but requires further clinical trials for validation. Its resilience is suitable for land restoration and food security in arid areas. AI and deep learning enhance Moringa breeding, allowing for faster, cost-effective development of improved varieties. MO’s diverse applications establish it as a key element for sustainable development in arid regions. Full article

Background: This study presents an innovative approach to developing bioactive natural fabrics for healthcare and medical applications. Methods: An ethanol extract of Origanum vulgare L. (in further text: OE), exhibiting exceptional antioxidant (100%) and antibacterial activity (>99% against E.coli and S.aureus), was employed to biofunctionalize cotton, wool, and silk fabrics. Results: All biofunctionalized fabrics demonstrated strong antioxidant activity (>99%), while antibacterial efficacy varied by fabric: cotton > 54%, wool > 99%, and silk > 89%. OE-biofunctionalized wool possessed the highest release of OE’s bioactive compounds, followed by silk and cotton, indicating substrate-dependent release behavior. This tunable fabrics’ OE release profile, along with their unique bioactivity, supports targeted applications: OE-functionalized silk for luxury or prolonged therapeutic use (skin-care textiles, post-surgical dressings, anti-aging products), cotton for disposable or short-term use (protective wipes, minor wound coverings), and wool for wound dressings. The biocompatibility and cytotoxicity of OE-biofunctionalized wool were evaluated via in vitro assays using healthy human keratinocytes and in vivo testing in Wistar albino male rats. The obtained results revealed that OE-functionalized wool significantly accelerated wound closure (97.8% by day 14), enhanced collagen synthesis (6.92 µg/mg hydroxyproline), and improved tissue and systemic antioxidant defense while reducing oxidative stress markers in skin and blood samples of rats treated with OE-biofunctionalized wool. Conclusions: OE-biofunctionalized wool demonstrates strong potential as an advanced natural solution for managing chronic wounds. Further clinical validation is recommended to confirm its performance in real-world healthcare settings. This work introduces an entirely new application of OE in textile biofunctionalization, offering alternatives for healthcare and medical textiles. Full article

Betalains are nitrogen-containing, water-soluble, and non-toxic natural pigments found in various plant species. Among these, Celosia argentea (Amaranthaceae) has garnered attention as a significant source, accumulating substantial quantities of both red–purple betacyanins and yellow–orange betaxanthins. Impressively, betalain concentrations in C. argentea inflorescences can reach up to 14.91 mg/g dry weight (DW), a level comparable to that reported in red beetroot. Beyond harvesting from inflorescences, betalains can also be produced using cell culture systems, which can yield even higher amounts, up to 42.08 mg/g DW. Beyond their role as vibrant natural colorants, betalains exhibit impressive health-promoting properties, most notably potent antioxidant activities. For instance, C. argentea inflorescence extracts demonstrate approximately 84.07% 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 88.70% 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging. Extracts derived from cell cultures show even higher scavenging capacities, reaching up to 99.28% for ABTS and 99.63% for DPPH, rivaling the antioxidant standard (ascorbic acid). Further research indicates additional potential benefits, including anti-inflammatory, antimicrobial, anticancer, antidiabetic, and hepatoprotective properties. This diverse bioactivity underpins their value across various industries. Betalains serve as natural colorants and functional ingredients in food and beverages, offer sustainable alternatives for textile dyeing, and hold therapeutic promise in cosmetics and pharmaceuticals. This review critically examines existing research on betalain production in C. argentea. Recognizing that research specific to C. argentea is less extensive compared with that on species such as Beta vulgaris and Hylocereus polyrhizus, this review analyzes its biosynthetic pathways, diverse biological properties, and wide-ranging applications. This is achieved by integrating available C. argentea-specific data with relevant insights drawn from these more broadly studied betalain sources. Furthermore, the review discusses perspectives on future research directions aimed at optimizing yield and exploring the full potential of betalains, specifically within C. argentea. Full article

AgNPs have gained significant attention due to their unique physicochemical properties, making them valuable across a range of fields including medicine, textiles, and household products. With their strong antimicrobial and antiviral properties, AgNPs have shown promise in treating infections, particularly in wound care management. This review explores the mechanisms underlying the antiviral activities of AgNPs, as well as the methods used for their synthesis, which include physical, chemical, and biological approaches. The review also addresses the potential limitations of AgNPs, including their cytotoxicity to humans and the environment. The interaction between AgNPs and microorganisms, particularly viruses, varies based on synthesis methods and particle morphology. As viral infections, including resistant strains, present major global health challenges, there is a growing need for alternative antiviral therapies. Metal nanoparticles like AgNPs offer potential advantages over conventional antiviral drugs due to their broad target range, which reduces the likelihood of resistance development. This review highlights AgNPs’ effectiveness against a variety of viruses, such as HIV, hepatitis B, and respiratory syncytial virus, and discusses their potential for use in novel antiviral treatments. The review also examines AgNPs’ toxicity, offering insights into their future therapeutic roles. Full article

A therapeutic glove, which enables medical non-professionals to perform physiotherapeutic gripping and holding movements on patients, would significantly improve the healthcare situation in physiotherapy. The glove aims to detect the orthogonal pressure load and provide feedback to the user. The use of textile materials for the glove assures comfort and a good fit for the user. This, in turn, implies a textile realization of the sensor system in order to manufacture both the glove and the sensor system in as few process steps as possible, using only one textile manufacturing technique. The flat knitting technology is an obvious choice here. The aim of the study is to develop a textile capacitive pressure sensor that can be integrated into the fingertips of a glove using flat knitting technology and to evaluate its sensor properties with regard to transmission behavior, hysteresis and drift. It was shown that the proposed method of a flat knitting sensor fabrication is suitable for producing both the sensors and the glove in one single process step. In addition, the implementation of an entire glove with integrated pressure sensors, including the necessary electrical connection of the sensor electrodes via knitted conductive paths in three fingers, was successfully demonstrated. Full article