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Article

476 Views

17 Pages

Tissue Microarray-Based Digital Spatial Profiling of Benign Breast Lobules and Breast Cancers: Feasibility, Biological Coherence, and Cross-Platform Benchmarks

Mark E. Sherman,
Jodi C. Carter,
Robert A. Vierkant,
Melody Stallings-Mann,
Laura Pacheco-Spann,
Stacey J. Winham,
Celine M. Vachon,
Chen Wang,
Matthew R. Jensen and
Derek C. Radisky
+ 4 authors

Cancers2025, 17(23), 3797;https://doi.org/10.3390/cancers17233797

27 November 2025

Background: Discovering risk biomarkers in small benign breast disease (BBD) biopsies is constrained by scarce tissue and microanatomic heterogeneity of terminal duct lobular units (TDLUs). We tested whether tissue-sparing tissue microarray (TMA)&nda...

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Article

10 Citations

4,181 Views

15 Pages

Involution of Breast Lobules, Mammographic Breast Density and Prognosis Among Tamoxifen-Treated Estrogen Receptor-Positive Breast Cancer Patients

Maeve Mullooly,
Sarah J. Nyante,
Ruth M. Pfeiffer,
Renata Cora,
Donna Butcher,
Lawrence Sternberg,
Erin J. Aiello Bowles,
Shaoqi Fan,
Jonine D. Figueroa and
Gretchen L. Gierach
+ 5 authors

J. Clin. Med.2019, 8(11), 1868;https://doi.org/10.3390/jcm8111868

4 November 2019

Mammographic breast density (MD) reflects breast fibroglandular content. Its decline following adjuvant tamoxifen treated, estrogen receptor (ER)-positive breast cancer has been associated with improved outcomes. Breast cancers arise from structures...

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Article

8 Citations

2,835 Views

15 Pages

Does Diffusely Infiltrating Lobular Carcinoma of the Breast Arise from Epithelial–Mesenchymal Hybrid Cells?

László Tabár,
Renáta Bozó,
Peter B. Dean,
Katalin Ormándi,
Olga Puchkova,
Orsolya Oláh-Németh,
István Balázs Németh,
Zoltán Veréb,
Ming-Fang Yen and
András Vörös
+ 1 author

Int. J. Mol. Sci.2023, 24(13), 10752;https://doi.org/10.3390/ijms241310752

28 June 2023

Classic diffusely infiltrating lobular carcinoma has imaging features divergent from the breast cancers originating from the terminal ductal lobular units and from the major lactiferous ducts. Although the term “invasive lobular carcinoma&rdquo...

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Review

5 Citations

6,213 Views

18 Pages

Are Columnar Cell Lesions the Earliest Non-Obligate Precursor in the Low-Grade Breast Neoplasia Pathway?

Sarah Strickland and
Gulisa Turashvili

Curr. Oncol.2022, 29(8), 5664-5681;https://doi.org/10.3390/curroncol29080447

11 August 2022

Columnar cell lesions (CCLs) of the breast comprise a spectrum of morphologic alterations of the terminal duct lobular unit involving variably dilated and enlarged acini lined by columnar epithelial cells. The World Health Organization currently clas...

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Article

9 Citations

3,742 Views

20 Pages

Relationship of Serum Progesterone and Progesterone Metabolites with Mammographic Breast Density and Terminal Ductal Lobular Unit Involution among Women Undergoing Diagnostic Breast Biopsy

Manila Hada,
Hannah Oh,
Shaoqi Fan,
Roni T. Falk,
Berta Geller,
Pamela Vacek,
Donald Weaver,
John Shepherd,
Jeff Wang and
Gretchen L. Gierach
+ 5 authors

J. Clin. Med.2020, 9(1), 245;https://doi.org/10.3390/jcm9010245

17 January 2020

The association of progesterone/progesterone metabolites with elevated mammographic breast density (MBD) and delayed age-related terminal duct lobular unit (TDLU) involution, strong breast cancer risk factors, has received limited attention. Using a...

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Review

22 Citations

4,710 Views

24 Pages

Insight into the Crosstalk between Photodynamic Therapy and Immunotherapy in Breast Cancer

Hongzhong Jin,
Shichong Liao,
Feng Yao,
Juanjuan Li,
Zhiliang Xu,
Kailiang Zhao,
Ximing Xu and
Shengrong Sun

Cancers2023, 15(5), 1532;https://doi.org/10.3390/cancers15051532

28 February 2023

Breast cancer (BC) is the world’s second most frequent malignancy and the leading cause of mortality among women. All in situ or invasive breast cancer derives from terminal tubulobular units; when the tumor is present only in the ducts or lobu...

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