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T3P-Promoted Synthesis of a Series of 2-Aryl-3-phenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-ones and Their Activity against the Kinetoplastid Parasite Trypanosoma brucei

  • Lee J. Silverberg,
  • Tapas K. Mal,
  • Carlos N. Pacheco,
  • Megan L. Povelones and ,
  • Madeline F. Malfara,
  • Anthony F. Lagalante,
  • Mark A. Olsen,
  • Hemant P. Yennawar,
  • Hany F. Sobhi and
  • Soroush F. Yazdani
  • + 24 authors+ 19 authors
Molecules2021, 26(20), 6099;https://doi.org/10.3390/molecules26206099

9 October 2021

A series of fourteen 2-aryl-3-phenyl-2,3-dihydro-4H-pyrido[3,2-e][1,3]thiazin-4-ones was prepared at room temperature by T3P-mediated cyclization of N-phenyl-C-aryl imines with thionicotinic acid, two difficult substrates. The reactions were operatio...

(This article belongs to the Special Issue Organic Synthesis in Drug Discovery)
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