Search Results (383)

Plasma-activated water (PAW), enriched with reactive oxygen and nitrogen species (RONS), presents oxidative and antimicrobial characteristics with potential in cosmetic applications. This study examined the effects of two PAW formulations—nitrate-rich (PAW-N) and peroxide-rich (PAW-P)—on human hair types classified as straight (Type 1), wavy (Type 2), and coily/kinky (Type 4). The impact of PAW on hair structure and chemistry was evaluated using Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), UV–Vis spectrophotometry, and physicochemical analyses of the liquids (pH, ORP, conductivity, and TDS). PAW-N, with high nitrate content (~500 mg/L), low pH (2.15), and elevated conductivity (6244 µS/cm), induced significant damage to porous hair types, including disulfide bond cleavage, protein oxidation, and lipid degradation, as indicated by FTIR and EDS data. SEM confirmed severe cuticle disruption. In contrast, PAW-P, containing >25 mg/L of hydrogen peroxide and exhibiting milder acidity and lower ionic strength, caused more localized and controlled oxidation with minimal morphological damage. Straight hair showed greater resistance to both treatments, while coily and wavy hair were more susceptible, particularly to PAW-N. These findings suggest that the formulation and ionic profile of PAW should be matched to hair porosity for safe oxidative treatments, supporting the use of PAW-P as a gentler alternative in hair care technologies. Full article

Leishmaniasis is an infectious disease common in tropical and subtropical regions worldwide. This study aimed to develop a topical meglumine antimoniate gel (MA-gel) for the treatment of cutaneous leishmaniasis. The MA-gel was characterized in terms of morphology, pH, swelling, porosity, rheology, and thermal properties by differential scanning calorimetry (DSC). Biopharmaceutical evaluation included in vitro drug release and ex vivo skin permeation. Safety was evaluated through biomechanical skin property measurements and cytotoxicity in HaCaT and RAW 267 cells. Leishmanicidal activity was tested against promastigotes and amastigotes of Leishmania infantum, and in silico studies were conducted to explore possible mechanisms of action. The composition of the MA-gel included 30% MA, 20% Pluronic^® F127 (P407), and 50% water. Scanning electron microscopy revealed a sponge-like and porous internal structure of the MA-gel. This formula exhibited a pH of 5.45, swelling at approximately 12 min, and a porosity of 85.07%. The DSC showed that there was no incompatibility between MA and P407. Drug release followed a first-order kinetic profile, with 22.11 µg/g/cm² of the drug retained in the skin and no permeation into the receptor compartment. The MA-gel showed no microbial growth, no cytotoxicity in keratinocytes, and no skin damage. The IC₅₀ for promastigotes and amastigotes of L. infantum were 3.56 and 23.11 µg/mL, respectively. In silico studies suggested that MA could act on three potential therapeutic targets according to its binding mode. The MA-gel demonstrated promising physicochemical, safety, and antiparasitic properties, supporting its potential as a topical treatment for cutaneous leishmaniasis. Full article

Background: Precision medicine refers to the formulation of personalized drug regimens according to the individual characteristics of patients to achieve optimal efficacy and minimize adverse reactions. Additive manufacturing (AM), also known as three-dimensional (3D) printing, has emerged as an optimal solution for precision drug delivery, enabling customizable and the fabrication of multifunctional structures with precise control over morphology and release behavior in pharmaceutics. However, the influence of 3D printing parameters on the printed tablets, especially regarding in vitro and in vivo performance, remains poorly understood, limiting the optimization of manufacturing processes for controlled-release profiles. Objective: To establish the fabrication process of 3D-printed controlled-release tablets via comprehensively understanding the printing parameters using fused deposition modeling (FDM) combined with hot-melt extrusion (HME) technologies. HPMC-AS/HPC-EF was used as the drug delivery matrix and carbamazepine (CBZ) was used as a model drug to investigate the in vitro drug delivery performance of the printed tablets. Methodology: Thermogravimetric analysis (TGA) was employed to assess the thermal compatibility of CBZ with HPMC-AS/HPC-EF excipients up to 230 °C, surpassing typical processing temperatures (160–200 °C). The formation of stable amorphous solid dispersions (ASDs) was validated using differential scanning calorimetry (DSC), hot-stage polarized light microscopy (PLM), and powder X-ray diffraction (PXRD). A 15-group full factorial design was then used to evaluate the effects of the fan speed (20–100%), platform temperature (40–80 °C), and printing speed (20–100 mm/s) on the tablet properties. Response surface modeling (RSM) with inverse square-root transformation was applied to analyze the dissolution kinetics, specifically t_50% (time for 50% drug release) and Q_4h (drug released at 4 h). Results: TGA confirmed the thermal compatibility of CBZ with HPMC-AS/HPC-EF, enabling stable ASD formation validated by DSC, PLM, and PXRD. The full factorial design revealed that printing speed was the dominant parameter governing dissolution behavior, with high speeds accelerating release and low speeds prolonging release through porosity-modulated diffusion control. RSM quadratic models showed optimal fits for t_50% (R² = 0.9936) and Q_4h (R² = 0.9019), highlighting the predictability of release kinetics via process parameter tuning. This work demonstrates the adaptability of polymer composite AM for tailoring drug release profiles, balancing mechanical integrity, release kinetics, and manufacturing scalability to advance multifunctional 3D-printed drug delivery devices in pharmaceutics. Full article

In response to the growing demand for improving the nutritional profile of widely consumed products, such as cookies, there has been an increasing interest in fat replacers that preserve sensory attributes and have a more positive health effect. Among the novel fat replacement strategies, the incorporation of bigels into food formulations has been studied; however, the impact of Arabic gum hydrogel-based bigels on microstructural properties and their correlation with the texture and quality of bakery products remains underexplored. In this study, cookies were formulated using a plant-based bigel (canola oil-carnauba wax oleogel mixed with Arabic gum hydrogel) as a fat substitute, and their microstructural, textural, and quality parameters were compared with those of commercial butter-based cookies. Compared to butter (firmness of 29,102 g, spreadability of 59,624 g∙s, and adhesiveness of 2282 g), bigel exhibited a softer (firmness of 576 g), more spreadable (spreadability of 457 g∙s), and less adhesive texture (adhesiveness of 136 g), while its rheological properties showed similar behavior but at a lower magnitude. Bigel exhibited high thermal stability and good elastic and thixotropic behaviors, indicating reversible structural breakdown and recovery. Cookies prepared with bigels instead of butter exhibited a similar proximate composition, with a slight increase in lipid content (11.7%). The physical dimensions and density were similar across the formulations. However, the microstructural analysis revealed differences when bigels were incorporated into cookies, reducing porosity (55%) and increasing the mean pore size (1781 µm); in contrast, mean wall thickness remained unaffected. Despite these structural modifications, the potential of bigels as viable and nutritionally enhanced substitutes for conventional fats in bakery products was demonstrated. Full article

The research investigated the influence of laser powder bed fusion (LPBF) parameters for NickelAlloy HX, a nickel-based superalloy, to achieve high-density components with superior mechanical properties. A systematic approach was employed, involving printing 40 cylindrical specimens with varying energy densities (50–240 J/mm³) to evaluate porosity, hardness, and anisotropy. Results revealed that energy density significantly influences relative density, with optimal parameters identified at 111 J/mm³ (900 mm/s scan speed, 120 W laser power). Microstructural examination revealed columnar grains aligned with the build direction in as-printed samples. The findings highlight the trade-offs between density, hardness, and microstructure in the additive manufacturing of nickel-based superalloys, providing actionable insights for industrial applications requiring specific property profiles. Full article

This paper presents a numerical investigation into the generation of 2D ordered pillar array columns for liquid chromatography columns, focusing on the development of an algorithm for the automatic creation of unit-cell morphologies and their subsequent computational fluid dynamics (CFD) simulation. The algorithm is developed to incorporate functional and operational constraints, which ensure that the generated structures are permeable and suitable for chromatographic separations. The functional constraints include the principal pathway and no dry void constraints, while the operational constraints involve symmetry and porosity thresholds. The algorithm’s efficacy is demonstrated with a reduction rate of 97.8% for order 5 matrices. CFD simulations of the generated morphologies reveal that the homogeneity of the fluid velocity profile within the unit cell is a key determinant of separation performance, suggesting that refining the resolution of discrete unit cells could enhance separation efficiency. Future work will explore the inclusion of more complex morphologies and the impact of particle shape and size on separation efficiency. Full article

The crystallization of soluble salts is one of the most significant agents of deterioration affecting porous building materials in historical architecture. This process not only compromises the physical integrity of the materials but also results in considerable aesthetic, structural, and economic consequences. Soluble salts involved in these processes may originate from geogenic sources—including soil leachate, marine aerosols, and the natural weathering of parent rocks—or from anthropogenic factors such as air pollution, wastewater infiltration, and the use of incompatible restoration materials. This study examines the role of capillary rise as a primary mechanism responsible for the vertical migration of saline solutions from the soil profile into historic masonry structures, especially those constructed with calcareous stones. It describes how water retained or sustained within the soil matrix ascends via capillarity, carrying dissolved salts that eventually crystallize within the pore network of the stone. This phenomenon leads to a variety of damage types, ranging from superficial staining and efflorescence to more severe forms such as subflorescence, microfracturing, and progressive mass loss. By adopting a multidisciplinary approach that integrates concepts and methods from soil physics, hydrology, petrophysics, and conservation science, this paper examines the mechanisms that govern saline water movement, salt precipitation patterns, and their cumulative effects on stone durability. It highlights the influence of key variables such as soil texture and structure, matric potential, hydraulic conductivity, climatic conditions, and stone porosity on the severity and progression of deterioration. This paper also addresses regional considerations by focusing on the context of Spain, which holds one of the highest concentrations of World Heritage Sites globally and where many monuments are constructed from vulnerable calcareous materials such as fossiliferous calcarenites and marly limestones. Special attention is given to the types of salts most commonly encountered in Spanish soils—particularly chlorides and sulfates—and their thermodynamic behavior under fluctuating environmental conditions. Ultimately, this study underscores the pressing need for integrated, preventive conservation strategies. These include the implementation of drainage systems, capillary barriers, and the use of compatible materials in restoration, as well as the application of non-destructive diagnostic techniques such as electrical resistivity tomography and hyperspectral imaging. Understanding the interplay between soil moisture dynamics, salt crystallization, and material degradation is essential for safeguarding the cultural and structural value of historic buildings in the face of ongoing environmental challenges and climate variability. Full article

In this investigation, a comprehensive validation framework for an integrated electrochemical-thermal model that addresses critical thermal management challenges in lithium-ion batteries (LIBs) is presented. The two-dimensional numerical model combines the Newman–Tiedemann–Gu–Kim (NTGK) electrochemical-thermal battery framework with the enthalpy-porosity approach for phase change material (PCM) battery thermal management systems (BTMSs). Rigorous validation against benchmarks demonstrates the model’s exceptional predictive capability across a wide range of operating conditions. Simulated temperature distribution and voltage capacity profiles at multiple discharge rates show excellent agreement with the experimental data, accurately capturing the underlying electrochemical-thermal mechanisms. Incorporating Capric acid (with a phase transition range of 302–305 K) as the PCM, the thermal management model demonstrates significantly improved accuracy over existing models in the literature. Notable error reductions include a 78.3% decrease in the Mean Squared Error (0.477 vs. 2.202), a 53.4% reduction in the Root Mean Squared Error (0.619 vs. 1.483), and a 55.5% drop in the Mean Absolute Percentage Error. Statistical analysis further confirms the model’s robustness, with a high coefficient of determination (R² = 0.968858) and well-distributed residuals. Liquid fraction evolution analysis highlights the PCM’s ability to absorb thermal energy effectively during high-discharge operations, enhancing thermal regulation. This validated model provides a reliable foundation for the design of next-generation BTMS, aiming to improve the safety, performance, and lifespan of LIBs in advanced energy storage applications where thermal stability is critical. Full article

Proton exchange membrane water electrolyzers (PEMWEs) are a promising technology for green hydrogen production. However, the adoption of PEMWE-based hydrogen production systems remains limited due to several challenges, including high material costs, limited performance and durability, and difficulties in scaling the technology. Computational modeling serves as a powerful tool to address these challenges by optimizing system design, improving material performance, and reducing overall costs, thereby accelerating the commercial rollout of PEMWE technology. Despite this, conventional models often oversimplify key components, such as porous transport and catalyst layers, by assuming constant porosity and neglecting the spatial heterogeneity found in real electrodes. This simplification can significantly impact the accuracy of performance predictions and the overall efficiency of electrolyzers. This study develops a mathematical framework for modeling variable porosity distributions—including constant, linearly graded, and stepwise profiles—and derives analytical expressions for permeability, effective diffusivity, and electrical conductivity. These functions are integrated into a three-dimensional multi-domain COMSOL simulation to assess their impact on electrochemical performance and transport behavior. The results reveal that although porosity variations have minimal effect on polarization at low voltages, they significantly influence internal pressure, species distribution, and gas evacuation at higher loads. A notable finding is that reversing stepwise porosity—placing high porosity near the membrane rather than the channel—can alleviate oxygen accumulation and improve current density. A multi-factor comparison highlights this reversed configuration as the most favorable among the tested strategies. The proposed modeling approach effectively connects porous media theory and system-level electrochemical analysis, offering a flexible platform for the future design of porous electrodes in PEMWE and other energy conversion systems. Full article

Advancements in load-bearing tissue repair increasingly demand biomaterials that not only support structural integrity but also interact dynamically with the physiological environment. This review examines the latest progress in smart biomaterials designed for skeletal reconstruction, with emphasis on mechanoresponsive scaffolds, bioactive composites, and integrated microsensors for real-time monitoring. We explore material formulations that enhance osseointegration, resist micromotion-induced loosening, and modulate inflammatory responses at the bone–implant interface. Additionally, we assess novel fabrication methods—such as additive manufacturing and gradient-based material deposition—for tailoring stiffness, porosity, and degradation profiles to match host biomechanics. Special attention is given to sensor-augmented platforms capable of detecting mechanical strain, biofilm formation, and early-stage implant failure. Together, these technologies promise a new class of bioresponsive, diagnostic-capable constructs that extend beyond static support to become active agents in regenerative healing and post-operative monitoring. This multidisciplinary review integrates insights from materials science, mechanobiology, and device engineering to inform the future of implantable systems in skeletal tissue repair. Full article

Patient-specific scaffolds for tissue and organ regeneration are still limited by the difficulty of simultaneously shaping complex geometries, preserving hierarchical porosity, and guaranteeing sterility. Additive technologies represent a promising approach for addressing problems in tissue engineering, with the potential to develop personalized matrices for the growth of tissue and organ cells. The utilization of supercritical technologies, encompassing the processes of drying and sterilization within a supercritical fluid environment, has demonstrated significant opportunities for obtaining highly effective matrices for cell growth based on biocompatible materials. We present a comprehensive methodology for fabricating intricately structured, sterile aerogels based on alginate–chitosan polyelectrolyte complexes. The target three-dimensional macrostructure is achieved through (i) direct ink writing or (ii) heterophase printing, enabling the deposition of inks with diverse rheological profiles (viscosities ranging from 0.8 to 2500 Pa·s). A coupled supercritical carbon dioxide drying–sterilization regimen at 120 bar and 40 °C is employed to preserve the highly porous architecture of the printed constructs. The resulting aerogels exhibit 96 ± 2% porosity, a BET surface area of 108–238 m² g⁻¹, and complete sterility. The proposed integration of 3D printing and supercritical processing yields sterile, intricately structured aerogels with substantial potential for the fabrication of patient-specific scaffolds for tissue and organ regeneration. Full article

Fins are extended surfaces designed to increase heat dissipation from hot sources to their surroundings. Heat transfer is improved by utilising fins of different geometrical shapes. Fins are extensively used in automobile parts, solar panels, electrical equipment, computer CPUs, refrigeration systems, and superheaters. Motivated by these applications, this study investigates the incorporation of magnetic fields and porosity into a convective–radiative triangular fin to enhance heat transfer performance. The shooting technique is applied to study thermal profile and efficiency of the fin. It is found that the magnetic number (Hartmann number), porosity, convective, and radiative parameters reduce the thermal profile, while the Peclet number and ambient temperature increase it. Moreover, the efficiency increases with an increase in the magnetic number, porosity, convective, and radiative parameters, whereas it declines with an increase in the Peclet number and ambient temperature. Increasing the magnetic number from $0.1$ to $0.7$ leads to a $4\%$ reduction in the temperature profile. Similarly, raising the porosity parameter within the same range results in an approximate $3\%$ decrease in the thermal profile. An increase in the convective parameter from $0.1$ to $0.7$ causes about an $8\%$ decline in the thermal profile, while an elevation in the radiative parameter within the same range reduces it by approximately $2\%$. In contrast, enhancing the Peclet number from $0.1$ to $0.7$ increases the thermal profile by nearly $2\%$, and a rise in the ambient temperature within this range leads to an approximate $4\%$ enhancement in the thermal profile. Magnetised triangular fins are observed to have higher thermal transfer ability and efficiency than non-magnetised triangular fins. It is found that the incorporation of a magnetic field into a triangular fin, in conjunction with the porosity, improves the performance and efficiency of the triangular fin. Full article

This study presents a systematic optimization of GTAW welding parameters to achieve a pipe-to-pipe butt weld with a root height consistently below 2 mm when joining stainless-steel 316L material, employing the Taguchi design of experiments. To the authors’ knowledge, no similar studies have been conducted to explore the optimization of welding parameters specifically aimed at minimizing weld root height under 2 mm in stainless-steel EO pipeline welding applications. This gap in the existing literature highlights the innovative aspect of the current study, which seeks to address these challenges and improve welding precision and joint reliability. Root height, also referred to as weld root reinforcement, is defined as the excess weld metal protruding beyond the inner surface root side of a butt-welded joint. The input parameters considered are the welding current, voltage, speed, and root gap configurations of 1, 1.5, and 2 mm. Welding was performed according to the Taguchi L-09 experimental design. Nine weld samples were evaluated using liquid penetrant testing to detect surface-breaking defects, such as porosity, laps, and cracks; X-ray radiography to identify internal defects; and profile radiography to assess erosion, corrosion, and root height. Among the nine welded plate samples, the optimal root height (less than 2 mm) was selected and further validated through the welding of a one-pipe sample. An additional macro examination was conducted to confirm the root height and assess the overall root weld integrity and quality. Full article

The snack market is shifting toward healthier options, leading to a growing interest in organic snacks. Dried fruits are particularly popular due to their long shelf life and convenience. Freeze-drying helps preserve both the taste and nutrients of these fruits. Among them, peaches are noteworthy for their antioxidant and anti-inflammatory properties. The research assessed the impact of lactic fermentation using Lactiplantibacillus plantarum (P_LP) and Fructilactobacillus fructivorans (P_FF), followed by freeze-drying, on the physicochemical, structural, and sensory properties of peach slices. Fermentation increased acidity (>22 mg/kg), decreased sugars (up to 43.5%), and raised salt content (to ~0.5%), effectively altering the fruit’s chemical profile. Dry matter content decreased by 6.0% (P_LP) and 7.2% (P_FF), while water activity remained low (0.13–0.15). Color parameters changed notably: L* values decreased, and a* values increased, with total color differences (ΔE) exceeding 15. Structural changes included higher porosity (to 71.4% in P_LP and 72.8% in P_FF) and reduced hardness from 50.1 N (control) to 35.7 N (P_LP) and 28.2 N (P_FF), which may benefit processing. Water sorption isotherms suggested improved stability under elevated humidity. However, sensory analysis showed lower consumer acceptance of the fermented samples due to reduced sweetness, crunchiness, and overall palatability, along with undesirable flavors from F. fructivorans. While lactic fermentation holds the potential for creating fruit snacks with better functional value, further optimization is needed to enhance sensory appeal and market potential. Full article

The rising concern over carbon dioxide (CO₂) emissions has led to increased research on its conversion into value-added chemicals. Glycerol carbonate (GC), a versatile and eco-friendly compound, can be synthesized via the catalytic carbonylation of glycerol with CO₂. This study investigates the catalytic performance of three novel mixed metal oxide catalysts, Ti-Al-Mg, Ti-Cr-Mg, and Ti-Fe-Mg, synthesized via co-precipitation. The catalysts were characterized using XRD, SEM, XPS, CO₂-TPD, FTIR, TGA-DTG, and nitrogen adsorption–desorption isotherms. Among the tested systems, Ti-Al-Mg demonstrated the highest surface area, optimal porosity, and a balanced acid–base profile, resulting in superior catalytic activity. Under optimized conditions (175 °C, 10 bar CO₂, 4 h), Ti-Al-Mg achieved a maximum GC yield of 36.1%, outperforming Ti-Cr-Mg and Ti-Fe-Mg. The improved performance was attributed to the synergistic effects of its physicochemical properties, including high magnesium content and lower CO₂ binding energy, which favored CO₂ activation and glycerol conversion while minimizing side reactions. These findings highlight the potential of tailored mixed metal oxide systems for efficient CO₂ immobilization and sustainable glycerol valorization. Full article