Functional Hydrogels: Design, Processing and Biomedical Applications

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 116

Special Issue Editors


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Guest Editor
School of Pharmacy and School of Biological and Food Engineering, Changzhou University, Changzhou 213164, China
Interests: biomedical engineering; hydrogel; collagen
Special Issues, Collections and Topics in MDPI journals
School of Pharmacy and School of Biological and Food Engineering, Changzhou University, Changzhou 213164, China
Interests: lipid nanoparticles; drug delivery; pharmaceutics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Functional hydrogels have emerged as a transformative class of biomaterials, offering unparalleled versatility in biomedical applications due to their tunable physicochemical properties, high biocompatibility, and stimuli-responsive behavior. Recent advances in hydrogel design and processing—including dynamic crosslinking strategies, 3D bioprinting, and nanocomposite integration—have unlocked new possibilities for tailored drug delivery, tissue engineering, wound healing, and diagnostic platforms. However, challenges remain in optimizing hydrogel performance for site-specific therapeutic delivery, long-term stability, and seamless integration with biological systems.

This Special Issue aims to highlight cutting-edge research and reviews regarding the development and application of functional hydrogels, with a focus on innovative strategies to enhance their functionality, adaptability, and clinical utility. Topics of interest include, but are not limited to:

  • Smart drug delivery systems with controlled release kinetics and targeting capabilities;
  • Bioinspired hydrogels mimicking extracellular matrix features for tissue regeneration;
  • Advanced fabrication techniques (e.g., photopolymerization, microfluidics) to improve scalability and precision;
  • Multifunctional hydrogels integrating antimicrobial, conductive, or self-healing properties;
  • Applications in regenerative medicine, wearable sensors, and minimally invasive therapies.

We welcome contributions addressing mechanistic insights, computational modeling, and translational studies that bridge material innovation with clinical needs. Interdisciplinary research exploring synergies between hydrogels and emerging technologies (e.g., CRISPR, organ-on-a-chip) is particularly encouraged.

This Special Issue seeks to foster collaboration among researchers in materials science, chemistry, bioengineering, and medicine in order to accelerate the development of next-generation hydrogel-based solutions for global healthcare challenges.

Prof. Dr. Jianhao Wang
Dr. Cheng Wang
Guest Editors

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Keywords

  • functional hydrogels
  • biomedical applications
  • drug delivery systems
  • tissue engineering
  • 3D bioprinting
  • stimuli-responsive materials
  • regenerative medicine

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Published Papers (1 paper)

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Research

20 pages, 8369 KiB  
Article
Drying of Functional Hydrogels: Development of a Workflow for Bioreactor-Integrated Freeze-Drying of Protein-Coated Alginate Microcarriers for iPS Cell-Based Screenings
by Johnn Majd Balsters, Alexander Bäumchen, Michael Roland, Stefan Diebels, Julia C. Neubauer, Michael M. Gepp and Heiko Zimmermann
Gels 2025, 11(6), 439; https://doi.org/10.3390/gels11060439 (registering DOI) - 7 Jun 2025
Abstract
Protein-coated ultra-high viscosity (UHV)-alginate hydrogels are essential to mimic the physiological in vivo environment of humans in several in vitro applications. This work presents an optimized bioreactor-integrated freeze-drying process for MatrigelTM-coated UHV-alginate microcarriers in the context of human induced pluripotent stem [...] Read more.
Protein-coated ultra-high viscosity (UHV)-alginate hydrogels are essential to mimic the physiological in vivo environment of humans in several in vitro applications. This work presents an optimized bioreactor-integrated freeze-drying process for MatrigelTM-coated UHV-alginate microcarriers in the context of human induced pluripotent stem cell (hiPSC) expansion. The impact of freeze-drying on the UHV-alginate microcarriers using trehalose 100 mg/mL in 0.9% NaCl as a lyoprotective agent, as well as the stem cell response using hiPSCs, was analyzed using microscopy-based screenings. First observations of the process showed that the integrity of the cake was preserved in the samples with a maximum vapor exchanging rate. Following rehydration, the UHV-alginate microcarriers retained their original morphology. Upon the addition of Poloxamer 188, stickiness and bubble formation were reduced. The expansion of hiPSCs in a suspension bioreactor resulted in a 5–7-fold increase in total cell count, yielding at least 1.3 × 107 cells with viability exceeding 80% after seven days of cultivation. In flow cytometry analysis, the pluripotency factors OCT3/4 and SSEA4 resulted in positive signals in over 98% of cells, while the differentiation factor SSEA1 was positive in fewer than 10% of cells. Supported by preceding in silico predictions of drying time, this study presents, for the first time, basic steps toward a “ready-to-use” bioreactor-integrated freeze-drying process for UHV-alginate microcarriers in the iPSC context. Full article
(This article belongs to the Special Issue Functional Hydrogels: Design, Processing and Biomedical Applications)
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