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22 Citations

3,032 Views

17 Pages

Downregulation of miR-99b-5p and Upregulation of Nuclear mTOR Cooperatively Promotes the Tumor Aggressiveness and Drug Resistance in African American Prostate Cancer

Himali Gujrati,
Siyoung Ha,
Mohammad Waseem and
Bi-Dar Wang

Int. J. Mol. Sci.2022, 23(17), 9643;https://doi.org/10.3390/ijms23179643

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25 August 2022

Mammalian target of rapamycin (mTOR) regulates various fundamental cellular events including cell proliferation, protein synthesis, metabolism, apoptosis, and autophagy. Tumor suppressive miR-99b-5p has been implicated in regulating PI3K/AKT/mTOR sig...

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Article

8 Citations

4,534 Views

19 Pages

Alpha-Lipoic Acid Reduces Cell Growth, Inhibits Autophagy, and Counteracts Prostate Cancer Cell Migration and Invasion: Evidence from In Vitro Studies

Sabrina Bossio,
Anna Perri,
Raffaella Gallo,
Anna De Bartolo,
Vittoria Rago,
Daniele La Russa,
Michele Di Dio,
Sandro La Vignera,
Aldo E. Calogero and
Giovanni Vitale
+ 1 author

Int. J. Mol. Sci.2023, 24(23), 17111;https://doi.org/10.3390/ijms242317111

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4 December 2023

Alpha-lipoic acid (ALA) is a natural antioxidant dithiol compound, exerting antiproliferative and antimetastatic effects in various cancer cell lines. In our study, we demonstrated that ALA reduces the cell growth of prostate cancer cells LNCaP and D...

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Article

28 Citations

5,501 Views

14 Pages

Role of SIRT-3, p-mTOR and HIF-1α in Hepatocellular Carcinoma Patients Affected by Metabolic Dysfunctions and in Chronic Treatment with Metformin

Serena De Matteis,
Emanuela Scarpi,
Anna Maria Granato,
Umberto Vespasiani-Gentilucci,
Giuliano La Barba,
Francesco Giuseppe Foschi,
Erika Bandini,
Martina Ghetti,
Giorgia Marisi and
Paola Cravero
+ 9 authors

Int. J. Mol. Sci.2019, 20(6), 1503;https://doi.org/10.3390/ijms20061503

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26 March 2019

The incidence of hepatocellular carcinoma deriving from metabolic dysfunctions has increased in the last years. Sirtuin- (SIRT-3), phospho-mammalian target of rapamycin (p-mTOR) and hypoxia-inducible factor- (HIF-1α) are involved in metabolism...

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Article

3 Citations

1,417 Views

20 Pages

Sparstolonin B Reduces Estrogen-Dependent Proliferation in Cancer Cells: Possible Role of Ceramide and PI3K/AKT/mTOR Inhibition

Yağmur Dilber,
Hanife Tuğçe Çeker,
Aleyna Öztüzün,
Bürke Çırçırlı,
Esma Kırımlıoğlu,
Zerrin Barut and
Mutay Aslan

Pharmaceuticals2024, 17(12), 1564;https://doi.org/10.3390/ph17121564

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21 November 2024

Background: The aim of this study was to determine the effect of Sparstolonin B (SsnB) on cell proliferation and apoptosis in human breast cancer (MCF-7) and human ovarian epithelial cancer (OVCAR-3) cell lines in the presence and absence of estradio...

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Article

61 Citations

7,805 Views

17 Pages

Fucoidan Suppresses Hypoxia-Induced Lymphangiogenesis and Lymphatic Metastasis in Mouse Hepatocarcinoma

Hongming Teng,
Yazong Yang,
Hengyun Wei,
Zundong Liu,
Zhichao Liu,
Yanhong Ma,
Zixiang Gao,
Lin Hou and
Xiangyang Zou

Mar. Drugs2015, 13(6), 3514-3530;https://doi.org/10.3390/md13063514

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3 June 2015

Metastasis, the greatest clinical challenge associated with cancer, is closely connected to multiple biological processes, including invasion and adhesion. The hypoxic environment in tumors is an important factor that causes tumor metastasis by activ...

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Article

3 Citations

1,858 Views

19 Pages

Arginine Promoted Ovarian Development in Pacific White Shrimp Litopenaeus vannamei via the NO-sGC-cGMP and TORC1 Signaling Pathways

Xin Zhang,
Yanan Yin,
Haitao Fan,
Qicun Zhou and
Lefei Jiao

Animals2024, 14(13), 1986;https://doi.org/10.3390/ani14131986

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5 July 2024

This study aimed to evaluate the effects of arginine (0.5%, 1%, 1.5%, 2%, and 2.5% arginine supplementation levels were selected) on the ovarian development of Pacific white shrimp (Litopenaeus vannamei). The analyzed arginine supplementation levels...

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Article

75 Citations

10,431 Views

16 Pages

The Antidiabetic Drug Metformin Inhibits the Proliferation of Bladder Cancer Cells in Vitro and in Vivo

Tao Zhang,
Peng Guo,
Yinan Zhang,
Hui Xiong,
Xiao Yu,
Shan Xu,
Xinyang Wang,
Dalin He and
Xunbo Jin

Int. J. Mol. Sci.2013, 14(12), 24603-24618;https://doi.org/10.3390/ijms141224603

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18 December 2013

Recent studies suggest that metformin, a widely used antidiabetic agent, may reduce cancer risk and improve prognosis of certain malignancies. However, the mechanisms for the anti-cancer effects of metformin remain uncertain. In this study, we invest...

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Article

16 Citations

5,578 Views

15 Pages

Rumen-Protected Glucose Stimulates the Insulin-Like Growth Factor System and mTOR/AKT Pathway in the Endometrium of Early Postpartum Dairy Cows

Yan Wang,
Xuefeng Han,
Zhiliang Tan,
Jinhe Kang and
Zheng Wang

Animals2020, 10(2), 357;https://doi.org/10.3390/ani10020357

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23 February 2020

This study aimed to elucidate the effects of a dietary rumen-protected glucose (RPG) addition on uterine involution through the analysis of an insulin-like growth factor (IGF) system and associated pathways in the post-natal endometrium. Twelve Holst...

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Article

1 Citations

1,699 Views

14 Pages

Oncogene Downregulation by Mahanine Suppresses Drug-Sensitive and Drug-Resistant Lung Cancer and Inhibits Orthotopic Tumor Progression

Raghuram Kandimalla,
Disha N. Moholkar,
Suman Kumar Samanta,
Neha Tyagi,
Farrukh Aqil and
Ramesh Gupta

Cancers2024, 16(21), 3572;https://doi.org/10.3390/cancers16213572

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23 October 2024

Background/Objectives: Lung cancer is one of the deadliest cancers, and drug resistance complicates its treatment. Mahanine (MH), an alkaloid from Murraya koenigii has been known for its anti-cancer properties. However, its effectiveness and mechanis...

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9 Results Found

Downregulation of miR-99b-5p and Upregulation of Nuclear mTOR Cooperatively Promotes the Tumor Aggressiveness and Drug Resistance in African American Prostate Cancer

Alpha-Lipoic Acid Reduces Cell Growth, Inhibits Autophagy, and Counteracts Prostate Cancer Cell Migration and Invasion: Evidence from In Vitro Studies

Role of SIRT-3, p-mTOR and HIF-1α in Hepatocellular Carcinoma Patients Affected by Metabolic Dysfunctions and in Chronic Treatment with Metformin

Sparstolonin B Reduces Estrogen-Dependent Proliferation in Cancer Cells: Possible Role of Ceramide and PI3K/AKT/mTOR Inhibition

Fucoidan Suppresses Hypoxia-Induced Lymphangiogenesis and Lymphatic Metastasis in Mouse Hepatocarcinoma

Arginine Promoted Ovarian Development in Pacific White Shrimp Litopenaeus vannamei via the NO-sGC-cGMP and TORC1 Signaling Pathways

The Antidiabetic Drug Metformin Inhibits the Proliferation of Bladder Cancer Cells in Vitro and in Vivo

Rumen-Protected Glucose Stimulates the Insulin-Like Growth Factor System and mTOR/AKT Pathway in the Endometrium of Early Postpartum Dairy Cows

Oncogene Downregulation by Mahanine Suppresses Drug-Sensitive and Drug-Resistant Lung Cancer and Inhibits Orthotopic Tumor Progression