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1,427 Results Found

  • Review
  • Open Access
1 Citations
2,378 Views
19 Pages

Overview of Pectin-Derived Microparticles through Microfluidic Technology

  • Pedro Brivaldo Viana da Silva and
  • João Paulo Fabi

16 August 2024

The scientific field of microcarrier systems has gained significant advancements, especially in drug delivery and controlled release mechanisms. This manuscript provides a comprehensive overview of the progress in developing pectin-derived microcarri...

  • Article
  • Open Access
5 Citations
2,786 Views
16 Pages

Preparation and Regulation of Natural Amphiphilic Zein Nanoparticles by Microfluidic Technology

  • Zhe Liu,
  • Xiaojie Ma,
  • Yanzheng Ge,
  • Xue Hei,
  • Xinyu Zhang,
  • Hui Hu,
  • Jinjin Zhu,
  • Benu Adhari,
  • Qiang Wang and
  • Aimin Shi

31 May 2024

Microfluidic technology, as a continuous and mass preparation method of nanoparticles, has attracted much attention in recent years. In this study, zein nanoparticles (ZNPs) were continuously fabricated in a highly controlled manner by combining a mi...

  • Review
  • Open Access
19 Citations
7,472 Views
23 Pages

Advances of 3D Cell Co-Culture Technology Based on Microfluidic Chips

  • Can Li,
  • Wei He,
  • Yihua Song,
  • Xia Zhang,
  • Jianfei Sun and
  • Zuojian Zhou

10 July 2024

Cell co-culture technology aims to study the communication mechanism between cells and to better reveal the interactions and regulatory mechanisms involved in processes such as cell growth, differentiation, apoptosis, and other cellular activities. T...

  • Review
  • Open Access
17 Citations
5,893 Views
19 Pages

Microfluidic Technology for the Production of Well-Ordered Porous Polymer Scaffolds

  • Pei Zhao,
  • Jianchun Wang,
  • Yan Li,
  • Xueying Wang,
  • Chengmin Chen and
  • Guangxia Liu

19 August 2020

Advances in tissue engineering (TE) have revealed that porosity architectures, such as pore shape, pore size and pore interconnectivity are the key morphological properties of scaffolds. Well-ordered porous polymer scaffolds, which have uniform pore...

  • Article
  • Open Access
16 Citations
5,664 Views
19 Pages

Study of the Fabrication Technology of Hybrid Microfluidic Biochips for Label-Free Detection of Proteins

  • Nikita Sitkov,
  • Tatiana Zimina,
  • Alexey Kolobov,
  • Evgeny Sevostyanov,
  • Valentina Trushlyakova,
  • Viktor Luchinin,
  • Alexander Krasichkov,
  • Oleg Markelov,
  • Michael Galagudza and
  • Dmitry Kaplun

24 December 2021

A study of the peculiarities and a comparative analysis of the technologies used for the fabrication of elements of novel hybrid microfluidic biochips for express biomedical analysis have been carried out. The biochips were designed with an incorpora...

  • Review
  • Open Access
1,238 Views
29 Pages

5 February 2026

Microfluidic chip technologies, also known as lab-on-a-chip systems, have profoundly transformed laboratory medicine by enabling the miniaturization, automation, and rapid processing of complex diagnostic assays using minimal sample volumes. Recent a...

  • Article
  • Open Access
4 Citations
3,474 Views
19 Pages

Heavily-Doped Bulk Silicon Sidewall Electrodes Embedded between Free-Hanging Microfluidic Channels by Modified Surface Channel Technology

  • Yiyuan Zhao,
  • Henk-Willem Veltkamp,
  • Thomas V. P. Schut,
  • Remco G. P. Sanders,
  • Bogdan Breazu,
  • Jarno Groenesteijn,
  • Meint J. de Boer,
  • Remco J. Wiegerink and
  • Joost C. Lötters

Surface Channel Technology is known as the fabrication platform to make free-hanging microchannels for various microfluidic sensors and actuators. In this technology, thin film metal electrodes, such as platinum or gold, are often used for electrical...

  • Article
  • Open Access
11 Citations
4,031 Views
11 Pages

A New 3D Cultured Liver Chip and Real-Time Monitoring System Based on Microfluidic Technology

  • Yao Zhang,
  • Ning Yang,
  • Liangliang Xie,
  • Fangyu Shu,
  • Qian Shi and
  • Naila Shaheen

16 December 2020

In vitro models of the liver have a good simulation of the micro-liquid environment inside the human liver and the communication between cell tissues, which provides an important research tool for drug research and liver disease treatment. In this pa...

  • Article
  • Open Access
10 Citations
3,729 Views
15 Pages

6 April 2022

The water blocking damage to the reservoir caused by the invasion of external fluid is one of the main factors that affect the efficient development of tight sandstone gas reservoirs. In this paper, microfluidic chip technology is used to explore the...

  • Article
  • Open Access
4 Citations
3,178 Views
16 Pages

Design and Parameter Research of Time-Harmonic Magnetic Field Sensor Based on PDMS in Microfluidic Technology

  • Chenzhao Bai,
  • Hongpeng Zhang,
  • Chengjie Wang,
  • Lebile Ilerioluwa Joseph,
  • Qiang Wang,
  • Yucai Xie and
  • Guobin Li

4 September 2020

In order to improve the throughput and sensitivity of the inductive metal micro-abrasive particle detection sensor, this paper uses microfluidic detection technology to design a high-throughput abrasive particle detection sensor based on PDMS (Polydi...

  • Article
  • Open Access
2 Citations
1,598 Views
31 Pages

Background/Objectives: Alginate nanoparticles (NPs) are commonly synthesised using either an emulsion technique that involves organic solvent use or ionotropic gelation utilising multivalent cations, e.g., Ca+2. However, the extensive use of organic...

  • Review
  • Open Access
18 Citations
6,670 Views
38 Pages

24 June 2023

Microfluidic technology is a powerful tool to enable the rapid, accurate, and on-site analysis of forensically relevant evidence on a crime scene. This review paper provides a summary on the application of this technology in various forensic investig...

  • Review
  • Open Access
37 Citations
9,941 Views
20 Pages

20 November 2022

The development of novel materials with microstructures is now a trend in food science and technology. These microscale materials may be applied across all steps in food manufacturing, from raw materials to the final food products, as well as in the...

  • Review
  • Open Access
42 Citations
8,003 Views
21 Pages

A Review of Optical Imaging Technologies for Microfluidics

  • Pan Zhou,
  • Haipeng He,
  • Hanbin Ma,
  • Shurong Wang and
  • Siyi Hu

8 February 2022

Microfluidics can precisely control and manipulate micro-scale fluids, and are also known as lab-on-a-chip or micro total analysis systems. Microfluidics have huge application potential in biology, chemistry, and medicine, among other fields. Coupled...

  • Review
  • Open Access
77 Citations
8,147 Views
17 Pages

Microfluidic Technology for the Isolation and Analysis of Exosomes

  • Yusong Wu,
  • Yuqing Wang,
  • Yanjun Lu,
  • Xiaomei Luo,
  • Yinghong Huang,
  • Ting Xie,
  • Christian Pilarsky,
  • Yuanye Dang and
  • Jianye Zhang

22 September 2022

Exosomes are lipid-bilayer enclosed vesicles with diameters of 30–150 nm, which play a pivotal role in cell communication by transporting their cargoes such as proteins, lipids, and genetic materials. In recent years, exosomes have been under i...

  • Review
  • Open Access
6 Citations
3,833 Views
20 Pages

Innovative Microfluidic Technologies for Rapid Heavy Metal Ion Detection

  • Muhammad Furqan Rauf,
  • Zhenda Lin,
  • Muhammad Kamran Rauf and
  • Jin-Ming Lin

Heavy metal ion (HMI) contamination poses significant threats to public health and environmental safety, necessitating advanced detection technologies that are rapid, sensitive, and field-deployable. While conventional methods like atomic absorption...

  • Article
  • Open Access
21 Citations
4,346 Views
16 Pages

Microfluidic Technology for the Production of Hybrid Nanomedicines

  • Ilaria Ottonelli,
  • Jason Thomas Duskey,
  • Arianna Rinaldi,
  • Maria Vittoria Grazioli,
  • Irene Parmeggiani,
  • Maria Angela Vandelli,
  • Leon Z. Wang,
  • Robert K. Prud’homme,
  • Giovanni Tosi and
  • Barbara Ruozi

Microfluidic technologies have recently been applied as innovative methods for the production of a variety of nanomedicines (NMeds), demonstrating their potential on a global scale. The capacity to precisely control variables, such as the flow rate r...

  • Review
  • Open Access
59 Citations
7,944 Views
28 Pages

Synthesis of Biomaterials Utilizing Microfluidic Technology

  • Xiaohong Wang,
  • Jinfeng Liu,
  • Peizhou Wang,
  • Andrew DeMello,
  • Lingyan Feng,
  • Xiaoli Zhu,
  • Weijia Wen,
  • Rimantas Kodzius and
  • Xiuqing Gong

5 June 2018

Recently, microfluidic technologies have attracted an enormous amount of interest as potential new tools for a large range of applications including materials synthesis, chemical and biological detection, drug delivery and screening, point-of-care di...

  • Perspective
  • Open Access
36 Citations
8,441 Views
23 Pages

Prospects of Microfluidic Technology in Nucleic Acid Detection Approaches

  • Zilwa Mumtaz,
  • Zubia Rashid,
  • Ashaq Ali,
  • Afsheen Arif,
  • Fuad Ameen,
  • Mona S. AlTami and
  • Muhammad Zubair Yousaf

27 May 2023

Conventional diagnostic techniques are based on the utilization of analyte sampling, sensing and signaling on separate platforms for detection purposes, which must be integrated to a single step procedure in point of care (POC) testing devices. Due t...

  • Article
  • Open Access
5 Citations
3,941 Views
15 Pages

Microfluidics for High Pressure: Integration on GaAs Acoustic Biosensors with a Leakage-Free PDMS Based on Bonding Technology

  • Saber Hammami,
  • Aleksandr Oseev,
  • Sylwester Bargiel,
  • Rabah Zeggari,
  • Céline Elie-Caille and
  • Thérèse Leblois

Microfluidics integration of acoustic biosensors is an actively developing field. Despite significant progress in “passive” microfluidic technology, integration with microacoustic devices is still in its research state. The major challeng...

  • Review
  • Open Access
117 Citations
17,106 Views
23 Pages

Microfluidic Technology for the Generation of Cell Spheroids and Their Applications

  • Raja K. Vadivelu,
  • Harshad Kamble,
  • Muhammad J. A. Shiddiky and
  • Nam-Trung Nguyen

23 March 2017

A three-dimensional (3D) tissue model has significant advantages over the conventional two-dimensional (2D) model. A 3D model mimics the relevant in-vivo physiological conditions, allowing a cell culture to serve as an effective tool for drug discove...

  • Review
  • Open Access
32 Citations
8,331 Views
19 Pages

A Review on Microfluidics: An Aid to Assisted Reproductive Technology

  • Anand Baby Alias,
  • Hong-Yuan Huang and
  • Da-Jeng Yao

19 July 2021

Infertility is a state of the male or female reproductive system that is defined as the failure to achieve pregnancy even after 12 or more months of regular unprotected sexual intercourse. Assisted reproductive technology (ART) plays a crucial role i...

  • Review
  • Open Access
23 Citations
7,106 Views
17 Pages

Anti-Cancer Drug Screening with Microfluidic Technology

  • Mojdeh Monjezi,
  • Milad Rismanian,
  • Hamidreza Jamaati and
  • Navid Kashaninejad

11 October 2021

The up-and-coming microfluidic technology is the most promising platform for designing anti-cancer drugs and new point-of-care diagnostics. Compared to conventional drug screening methods based on Petri dishes and animal studies, drug delivery in mic...

  • Review
  • Open Access
58 Citations
19,227 Views
22 Pages

The Use of Microfluidic Technology for Cancer Applications and Liquid Biopsy

  • Arutha Kulasinghe,
  • Hanjie Wu,
  • Chamindie Punyadeera and
  • Majid Ebrahimi Warkiani

10 August 2018

There is growing awareness for the need of early diagnostic tools to aid in point-of-care testing in cancer. Tumor biopsy remains the conventional means in which to sample a tumor and often presents with challenges and associated risks. Therefore, al...

  • Review
  • Open Access
8 Citations
3,725 Views
18 Pages

Electrochemical microfluidic technology has been extensively studied in many fields due to its significant advantages. Despite the increasing number of publications on the subject, there are no studies based on bibliometric analysis in this area. In...

  • Review
  • Open Access
96 Citations
10,242 Views
29 Pages

Microfluidic Technology for Clinical Applications of Exosomes

  • Florina S. Iliescu,
  • Danilo Vrtačnik,
  • Pavel Neuzil and
  • Ciprian Iliescu

12 June 2019

Exosomes, a type of nanovesicle, are distinct cellular entities specifically capable of carrying various cargos between cells. It has been hypothesized that exosomes, as an enriched source of biomolecules, may serve as biomarkers for various diseases...

  • Feature Paper
  • Article
  • Open Access
21 Citations
6,498 Views
9 Pages

Characterization and Integration of Terahertz Technology within Microfluidic Platforms

  • Salman Alfihed,
  • Mark H. Bergen,
  • Antonia Ciocoiu,
  • Jonathan F. Holzman and
  • Ian G. Foulds

11 September 2018

In this work, the prospects of integrating terahertz (THz) time-domain spectroscopy (TDS) within polymer-based microfluidic platforms are investigated. The work considers platforms based upon the polar polymers polyethylene terephthalate (PET), polyc...

  • Review
  • Open Access
91 Citations
10,425 Views
18 Pages

Application of Microfluidic Chip Technology in Food Safety Sensing

  • Hongwei Gao,
  • Chunlei Yan,
  • Wei Wu and
  • Juan Li

24 March 2020

Food safety analysis is an important procedure to control food contamination and supervision. It is urgently needed to construct effective methods for on-site, fast, accurate and popular food safety sensing. Among them, microfluidic chip technology e...

  • Article
  • Open Access
24 Citations
5,070 Views
21 Pages

A Systematic Analysis of Recent Technology Trends of Microfluidic Medical Devices in the United States

  • Rucha Natu,
  • Luke Herbertson,
  • Grazziela Sena,
  • Kate Strachan and
  • Suvajyoti Guha

24 June 2023

In recent years, the U.S. Food and Drug Administration (FDA) has seen an increase in microfluidic medical device submissions, likely stemming from recent advancements in microfluidic technologies. This recent trend has only been enhanced during the C...

  • Review
  • Open Access
2 Citations
2,368 Views
12 Pages

Cellular mechanical properties are critical for tissue and organ homeostasis, which are associated with many diseases and are very promising non-labeled biomarkers. Over the past two decades, many research tools based on microfluidic methods have bee...

  • Review
  • Open Access
33 Citations
6,086 Views
26 Pages

1 December 2021

Recent advances in cancer immunotherapy have led a paradigm shift in the treatment of multiple malignancies with renewed focus on the host immune system and tumor–immune dynamics. However, intrinsic and acquired resistance to immunotherapy limi...

  • Review
  • Open Access
47 Citations
8,308 Views
29 Pages

17 June 2020

The controlled synthesis and surface engineering of inorganic nanomaterials hold great promise for the design of functional nanoparticles for a variety of applications, such as drug delivery, bioimaging, biosensing, and catalysis. However, owing to t...

  • Review
  • Open Access
13 Citations
6,596 Views
17 Pages

Advances in Nucleic Acid Assays for Infectious Disease: The Role of Microfluidic Technology

  • Yiran Wang,
  • Jingwei Chen,
  • Zhijin Yang,
  • Xuanyu Wang,
  • Yule Zhang,
  • Mengya Chen,
  • Zizhen Ming,
  • Kaihuan Zhang,
  • Dawei Zhang and
  • Lulu Zheng

Within the fields of infectious disease diagnostics, microfluidic-based integrated technology systems have become a vital technology in enhancing the rapidity, accuracy, and portability of pathogen detection. These systems synergize microfluidic tech...

  • Article
  • Open Access
3 Citations
2,788 Views
12 Pages

Preparation of CL-20 with Controllable Particle Size Using Microfluidic Technology

  • Zihao Zhang,
  • Jin Yu,
  • Yujia Wen,
  • Hanyu Jiang,
  • Siyu Xu,
  • Yubao Shao,
  • Ergang Yao,
  • Heng Li and
  • Fengqi Zhao

As a typical high-energy-density material, the sensitivity of CL-20 severely limits its application in explosives and propellants. Adjusting its structure at the microscopic level can effectively solve such problems. In this study, a microfluidic rec...

  • Review
  • Open Access
22 Citations
4,300 Views
22 Pages

Recent Progress and Challenges on the Microfluidic Assay of Pathogenic Bacteria Using Biosensor Technology

  • Farnaz Bahavarnia,
  • Mohammad Hasanzadeh,
  • Deniz Sadighbayan and
  • Farzad Seidi

Microfluidic technology is one of the new technologies that has been able to take advantage of the specific properties of micro and nanoliters, and by reducing the costs and duration of tests, it has been widely used in research and treatment in biol...

  • Feature Paper
  • Article
  • Open Access
22 Citations
6,798 Views
13 Pages

Encapsulation of Lutein via Microfluidic Technology: Evaluation of Stability and In Vitro Bioaccessibility

  • Yuanhang Yao,
  • Jiaxing Jansen Lin,
  • Xin Yi Jolene Chee,
  • Mei Hui Liu,
  • Saif A. Khan and
  • Jung Eun Kim

1 November 2021

Inadequate intake of lutein is relevant to a higher risk of age-related eye diseases. However, lutein has been barely incorporated into foods efficiently because it is prone to degradation and is poorly bioaccessible in the gastrointestinal tract. Mi...

  • Review
  • Open Access
8 Citations
6,549 Views
31 Pages

19 February 2025

Cell sorting plays a crucial role in both medical and biological research. As a key passive sorting technique in the field of microfluidics, deterministic lateral displacement (DLD) has been widely applied to cell separation and sorting. This review...

  • Review
  • Open Access
32 Citations
8,162 Views
31 Pages

5 October 2020

Microfluidic technology has emerged from the MEMS (Micro-Electro-Mechanical System)-technology as an important research field. During the last decade, various microfluidic technologies have been developed to open up a new era for biological studies....

  • Review
  • Open Access
19 Citations
12,310 Views
14 Pages

11 October 2016

One goal of metabolic engineering and synthetic biology for cyanobacteria and microalgae is to engineer strains that can optimally produce biofuels and commodity chemicals. However, the current workflow is slow and labor intensive with respect to ass...

  • Article
  • Open Access
9 Citations
3,165 Views
13 Pages

Design of a Digital LAMP Detection Platform Based on Droplet Microfluidic Technology

  • Liying Jiang,
  • Xianghao Lan,
  • Linjiao Ren,
  • Mingzhu Yang,
  • Bo Wei and
  • Yang Wang

19 May 2023

Loop-mediated isothermal amplification (LAMP) is a rapid and high-yield amplification technology for specific DNA or RNA molecules. In this study, we designed a digital loop-mediated isothermal amplification (digital-LAMP)-functioning microfluidic ch...

  • Article
  • Open Access
8 Citations
2,989 Views
14 Pages

Evaluation of Adjuvant Activity and Bio-Distribution of Archaeosomes Prepared Using Microfluidic Technology

  • Yimei Jia,
  • Gerard Agbayani,
  • Vandana Chandan,
  • Umar Iqbal,
  • Renu Dudani,
  • Hui Qian,
  • Zygmunt Jakubek,
  • Kenneth Chan,
  • Blair Harrison and
  • Michael J. McCluskie
  • + 2 authors

Archaeosomes, composed of sulfated lactosyl archaeol (SLA) glycolipids, have been proven to be an effective vaccine adjuvant in multiple preclinical models of infectious disease or cancer. They have classically been prepared using a thin-film hydrati...

  • Review
  • Open Access
38 Citations
10,358 Views
21 Pages

Giant lipid vesicles or liposomes are primarily composed of phospholipids and form a lipid bilayer structurally similar to that of the cell membrane. These vesicles, like living cells, are 5–100 μm in diameter and can be easily observed usin...

  • Article
  • Open Access
26 Citations
7,079 Views
14 Pages

18 April 2017

In this article, we propose a novel microfluidic microstrip electromagnetic band gap (EBG) sensor realized using cost-effective 3D printing technology. Microstrip sensor allows monitoring of the fluid properties flowing in the microchannel embedded b...

  • Article
  • Open Access
18 Citations
7,870 Views
12 Pages

Preparation and Properties of RDX@FOX-7 Composites by Microfluidic Technology

  • Jin Yu,
  • Hanyu Jiang,
  • Siyu Xu,
  • Heng Li,
  • Yiping Wang,
  • Ergang Yao,
  • Qing Pei,
  • Meng Li,
  • Yang Zhang and
  • Fengqi Zhao

18 January 2023

1,3,5-trinitro-1,3,5-triazacyclohexane (RDX) is a type of high energy explosive, its application in weapon systems is limited by its high mechanical sensitivity. At the same time, 1,1-diamino-2,2-dinitroethylene (FOX-7) is a famous insensitive explos...

  • Review
  • Open Access
2 Citations
2,501 Views
13 Pages

14 October 2022

Cellular chemotaxis has been the subject of a variety of studies due to its relevance in physiological processes, disease pathogenesis, and systems biology, among others. The migration of cells towards a chemical source remains a closely studied topi...

  • Article
  • Open Access
34 Citations
6,570 Views
11 Pages

An LC Wireless Microfluidic Sensor Based on Low Temperature Co-Fired Ceramic (LTCC) Technology

  • Yongyuan Liang,
  • Mingsheng Ma,
  • Faqiang Zhang,
  • Feng Liu,
  • Zhifu Liu,
  • Dong Wang and
  • Yongxiang Li

8 March 2019

This work reports a novel wireless microfluidic biosensor based on low temperature co-fired ceramic (LTCC) technology. The wireless biosensor consists of a planar spiral inductor and parallel plate capacitor (LC) resonant antenna, which integrates wi...

  • Article
  • Open Access
38 Citations
4,823 Views
17 Pages

Folate Receptor-Targeted Albumin Nanoparticles Based on Microfluidic Technology to Deliver Cabazitaxel

  • Fanchao Meng,
  • Yating Sun,
  • Robert J. Lee,
  • Guiyuan Wang,
  • Xiaolong Zheng,
  • Huan Zhang,
  • Yige Fu,
  • Guojun Yan,
  • Yifan Wang and
  • Lesheng Teng
  • + 5 authors

16 October 2019

Microfluidic technology (MF) has improved the formulation of nanoparticles (NPs) by achieving uniform particle size distribution, controllable particle size, and consistency. Moreover, because liquid mixing can be precisely controlled in the pores of...

  • Review
  • Open Access
5 Citations
2,960 Views
22 Pages

26 September 2022

One of the approaches widely used today to intensify processes is their miniaturization. Small, compact, portable devices that can be used directly in the field will become popular in the near future. The use of microstructured devices is becoming mo...

  • Article
  • Open Access
7 Citations
2,672 Views
14 Pages

Sensitivity Enhancement and Probiotic Detection of Microfluidic Chips Based on Terahertz Radiation Combined with Metamaterial Technology

  • Yen-Shuo Lin,
  • Shih-Ting Huang,
  • Shen-Fu Steve Hsu,
  • Kai-Yuan Tang,
  • Ta-Jen Yen and
  • Da-Jeng Yao

Terahertz (THz) radiation has attracted wide attention in recent years due to its non-destructive properties and ability to sense molecular structures. In applications combining terahertz radiation with metamaterial technology, the interaction betwee...

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