Research Trends and Applications of Hematopoietic Stem Cell Transplantation

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Hematology".

Deadline for manuscript submissions: 28 August 2025 | Viewed by 1254

Special Issue Editors


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Guest Editor
Clinical assistant professor of Pediatrics, Pediatric Hematology/Oncology, Stem Cell Transplantation and Regenerative Medicine, Stanford School of Medicine, Stanford University, Palo Alto, CA 94304, USA
Interests: haploidentical stem cell transplant; machine learning; gene therapy; conditioning regimen; transplant related

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Guest Editor
1. Emeritus Professor of Pediatrics, Immunology and Microbiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA
2. Adjunct Professor of Pediatrics, Stem Cell Transplantation and Regenerative Medicine, Stanford School of Medicine, Stanford University, Palo Alto, CA 94304, USA
Interests: hematopoietic stem cell transplant; graft-versus-host disease; immunology; primary immunodeficiency

Special Issue Information

Dear Colleagues,

The field of hematopoietic stem cell transplant has always been progressing rapidly with innovative therapeutic approaches. Since the seminal works by Dr. E. Donnall Thomas, the field has transformed medicine by offering cures for diseases that were previously thought to be incurable. This feat has been achieved by breakthroughs in conditioning regimens, alternative donor sources, peri-transplant supportive cares and graft-versus-host disease management. The most notable recent breakthrough is of hematopoietic stem cell-based gene therapies for monogenetic diseases, providing treatment for not only hematological but also metabolic as well as neurological conditions. This Special Issue of Journal of Clinical Medicine titled, “Research Trends and Applications of Hematopoietic Stem Cell Transplantation”, aims to provide its broad readership the most current updates on innovations in HSCT including alternative donor stem cell transplant for both malignant and non-malignant disorders, novel conditioning approaches that reduce transplant-related toxicities, management of graft-versus-host diseases and gene therapies for various monogenetic diseases including both gene-editing and gene-insertion strategies. With an emphasis on clinical applications, we would like to solicit your original translational and clinical studies as well as systemic reviews in any of the aforementioned areas of hematopoietic stem cell transplantation.

Dr. David C. Shyr
Prof. Dr. Robertson Parkman
Guest Editors

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Keywords

  • hematopoietic stem cell transplant
  • conditioning regimen
  • immunology
  • graft-versus-host disease
  • gene therapy
  • transplant-related toxicities
  • alternative donor stem cell transplant
  • supportive care

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Published Papers (1 paper)

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11 pages, 1091 KiB  
Article
A New Tool Supporting the Selection of the Best Hematopoietic Stem Cell Donor by Modelling Local Own Real-World Data
by Roberto Crocchiolo, Stefania Cacace, Giuseppe Milone, Barbara Sarina, Alessandra Cupri, Salvatore Leotta, Giulia Giuffrida, Andrea Spadaro, Jacopo Mariotti, Stefania Bramanti, Alice Fumagalli, Maria Pia Azzaro, Sebastiana Toscano and Quirico Semeraro
J. Clin. Med. 2024, 13(22), 6869; https://doi.org/10.3390/jcm13226869 - 15 Nov 2024
Viewed by 969
Abstract
Background: The selection of the best donor for each specific patient is crucial for the success of allogeneic hematopoietic stem cell transplantation (HSCT). However, there is debate on the choice of the best donor when multiple suitable donors exist. Methods: By using own [...] Read more.
Background: The selection of the best donor for each specific patient is crucial for the success of allogeneic hematopoietic stem cell transplantation (HSCT). However, there is debate on the choice of the best donor when multiple suitable donors exist. Methods: By using own data from two transplant centers, we have developed a calculator able to provide the patients’ 2-year overall survival (OS) associated with each of the potential donor options during the selection process, in order to support the transplant physician during the choice. Data on 737 HSCTs with HLA-identical siblings, and unrelated or related haploidentical donors from January 2010 to July 2022 have been retrospectively obtained. Results: Patients’ age, disease, comorbidity index, and donor type were found to be significant variables able to predict the outcome with robustness (concordance index: 0.677). Estimates are provided within an example in the text showing outcomes with four donor options for a specific patient. Conclusions: We present the prototype of a tool supporting the selection of the best donor, guiding transplant physicians during the delicate process of donor selection before HSCT. This approach relies on real data from the centers, reflecting their local clinical experience. Improvements are underway with a larger, ongoing multicenter study. Full article
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