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Leukemia-Induced Cellular Senescence and Stemness Alterations in Mesenchymal Stem Cells Are Reversible upon Withdrawal of B-Cell Acute Lymphoblastic Leukemia Cells

  • Natalia-Del Pilar Vanegas,
  • Paola Fernanda Ruiz-Aparicio,
  • Gloria Inés Uribe,
  • Adriana Linares-Ballesteros and
  • Jean-Paul Vernot
Int. J. Mol. Sci.2021, 22(15), 8166;https://doi.org/10.3390/ijms22158166

29 July 2021

Leukemic cell growth in the bone marrow (BM) induces a very stressful condition. Mesenchymal stem cells (MSC), a key component of this BM niche, are affected in several ways with unfavorable consequences on hematopoietic stem cells favoring leukemic...

(This article belongs to the Section Molecular Oncology)
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