Search Results (3,263)

Oil spill simulation models are essential for predicting the oil spill behavior and movement in marine environments. In this study, we comprehensively reviewed a large and diverse body of peer-reviewed literature obtained from Scopus and Web of Science. Our initial analysis phase focused on examining trends in scientific publications, utilizing the complete dataset derived after systematic screening and database integration. In the second phase, we applied elements of a systematic review to identify and evaluate the most influential contributions in the scientific field of oil spill simulations. Our analysis revealed a steady and accelerating growth of research activity over the past five decades, with a particularly notable expansion in the last two. The field has also experienced a marked increase in collaborative practices, including a rise in international co-authorship and multi-authored contributions, reflecting a more global and interdisciplinary research landscape. We cataloged the key modeling frameworks that have shaped the field from established systems such as OSCAR, OIL-MAP/SIMAP, and GNOME to emerging hybrid and Lagrangian approaches. Hydrodynamic models were consistently central, often integrated with biogeochemical, wave, atmospheric, and oil-spill-specific modules. Environmental variables such as wind, ocean currents, and temperature were frequently used to drive model behavior. Geographically, research has concentrated on ecologically and economically sensitive coastal and marine regions. We conclude that future progress will rely on the real-time integration of high-resolution environmental data streams, the development of machine-learning-based surrogate models to accelerate computations, and the incorporation of advanced biodegradation and weathering mechanisms supported by experimental data. These advancements are expected to enhance the accuracy, responsiveness, and operational value of oil spill modeling tools, supporting environmental monitoring and emergency response. Full article

Acalitus simplex is an eriophyoid mite pest of the ornamental plant Ruellia simplex. Acalitus simplex compromises the esthetics of R. simplex by inducing erinea formation. Management practices for A. simplex are currently lacking. This study assessed the potential of commercial biorational (citric acid, potassium salt of fatty acids, garlic, thyme, and mineral oil) and conventional (abamectin, fenpyroximate, bifenthrin, spiromesifen) pesticides under laboratory conditions, using two types of spray applications: (A) curative, after erinea formation, and (B) prophylactic, before erinea formation. In the curative application, abamectin, garlic oil, and mineral oil were most effective; in the prophylactic application, abamectin and mineral oil showed the highest efficacies. Abamectin and mineral oil were further tested under greenhouse conditions. Both treatments effectively controlled A. simplex by preventing erinea formation over a four-week post-application period, regardless of the application type. At the end of the experiment, mites were extracted from R. simplex plants. In the curative application, significantly fewer mites were extracted from abamectin and mineral oil treatments than in the control. In the prophylactic application, mites were absent in abamectin and mineral oil treatments but present in the control. Abamectin and mineral oil can be used to manage A. simplex in landscapes. Full article

Container liner shipping companies operate within a complex environment where they must balance profitability and service reliability. Meanwhile, evolving regulatory policies, such as surcharges imposed on ships of a particular origin or type on specific trade lanes, introduce new operational challenges. This study addresses the heterogeneous ship routing and demand acceptance problem, aiming to maximize two conflicting objectives: weekly profit and total transport volume. We formulate the problem as a bi-objective mixed-integer programming model and prove that the ship chartering constraint matrix is totally unimodular, enabling the reformulation of the model into a partially relaxed MIP that preserves optimality while improving computational efficiency. We further analyze key mathematical properties showing that the Pareto frontier consists of a finite union of continuous, piecewise linear segments but is generally non-convex with discontinuities. A case study based on a realistic liner shipping network confirms the model’s effectiveness in capturing the trade-off between profit and transport volume. Sensitivity analyses show that increasing freight rates enables higher profits without large losses in volume. Notably, this paper provides a practical risk management framework for shipping companies to enhance their adaptability under shifting regulatory landscapes. Full article

The implementation of the trans-European tourist cycle route network “EuroVelo” is fostering new strategic importance for non-motorized mobility and the associated practice of cycling tourism. Indeed, slow tourism offers a pathway for the development of inland areas. The infrastructure supporting it, such as long-distance cycling and walking paths, can act as a vital connection, stimulating regeneration in peripheral territories by enhancing environmental and landscape assets, as well as preserving heritage, local identity, and culture. The regeneration of peri-urban landscapes through soft mobility is recognized as the cornerstone for accessibility to material and immaterial resources (including ecosystem services) for multiple categories of users, including the most vulnerable, especially following the restoration of green-area systems and non-urbanized areas with degraded ecosystems. Considering the forthcoming implementation of the Magna Grecia cycling route, the southernmost segment of the “EuroVelo” network traversing three regions in southern Italy, this contribution briefly examines the necessity of defining new development policies to effectively integrate sustainable slow tourism with the enhancement of environmental and landscape values in the coastal areas along the route. Specifically, this case study focuses on a coastal stretch characterized by significant morphological and environmental features and notable landscapes interwoven with densely built environments. In this area, environmental and landscape values face considerable threats from scattered, irregular, low-density settlements, abandoned sites, and other inappropriate constructions along the coastline. Full article

Heart failure (HF) poses a substantial global burden due to its high morbidity, mortality, and healthcare costs. Accurate prognostication is crucial for optimizing treatment, resource allocation, and patient counseling. Prognostic tools range from simple clinical scores such as ADHERE and MAGGIC to more complex models incorporating biomarkers (e.g., NT-proBNP, sST2), imaging, and artificial intelligence techniques. In acute HF, models like EHMRG and STRATIFY aid early triage, while in chronic HF, tools like SHFM and BCN Bio-HF support long-term management decisions. Despite their utility, most models are limited by poor generalizability, reliance on static inputs, lack of integration into electronic health records, and underuse in clinical practice. Novel approaches involving machine learning, multi-omics profiling, and remote monitoring hold promise for dynamic and individualized risk assessment. However, these innovations face challenges regarding interpretability, validation, and ethical implementation. For prognostic models to transition from theoretical promise to practical impact, they must be continuously updated, externally validated, and seamlessly embedded into clinical workflows. This review emphasizes the potential of prognostic models to transform HF care but cautions against uncritical adoption without robust evidence and practical integration. In the evolving landscape of HF management, prognostic models represent a hopeful avenue, provided their limitations are acknowledged and addressed through interdisciplinary collaboration and patient-centered innovation. Full article

In an era where digitalization shapes economic and social landscapes, the intersection of digital skills, ethics, and integrity plays a crucial role in understanding the vulnerability of youth classified as NEET (Not in Education, Employment, or Training). This study explores how risky internet use and digital skill gaps contribute to socio-economic exclusion, integrating a multivariate and spatial approach to assess regional disparities in Europe. This study adopts a systems thinking perspective to explore digital exclusion as an emergent outcome of multiple interrelated subsystems. The research employs logistic regression, Principal Component Analysis (PCA) with Promax rotation, and Geographic Information Systems (GIS) to examine the impact of digital behaviors on NEET status. Using Eurostat data aggregated at the country level for the period (2000–2023) across 28 European countries, this study evaluates 24 digital indicators covering social media usage, instant messaging, daily internet access, data protection awareness, and digital literacy levels. The findings reveal that low digital skills significantly increase the likelihood of being NEET, while excessive social media and internet use show mixed effects depending on socio-economic context. A strong negative correlation between digital security practices and NEET status suggests that youths with a higher awareness of online risks are less prone to socio-economic exclusion. The GIS analysis highlights regional disparities, where countries with limited digital access and lower literacy levels exhibit higher NEET rates. Digital exclusion is not merely a technological issue but a multidimensional socio-economic challenge. To reduce the NEET rate, policies must focus on enhancing digital skills, fostering online security awareness, and addressing regional disparities. Integrating GIS methods allows for the identification of territorial clusters with heightened digital vulnerabilities, guiding targeted interventions for improving youth employability in the digital economy. Full article

Through a systematic review of sustainable rural dwelling recovery, this study offers a broader reflection on retrofitting practices, viewing eco-efficiency as a means to enhance both cultural heritage and agricultural landscapes. The work is based on the assumption that vernacular architecture in rural contexts embodies historical, cultural, and typological values worthy of preservation, while remaining adaptable to reuse through eco-efficient solutions and technological innovation. Using the PRISMA protocol, 115 scientific contributions were selected from 1711 initial records and classified into four macro-groups: landscape relationships; seismic and energy retrofitting; construction techniques and innovative materials; and morphological–typological analysis. Results show a predominance (over 50%) of passive design strategies, compatible materials, and low-impact techniques, while active systems are applied more selectively to protect cultural integrity. The study identifies replicable methodological models combining sustainability, cultural continuity, and functional adaptation, offering recommendations for future operational guidelines. Conscious eco-efficient retrofitting thus emerges as a strategic tool for the integrated valorization of rural landscapes and heritage. Full article

Ongoing interest in the intersection of spirituality and health has prompted a need for integrated research. This report proposes a distinct approach in a model that allows for successful and harmonious cross-fertilization within these latter two areas of interest. Our work is especially pertinent to inquiries around the role of spirituality in mental health, with special attention to chronic pain conditions. The latter have become an open channel for novel avenues to explore the field of spirituality-based interventions within the arena of psychological inquiry. To address this, the authors developed and implemented the Church and Academia Model, a prototype for an innovative collaborative research project, with the aim of exploring the role of devotional practices, and their potential to be used as therapeutic co-adjuvants or tools to enhance the coping skills of patients with chronic pain. Keeping in mind that the church presents a rich landscape for clinical inquiry with broad relevance for clinicians and society at large, we created a unique hybrid research model. This is a new paradigm that focuses on distinct and well-defined studies where the funding, protocol writing, study design, and implementation are shared by experts from both the pastoral and clinical spaces. A team of theologians, researchers, and healthcare providers, including clinical pain psychologists, built a coalition leveraging their respective skill sets. Each expert is housed in their own environs, creating a functional network that has proven academically productive and pastorally effective. Key outputs include the creation and validation of a new psychometric measure, the Pain-related PRAYER Scale (PPRAYERS), an associated bedside prayer tool and a full-scale dissemination strategy through journal publications and specialty society conferences. This collaborative prototype is also an ideal fit for integrated knowledge translation platforms, and it is a promising paradigm for future collaborative projects focused on spirituality and mental health. Full article

Extracellular vesicle (EV)-based therapies have attracted considerable attention as a novel class of biologics with broad clinical potential. However, their clinical translation is impeded by the fragmented and rapidly evolving regulatory landscape, with significant disparities between the United States, European Union, and key Asian jurisdictions. In this review, we systematically analyze regional guidelines and strategic frameworks governing EV therapeutics, emphasizing critical hurdles in quality control, safety evaluation, and efficacy demonstration. We further explore the implications of EVs’ heterogeneity on product characterization and the emerging direct-to-consumer market for EVs and secretome preparations. Drawing on these insights, in this review, we aim to provide a roadmap for harmonizing regulatory requirements, advancing standardized analytical approaches, and fostering ongoing collaboration among regulatory authorities, industry stakeholders, and academic investigators. Such coordinated efforts are essential to safeguard patient welfare, ensure product consistency, and accelerate the responsible integration of EV-based interventions into clinical practice. Full article

We investigated the dispersal ability of Euphydryas aurinia provincialis in a local-scale analysis within a single habitat patch of the Colfiorito highlands metapopulation. Our findings indicate that inside a single node, the organization of nesting patches can be conceptualized as a metapopulation itself, where reproductive sites, despite their spatial proximity, can act as either source or sink habitats depending on environmental conditions. We conducted fieldwork in six nesting patches inside a single node, capturing, marking, and recapturing individuals to assess their spatial distribution and movement tendencies at a large landscape scale. We found a high degree of site fidelity among individuals, with many recaptures occurring within the original marking site, but also a sex-based difference in movement patterns; females dispersed farther than males, likely driven by reproductive strategies, while males remained more localized, prioritizing mate-searching. Our findings suggest a complex dynamic in habitat connectivity: pastures and abandoned fields, despite being open, seem to act like sink areas, while breeding sites with shrub and tree cover act as source habitats, offering optimal conditions for reproduction. Individuals, especially females, from these source areas were later compelled to disperse into open habitats, highlighting a nuanced interaction between landscape structure and population dynamics. These results highlight the importance of maintaining habitat corridors to support metapopulation dynamics and prevent genetic isolation; the abandonment of traditional grazing practices is leading to the rapid closure of these source habitats, posing a severe risk of local extinction. Conservation efforts should prioritize the preservation of these source habitats to ensure the long-term viability of E. a. provincialis populations in fragmented landscapes. Full article

Freshwater ecosystems—home to roughly 10% of known species—are losing biodiversity to river-morphology alteration, hydraulic infrastructure, and pollution, yet most ecological network (EN) studies focus on terrestrial systems and overlook hydrological connectivity under human disturbance. To address this, we devised and tested a dual EN framework in the Yangtze River Delta’s Ecological Green Integration Demonstration Zone, constructing freshwater and terrestrial networks independently before merging them. Using InVEST Habitat Quality, MSPA, the MCR model, and Linkage Mapper, we delineated sources and corridors: freshwater sources combined NDWI-InVEST indicators with a modified, sluice-weighted resistance surface, producing 78 patches (mean 348.7 ha) clustered around major lakes and 456.4 km of corridors (42.50% primary). Terrestrial sources used NDVI-InVEST with a conventional resistance surface, yielding 100 smaller patches (mean 121.6 ha) dispersed across woodlands and agricultural belts and 658.8 km of corridors (36.45% primary). Unified models typically favor large sources from dominant ecosystems while overlooking small, high-value patches in non-dominant systems, generating corridors that span both freshwater and terrestrial habitats and mismatch species migration patterns. Our dual framework better reflects species migration characteristics, accurately captures dispersal paths, and successfully integrates key agroforestry-complex patches that unified models miss, providing a practical tool for biodiversity protection in disturbed freshwater–terrestrial landscapes. Full article

Hypertrophic cardiomyopathy (HCM) is a prevalent and often underdiagnosed genetic cardiac disorder characterized by left ventricular hypertrophy and, in many cases, dynamic left ventricular outflow tract obstruction (LVOTO). The development of cardiac myosin inhibitors (CMIs) represents an emerging therapeutic approach in the pharmacological management of obstructive HCM (oHCM). This review offers an integrated and up-to-date synthesis of the cardiac myosin inhibitor class, with a focus on mavacamten, aficamten, and the broader landscape of emerging agents. It also highlights recent clinical trial outcomes, pharmacokinetic and pharmacogenetic considerations, and potential future directions in therapy. Furthermore, we incorporate the most recent data up to May 2025, including late-breaking trial results and real-world safety findings, aiming to provide clinicians with a practical and comprehensive perspective on this evolving drug class. A narrative review was conducted by systematically searching PubMed, Scopus, Google Scholar, and ClinicalTrials.gov for English-language articles and trials published between January 2016 and May 2025. Keywords included “cardiac myosin inhibitor”, mavacamten”, “aficamten”, “MYK-224”, and “hypertrophic cardiomyopathy.” Inclusion criteria encompassed clinical trials and comprehensive reviews specifically addressing CMIs in cardiac applications. CMIs such as mavacamten and aficamten have demonstrated significant clinical benefits in reducing LVOT gradients, improving exercise capacity, and alleviating symptoms in patients with oHCM. Mavacamten is currently approved for clinical use, while aficamten is in advanced regulatory review. Comparative data suggest potential advantages of aficamten in the onset of action, pharmacokinetic profile, and tolerability. Emerging evidence supports the exploration of CMIs in pediatric populations, heart failure with preserved ejection fraction (HFpEF), and non-obstructive HCM (nHCM), although results are still preliminary. Cardiac myosin inhibitors offer a novel, pathophysiology-targeted approach to managing oHCM. While mavacamten has established efficacy, next-generation agents like aficamten may offer improved safety and versatility. Further long-term studies are needed to clarify their role across broader patient populations. Full article

Rangelands form the ecological and economic backbone of Namibia, yet the woody plant dynamics that sustain these landscapes remain sporadically quantified across the semi-arid interior. We investigated the characteristics (stand structure, regeneration, richness, diversity, composition, ecological importance, and indicator species) of woody communities along a pronounced south-to-north rainfall gradient (85–346 mm yr⁻¹) at five representative sites: Warmbad, Gibeon, Otjimbingwe, Ovitoto, and Sesfontein. Field sampling combined point-centered quarter surveys (10 points site⁻¹) and belt transects (15 plots site⁻¹). The basal area increased almost ten-fold along the gradient (0.4–3.4 m² ha⁻¹). Principal Coordinates Analysis (PCoA) arranged plots in near-perfect rainfall order, and Permutational Multivariate Analysis of Variance (PERMANOVA) confirmed significant site differences (F_3,56 = 9.1, p < 0.001). Nanophanerophytes dominated hyper-arid zones, while microphanerophytes appeared progressively with increasing rainfall. Mean annual precipitation explained 45% of the variance in mean height and 34% of Shannon diversity but only 5% of stem density. Indicator value analysis highlighted Montinia caryophyllacea for Warmbad (IndVal = 100), Rhigozum trichotomum (75.8) for Gibeon, Senegalia senegal (72.6) for Otjimbingwe, and Senegalia mellifera (97.3) for Ovitoto. Rainfall significantly influences woody structure and diversity; however, other factors also modulate density and regeneration dynamics. This quantitative baseline can serve as a practical toolkit for designing site-specific management strategies across Namibia’s aridity gradient. Full article

Advanced technologies increase both the speed and the efficiency of work, saving time and money for practitioners. These technologies manifest in tools and resources that equip professionals across various sectors to carry out their work more effectively. Unfortunately, these resources can be confusing, convoluted, and critically misunderstood. Therefore, understanding emerging and advanced technology positions professionals to fill in gaps in knowledge and provides unrivaled value for the profession. This study examines advanced technology in the field of landscape architecture, analyzes applications of tools and resources, and provides a guide for implementation to answer the following research question: How can UAVs improve site analysis workflows for small landscape architecture firms? Focused on Unmanned Aerial Vehicles (UAVs), the discussion finds a multi-resource workflow leads to higher quality data, faster analysis, and more targeted solutions. Full article

Mining activities in a quarry significantly interfere with the landscape, weaken its ecological functions, disrupt the continuity of habitats and change its natural character. The aim of this study is to present a robust, transparent, and participatory methodological framework centered on the Reclamation Quality Index, which enables a comprehensive and repeatable assessment of reclamation quality. At a time when the restoration of functional, ecologically stable and long-term sustainable landscapes is increasingly important, there is a need for reliable tools to assess the quality of restoration. This article presents an original methodology for the evaluation of quarry reclamation, which combines scientific precision with practical applicability. The proposed Reclamation Quality Index is built on multidisciplinary foundations and uses the Delphi methodology, through which expert knowledge and weighted preferences enter the evaluation process. A tool designed in this way makes it possible to quantify the quality of land restoration, identify the benefits of individual interventions, support effective planning, and strengthen the strategic management of post-mining transformation. At the same time, the Reclamation Quality Index creates space for the application of the principles of ecological stability and integration of the landscape as a living, dynamic system in the process of restoration. With its structure and philosophy, the methodology represents a prospective approach to the evaluation and planning of the post-extraction landscape. Its application goes beyond academia, as it can serve as a support for environmental policymaking, landscape planning, and assessing the quality of restoration in practice. Full article