Search Results (963)

In this study, the efficacy of super white cement (SWC) to improve organic soils was researched. For stabilization, 10%, 15%, and 20% proportions of SWC were added to organic soil. After improvement with SWC, Atterberg limit testing, standard Proctor tests, triaxial compression tests, and swelling and compressibility tests were performed on the organic soil. Proctor tests showed that stabilization of organic soil with SWC increased maximum dry density (MDD) and optimum moisture content (OMC) values. After stabilization, the unconfined compressional strength values of the soil increased. This increase continued until the 28th day and had a reducing trend after improvement with SWC, linked to time. In addition to the reaction between SWC and OS, the time-dependent behavior of OS also contributed to this behavior. With the increase in SWC proportions, the cohesion intercept and internal friction angle values rapidly increased until the 56th day. This increase began to reduce after the 56th day. After stabilization, the swelling percentage and compressibility values for the soil reduced. The addition of SWC within organic soil appeared to improve the engineering properties of the soil. Full article

The depletion of water resources caused by climate change and human activities is a pressing global issue. Lake Ereen is one of the ten natural landmarks of the Gobi-Altai of western Mongolia is included in the list of “important areas for birds” recognized by the international organization Birdlife. However, the construction of the Taishir Hydroelectric Power Station, aimed at supplying electricity to the western provinces of Mongolia, had a detrimental effect on the flow of the Zavkhan River, resulting in a drying-up and pollution of Lake Ereen, which relies on the river as its water source. This study assesses the pollution levels in Ereen Lake and determines the feasibility of its rehabilitation by redirecting the flow of the Zavkhan River. Field studies included the analysis of water quality, sediment contamination, and the composition of flora. The results show that the concentrations of ammonium, chlorine, fluorine, and sulfate in the lake water exceed the permissible levels set by the Mongolian standard. Analyses of elements from sediments revealed elevated levels of arsenic, chromium, and copper, exceeding international sediment quality guidelines and posing risks to biological organisms. Furthermore, several species of diatoms indicative of polluted water were discovered. Lake Ereen is currently in a eutrophic state and, based on a water quality index (WQI) of 49.4, also in a “polluted” state. Mass balance calculations and box model analysis determined the period of pollutant replacement for two restoration options: drying-up and complete removal of contaminated sediments and plants vs. dilution-flushing without direct interventions in the lake. We recommend the latter being the most efficient, eco-friendly, and cost-effective approach to rehabilitate Lake Ereen. Full article

The dimensional accuracy of the intaglio surface of complete dentures fabricated using liquid crystal display (LCD) three-dimensional (3D) printing might be influenced by the build angle and post-processing storage conditions. This study evaluated the effect of build angle and natural light exposure duration on the intaglio surface trueness of maxillary complete denture bases. Standardized denture base designs (2 mm uniform thickness) were fabricated using an LCD 3D printer (Lilivis Print; Huvitz, Seoul, Republic of Korea) at build angles of 0°, 45°, and 90° (n = 7 per group). All specimens were printed using the same photopolymer resin (Tera Harz Denture; Graphy, Seoul, Republic of Korea) and identical printing parameters, followed by ultrasonic cleaning and ultraviolet post-curing. Specimens were stored under controlled light-emitting diode lighting and exposed to natural light (400–800 lux) for 0, 14, or 30 days. The intaglio surfaces were scanned and superimposed on the original design data, following the International Organization for Standardization 12836. Quantitative assessment included root mean square deviation, mean deviation, and tolerance percentage. Statistical analyses were performed using one-way analysis of variance and paired t-tests (α = 0.05). Build angle and light exposure duration significantly affected surface trueness (p < 0.05). The 90° build angle group exhibited the highest accuracy and dimensional stability, while the 0° group showed the greatest deviations (p < 0.05). These findings underscore the importance of optimizing build orientation and storage conditions in denture 3D printing. Full article

Background: The quality of decision-making processes is increasingly recognized as critical to public trust and policy sustainability. Objectives: This narrative review aims to identify and describe process-focused decision support models (DSMs) applied in pharmaceutical policy, and to examine their potential contributions to improving procedural quality in decisions related to pricing, reimbursement, and access to medicines. Methods: Relevant peer-reviewed and gray literature published between 2000 and 2025 was considered, drawing from key databases (e.g., PubMed and Scopus) and international policy reports (e.g., WHO, ISPOR, and HTA agencies). Studies were included if they provided insights into DSMs addressing at least one dimension of decision process quality. Results: Findings are synthesized narratively and organized by tool type, application context, and key quality dimensions. Frequently referenced tools included the Quality of Decision-Making Orientation Scheme (QoDoS), WHO-INTEGRATE, and AGREE II. QoDoS emerged as the only tool applied across regulatory, HTA, and industry settings, evaluating both individual- and organizational-level practices. WHO-INTEGRATE highlighted equity and legitimacy considerations but lacked a structured format. Overall, most tools demonstrated benefits in promoting internal consistency, transparency, and stakeholder engagement; however, their adoption remains limited, especially in low- and middle-income countries. Conclusions: Process-focused DSMs offer promising avenues for enhancing transparency, consistency, and legitimacy in pharmaceutical policy. Further exploration is needed to standardize evaluation approaches and expand the use of DSMs in diverse health systems. Full article

The digital business environment is rapidly evolving with advancements in information technology (IT), increasing the risk of information security incidents. Grounded in the resource-based view and in contingency theory, this study adopts a different approach from prior research by conceptualizing security management activities not as mere risk control mechanisms, but as strategic innovation drivers that can enhance corporate performance (sales revenue and operating profit). The authors develop a research model with six independent variables, including internal and external security management activities, CISO role configuration (independent or dual-role with CIO), and investment levels in IT and information security. The dependent variables include sales revenue and operating profit, with ISMS or ISO certification as a moderating variable. Using information security (IS) disclosures and financial data from 545 Korean firms that have reported their security management activities to the Ministry of Science and ICT, multiple regression and moderation analyses reveal that high IT investment negatively impacts performance, but this effect is mitigated when formal security systems, like ISMS or ISO, are in place. The results suggest that integrating recognized security frameworks into management strategies can enhance both innovation and financial outcomes, encouraging a proactive approach to security management. Full article

Patient involvement in health technology assessment (HTA) processes is increasingly recognized as pivotal for informed, equitable, and patient-relevant health care decision-making. With the implementation of Joint Scientific Consultations (JSCs) and Joint Clinical Assessments (JCAs) under Regulation (EU) 2021/2282, the European Union has a unique opportunity to design harmonized mechanisms that reflect best practices from established HTA systems. This article, drawing on the Acute Leukemia Advocates Network (ALAN)’s comparative analysis of HTA practices across seven countries (Canada, England, Scotland, France, Germany, Spain, and Italy), examines how current patient involvement processes can inform the JCA framework. It identifies opportunities to replicate effective practices and proposes strategies to embed patient voices meaningfully into the JCA process. By prioritizing robust and inclusive patient involvement, the EU can establish a global benchmark for impactful and consistent HTA processes. By leveraging lessons from international HTA systems and prioritizing clear frameworks, early involvement, and capacity building, the EU can set a global standard for meaningful patient participation in HTA processes. ALAN is an independent global network of patient organizations dedicated to improving outcomes for patients with acute leukemia. Full article

Mycotoxins are toxic secondary metabolites produced by various fungi that contaminate livestock feed, posing serious threats to animal health, productivity, and food safety. Although historical research has often examined individual mycotoxins in isolation, real-world conditions typically involve the simultaneous presence of multiple mycotoxins, resulting in additive or synergistic toxic effects that are often more severe than those observed with single toxin exposures. This review comprehensively synthesizes recent findings on multi-mycotoxin contamination in livestock feed, highlighting their physiological effects, mechanisms of action, and implications for regulatory frameworks. Multi-mycotoxin interactions exacerbate oxidative stress, immune suppression, impaired reproduction, and organ damage across species, leading to reduced growth performance, decreased milk and egg production, compromised carcass and wool quality, and increased mortality rates. A major concern is that current international regulatory standards mainly address individual mycotoxins, overlooking the compounded risks of co-occurrence. Global surveillance studies consistently reveal high prevalence rates of mycotoxin mixtures in feedstuffs, especially combinations involving DON, ZEN, AFB₁, FB₁, and OTA. Understanding these interactions and their underlying cellular mechanisms is critical for improving risk assessment models, formulating integrated mitigation strategies, and safeguarding both livestock productivity and human food security. Full article

Background: Accuracy of optical impressions—defined by the intraoral scanner (IOS)’s trueness and precision per International Organization for Standardization (ISO) standards—is influenced by both operator- and patient-related factors. Thus, this in vitro study aimed to (1) evaluate how scanning distance affects the accuracy of three different intraoral scanners (IOSs), and (2) identify the optimal scanning distance for each scanner. Methods: A maxillary arch model was obtained using polyvinyl siloxane impression material and poured with Type IV stone (Octa-rock royal^®, Kulzer, Germany). Using three different types of IOSs—the trios 3 shape (TRIOS ^® cart, 3Shape, Copenhagen, Denmark); the Helios 500 (Eighteeth ^®, Changzhou, China); and the Heron (3Disc ^®, Herndon, VA 20170, USA)—ten scans were performed with each of the IOSs with five predetermined distances: 0 mm, 2.5 mm, 5 mm, 7.5 mm, and 10 mm. Spacers of varying heights were designed using Meshmixer version 3.5 (Autodesk, Inc., Mill Valley, CA, USA) and three-dimensional printed with the Form 2 printer (Formlabs, Somerville, MA, USA). The scanned data was processed using Geomagic Control X (Version 16.0.2.16496, 3D Systems, Wilsonville, OR, USA). Statistical analyses were performed using R Statistical Software (version 4.2.2), with significance set at α = 0.05. Results: Scanning distance significantly influenced scan accuracy for all three scanners. The 3Disc scanner (3Disc, Herndon, VA, USA) demonstrated the highest accuracy at a 7.5 mm distance, while both the Helios 500 (Eighteeth, Changzhou, China) and Trios 3 (3Shape, Copenhagen, Denmark) scanners achieved their best accuracy at a 5 mm distance, as indicated by the lowest root mean square (RMS) values (p < 0.05). Conclusions: To conclude, each IOS has an optimal scanning distance for best accuracy. Trios 3 (3Shape, Copenhagen, Denmark) outperformed the others in both trueness and precision. Future studies should examine these effects under full-arch and clinical conditions. Full article

In recent years, advances in organ transplantation medicine have led to an increase in pregnancies and births following transplantation. Pregnancy after organ transplantation is considered high-risk, and its impact on both the recipient and the child must be carefully evaluated. In this review, we summarize the current landscape of pregnancy and childbirth after organ transplantation, with a particular focus on uterus transplantation (UTx). Traditionally, organ transplants have involved vital organs; however, UTx, developed for women with absolute uterine factor infertility, represents a novel approach. Although the number of births following UTx remains limited, it is expected to grow due to the international expansion of this procedure. Importantly, the concept of pregnancy and delivery following UTx is fundamentally different from that of other organ transplants. UTx is a life-enhancing, non-vital, and temporary transplant uniquely intended to enable the creation of new life. Pregnancy after UTx carries specific risks such as a higher incidence of miscarriage, preterm birth, hypertensive disorders of pregnancy, and gestational diabetes. All deliveries are performed via cesarean section, and conception is typically allowed after a relatively short period following transplantation, given the temporary nature of the graft and the goal to minimize recipient burden, with generally good neonatal outcomes. As pregnancies after both solid organ transplantation and UTx continue to rise worldwide, the development of standardized, organ-specific perinatal management strategies, particularly for UTx, is essential. Multidisciplinary collaboration will be critical to supporting these high-risk pregnancies and ensuring the best possible maternal and neonatal outcomes. Full article

Recycling washed mineral waste, generated as a byproduct of the mechanical wastewater treatment process, can be a beneficial alternative to widely used natural sand in construction. Studies on material from the Warsaw agglomeration, available in quantities sufficient for construction applications, demonstrated its high usability in specific hydrotechnical applications. Key laboratory tests for material characterization included physical, permeability, mechanical, and chemical property analyses. The tested waste corresponds to uniformly graded medium sands (uniformity coefficient: 2.20) and weakly calcareous (calcium carbonate content: 2.25–3.29%) mineral soils with organic content ranging from 0.24% to 1.49%. The minimum heavy metal immobilization level reached 91.45%. At maximum dry density of the soil skeleton (1.78/1.79 g/cm³) and optimal moisture content (11.34/11.95%), the hydraulic conductivity reached 4.38/7.71 m/d. The mechanical parameters of washed mineral waste included internal friction angle (34.4/37.8°) and apparent cohesion (9.37/14.98 kPa). The values of the determined parameters are comparable to those of natural sands used as construction aggregates. As a result, washed mineral waste has a high potential for use as an alternative material to natural sand in the analyzed hydrotechnical applications, particularly for flood embankment construction, by applicable technical standards and construction guidelines. Full article

Background: Computed Tomography (CT) imaging is widely recognised for its high capability in assessing multiple organs. However, concerns about patient radiation exposure, particularly in children, pose significant challenges. Objective: This study aimed to establish diagnostic reference levels (DRLs) for paediatric patients in the most common CT examinations to monitor and better control radiation doses. Methods: Dosimetry records from 5956 patients’ scans for the four most common CT imaging examinations—Head, Chest, Abdomen Pelvis (AP), and Chest Abdomen Pelvis (CAP)—were considered. The CT dosimetric quantities (CT dose-index volume (CTDI_vol) and dose-length product (DLP)), along with patient demographics (age and weight), were collected from radiology data storage systems. DRLs for CTDI_vol and DLP were determined for each imaging examination, stratified by patient age and weight groups, in accordance with ICRP recommendations. Results: The derived DRLs are presented as [median CTDI_vol (mGy): median DLP (mGy·cm)]. For (<1 yr): Head: 13:187, Chest: 0.4:7, AP: 0.9:19, CAP: 0.4:10. For (1–5 yrs): Head: 16:276, Chest: 1:22, AP: 1.5:58, CAP: 1.6:63. For (6–10 yrs): Head: 19:332, Chest: 1.4:35, AP: 1.9:74, CAP: 2:121. For (11–15 yrs): Head: 21:391, Chest: 3:86, AP: 4.1:191, CAP: 3:165. We observed that both the CTDI_vol and DLP DRL values increase with patient age. Weight-based DRLs follow similar trends for CTDI_vol, while DLP values show noticeable variations in Chest and AP examinations. Conclusions: The study findings highlight the need for review and optimisation of certain scanning protocols, particularly for chest and AP examinations. The derived DRLs are consistent with findings from other studies. The study recommends establishing national paediatric DRLs to enhance radiology practice across the country and ensure adherence to international safety standards. Full article

The energy sector uses artificial intelligence (AI) as a crucial instrument to achieve environmental sustainability targets by improving resource efficiency and decreasing emissions while minimizing waste production. This paper establishes an industry-specific executive playbook that guides energy sector leaders by implementing AI technologies for sustainability management with approaches suitable for industrial needs. The playbook provides an industry-specific framework along with strategies and AI-based solutions to help organizations overcome their sustainability challenges. Predictive analytics combined with smart grid management implemented through AI applications produced 15% less energy waste and reduced carbon emissions by 20% according to industry pilot project data. AI has proven its transformative capabilities by optimizing energy consumption while detecting inefficiencies to create both operational improvements and cost savings. The real-time monitoring capabilities of AI systems help companies meet strict environmental regulations and international climate goals by optimizing resource use and waste reduction, supporting circular economy practices for sustainable operations and enduring profitability. Leaders can establish impactful technology-based sustainability initiatives through the playbook which addresses the energy sector requirements for corporate goals and regulatory standards. Full article

This paper introduces arguments in favor of the intensive use of standards in both teaching the Machine Elements discipline and solving the first projects of mechanical design (gearboxes, jacks, pumps, tanks, etc.). The paper presents a SWOTT approach to the use of new in-force standards in teaching the design of machine elements. The use of information from standards in courses and design handbooks is regulated by various standardization associations at different levels internationally, such as the ISO (International Organization of Standardization), IEC (International Electrotechnical Commission), and ITU (International Telecommunication), and regional associations such as the CEN (European Commission for Standardization), CENELEC (European Committee for Electrotechnical Standardization) and ETSI (European Telecommunications Standards Institute), and national associations (for instance, the ASRO—Association of Standardization of Romania). In general, the conditions for using partial information from standards vary, but the authors present common lines and recommendations for introducing information from standards in books and design handbooks for engineering students. The use of information from standards for terms, materials, calculation models, test methods etc. is beneficial for students. This will provide them a good professional education towards adapting to a specific job in the field of mechanical engineering, where conformity to norms and standards is required by the dynamics of production, product quality and, not least, the safety of machines and operators. Full article

The generation of fine coal particles during mining and processing presents significant environmental and logistical challenges, particularly in coal-dependent, developing countries like South Africa (SA). This review critically evaluates the technical viability of fine coal briquetting as a sustainable waste-to-energy solution within a SA context, while drawing from global best practices and comparative benchmarks. It examines abundant feedstocks that can be used for valorization strategies, including fine coal and agricultural biomass residues. Furthermore, binder types, manufacturing parameters, and quality optimization strategies that influence briquette performance are assessed. The co-densification of fine coal with biomass offers a means to enhance combustion efficiency, reduce dust emissions, and convert low-value waste into a high-calorific, manageable fuel. Attention is also given to briquette testing standards (i.e., South African Bureau of Standards, ASTM International, and International Organization of Standardization) and end-use applications across domestic, industrial, and off-grid settings. Moreover, the review explores socio-economic implications, including rural job creation, energy poverty alleviation, and the potential role of briquetting in SA’s ‘Just Energy Transition’ (JET). This paper uniquely integrates technical analysis with policy relevance, rural energy needs, and practical challenges specific to South Africa, while offering a structured framework for bio-coal briquetting adoption in developing countries. While technical and economic barriers remain, such as binder costs and feedstock variability, the integration of briquetting into circular economy frameworks represents a promising path toward cleaner, decentralized energy and coal waste valorization. Full article

Background: Early identification of sepsis is critical for improving outcomes, particularly in low-resource emergency settings. In Thai community hospitals, where physicians may not always be available, triage is often nurse-led. Selecting accurate and practical sepsis screening tools is essential not only for timely clinical decision-making but also for timely diagnosis and promoting appropriate antibiotic use. Methods: This cross-sectional study analyzed 475 adult patients with suspected sepsis who presented to the emergency department of a Thai community hospital, using retrospective data from January 2021 to December 2022. Six screening tools were evaluated: Systemic Inflammatory Response Syndrome (SIRS), Quick Sequential Organ Failure Assessment (qSOFA), Modified Early Warning Score (MEWS), National Early Warning Score (NEWS), National Early Warning Score version 2 (NEWS2), and Search Out Severity (SOS). Diagnostic accuracy was assessed using International Classification of Diseases, Tenth Revision (ICD-10) codes as the reference standard. Performance metrics included sensitivity, specificity, predictive values, likelihood ratios, and the area under the receiver operating characteristic (AUROC) curve, all reported with 95% confidence intervals. Results: SIRS had the highest sensitivity (84%), while qSOFA demonstrated the highest specificity (91%). NEWS2, NEWS, and MEWS showed moderate and balanced diagnostic accuracy. SOS also demonstrated moderate accuracy. Conclusions: A two-step screening approach—using SIRS for initial triage followed by NEWS2 for confirmation—is recommended. This strategy enhances nurse-led screening and optimizes limited resources in emergency care. Early sepsis detection through accurate screening tools constitutes a feasible public health intervention to support appropriate antibiotic use and mitigate antimicrobial resistance, especially in resource-limited community hospital settings. Full article