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Search Results (494)

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Keywords = ice velocity

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17 pages, 7203 KB  
Article
Numerical Study on the Crushing Failure of Sea Ice Against a Vertical Structure Using the S-ALE Method
by Yukui Tian, Yunjing Zhao, Haidian Zhang, Chaoge Yu, Yan Qu, Haoyang Yin and Shaowei Tang
J. Mar. Sci. Eng. 2026, 14(10), 938; https://doi.org/10.3390/jmse14100938 (registering DOI) - 19 May 2026
Abstract
The crushing failure of sea ice is a critical design issue for polar offshore structures and ship structures because ice-induced loads may generate pronounced local damage and dynamic responses. Accurately modelling this process remains challenging because ice crushing involves localized fragmentation, crack propagation, [...] Read more.
The crushing failure of sea ice is a critical design issue for polar offshore structures and ship structures because ice-induced loads may generate pronounced local damage and dynamic responses. Accurately modelling this process remains challenging because ice crushing involves localized fragmentation, crack propagation, rubble accumulation, and repeated contact release. This paper presents a controlled numerical sensitivity study of level-ice crushing against a vertical structure using a coupled LS-DYNA framework that combines the Structured Arbitrary Lagrangian–Eulerian (S-ALE) formulation with the Cohesive Element Method (CEM). The study focuses on a benchmark-scale indentation configuration and examines how mesh topology, mesh size, and imposed indentation velocity affect the predicted fracture morphology and load-time histories. The results show that random triangular meshes better reproduce stochastic fragmentation and lateral flaking than regular triangular or quadrilateral meshes, while finer meshes reduce excessive load oscillations and provide more stable force histories. The velocity study indicates a transition from gradual crushing and fragment retention at lower velocities to more rapid brittle chipping and stronger dynamic fluctuations at higher velocities. A benchmark-level comparison with published ice-indentation simulations shows that the predicted peak line load is of the same order of magnitude as reference results. The proposed framework is therefore useful for investigating numerical sensitivities and failure-mode trends in ice-crushing simulations, although final design-load application requires further calibration and formal mesh-independence assessment. Full article
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28 pages, 4830 KB  
Article
Wave Transmission and Ice Drift for Ice Floe Under Waves
by Izmail Kantarzhi and Maksim Afonyushkin
Water 2026, 18(9), 1091; https://doi.org/10.3390/w18091091 - 2 May 2026
Viewed by 725
Abstract
A study was conducted on the interaction of surface gravity waves with a relatively thin, free-floating ice floe compared to the height of the waves. Physical and numerical modeling, as well as analytical research, were used. An overview of scientific works on the [...] Read more.
A study was conducted on the interaction of surface gravity waves with a relatively thin, free-floating ice floe compared to the height of the waves. Physical and numerical modeling, as well as analytical research, were used. An overview of scientific works on the research topic is presented. The physical model consisted of an experimental setup (wave flume) with a wooden plate exposed to gravitational harmonic waves of different lengths and periods. The numerical model is based on calculations performed in the LS-DYNA program, where the fluid was simulated using the Euler–Lagrange method, and solid bodies were considered rigid. Analytical studies use the theory of interaction of small-amplitude waves with floating breakwaters. It is shown that as the wave height increases for conditions of interaction between waves and ice floes of almost identical horizontal dimensions, one end of the floating body sinks into the water, which leads to a significant reduction in the drift speed of the ice floe. Formulas have been obtained that express the ratio of the ice floe’s speed to the wave velocity, as well as the ratio of the height of the incident waves to the height of the transmitted waves, depending on the ratio of the wavelength to the horizontal dimensions of the floating ice floe. Full article
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27 pages, 3527 KB  
Article
Molecular Dynamics of Ice Ih Impacts on FCC Metals: Interfacial Melting and an Anti-Icing Index of Merit
by Alexandre Brailovski, Ali Beydoun, André Guerra, Alejandro D. Rey and Phillip Servio
Crystals 2026, 16(4), 276; https://doi.org/10.3390/cryst16040276 - 19 Apr 2026
Viewed by 978
Abstract
Ice adhesion on exposed structures remains a major operational challenge, motivating the search for passive, material-based anti-icing strategies. Molecular dynamics offers a controlled way to investigate ice–surface interactions beyond the limits of experimental setups. In this work, we develop a simulation framework to [...] Read more.
Ice adhesion on exposed structures remains a major operational challenge, motivating the search for passive, material-based anti-icing strategies. Molecular dynamics offers a controlled way to investigate ice–surface interactions beyond the limits of experimental setups. In this work, we develop a simulation framework to model the impact of solid hexagonal ice droplets on metallic substrates. Ice impacts are simulated across a range of velocities (10–120 m/s), temperatures (120–250 K), and face-centred cubic surface materials (gold, copper, silver, aluminum, and nickel). Using LAMMPS, mW water force-field, EAM/Alloy metal potentials, and Lennard-Jones water–surface interactions, we quantify phase evolution through angular order parameter and quasi-liquid layer measurements, complemented by the CHILL+ algorithm in OVITO. By isolating all external factors, we show that melting increases with velocity and temperature and correlates with substrate properties: metals with high thermal diffusivity and low Young’s modulus tend to decrease post-collision ice melting. The ratio of the former to the latter, a derived index of merit Υ, significantly correlates with melting percentage and identifies silver as the most effective anti-ice material examined. Statistical analyses strongly suggest that these surface properties influence interfacial melting, supporting the use of this modelling framework for screening and designing anti-icing materials. Full article
(This article belongs to the Section Crystalline Metals and Alloys)
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25 pages, 6996 KB  
Article
Uncertainty and Sensitivity Analysis of Input Parameters in the CANDLE Module: A Morris–Sobol–LHS–Iman–Conover Framework
by Fenghui Yang, Wanhong Wang, Rubing Ma and Xiaoming Yang
J. Nucl. Eng. 2026, 7(2), 27; https://doi.org/10.3390/jne7020027 - 6 Apr 2026
Viewed by 532
Abstract
In this study, an uncertainty quantification (UQ) and sensitivity analysis (SA) workflow was developed for the input parameters of the CANDLE module, which is currently being tested and verified for calculating the downward relocation and solidification of molten core material. The workflow consists [...] Read more.
In this study, an uncertainty quantification (UQ) and sensitivity analysis (SA) workflow was developed for the input parameters of the CANDLE module, which is currently being tested and verified for calculating the downward relocation and solidification of molten core material. The workflow consists of three steps: (i) Morris screening to reduce the input set, (ii) Sobol variance decomposition on the screened subset to compute Sobol sensitivity indices, and (iii) uncertainty propagation using a 2 × 2 design that combines two sampling schemes (MC and LHS) with two dependence settings (independent and correlated inputs). The four cases considered were independent MC, correlated MC, independent LHS, and correlated LHS–Iman–Conover (LHS-IC). We considered 16 input parameters and three output figures of merit (FOMs) and compared the four cases in terms of propagated uncertainty and Shapley-based importance rankings, thereby distinguishing the effects of the sampling scheme, the imposed input dependence, and their interaction. The results show that the molten mass of the current material in the source node is the dominant factor governing the drained melt mass and the remaining melt mass in the receiving node, whereas the cold-wall surface temperature has a significant effect on the mass of molten material that solidifies in the receiving node. The mass of molten material that remains available in the receiving node is mainly governed by the coupled effects of the molten mass of the current material at the source node, the length of the receiving node, and the velocity limit. Under the non-uniform input-parameter distributions adopted in this study, LHS broadened the range of the outputs. After input correlations were introduced, the output distributions changed slightly. This study improves the understanding of input parameter sensitivities and uncertainty propagation in the CANDLE module. It also demonstrates the practical use of LHS-IC for module-level UQ/SA with correlated inputs, providing guidance for subsequent model improvements and parameter tuning. Full article
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18 pages, 1861 KB  
Article
Ice Crystal Sedimentation Errors Arising from Weighted Fall Velocity in Three-Moment Bulk Cloud Microphysics Scheme
by Xiangjun Shi, Gongqi Jin and Jiarui Ma
Atmosphere 2026, 17(4), 357; https://doi.org/10.3390/atmos17040357 - 31 Mar 2026
Viewed by 399
Abstract
This study investigates ice crystal sedimentation calculation errors arising from three-moment bulk cloud scheme. Both offline tests and one-dimensional cloud model simulations indicate that sedimentation calculation errors are most pronounced at both the cloud bottom and cloud top. At the cloud bottom, the [...] Read more.
This study investigates ice crystal sedimentation calculation errors arising from three-moment bulk cloud scheme. Both offline tests and one-dimensional cloud model simulations indicate that sedimentation calculation errors are most pronounced at both the cloud bottom and cloud top. At the cloud bottom, the error stems from how the bulk method treats ice crystal sedimentation. Specifically, the method uses three weighted fall velocities (corresponding to the three moments) to represent instantaneous fluxes through a fixed altitude, which inherently assumes that falling ice crystals can only affect the adjacent model layer below. This assumption artificially constrains the falling distance of larger ice crystals. At the cloud top, the differences among these three weighted fall velocities can give rise to physical inconsistencies. This issue is handled by artificial adjustment, which leads to a spurious narrow size distribution shape of ice crystals, especially under model configurations with coarse temporal resolution (large dT) and fine vertical resolution (small dH). If only the sedimentation process is considered, the above calculation errors can be effectively minimized by lowering the dT/dH ratio. Full article
(This article belongs to the Section Atmospheric Techniques, Instruments, and Modeling)
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19 pages, 2091 KB  
Article
An Investigation of Atmospheric Icing Effects on Wind Turbine Blade Aerodynamics and Power Output: A Case Study of the NREL 5 MW Turbine
by Berkay Öztürk and Eyup Koçak
Appl. Sci. 2026, 16(6), 2991; https://doi.org/10.3390/app16062991 - 20 Mar 2026
Viewed by 484
Abstract
This study presents a numerical investigation of the effects of atmospheric icing on the aerodynamic performance and power output of the NREL 5 MW reference wind turbine. In cold climate regions, ice accretion on wind turbine blades significantly alters the airfoil geometry, leading [...] Read more.
This study presents a numerical investigation of the effects of atmospheric icing on the aerodynamic performance and power output of the NREL 5 MW reference wind turbine. In cold climate regions, ice accretion on wind turbine blades significantly alters the airfoil geometry, leading to aerodynamic degradation characterized by increased drag, reduced lift, and substantial power losses. Understanding these effects is therefore essential for reliable performance prediction and efficient turbine operation under icing conditions. To address this problem, numerical simulations were conducted on six representative blade sections using the FENSAP-ICE framework, which integrates flow field calculations, droplet transport, and ice accretion modeling within a unified computational environment. The analyses were performed under different atmospheric icing conditions, considering liquid water content values of 0.22 g/m3 and 0.50 g/m3 and ambient temperatures of −2.5 °C and −10 °C. The median volumetric diameter was fixed at 20 µm, and the icing duration was set to one hour for all cases, allowing for both glaze and rime ice formations to be systematically examined. The results reveal that ice accretion becomes increasingly pronounced toward the blade tip, mainly due to higher relative velocities and increased collection efficiency in the outer sections. Glaze icing conditions produce irregular horn-shaped ice formations and lead to severe aerodynamic degradation, whereas rime ice forms more compact structures near the leading edge and results in comparatively lower performance losses. The degraded aerodynamic coefficients obtained from the iced airfoils were subsequently incorporated into BEM-based power calculations, indicating that total power losses can reach up to 40% under severe icing conditions, with the outer blade sections contributing most significantly to this reduction. Furthermore, an economic assessment based on annual energy losses highlights the substantial impact of atmospheric icing on wind turbine performance and operational costs. Full article
(This article belongs to the Section Mechanical Engineering)
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19 pages, 20315 KB  
Article
Experimental Quantization of Droplet Spatial Distribution in Icing Wind Tunnel with HACPI
by Letian Zhang, Boyi Wang, Yingchun Wu, Si Li, Zhiqiang Zhang, Xiangdong Guo, Xuecheng Wu, Quanzhong Xia and Zhen Liu
Aerospace 2026, 13(3), 274; https://doi.org/10.3390/aerospace13030274 - 15 Mar 2026
Viewed by 475
Abstract
The cloud spatial uniformity in the test section is crucial for icing wind tunnels in aircraft icing research and airworthiness certification. To achieve uniform supercooled large droplet (SLD) icing conditions, both the spatial variation in droplet size distribution and the concentration should be [...] Read more.
The cloud spatial uniformity in the test section is crucial for icing wind tunnels in aircraft icing research and airworthiness certification. To achieve uniform supercooled large droplet (SLD) icing conditions, both the spatial variation in droplet size distribution and the concentration should be considered. In this study, the spatial distribution of droplets under three SLD conditions is explored in the Aviation Industry Corporation of China Aerodynamics Research Institute (AVICARI)’s FL-61 icing wind tunnel. Measurements are conducted at 12 test points in vertical and horizontal directions using the holographic airborne cloud particle imager (HACPI) in conjunction with a two-axis traversing system. The droplet images obtained at specific test points below the test section centerline show deformation phenomena for droplets larger than 400 μm. Additionally, the aspect ratio of deformed droplets increases with droplet size. The spatial evolution of the median volume diameter (MVD) and liquid water content (LWC) is examined. For two spray arrangements where the activated nozzles are positioned close, the test point where the LWC peak in the vertical direction occurs is higher than that of the MVD peak. Further analysis focuses on the size distribution of droplets in the vertical direction. The results show that the settling effect of the droplets larger than 50 μm is evident under a flow velocity of 78 m/s. Meanwhile, the position where large droplets tend to appear lowers as the droplet size increases. Finally, the spatial uniformity of droplet size distributions at the same radial distance is discussed. Full article
(This article belongs to the Special Issue Deicing and Anti-Icing of Aircraft (Volume IV))
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29 pages, 5742 KB  
Article
3D Velocity Time Series Inversion of Petermann Glacier Using Ascending and Descending Sentinel-1 Images
by Zongze Li, Yawei Zhao, Yanlei Du, Haimei Mo and Jinsong Chong
Remote Sens. 2026, 18(6), 869; https://doi.org/10.3390/rs18060869 - 11 Mar 2026
Viewed by 357
Abstract
Three-dimensional (3D) glacier velocities capture the full dynamic behavior of ice masses. For marine-terminating glaciers, acquiring 3D velocity fields is particularly critical for quantifying ice discharge into the ocean, assessing the stability of floating ice tongues, and constraining ice–ocean interactions that govern submarine [...] Read more.
Three-dimensional (3D) glacier velocities capture the full dynamic behavior of ice masses. For marine-terminating glaciers, acquiring 3D velocity fields is particularly critical for quantifying ice discharge into the ocean, assessing the stability of floating ice tongues, and constraining ice–ocean interactions that govern submarine melting, calving processes, and freshwater fluxes to the ocean. To further investigate glacier dynamics and elucidate ice–ocean interaction mechanisms, this study analyzed the 3D velocity of the Petermann Glacier throughout 2021 using long-term Sentinel-1 synthetic aperture radar (SAR) observations. First, two-dimensional velocity time series were derived from ascending and descending SAR images, and the glacier’s 3D velocity components were reconstructed based on the geometric relationships between the two viewing geometries. The estimated 3D velocities were then used as prior constraints, and glacier motion was treated as a continuously evolving state variable within a Kalman filtering framework. Multi-track, asynchronous remote sensing observations were integrated into a unified system to obtain a stable and temporally continuous 3D velocity field. Finally, statistical analyses of the 3D velocity time series were conducted to characterize spatiotemporal variations, seasonal patterns, and topographic influences on glacier motion, thereby providing quantitative insights into the dynamic coupling between glacier and ocean. Full article
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15 pages, 3306 KB  
Article
A Numerical Study of Frost Formation from Humid Air on Horizontal Cold Plate Surfaces Under Natural Convection
by Zhengsheng Yang, Fan Shi, Jiawang Li and Shukun Liu
Fluids 2026, 11(3), 74; https://doi.org/10.3390/fluids11030074 - 10 Mar 2026
Viewed by 501
Abstract
Based on a previously proposed dimensionless phase-change-driven frosting model, this study numerically investigates frost formation on a horizontal cold plate under natural convection using a Eulerian multiphase framework coupled with species transport. The model is validated against experimental data, showing errors within 5–18%; [...] Read more.
Based on a previously proposed dimensionless phase-change-driven frosting model, this study numerically investigates frost formation on a horizontal cold plate under natural convection using a Eulerian multiphase framework coupled with species transport. The model is validated against experimental data, showing errors within 5–18%; the maximum deviation of 17.07% occurs at Tw = −25 °C, possibly due to increased experimental uncertainty at very low temperatures. Results demonstrate that lower cold plate temperatures lead to greater frost thickness and higher ice volume fraction. A key physical insight is that under natural convection, local convective circulation causes enhanced frosting at the plate edges, resulting in spatial non-uniformity in both thickness and density. The study covers cold plate temperatures from −10 °C to −25 °C at relative humidity of 60%. The frost growth rate and density at both ends of the cold plate exceed those in the central region, and this difference intensifies with decreasing temperature. Within the frost layer, humid air velocity is nearly zero, while maximum velocity occurs near the sides due to natural convection. The simulation results show good agreement with experimental data, confirming the model’s reliability for natural convection scenarios. Full article
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24 pages, 2029 KB  
Article
Multimodal Rehabilitative Outcome Measures of Fatigue in Patients with Diabetic Neuropathy
by Cira Fundarò, Dibo Mesembe Mosah, Fabio Plano, Roberto Maestri, Stefania Ghilotti, Pierluigi Chimento, Marina Maffoni, Monica Panigazzi, Guido Magistrali, Stefano Bruciamonti, Manuela Ravasio and Chiara Ferretti
Brain Sci. 2026, 16(3), 298; https://doi.org/10.3390/brainsci16030298 - 7 Mar 2026
Viewed by 630
Abstract
Background/Objectives: Diabetic neuropathy (DN), a common complication of type 2 diabetes mellitus, manifests as peripheral nerve dysfunction with symptoms such as fatigue. Although exercise effectively reduces fatigue in neuropathy patients, precise detection methods are crucial to elucidate the role of rehabilitation. Accordingly, [...] Read more.
Background/Objectives: Diabetic neuropathy (DN), a common complication of type 2 diabetes mellitus, manifests as peripheral nerve dysfunction with symptoms such as fatigue. Although exercise effectively reduces fatigue in neuropathy patients, precise detection methods are crucial to elucidate the role of rehabilitation. Accordingly, this study aimed to evaluate fatigue in DN patients using a multimodal approach (clinical and instrumental) and to compare the efficacy of aerobic versus resistance training on fatigue parameters. Methods: Eligible DN inpatients admitted for rehabilitation at the Neuromotor Rehabilitation Unit of the IRCCS ICS Maugeri Institute of Montescano (PV) were enrolled. Inclusion criteria included age between 65 and 85 years and confirmation via the Michigan Neuropathy Screening Instrument (anamnestic section: ≥7; clinical section: ≥2.5). Patients with confounding orthopedic, neurologic, or unstable cardiopulmonary/diabetic conditions were excluded. Overall, 36 participants were randomized into two groups: 17 underwent aerobic training (treadmill), while 19 received resistance training (elastic bands), both as supplements to a standard rehabilitation program. Assessments at baseline and post-training comprised clinical measures (Borg CR10 scale, Functional Independence Measure (FIM) total and subitems, Six-Minute Walk Test (6MWT), fasting blood glucose) and instrumental evaluations (sEMG of the tibialis anterior muscle to analyze conduction velocity intercept, slope, and changes). Results: All patients completed the protocol without dropout or adverse events. Both groups demonstrated significant improvements in FIM scores and post-exercise perceived exertion over time. Instrumental sEMG analysis confirmed a physiological fatigue trend manifested as conduction velocity reduction, yet revealed no significant differences between groups. Conclusions: Multimodal assessment provides an effective means to characterize fatigue in DN patients. Both aerobic and resistance modalities enhance functional independence and fatigue perception. Its early identification enables clinicians to tailor rehabilitation strategies to overcome exercise barriers. Full article
(This article belongs to the Special Issue Outcome Measures in Rehabilitation)
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25 pages, 15027 KB  
Article
Characterization of Local and Long-Distance Ice Floe Motion in the Yellow River Using UAV–GPS Joint Observations
by Chunjiang Li, Jiaqi Dai, Yupeng Leng, Xiaohua Hao, Weiping Li, Shamshodbek Akmalov, Xiangqian Li, Zhichao Wang, Han Gao, Xiang Fu, Shengbo Hu and Yu Zheng
Remote Sens. 2026, 18(5), 823; https://doi.org/10.3390/rs18050823 - 6 Mar 2026
Viewed by 457
Abstract
Understanding the motion parameters of floating ice is very important for characterizing the ice water dynamics of rivers during freezing periods. Due to the low spatiotemporal resolution of satellite images, limited observation range of unmanned aerial vehicles, and deformation of shore-based camera images, [...] Read more.
Understanding the motion parameters of floating ice is very important for characterizing the ice water dynamics of rivers during freezing periods. Due to the low spatiotemporal resolution of satellite images, limited observation range of unmanned aerial vehicles, and deformation of shore-based camera images, it is difficult to simultaneously quantify the translational and rotational motion characteristics of floating ice and long-distance transportation. This study used the unmanned aerial vehicle GPS joint observation method to observe and obtain various motion parameters such as local translation, rotation, and long-distance transportation in the curved section of the upper reaches of the Yellow River and the straight section of the middle reaches of the Yellow River during the winter of 2024–2025 under conditions of ice density of 50–90%. The velocity field obtained by the drone shows an average ice velocity of 1.27 m/s at the bend and 1.18 m/s in the straight section, with lateral velocity gradients of −0.245 to 0.050 s−1 and −0.141 to 0.222 s−1, respectively. The angular velocity of a single floating ice block is 0.008–0.016 rad/s at bends and 0.010–0.036 rad/s in straight sections. The angular velocity is positively correlated with the local shear strength, and the rotation direction is consistent with the sign of the velocity gradient. GPS tracking provides long-distance transportation trajectories, and the average difference between the speeds obtained by GPS and drones is 0.10 m/s, confirming the reliability of speed estimation based on drones. These results indicate that integrated unmanned aerial vehicle GPS observation can quantitatively characterize local floating ice movement and long-distance floating ice transport behavior, providing on-site parameters for river ice water dynamics research and hazard assessment, and has the potential to be applied to rivers in other cold regions. Full article
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18 pages, 2459 KB  
Article
Influence of Groove Structures on Flow Field and Bacterial Adhesion: A CFD-DEM Coupling Study
by Lei Chen, Hongjun Ye and Xiaodong Ruan
Coatings 2026, 16(3), 321; https://doi.org/10.3390/coatings16030321 - 6 Mar 2026
Viewed by 344
Abstract
Stringent cleanliness standards govern process fluid transport in integrated circuit (IC) manufacturing. Cavitation-induced surface defects on flow control components promote bacterial adhesion, thereby compromising wafer fabrication. To elucidate the coupling mechanisms among surface topography, hydrodynamics, and bacterial retention, this study utilizes a one-way [...] Read more.
Stringent cleanliness standards govern process fluid transport in integrated circuit (IC) manufacturing. Cavitation-induced surface defects on flow control components promote bacterial adhesion, thereby compromising wafer fabrication. To elucidate the coupling mechanisms among surface topography, hydrodynamics, and bacterial retention, this study utilizes a one-way coupled Computational Fluid Dynamics and Discrete Element Method (CFD-DEM) approach integrated with extended Derjaguin–Landau–Verwey–Overbeek (XDLVO) theory. We constructed a numerical model of rod-shaped Pseudomonas aeruginosa, integrated with a customized API-based coupling scheme to resolve temporal scale disparities, and systematically simulated flow evolution and adhesion behaviors across varying groove geometries (quadrilateral, triangular, and semicircular) and inlet velocities (1–3 m/s). The results indicate that groove-induced flow separation and recirculation vortices drive bacterial accumulation at the trailing edge. Triangular profiles exhibited superior flow stability, yielding significantly lower adhesion than quadrilateral and semicircular shapes. Bacterial retention scaled inversely with flow velocity due to enhanced hydrodynamic shear. These findings provide theoretical and engineering insights for the anti-contamination design of ultra-clean flow control components in IC manufacturing. Full article
(This article belongs to the Section Environmental Aspects in Colloid and Interface Science)
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25 pages, 2542 KB  
Article
Ice Cavitation Deicing for Aerospace Applications
by Victor F. Petrenko
Aerospace 2026, 13(3), 217; https://doi.org/10.3390/aerospace13030217 - 27 Feb 2026
Viewed by 481
Abstract
Ice accretion along aircraft leading edges, particularly at stagnation line parting strips, remains difficult to remove using conventional electrothermal anti-icing systems. These systems require continuous high-power heating to maintain the stagnation region above the melting point, often exceeding 10–12 kW/m2. This [...] Read more.
Ice accretion along aircraft leading edges, particularly at stagnation line parting strips, remains difficult to remove using conventional electrothermal anti-icing systems. These systems require continuous high-power heating to maintain the stagnation region above the melting point, often exceeding 10–12 kW/m2. This study introduces an Ice Cavitation Deicer (ICD) that removes ice through rapid, localized cavitation generated within a thin melt layer formed at the ice–surface interface. In the proposed approach, a short pulse of electric current melts a 1–10 µm interfacial layer and causes a cavitation impulse of approximately 1–10 MPa. This impulse ejects the stagnation-line ice in a direction normal to the surface, often against the external airflow, enabling the immediate aerodynamic removal of the remaining ice. Analytical modeling based on the energy conservation principle was used to determine the optimal foil geometry, thermal pulse parameters, thermal stress, and material selection. Experiments with various metallic foils and substrate materials validated the predicted ejection behavior. The impulses were sufficient to fracture and eject ice 1–10 mm thick. The observed ice fragment velocities varied from 1 m/s to 10 m/s. Compared with conventional thermal anti-icing, the ICD concept reduces power consumption by approximately two orders of magnitude while offering rapid and reliable leading-edge deicing. The low power requirements, rapid response, and compatibility with thin-foil heater architectures make ICD a promising technology for both conventional and electrified aircrafts, UAVs, rotorcrafts, and other platforms where power availability is limited. This manuscript presents the first theoretical and experimental research on the ICD method and is a concept-proof work. Further research and development are required before the ICD is ready to be tested in flight. Full article
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19 pages, 4507 KB  
Article
Cytotoxic and Cytostatic Effects of Nanoformulated Fenretinide on MG63 Osteosarcoma Cells
by Lorenzo Anconelli, Francesca Farioli, Martina Rossi, Pietro Lodeserto, Aikaterini Andreadi, Giovanna Farruggia, Concettina Cappadone, Paolo Blasi and Isabella Orienti
Pharmaceutics 2026, 18(2), 278; https://doi.org/10.3390/pharmaceutics18020278 - 23 Feb 2026
Viewed by 915
Abstract
Background: Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. At present, multi-agent chemotherapy and surgery provide only limited effects and the prognosis for patients with recurrent or metastatic disease remains poor, with 5-year survival rates below 30%. [...] Read more.
Background: Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. At present, multi-agent chemotherapy and surgery provide only limited effects and the prognosis for patients with recurrent or metastatic disease remains poor, with 5-year survival rates below 30%. These challenges highlight the need for innovative therapeutic approaches targeting osteosarcoma more effectively. Fenretinide, a synthetic derivative of all-trans retinoic acid, has shown significant antitumor activity in various cancers. In a recent high-throughput drug screening study, fenretinide emerged as the most active molecule against diffuse midline glioma over more than 3500 compounds. Fenretinide also demonstrated cytotoxic activity against osteosarcoma cell lines in vitro and in preclinical models and is endowed with a favorable safety and toxicity profile. However, its poor water solubility and limited bioavailability have hindered its clinical translation. To improve fenretinide bioavailability and enhance tumor exposure, different nanotechnology-based drug delivery systems have been proposed. Here we propose a tertiary complex made of fenretinide, bovine serum albumin, and hydroxypropyl-betacyclodextrin, indicated as BSAF. Methods: BSAF was evaluated for the main physico-chemical parameters such as hydrodynamic size, zeta potential, stability to drug leakage, and the biological effect on the osteosarcoma cell line MG63. Results: BSAF showed hydrodynamic size at the nanoscale, enhanced drug solubilization, high drug loading and size stability to dilution, characteristics that make this complex useful for targeted therapy. When tested on the MG63 osteosarcoma cell line, BSAF demonstrated significantly enhanced cytotoxicity, with half-maximal inhibitory concentration (IC50) values ~50% lower than free fenretinide. The complex was more efficient than free fenretinide in inhibiting cell migration as demonstrated by wound healing assay. Live-cell imaging analyses revealed a cytostatic effect at sub-cytotoxic concentrations. Specifically, treatment with concentrations below the IC50 resulted in significantly prolonged cell doubling time, decreased cell divisions, increased cellular sphericity and thickness, and decreased cell area. These morphological changes are more consistent with cell cycle arrest rather than apoptosis. These findings were corroborated by stable dry mass measurements, an indication of a cytostatic state rather than progressive cell death. In addition, cell motility parameters (e.g., instantaneous velocity, track speed, and displacement) at the single-cell and population level were markedly reduced at sub-IC50 concentrations, further supporting a cytostatic phenotype. Conclusions: Collectively, the new BSAF complex showed promise as a potential therapeutic agent for treating osteosarcoma cancer, due to the favorable physico-chemical characteristics and the cytotoxic/cytostatic effects on MG63 cells. BSAF effects may be therapeutically valuable, particularly in preventing tumor recurrence by suppressing the proliferative and migratory potential of residual drug-resistant clones. Unlike conventional anticancer agents that mainly rely on cell death, fenretinide, when complexed, demonstrates a dual capacity to induce both cytotoxic and cytostatic responses, depending on concentrations, potentially overcoming multiple resistance mechanisms that are generally associated with tumor exposure to drug sub-cytotoxic concentrations. Full article
(This article belongs to the Special Issue Nanomedicine and Nanotechnology: Recent Advances and Applications)
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20 pages, 2800 KB  
Article
Dual Fuel Combustion Modelling Using the G-Equation Model and the Respective Tuning of Flame Stretch Parameters
by Anthony Theodore Saliba, La Xiang, Jean-Paul Mollicone, Yu Ding and Mario Farrugia
Energies 2026, 19(4), 1021; https://doi.org/10.3390/en19041021 - 14 Feb 2026
Cited by 1 | Viewed by 683
Abstract
This article presents the simulation methodology and results of dual-fuel combustion for internal combustion engines (ICE). Simulations were performed in ANSYS Forte®, which modeled flame propagation using the G-equation model, and results were validated against experimental data. The article also presents [...] Read more.
This article presents the simulation methodology and results of dual-fuel combustion for internal combustion engines (ICE). Simulations were performed in ANSYS Forte®, which modeled flame propagation using the G-equation model, and results were validated against experimental data. The article also presents results from simulations performed in Converge CFD®, which used the SAGE combustion model, presented in previous work. Typical combustion modelling challenges in such ICE simulations are discussed, and the applied methodology is described. The range of methane-air equivalence ratio was 0.47 ≤ ϕ ≤ 0.57 across four load conditions with a rotational velocity range of 1228 ≤ RPM ≤ 1800. The methane-air combustion at these low equivalence ratios led to the required tuning of the stretch factor coefficient used in the flame speed model in ANSYS Forte® due to methane’s thermo-diffusive effects at lean equivalence ratios. As a result, the flame stretch factor coefficient was found to increase with decreasing equivalence ratio. The study thus demonstrates the importance of flame stretch sensitivity and thermo-diffusive instabilities in ICE combustion through CFD combustion simulations. Full article
(This article belongs to the Section I2: Energy and Combustion Science)
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