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30 pages, 6895 KB  
Article
A Three-Dimensional Analytical Model for Wind Turbine Wakes from near to Far Field: Incorporating Atmospheric Stability Effects
by Xiangyan Chen, Hao Zhang, Ziliang Zhang, Zhiyong Shao, Rui Ying and Xiangyin Liu
Energies 2026, 19(2), 467; https://doi.org/10.3390/en19020467 (registering DOI) - 17 Jan 2026
Abstract
In response to the critical demand for improved characterization of atmospheric stability effects in wind turbine wake prediction, this study proposes and systematically validates a new analytical wake model that incorporates atmospheric stability effects. In recent years, research on wake models with atmospheric [...] Read more.
In response to the critical demand for improved characterization of atmospheric stability effects in wind turbine wake prediction, this study proposes and systematically validates a new analytical wake model that incorporates atmospheric stability effects. In recent years, research on wake models with atmospheric stability effects has primarily followed two approaches: incorporating stability through high-fidelity numerical simulations or modifying classical analytical wake models. While the former offers clear mechanical insights, it incurs high computational costs, whereas the latter improves efficiency yet often suffers from near-wake prediction biases under stable stratification, lacks a unified framework covering the entire wake region, and relies heavily on case-specific calibration of key parameters. To overcome these limitations, this study introduces a stability-dependent turbulence expansion term with a square of a cosine function and the stability sign parameter, enabling the model to dynamically respond to varying atmospheric conditions and overcome the reliance of traditional models on neutral atmospheric assumptions. It achieves physically consistent descriptions of turbulence suppression under stable conditions and convective enhancement under unstable conditions. A newly developed far-field decay function effectively coordinates near-wake and far-wake evolution, maintaining computational efficiency while significantly improving prediction accuracy under complex stability conditions. The Present model has been validated against field measurements from the Scaled Wind Farm Technology (SWiFT) facility and the Alsvik wind farm, demonstrating superior performance in predicting wake velocity distributions on both vertical and horizontal planes. It also exhibits strong adaptability under neutral, stable, and unstable atmospheric conditions. This proposed framework provides a reliable tool for wind turbine layout optimization and power output forecasting under realistic atmospheric stability conditions. Full article
(This article belongs to the Section A3: Wind, Wave and Tidal Energy)
21 pages, 5218 KB  
Article
Groundwater Pollution Transport in Plain-Type Landfills: Numerical Simulation of Coupled Impacts of Precipitation and Pumping
by Tengchao Li, Shengyan Zhang, Xiaoming Mao, Yuqin He, Ninghao Wang, Daoyuan Zheng, Henghua Gong and Tianye Wang
Hydrology 2026, 13(1), 36; https://doi.org/10.3390/hydrology13010036 (registering DOI) - 17 Jan 2026
Abstract
Landfills serve as a primary disposal method for municipal solid waste in China, with over 20,000 operational sites nationwide; however, long-term operations risk leachate leakage and groundwater contamination. Amid intensifying climate change and human activities, understanding contaminant evolution mechanisms in landfills has become [...] Read more.
Landfills serve as a primary disposal method for municipal solid waste in China, with over 20,000 operational sites nationwide; however, long-term operations risk leachate leakage and groundwater contamination. Amid intensifying climate change and human activities, understanding contaminant evolution mechanisms in landfills has become critically urgent. Focusing on a representative plain-based landfill in North China, this study integrated field investigations and groundwater monitoring to establish a monthly coupled groundwater flow–solute transport model (using MODFLOW and MT3DMS codes) based on site-specific hydrogeological boundaries and multi-year monitoring data, analyzing spatiotemporal plume evolution under the coupled impacts of precipitation variability (climate change) and intensive groundwater extraction (human activities), spanning the historical period (2021–2024) and future projections (2025–2040). Historical simulations demonstrated robust model performance with satisfactory calibration against observed water levels and chloride concentrations, revealing that the current contamination plume exhibits a distinct distribution beneath the site. Future projections indicate nonlinear concentration increases: in the plume core zone, concentrations rise with precipitation, whereas at the advancing front, concentrations escalate with extraction intensity. Spatially, high-risk zones (>200 mg/L) emerge earlier under wetter conditions—under the baseline scenario (S0), such zones form by 2033 and exceed site boundaries by 2037. Plume expansion scales positively with extraction intensity, reaching its maximum advancement and coverage under the high-extraction scenario. These findings demonstrate dual drivers—precipitation accelerates contaminant accumulation through enhanced leaching, while groundwater extraction promotes plume expansion via heightened hydraulic gradients. This work elucidates coupled climate–human activity impacts on landfill contamination mechanisms, proposing a transferable numerical modeling framework that provides a quantitative scientific basis for post-closure supervision, risk assessment, and regional groundwater protection strategies, thereby aligning with China’s Standard for Pollution Control on the Landfill Site of Municipal Solid Waste and the Zero-Waste City initiative. Full article
20 pages, 3094 KB  
Article
The PIN-LIKES Auxin Transport Genes Involved in Regulating Yield in Soybean
by Siming Wei, Jiayin Han, Chun Tang, Lei Zhang, Mingliang Yang, Fubin Cao, Yuyao Zhao, Xinghua Li, Hao Xu, Zhaoming Qi and Qingshan Chen
Agronomy 2026, 16(2), 226; https://doi.org/10.3390/agronomy16020226 (registering DOI) - 17 Jan 2026
Abstract
PIN-LIKES (PILS) auxin transport genes play key roles in plant development, but their functions and molecular mechanism in soybean yield remain unclear. Here, we characterized the 44-member soybean GmPILS genes via comprehensive analyses. Phylogenetic analysis classified GmPILS into three subfamilies, with [...] Read more.
PIN-LIKES (PILS) auxin transport genes play key roles in plant development, but their functions and molecular mechanism in soybean yield remain unclear. Here, we characterized the 44-member soybean GmPILS genes via comprehensive analyses. Phylogenetic analysis classified GmPILS into three subfamilies, with most proteins being hydrophobic, stable, and membrane-localized. Chromosomal distribution showed random scattering across 17 chromosomes, with gene duplication driving family expansion. Expression profiling identified GmPILS36 and GmPILS40 as seed-specific and differentially expressed between cultivated Suinong14 (SN14) and wild ZYD00006 (ZYD06) soybeans. Population genetic analyses revealed GmPILS40 experienced a domestication bottleneck without yield-related superior haplotypes, while GmPILS36 underwent selection during landrace-to-improved variety domestication. A coding region CC/TT natural variation in GmPILS36 (S/A substitution) was significantly associated with seed weight per plant and 100-seed weight, with the TT genotype conferring superior traits. This study provides insights into GmPILS genes’ evolution and identifies GmPILS36 as an important candidate gene for further functional study and investigation of the molecular mechanisms regulating soybean yield. Full article
(This article belongs to the Special Issue Functional Genomics and Molecular Breeding of Soybeans—2nd Edition)
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32 pages, 3933 KB  
Article
Nanosilica Gel-Stabilized Phase-Change Materials Based on Epoxy Resin and Wood’s Metal
by Svetlana O. Ilyina, Irina Y. Gorbunova, Vyacheslav V. Shutov, Michael L. Kerber and Sergey O. Ilyin
Gels 2026, 12(1), 79; https://doi.org/10.3390/gels12010079 - 16 Jan 2026
Abstract
The emulsification of a molten fusible metal alloy in a liquid epoxy matrix with its subsequent curing is a novel way to create a highly concentrated phase-change material. However, numerous challenges have arisen. The high interfacial tension between the molten metal and epoxy [...] Read more.
The emulsification of a molten fusible metal alloy in a liquid epoxy matrix with its subsequent curing is a novel way to create a highly concentrated phase-change material. However, numerous challenges have arisen. The high interfacial tension between the molten metal and epoxy resin and the difference in their viscosities hinder the stretching and breaking of metal droplets during stirring. Further, the high density of metal droplets and lack of suitable surfactants lead to their rapid coalescence and sedimentation in the non-cross-linked resin. Finally, the high differences in the thermal expansion coefficients of the metal alloy and cross-linked epoxy polymer may cause cracking of the resulting phase-change material. This work overcomes the above problems by using nanosilica-induced physical gelation to thicken the epoxy medium containing Wood’s metal, stabilize their interfacial boundary, and immobilize the molten metal droplets through the creation of a gel-like network with a yield stress. In turn, the yield stress and the subsequent low-temperature curing with diethylenetriamine prevent delamination and cracking, while the transformation of the epoxy resin as a physical gel into a cross-linked polymer gel ensures form stability. The stabilization mechanism is shown to combine Pickering-like interfacial anchoring of hydrophilic silica at the metal/epoxy boundary with bulk gelation of the epoxy phase, enabling high metal loadings. As a result, epoxy shape-stable phase-change materials containing up to 80 wt% of Wood’s metal were produced. Wood’s metal forms fine dispersed droplets in epoxy medium with an average size of 2–5 µm, which can store thermal energy with an efficiency of up to 120.8 J/cm3. Wood’s metal plasticizes the epoxy matrix and decreases its glass transition temperature because of interactions with the epoxy resin and its hardener. However, the reinforcing effect of the metal particles compensates for this adverse effect, increasing Young’s modulus of the cured phase-change system up to 825 MPa. These form-stable, high-energy-density composites are promising for thermal energy storage in building envelopes, radiation-protective shielding, or industrial heat management systems where leakage-free operation and mechanical integrity are critical. Full article
(This article belongs to the Special Issue Energy Storage and Conductive Gel Polymers)
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18 pages, 1480 KB  
Article
Water-Soluble Epoxy Resins as an Innovative Method of Protecting Concrete Against Sulfate Corrosion
by Wojciech Kostrzewski, Ireneusz Laks and Marta Sybis
Materials 2026, 19(2), 364; https://doi.org/10.3390/ma19020364 - 16 Jan 2026
Abstract
Sulfate corrosion is a significant durability issue for concrete used in sewage and hydraulic infrastructure. In sulfate-rich environments, the formation of expansive products (e.g., ettringite and thaumasite) leads to a progressive loss of performance. Unlike conventional protection methods, which rely on surface-applied coatings [...] Read more.
Sulfate corrosion is a significant durability issue for concrete used in sewage and hydraulic infrastructure. In sulfate-rich environments, the formation of expansive products (e.g., ettringite and thaumasite) leads to a progressive loss of performance. Unlike conventional protection methods, which rely on surface-applied coatings or impregnation, this study examines the use of water-dilutable epoxy resins as an internal, volume-wide admixture dispersed throughout the concrete matrix to provide whole-body protection. The experimental program evaluated the mechanical performance, microstructure, and sulfate ion ingress/penetration dynamics of resin-modified concretes. The results suggest that using the appropriate amount of resin can limit the penetration of aggressive ions and slow the harmful changes associated with sulfate attack while maintaining the material’s overall performance. Overall, these findings suggest that water-based epoxy admixtures are a promising strategy for improving the durability of concrete in sulfate-exposed environments. They also provide guidance for designing more resistant cementitious materials for modern infrastructure applications. Full article
(This article belongs to the Section Construction and Building Materials)
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18 pages, 6562 KB  
Article
Optimal CeO2 Doping for Synergistically Enhanced Mechanical, Tribological, and Thermal Properties in Zirconia Ceramics
by Feifan Chen, Yongkang Liu, Zhenye Tang, Xianwen Zeng, Yuwei Ye and Hao Chen
Materials 2026, 19(2), 362; https://doi.org/10.3390/ma19020362 - 16 Jan 2026
Abstract
CeO2 doping is a well-established strategy for enhancing the properties of zirconia (ZrO2) ceramics, with the prior literature indicating an optimal doping range of around 10–15 wt.% for specific attributes. Building upon this foundation, this study provides a systematic investigation [...] Read more.
CeO2 doping is a well-established strategy for enhancing the properties of zirconia (ZrO2) ceramics, with the prior literature indicating an optimal doping range of around 10–15 wt.% for specific attributes. Building upon this foundation, this study provides a systematic investigation into the concurrent evolution of mechanical, tribological, and thermophysical properties across a broad compositional spectrum (0–20 wt.% CeO2). The primary novelty lies in the holistic correlation of these often separately examined properties, revealing their interdependent trade-offs governed by microstructural development. The 15Ce-ZrO2 composition, consistent with the established optimal range, achieved a synergistic balance: hardness increased by 27.6% to 310 HV1, the friction coefficient was minimized to 0.205, and the wear rate was reduced to 1.81 × 10−3 mm3/(N m). Thermally, it exhibited a 72.2% reduction in the thermal expansion coefficient magnitude at 1200 °C and a low thermal conductivity of 0.612 W/(m·K). The enhancement mechanisms are consistent with solid solution strengthening, grain refinement, and likely enhanced phonon scattering, potentially from point defects such as oxygen vacancies commonly associated with aliovalent doping in oxide ceramics, while performance degradation beyond 15 wt.% is linked to CeO2 agglomeration and duplex microstructure formation. This work provides a relatively comprehensive insight into the dataset and mechanism, which is conducive to the fine design of multifunctional ZrO2 bulk ceramics. It is not limited to determining the optimal doping level, but also aims to clarify the comprehensive performance map, providing reference significance for the development of advanced ceramic materials with synergistically optimized hardness, wear resistance, and thermal properties. Full article
(This article belongs to the Section Advanced and Functional Ceramics and Glasses)
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20 pages, 1826 KB  
Article
Tension-Dominant Orthodontic Loading and Buccal Periodontal Phenotype Preservation: An Integrative Mechanobiological Model Supported by FEM and a Proof-of-Concept CBCT
by Anna Ewa Kuc, Jacek Kotuła, Kamil Sybilski, Szymon Saternus, Jerzy Małachowski, Natalia Kuc, Grzegorz Hajduk, Joanna Lis, Beata Kawala, Michał Sarul and Magdalena Sulewska
J. Funct. Biomater. 2026, 17(1), 47; https://doi.org/10.3390/jfb17010047 - 16 Jan 2026
Abstract
Background: Adult patients with a thin buccal cortical plate and fragile periodontal phenotype are at high risk of dehiscence, fenestration and recession during transverse orthodontic expansion. Conventional mechanics often create a cervical compression-dominant environment that exceeds the adaptive capacity of the periodontal ligament [...] Read more.
Background: Adult patients with a thin buccal cortical plate and fragile periodontal phenotype are at high risk of dehiscence, fenestration and recession during transverse orthodontic expansion. Conventional mechanics often create a cervical compression-dominant environment that exceeds the adaptive capacity of the periodontal ligament (PDL)–bone complex. Objectives: This study proposes an integrative mechanobiological model in which a skeletal-anchorage-assisted loading protocol (Bone Protection System, BPS) transforms expansion into a tension-dominant regime that favours buccal phenotype preservation. Methods: Patient-specific finite element models were used to compare conventional expansion with a BPS-modified force system. Regional PDL stress patterns and crown/apex displacement vectors were analysed to distinguish tipping-dominant from translation-dominated mechanics. A pilot CBCT proof-of-concept (n = 1 thin-phenotype adult) with voxel-based registration quantified changes in maxillary and mandibular alveolar ridge width and buccal cortical plate thickness before and after BPS-assisted expansion. The mechanical findings were integrated with current evidence on compression- versus tension-driven inflammatory and osteogenic pathways in the PDL and cortical bone. Results: FEM demonstrated that conventional expansion concentrates high cervical compressive stress along the buccal PDL and cortical surface, accompanied by bending-like crown–root divergence. In contrast, the BPS protocol redirected forces to create a buccal tensile-favourable region and a more parallel crown–apex displacement pattern, indicative of translation-dominated movement. In the proof-of-concept (n = 1) CBCT case, BPS-assisted expansion was associated with preservation or increase of buccal ridge dimensions without radiographic signs of cortical breakdown. Conclusions: A tension-dominant orthodontic loading environment generated by a skeletal-anchorage-assisted force system may support buccal cortical preservation and vestibular phenotype reinforcement in thin-phenotype patients. The proposed mechanobiological model links these imaging and FEM findings to known molecular pathways of inflammation, angiogenesis and osteogenesis. It suggests a functional biomaterial-based strategy for widening the biological envelope of safe tooth movement. Full article
(This article belongs to the Special Issue Functional Dental Materials for Orthodontics and Implants)
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19 pages, 2956 KB  
Article
Mechanisms and Efficacy of Thermally Modified Dolomite-Rich Phosphate Tailings as a Novel Adsorbent for Phosphorus Removal
by Yongjie Guo, Caixia Guo, Jiangli Li, Yuanchong Huang, Shuai Xu, Xing Zhao and Kunzhi Li
Water 2026, 18(2), 235; https://doi.org/10.3390/w18020235 - 16 Jan 2026
Abstract
The global environmental challenges of solid waste accumulation and aquatic eutrophication demand innovative and sustainable strategies. This study introduces a circular “waste-treats-waste” approach by converting dolomite-rich phosphate tailings (PT), a widespread industrial by-product, into a high-value adsorbent for phosphorus (P) removal. Thermal modification [...] Read more.
The global environmental challenges of solid waste accumulation and aquatic eutrophication demand innovative and sustainable strategies. This study introduces a circular “waste-treats-waste” approach by converting dolomite-rich phosphate tailings (PT), a widespread industrial by-product, into a high-value adsorbent for phosphorus (P) removal. Thermal modification at 950 °C for 1 h dramatically enhanced the adsorption capacity by approximately 45 times, from 2.52 mg/g (raw PT) to 112.41 mg/g. This performance is highly competitive with, and often superior to, many engineered adsorbents. The calcination process was pivotal, decomposing carbonates into highly active CaO and MgO while developing a porous structure. Using a multi-technique characterization approach (X-ray diffraction (XRD), Fourier transform infrared spectra (FTIR), TESCAN VEGA3 tungsten filament scanning electron microscope (SEM), the Brunauer–Emmett–Teller method (BET)), the key immobilization mechanism was identified as hydroxyapatite formation, driven by Ca2+/Mg2+-phosphate precipitation and surface complexation. Nonlinear regression analysis revealed that the adsorption kinetics obeyed the pseudo-second-order model, and the equilibrium data were best described by the Freundlich isotherm. This indicates a chemisorption process occurring on a heterogeneous surface, consistent with the complex structure created by thermal modification. Notably, post-adsorption pore structure expansion suggested synergistic pore-filling and surface reorganization. This work not only demonstrates a circular economy paradigm for repurposing industrial solid waste on a global scale but also offers a cost-effective and high-performance pathway for controlling phosphorus pollution in aquatic systems, contributing directly to resource efficiency and sustainable environmental remediation. Full article
(This article belongs to the Section Wastewater Treatment and Reuse)
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63 pages, 10763 KB  
Review
The State of HBIM in Digital Heritage: A Critical and Bibliometric Assessment of Six Emerging Frontiers (2015–2025)
by Fabrizio Banfi and Wanqin Liu
Appl. Sci. 2026, 16(2), 906; https://doi.org/10.3390/app16020906 - 15 Jan 2026
Viewed by 18
Abstract
After nearly two decades of developments in Historic/Heritage Building Information Modeling (HBIM), the field has reached a stage of maturity that calls for a critical reassessment of its evolution, achievements, and remaining challenges. Digital representation has become a central component of contemporary heritage [...] Read more.
After nearly two decades of developments in Historic/Heritage Building Information Modeling (HBIM), the field has reached a stage of maturity that calls for a critical reassessment of its evolution, achievements, and remaining challenges. Digital representation has become a central component of contemporary heritage conservation, enabling advanced methods for analysis, management, and communication. This review examines the maturation of HBIM as a comprehensive framework that integrates extended reality (XR), artificial intelligence (AI), machine learning (ML), semantic segmentation and Digital Twin (DT). Six major research domains that have shaped recent progress are outlined: (1) the application of HBIM to restoration and conservation workflows; (2) the expansion of public engagement through XR, virtual museums, and serious games; (3) the stratigraphic documentation of building archaeology, historical phases, and material decay; (4) data-exchange mechanisms and interoperability with open formats and Common Data Environments (CDEs); (5) strategies for modeling geometric and semantic complexity using traditional, applied, and AI-driven approaches; and (6) the emergence of heritage DT as dynamic, semantically enriched systems integrating real-time and lifecycle data. A comparative assessment of international case studies and bibliometric trends (2015–2025) illustrates how HBIM is transforming proactive and data-informed conservation practice. The review concludes by identifying persistent gaps and outlining strategic directions for the next phase of research and implementation. Full article
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19 pages, 623 KB  
Article
Effects of Internal Fat Content and Screw Configuration on Extrusion Traits and Kibble Characteristics of High-Protein, Low-Starch Fish Feed
by Lucas Bassi Scarpim, Mayara Aline Baller, Leticia Graziele Pacheco, Stephanie Souza Theodoro, Dalton José Carneiro and Aulus Cavalieri Carciofi
Processes 2026, 14(2), 310; https://doi.org/10.3390/pr14020310 - 15 Jan 2026
Viewed by 26
Abstract
In aquaculture, feed production influences nutrition, performance, water quality, and overall profitability. This study evaluated the effects of three levels of internal fat (IF), resulting from the inclusion of 0%, 2%, or 4% fat in the preconditioner during extrusion, and their interaction with [...] Read more.
In aquaculture, feed production influences nutrition, performance, water quality, and overall profitability. This study evaluated the effects of three levels of internal fat (IF), resulting from the inclusion of 0%, 2%, or 4% fat in the preconditioner during extrusion, and their interaction with two extruder screw configurations: medium-shear (MS) and high-shear (HS), on kibble physical quality and extrusion parameters. Increasing IF resulted in a quadratic increase in amylose–lipid complexation under the HS configuration (p = 0.030; r2 = 0.9) and a linear reduction (p < 0.001) in specific mechanical energy (SME) with a strong negative Pearson correlation (r −0.9; p = 0.009) in both configurations. Fat inclusion also reduced mass temperature and die pressure (p < 0.05), leading to lower starch gelatinization degree (p < 0.05) from 87.9 ± 0.6% to 83.4 ± 0.3% in MS configuration and 95.6 ± 0.7 to 86.3 ± 0.8% in HS configuration, increased bulk and piece density (p < 0.001), and reduced radial expansion (p < 0.001). These changes decreased floatability (p < 0.05) and water stability, increasing mushiness (p < 0.01). Increased shear partially improved SME transfer, starch cooking, expansion, floatability, and mushiness; however, the negative effects of 4% IF could not be fully mitigated. Overall, higher IF compromised kibble structure, starch gelatinization, and floatability, while screw configuration resulted in only a limited compensatory effect. Full article
(This article belongs to the Section Biological Processes and Systems)
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18 pages, 3113 KB  
Article
A Coupled Assessment of Collapse Triggered by Sand Leakage at Karst Sites During Pile Foundation Construction: From Cavity Expansion to Overburden Failure
by Zicheng Yang, Guangyin Lu, Bei Cao, Xudong Zhu, Xinlong Liu and Kang Ye
Buildings 2026, 16(2), 357; https://doi.org/10.3390/buildings16020357 - 15 Jan 2026
Viewed by 38
Abstract
Covered karst collapse is a key geotechnical hazard in infrastructure construction in karst regions of China. In particular, strata consisting of an overlying clay layer and an underlying sand layer are prone to abrupt collapse induced by sand leakage under construction disturbances, which [...] Read more.
Covered karst collapse is a key geotechnical hazard in infrastructure construction in karst regions of China. In particular, strata consisting of an overlying clay layer and an underlying sand layer are prone to abrupt collapse induced by sand leakage under construction disturbances, which poses serious risks to pile foundation safety. To clarify the disaster-forming mechanism and develop a quantitative analysis method, this study investigates the mechanical behaviour of the entire collapse process by combining theoretical analysis with numerical simulation. A continuous mechanical analysis framework is established that follows the sequence from sand layer leakage to cavity expansion and then clay layer instability. Within this framework, a calculation model for the angle of repose of the sand layer is proposed that considers seepage and confined pressure effects. Simultaneously accounting for the influence of the casing, stability models for overall and localised collapses are developed using limit equilibrium theory. A comprehensive safety factor criterion Kc based on the critical span (or radius) is then proposed, leading to a linked evaluation method that couples the potential span of the sand layer with the ultimate span of the clay layer. The results show that an increase in Δh/h significantly reduces the angle of repose of the sand layer; the mechanical mechanism is confirmed whereby an increase in the roof span leads to shear stress exceeding the soil’s shear strength, thus triggering instability; the proposed safety factor Kc can effectively predict both overall and localised collapse, and case verification demonstrates that the predicted spans match well with actual collapse dimensions. The results provide a theoretical and technical basis for risk prediction, as well as for the prevention and control of pile foundation construction in karst areas. Full article
(This article belongs to the Section Construction Management, and Computers & Digitization)
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15 pages, 5941 KB  
Article
Gene Expression as a Guide for the Development of Novel Therapies in Hypertensive and Diabetic Kidney Disease
by Maria Zaimi, Georgios Zagkotsis, Athanasios Kammenos, Eirini Grapsa, Smaragdi Marinaki and Eleni Frangou
J. Clin. Med. 2026, 15(2), 696; https://doi.org/10.3390/jcm15020696 - 15 Jan 2026
Viewed by 60
Abstract
Background/Objectives: Diabetes mellitus and hypertension are the first and second most common causes of chronic kidney disease, respectively. Despite improvements in elucidating the pathophysiology behind these diseases and the expansion of the therapeutic armamentarium, the knowledge about the implicated genes, epigenetics, and [...] Read more.
Background/Objectives: Diabetes mellitus and hypertension are the first and second most common causes of chronic kidney disease, respectively. Despite improvements in elucidating the pathophysiology behind these diseases and the expansion of the therapeutic armamentarium, the knowledge about the implicated genes, epigenetics, and biological pathways is limited. Methods: We sought to define diabetic nephropathy-specific and hypertensive nephropathy-specific gene signatures in human glomeruli through computational systems biology approaches. Results: Gene expression data of human glomeruli from patients with diabetic kidney disease (DKD) and hypertensive nephropathy (HTN) were collected and compared to gene expression patterns from healthy kidneys. Pathways were identified with functional enrichment analysis of DEGs. Transcription factor enrichment analysis, protein–protein interaction network expansion, and kinase enrichment analysis were also performed. Finally, novel drugs and small-molecule compounds that may reverse the kidney-specific phenotype of these disorders have been identified. Conclusions: These data suggest putative expansion of the therapeutic armamentarium in DKD and HTN, underscoring that understanding the molecular mechanisms occurring within tissue in kidney diseases may guide personalized therapy. Full article
(This article belongs to the Section Nephrology & Urology)
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22 pages, 2305 KB  
Article
Improving Graduate Job Matching Through Higher Education–Industry Alignment for SDG-Consistent Development in China
by Qing Yang and Muhd Khaizer Omar
Sustainability 2026, 18(2), 868; https://doi.org/10.3390/su18020868 - 14 Jan 2026
Viewed by 159
Abstract
Grounded in the United Nations Sustainable Development Goal 4 (SDG4), specifically addressing the urgent need to increase relevant skills for decent work (Target 4.4) while ensuring inclusive access and quality (Targets 4.3, 4.5, 4.c), this study develops a province-level indicator system for the [...] Read more.
Grounded in the United Nations Sustainable Development Goal 4 (SDG4), specifically addressing the urgent need to increase relevant skills for decent work (Target 4.4) while ensuring inclusive access and quality (Targets 4.3, 4.5, 4.c), this study develops a province-level indicator system for the “talent chain” and “industry chain” and integrates entropy-weighted composite evaluation, a coupling coordination model, correlation tests, and mismatch typology classification to systematically assess the alignment between higher education talent formation and industrial demand across 31 Chinese provinces during 2000–2022. The analysis aims to characterize China’s phase-specific progress in SDG4-consistent development at the education–industry interface and to provide a theoretical and empirical basis for improving graduate job matching. The results show that (1) overall talent–industry matching improved steadily from 2000 to 2022, yet pronounced regional disparities persist, with eastern provinces generally outperforming central and western regions; (2) educational quality and structural inputs—such as faculty capacity, per-student expenditure, and the composition of human capital—are the primary drivers of talent-chain performance, whereas expansion-oriented indicators exhibit limited marginal contributions, implying that sustainable graduate job matching hinges more on quality upgrading and supply-structure optimization than on quantitative expansion alone; (3) industry-chain advancement is jointly driven by industrial scale, structural upgrading, and employment absorptive capacity, with the tertiary sector playing a particularly prominent role in shaping demand for higher-skilled labor; and (4) a divergence in driving mechanisms—quality- and structure-oriented on the education side versus scale- and structure-oriented on the industry side—combined with regional heterogeneity produces stage-specific mismatch typologies, suggesting remaining scope for structural alignment between higher education systems and industrial upgrading. Overall, strengthening regional coordination, integration, quality, and upgrading drives synergistic development, advancing SDG 4 targets by validating that quality-driven education reform is the key lever for sustainable employment in China. Full article
(This article belongs to the Section Sustainable Education and Approaches)
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26 pages, 10014 KB  
Article
Dynamic Monitoring and Analysis of Mountain Excavation and Land Creation Projects in Lanzhou Using Multi-Source Remote Sensing and Machine Learning
by Quanfu Niu, Jiaojiao Lei, Qiong Fang and Lifeng Zhang
Remote Sens. 2026, 18(2), 273; https://doi.org/10.3390/rs18020273 - 14 Jan 2026
Viewed by 106
Abstract
Mountain Excavation and Land Creation Projects (MELCPs) have emerged as a critical strategy for expanding urban development space in mountainous regions facing land scarcity. Dynamic monitoring and risk management of these projects are essential for promoting sustainable urban development. This study develops an [...] Read more.
Mountain Excavation and Land Creation Projects (MELCPs) have emerged as a critical strategy for expanding urban development space in mountainous regions facing land scarcity. Dynamic monitoring and risk management of these projects are essential for promoting sustainable urban development. This study develops an integrated monitoring framework for MELCPs by combining ascending and descending Sentinel-1 SAR data, Sentinel-2 optical imagery, SRTM digital elevation models (DEM), and field survey data. The framework incorporates multi-temporal change detection, random forest classification, and time-series InSAR analysis to systematically capture the spatiotemporal evolution and subsidence mechanisms associated with MELCPs. Key findings include: (1) The use of dual-orbit SAR data significantly improves the detection accuracy of excavation areas, achieving an overall accuracy of 87.1% (Kappa = 0.85) and effectively overcoming observation limitations imposed by complex terrain. (2) By optimizing the combination of spectral, texture, topographic, and polarimetric features using a random forest algorithm, the classification accuracy of MELCPs is enhanced to 91.2% (Kappa = 0.889). This enables precise annual identification of MELCP progression from 2017 to 2022, revealing a three-stage evolution pattern: concentrated expansion, peak activity, and restricted slowdown. Specifically, the reclaimed area increased from 2.66 km2 (pre-2018) to a peak of 12.61 km2 in 2021, accounting for 34.56% of the total area of the study region, before decreasing to 2.69 km2 in 2022. (3) InSAR monitoring from 2017 to 2023 indicates that areas with only filling experience minor shallow subsidence (<50 mm), whereas subsequent building loads and underground engineering activities lead to continuous deep soil consolidation, with maximum cumulative subsidence reaching 333.8 mm. This study demonstrates that subsidence in MELCPs follows distinct spatiotemporal patterns and is predictable, offering important theoretical insights and practical tools for engineering safety management and territorial spatial optimization in mountainous cities. Full article
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Article
Quantifying Urban Expansion and Its Driving Forces in the Indus River Basin Using Multi-Source Spatial Data
by Wenfei Luan, Jingyao Zhu, Wensheng Wang, Chunfeng Ma, Qingkai Liu, Yu Wang, Haitao Jing, Bing Wang and Hui Li
Land 2026, 15(1), 164; https://doi.org/10.3390/land15010164 - 14 Jan 2026
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Abstract
Urban expansion and its driving factors are frequently analyzed within administrative regions to inform regional urban planning, yet such analyses often fall short at the natural basin scale (referring to the spatial extent defined by hydrological drainage boundaries) due to the scarcity of [...] Read more.
Urban expansion and its driving factors are frequently analyzed within administrative regions to inform regional urban planning, yet such analyses often fall short at the natural basin scale (referring to the spatial extent defined by hydrological drainage boundaries) due to the scarcity of statistical data. Geographic and socio-economic spatial data can offer more detailed information across various research scales compared to traditional data (such as administrative statistical data, survey-based data, etc.), providing a potential solution to this limitation. Thus, this study took the Indus Basin as an example to reveal its urban expansion patterns and driving mechanism based on natural–economic–social time-series (2000–2020) spatial data, landscape expansion index, and geographical detector model (GDM). Future urban expansion distribution under different scenarios was also projected using Cellular Automata and Markov model (CA-Markov). The results indicated the following: (1) The Indus River Basin experienced rapid urban expansion during 2000–2020 dominated by edge-expansion, with urban expansion intensity showing a continuous increase. (2) Between 2000 and 2010 as well as 2010 and 2020, the dominant factor influencing urban expansion shifted from altitude to population (Pop), while the strongest interacting factors shifted from fine particulate matter (PM2.5) and altitude to Gross Domestic Product (GDP) and Pop. (3) Future urban expansion probably occupies substantial mountainous area under the normal scenario, while the expansion region shifts towards the central plains to protect more ecological zones under a sustainable development scenario. Findings in this study would deepen the understanding of urban expansion characteristics of the Indus Basin and benefit its future urban planning. Full article
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