Search Results (1,855)

This study investigates how the expansion of Warsaw’s metro system—specifically the opening of the second underground line (M2)—affects urban vibrancy, defined as the diversity and intensity of social, economic, and cultural activities. Using a spatial panel Difference-in-Differences (DiD) model with two-way fixed effects, the analysis examines changes in local vibrancy, proxied by the density of small catering businesses (SCB), across four years (2019–2023). Our results show that while built environment features such as building footprint, parking area, and street furniture positively correlate with vibrancy, the short-term effect of new metro stations is negative: areas within a 15 min walking distance of new stations experienced a relative decline in local activity compared to control areas. This pattern likely reflects a behavioral shift, as residents and consumers increasingly use the metro to access amenities in central, already vibrant districts. However, the effect attenuates over time, suggesting that neighborhoods gradually adapt to new mobility conditions. The findings highlight that large-scale transport investments may generate temporary disruptions before fostering long-term equilibrium and renewed urban vitality, underscoring the need for adaptive urban policies that mitigate transitional impacts and support local socio-economic resilience. Full article

DC distribution networks exhibit inherent symmetry in their balanced power distribution and modular structure, offering high operational flexibility and making them particularly suitable for the integration of distributed generation and modern loads. This symmetric framework positions DC networks as a vital component of new power systems and a key development direction for future power supply systems in industrial and mining enterprises. However, pole-to-pole short-circuit faults disrupt this symmetry, characterized by low system damping, high fault currents, and extremely rapid current rise rates, which pose serious threats to system security and necessitate ultra-fast fault clearance. To address this issue, this paper proposes a novel pilot protection scheme inspired by symmetry principles, based on the slope of the line-mode current for pole-to-pole short-circuit faults in DC distribution networks. First, an equivalent circuit of the system before converter blocking under a pole-to-pole fault is established, and an analytical expression of the fault current is derived, incorporating symmetric analysis of modal components. Subsequently, the variation trends, amplitudes, and phase characteristics of the fault current under faults occurring in different zones of the DC line are analyzed from the perspective of modal symmetry, highlighting the symmetric and asymmetric behaviors of line-mode and zero-mode currents. Furthermore, considering the distinct symmetric properties of these currents during lightning disturbances and pole-to-pole faults, the least squares method is employed to perform linear fitting on the line-mode current, thereby capturing its symmetric variation trend. A pilot protection scheme utilizing the slope of the line-mode current is then proposed, leveraging symmetry in fault discrimination. Finally, simulation models built in MATLAB/Simulink (R2022a) are used for validation. The results demonstrate that the proposed protection method can quickly identify faults within 1.5 ms while exhibiting strong tolerance to a 20 Ω transitional resistance and 50 dB signal noise, indicating good feasibility and broad applicability, with symmetry-based analysis enhancing robustness. Full article

Ternary organic photovoltaics (OPVs) are considered as the next step beyond binary systems, aiming to achieve synergistic improvements in absorption, energetic alignment, and charge transport. However, despite their conceptual appeal, most ternary blends do not outperform binary counterparts, particularly under indoor illumination where photon flux and carrier dynamics impose strict limitations. To comprehensively understand this discrepancy, multiple ternary systems were systematically examined to ensure that the observed behaviors are representative rather than case specific. In this study, we systematically investigate this discrepancy by comparing representative donor–donor–acceptor (D–D–A) and donor–acceptor–acceptor (D–A–A) systems under both AM 1.5G and TL84 lighting. In all cases, the broadened absorption fails to yield effective photocurrent; instead, redundant excitations, reduced driving forces for charge separation, and disrupted percolation networks collectively diminish device performance. Recombination and transient analyses reveal that the third component often introduces energetic disorder and trap-assisted recombination instead of facilitating beneficial cascade pathways. Although the film morphology remains smooth, interfacial instability under low-light conditions further intensifies performance losses. The inclusion of several systems allows the identification of consistent mechanistic trends across different ternary architectures, reinforcing the generality of the conclusions. This work establishes a mechanistic framework linking molecular miscibility, energetic alignment, and percolation continuity to device-level behavior, clarifying why ternary strategies rarely deliver consistent efficiency improvements. Ultimately, indoor OPV performance is determined not by spectral breadth but by maintaining balanced charge transport and stable energetic landscapes, which represents an essential paradigm for advancing ternary OPVs from concept to practical application. Full article

Graphite anodes are widely used as consumable electrodes in the high-temperature electrolytic production of rare earth metals within fluoride molten salts. However, their rapid and complex corrosion presents significant economic and operational challenges, including high consumption costs, process instability, greenhouse gas emissions, and product contamination. While the corrosion morphology of specific graphite types has been studied, a systematic investigation linking the intrinsic properties of diverse graphite materials to their microstructural and chemical evolution during corrosion is lacking. This study elucidates the corrosion mechanisms of three distinct graphite anodes—fine-grained, isostatically pressed graphite anodes (#1), medium-coarse-grained, extruded graphite anodes (#2), and recycled, extruded graphite anodes (#3) in industrial PrNdF₃–LiF molten salt electrolytes at 1050 °C. Through a multifaceted analytical approach encompassing SEM, EDS, XRD, Raman, and FT-IR, we investigated the macro- and microscale corrosion behaviors across multiple scales. The results revealed markedly different degradation patterns: the #1 anode exhibited intergranular corrosion with granular exfoliation; the #2 anode developed a protective but cracked resolidified salt layer; and the #3 anode suffered the most severe uniform and pitting corrosion. Postcorrosion analysis confirmed surface enrichment with fluorine, praseodymium, and neodymium, the formation of PrF₃ and NdF₃ phases, and substantial degradation of the graphitic structure. Raman spectroscopy specifically revealed a reduction in the crystallite size, introduction of in-plane point defects, and disruption of the interlayer stacking order. On the base of infrared spectroscopy analysis, all key characteristic absorption peaks of the graphite anodes undergo consistent attenuation after corrosion. This work provides critical insights for the informed selection and optimization of graphite anodes to increase the efficiency and sustainability of rare earth electrolysis. Full article

Background/Objectives: The COVID-19 pandemic profoundly disrupted the daily lives of children with neurodevelopmental disorders, particularly Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD). Lockdowns, therapy interruptions, and reduced access to educational and healthcare services significantly affected developmental progress and family functioning. This pilot study aimed to assess the long-term impact of the pandemic on children with ASD and ADHD in Northern Greece and to explore consequences for their families in the post-pandemic period. Methods: Parents or legal guardians of 72 children (ages 2–17 years) with confirmed diagnoses of ASD (n = 57) or ADHD (n = 15) participated. A structured 25-item questionnaire captured information on developmental, psychological, and social functioning, family well-being, therapy disruption, screen use, and access to online support. Data were collected across urban, semi-urban, and rural areas of Northern Greece over six months. Descriptive and inferential analyses were performed. Results: Most participants were boys (77.8%) and in primary school (73.6%). Common co-occurring conditions included learning difficulties (33.3%), anxiety (8.3%), and epilepsy (6.9%). Nearly half of families (45.8%) reported therapy reductions exceeding 70%, while 29.2% accessed online therapy, often with limited perceived effectiveness. New behavioral symptoms emerged in 45.8% of children, including irritability, anxiety, and emotional instability. Parental psychological distress was reported by 29.2% of caregivers. Screen time increased in over 90% of cases, and 87.5% of parents perceived the pandemic as negatively affecting their child. Financial strain was noted by 37.5% of families. Conclusions: The findings highlight the significant developmental, psychological, and social consequences of the COVID-19 pandemic for children with ASD and ADHD and their families. Service disruptions, unmet therapeutic needs, and increased caregiver burden emphasize the urgency of sustainable, flexible care models. Strengthening telehealth, integrating community-based interventions, and enhancing educational accommodations are essential for resilience in the post-pandemic era. Full article

Epilepsy is one of the most prevalent neurological disorders, severely impacting quality of life. The burden of epilepsy is exacerbated by high rates of neuropsychiatric comorbidities such as depression, anxiety, and post-traumatic stress disorder. The molecular mechanisms linking epilepsy to these comorbidities remain unclear. Epileptogenesis and recurrent seizures implicate multiple processes including changes in the extracellular matrix, structural and functional neuroplasticity, neuroinflammation, and neurodegeneration. The plasminogen activation (PA) system—a complex system of proteins that function as both proteases and signaling molecules—modulates these processes in the central nervous system (CNS) under normal conditions and following potentially epileptogenic insults. Notably, the PA system is also dysregulated in stress-related psychiatric disorders. In this review, we first provide an overview of the role of PA system in the CNS with an emphasis on the mechanisms related to epilepsy. We then explore the hypothesis that the components of the PA system components constitute a shared pathological link implicated in both epileptogenesis and psychiatric disorders. We summarize clinical and preclinical evidence demonstrating that seizures and other brain insults disrupt the PA system, and that similar dysregulation is observed in stress-related psychiatric conditions. We propose that PA system dysregulation is a potential molecular substrate linking epileptogenesis and neuropsychiatric comorbidities, presenting a promising target for future research aimed at understanding the mechanisms underlying the development of behavioral comorbidities in epilepsy. Full article

Some special volatile organic compounds (VOCs) that significantly induce female oviposition preferences may be utilized to disrupt oviposition behavior and to enhance trapping strategies; such approaches offer a promising avenue for reducing insect infestations in stored commodities. Based on the significant differences in the oviposition preference of P. interpunctella among six normal-oleic varieties (NOPs), the key VOCs involved were further explored. Seventeen VOCs that may contribute the oviposition preference and that exhibited a high content in the peanut varieties were measured through electroantennogram (EAG) response measurements of female moths. The VOCs that produced significant EAG responses by the females were further assayed for behavioral responses by the Y-tube olfactometer method, wind tunnel tests, and a multiple-choice device for female oviposition. Heptanal, acetophenone, nonanal, hexanal, benzaldehyde, octanal, hexanoic acid, decanal, phenylacetaldehyde, and 1-octen-3-ol from peanuts elicited strong antennal EAG responses. These VOCs (especially heptanal, nonanal, hexanal, octanal, and decanal) attracted more females in both Y-tube olfactometer and wind tunnel assays and increased oviposition rates in oviposition tests. The results indicate that heptanal, decanal, octanal, nonanal, and hexanal may be utilized to develop oviposition attractants for female moths further. Full article

Aquatic ecosystems are increasingly threatened by multiple anthropogenic stressors, notably climate change and pollution by pharmaceuticals. Global warming is predicted to raise water temperatures by 2–5 °C by the end of the century. As ectotherms, fish are particularly vulnerable due to limited thermal tolerance and temperature-dependent physiology. Pharmaceuticals are introduced into aquatic systems at concentrations ranging from ng·L⁻¹ to µg·L⁻¹, including widely prescribed classes such as antibiotics, hormones, analgesics, antifungals, and neuropsychiatric drugs. This narrative review synthesizes experimental evidence on the interactive effects of warming and pharmaceutical exposure in fish. Thirty-nine peer-reviewed studies published since 2005 were analyzed. The findings indicate that higher temperatures often exacerbate pharmaceutical-induced toxicity, altering oxidative stress, metabolism, reproduction, and behavior. Antibiotic-focused studies showed temperature-dependent acceleration of absorption, distribution, metabolism, and excretion, with shorter half-lives and reduced tissue persistence at higher temperatures. Estrogenic hormones and antifungals have been shown to interact with thermal regimes, disrupting reproductive physiology and skewing sex ratios, particularly in species exhibiting temperature-dependent sex determination. Neuropsychiatric drugs exhibited altered uptake and metabolism under warming conditions, resulting in increased brain bioaccumulation and behavioral alterations affecting ecological fitness. Analgesics and anti-inflammatories remain understudied despite their widespread use, with evidence suggesting synergistic effects on oxidative stress at elevated temperatures. Significant research gaps persist regarding chronic exposures, early developmental stages, ecologically relevant temperature scenarios, and underrepresented or absent drug classes, such as hypolipidemic drugs. Ultimately, broader and integrated approaches are needed to better understand and predict the ecological risks of pharmaceutical pollution in a warming world. Full article

Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with neurodevelopmental toxicity, yet the effects of exposure during adolescence and adulthood remain underexplored. This scoping review evaluates the neurotoxic outcomes of post-weaning PCB exposure in rodent models. A comprehensive literature search was conducted across PubMed, Embase, and Scopus. Studies were screened according to PRISMA guidelines. Articles were included if they reported neurotoxic or behavioral outcomes in mice or rats exposed to PCBs during post-weaning stages. Thirty-five studies met the inclusion criteria, encompassing a variety of PCB congeners and mixtures administered via oral, inhalation, or intraperitoneal routes. Reported neurotoxic outcomes included histological and morphological brain changes, oxidative stress, disrupted calcium signaling, altered neurotransmitter systems, apoptosis, and gene expression alterations. These outcomes were assessed using diverse methodological approaches, including immunohistochemistry, biochemical assays, and gene expression profiling. Behavioral outcomes affected by PCB exposure included locomotion, anxiety-like behavior, learning and memory, motor coordination, and cognitive flexibility. Effects were often exposure-specific and sex-dependent, with limited female-focused studies and integrative molecular-behavioral assessments. These findings highlight the broad neurotoxic potential of PCBs following adolescent or adult exposure and underscore the need for further mechanistic, sex-specific research to inform health risk assessment and regulatory policy. Full article

Memory consolidation is the process by which newly acquired experiences are stabilized into long-term memory, involving coordinated cellular and network-level activity across brain regions such as the hippocampus and prefrontal cortex. Dysregulation of this process has been implicated in psychiatric disorders including post-traumatic stress disorder (PTSD), which is characterized by the over-consolidation of traumatic memories. LIM kinase 1 (LIMK1), a key regulator of synaptic plasticity, is believed to play an important role in memory consolidation across hippocampal–cortical circuits. In this study, we investigated the function of LIMK1 using Limk1 knockout mice. Behavioral tests such as the novel object location memory task revealed significant memory impairments in knockout animals. In vivo recordings during sleep showed disrupted communication between the hippocampus and prefrontal cortex, suggesting impaired systems-level consolidation. Furthermore, in an underwater trauma exposure model, pharmacological inhibition of LIMK1 with LIMK-i3 alleviated trauma-induced behavioral abnormalities. These findings highlight LIMK1 as a critical mediator of hippocampal–cortical memory consolidation and provide experimental evidence that LIMK1 inhibition can modulate maladaptive memory processes associated with PTSD-like symptoms. Full article

Background: Degenerin proteins, such as Acid-Sensing Ion Channel 2 (ASIC2) and β Epithelial Na⁺ Channel (βENaC), have been implicated in cardiovascular function. We previously demonstrated that mice lacking normal levels of βENaC and ASIC2 are protected from diet-induced obesity, metabolic disruption, and hepatic steatosis. Methods: To investigate the specific role of βENaC proteins in the progression of metabolic disease, we examined the impact of a high-fat diet (HFD) in the βENaC hypomorph mouse model (βMUT). Body composition and metabolic and behavioral phenotypes were examined in male and female and βMUT and WT mice (n = 6–14/group) fed a normal chow diet (NFD) from weaning until 16 weeks of age, then a 60% kcal-fat diet for 5 weeks. Results: Compared to WT mice, βMUT male mice have reduced lean and total body mass. No remarkable differences in energy expenditure, motor activity, or food consumption patterns were detected. HFD-fed male βMUT mice exhibited reduced liver fat content (mass and Oil Red O staining) yet increased abdominal fat depots. HFD-fed female βMUT mice exhibited lower heart mass. Conclusions: These novel findings suggest a role for βENaC in the maintenance of metabolic homeostasis and adipose tissue distribution. Full article

Corrosion of rock bolts in engineering exhibits random spatial distribution characteristics. To elucidate the influence mechanism of stochastic corrosion on the surface of rock bolts on the propagation behavior of ultrasonic guided waves, this study establishes a finite element model of rock bolts that incorporates stochastic corrosion characteristics. The coupled effects of corrosion depth and area ratio on guided wave propagation characteristics, time-domain response, energy distribution, and wave velocity variation are systematically investigated. Results indicate that corrosion depth and area ratio synergistically deteriorate guided wave morphology, transforming the stress field from symmetric and uniform to asymmetric and spiral. Reflections, scattering, and mode conversion induced by defects lead to a significant increase in the attenuation rate of pulse amplitude, with the two parameters governing the vertical interaction intensity and horizontal interference scope, respectively. Analysis of the Hilbert curve reveals that corrosion characteristics disrupt energy concentration. Under constant corrosion depth, an increase in area ratio disperses energy toward delayed scattered waves, while under constant area ratio, greater corrosion depth reduces the peak amplitude of the envelope curve. Overall, the energy integral exhibits an increasing trend with the degree of corrosion, whereas the peak-to-peak wave velocity shows a declining trend. The established multivariate nonlinear model accurately describes the coupled influence of corrosion parameters on wave velocity. This stochastic corrosion model overcomes the limitations of traditional simplified models and provides critical theoretical support for parameter calibration and engineering application of ultrasonic guided wave technology in the quantitative assessment of rock bolt corrosion. Full article

Background: While the positive relationship between mental health and physical activity (PA) is well established, numerous barriers are reported. This study analyzed PA levels and associated barriers in young people attending a national child and adolescent mental health service using a quantitatively driven mixed methods design. Methods: From contacted patient families (n = 1284) meeting inclusion criteria, 23.67% (n = 304; age 12 to 18 years) completed a questionnaire (quantitative component/supplementary qualitative component). Statistical tests and thematic analysis were used to interpret data. Results: 57.24% (n = 174) of participants practiced PA/sport. Those in a sporting discipline did more PA overall, and males were almost twice as likely (OR = 1.98) to do PA/sports than females. PA levels were significantly different across mental disorder groups (highest in personality disorders and related traits, and lowest in disruptive behavioral or dissocial disorders). Participants supported the positive association between mental health and athletic performance, including the use of exercise prescriptions. Barriers to PA included excessive screentime, reduced mental health support/awareness, lack of appropriate facilities, financial difficulties, etc. Conclusion: Further research is needed. However, such results will serve to inform the development of the first documented sport mental health clinic for young people. Full article

Diet influences brain health through many connected metabolic and molecular pathways, and these effects are stronger in obesity. This review links diet quality with cognitive decline and dementia risk. Ultra-processed, high-fat, high-sugar diets drive weight gain, insulin resistance, and chronic inflammation. These changes trigger brain oxidative stress, reduce DNA repair, deplete NAD⁺, disturb sirtuin/PARP balance, and alter epigenetic marks. Gut dysbiosis and leaky gut add inflammatory signals, weaken the blood–brain barrier, and disrupt microglia. Mediterranean and MIND diets, rich in plants, fiber, polyphenols, and omega-3 fats, slow cognitive decline and lower dementia risk. Trials show extra benefit when diet improves alongside exercise and vascular risk control. Specific nutrients can help in certain settings. DHA and EPA support brain health in people with low omega-3 status or early disease. B-vitamins slow brain shrinkage in mild cognitive impairment when homocysteine is high. Vitamin D correction is beneficial when levels are low. A practical plan emphasizes healthy eating and good metabolic control. It includes screening for deficiencies and supporting the microbiome with fiber and fermented foods. Mechanism-based add-ons, such as NAD⁺ boosters, deserve testing in lifestyle-focused trials. Together, these measures may reduce diet-related brain risk across the life span. At the same time, artificial intelligence can integrate diet exposures, adiposity, metabolic markers, multi-omics, neuroimaging, and digital phenotyping. This can identify high-risk phenotypes, refine causal links along the diet–obesity–brain axis, and personalize nutrition-plus-lifestyle interventions. It can also highlight safety, equity, and privacy considerations. Translationally, a pattern-first strategy can support early screening and personalized risk reduction by integrating diet quality, adiposity, vascular risk, micronutrient status, and microbiome-responsive behaviors. AI can aid measurement and risk stratification when developed with privacy, equity, and interpretability safeguards, but clinical decisions should remain mechanism-aligned and trial-anchored. Full article

This study aimed to characterize behavioral differences between true estrus (TE) and false estrus (FE) in cows using neck-mounted six-axis inertial measurement unit sensors to reduce false positives in automated detection systems. A retrospective analysis was conducted on 1464 validated estrus alerts from 414 Hanwoo cows across 13 commercial farms in South Korea. Alerts were classified as TE (625 alerts) or FE (839 alerts) based on comprehensive validation criteria, including standing heat observation, artificial insemination records, ovulation confirmation, and pregnancy outcomes. Mounting activity, rumination time, and lying time were analyzed. True estrus exhibited significantly higher (p < 0.0001) total number of mounts and maximum mounting duration compared to FE over the entire observation period. Notably, the maximum number of mounts per hour was higher (p < 0.0001) in FE before alert generation but higher (p < 0.0001) in TE afterward, with FE declining rapidly. Coefficients of variation for rumination and lying time were significantly higher (p < 0.0001) in TE than in FE, indicating greater behavioral disruption. These findings revealed that secondary behavioral signs exhibit distinct quantitative and temporal patterns between TE and FE, suggesting potential criteria that could be integrated into automated detection algorithms to reduce false-positive rates. Full article