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9 Results Found

  • Article
  • Open Access
2 Citations
6,945 Views
13 Pages

Comparison of the Efficacy of Dextrose Prolotherapy and Ozone in Patients with Knee Osteoarthritis: A Randomized Cross-Sectional Study

  • Fatih Baygutalp,
  • Mine Çelik,
  • Muhammet Uğur Öztürk,
  • Ahmet Murat Yayık and
  • Ali Ahıskalıoğlu

26 October 2021

This study aimed to compare the effectiveness of dextrose prolotherapy, ozone therapy, and home exercise programs in patients with knee osteoarthritis. Seventy-five patients with knee osteoarthritis were divided into three groups, with 25 in each gro...

  • Article
  • Open Access
3 Citations
4,343 Views
13 Pages

Rapid Decrease in Dextrose Concentration After Intra-Articular Knee Injection: Implications for Mechanism of Action of Dextrose Prolotherapy

  • Kenneth Dean Reeves,
  • Jordan R. Atkins,
  • Clare R. Solso,
  • Chin-I Cheng,
  • Ian M. Thornell,
  • King Hei Stanley Lam,
  • Yung-Tsan Wu,
  • Thomas Motyka and
  • David Rabago

Background: D-glucose (dextrose) is used as a 5000–25,000 mg% solution in the injection-based pain therapy known as dextrose prolotherapy (DPT). The number of peer-reviewed clinical trials supporting its use is growing. However, the mechanism o...

  • Article
  • Open Access
12 Citations
5,091 Views
13 Pages

Dextrose Prolotherapy for Symptomatic Grade IV Knee Osteoarthritis: A Pilot Study of Early and Longer-Term Analgesia and Pain-Specific Cytokine Concentrations

  • Gastón Andrés Topol,
  • Ines Guerrero Pestalardo,
  • Kenneth Dean Reeves,
  • Fernando Elias,
  • Neven J. Steinmetz,
  • An-Lin Cheng and
  • David Rabago

14 November 2022

Background: Neurocytokines may upregulate or downregulate neuropathic pain. We hypothesized that dextrose (D-glucose) injections for therapeutic purposes (dextrose prolotherapy: DPT) in painful knee osteoarthritis (KOA) would favorably affect synovia...

  • Systematic Review
  • Open Access
2,119 Views
14 Pages

Efficacy of Hyperosmolar Dextrose Injection for Osgood–Schlatter Disease: A Systematic Review with Meta-Analysis

  • Hye Chang Rhim,
  • Lori B. Bjork,
  • Jaehyung Shin,
  • Jewel Park,
  • Stephanie E. DeLuca,
  • Katelyn C. McCarron,
  • Ki-Mo Jang and
  • Chris Ha

Background/Objectives: Although Osgood–Schlatter disease (OSD) is often self-limiting following apophyseal closure, it may cause persistent symptoms into adulthood, affecting physical and functional activities. The purpose of this systematic re...

  • Systematic Review
  • Open Access
1 Citations
3,463 Views
17 Pages

Clinical Efficacy of Prolotherapy for Temporomandibular Joint Disorders: A Systematic Review and Meta-Analysis

  • Antonios Saramantos,
  • Athanassios Kyrgidis,
  • Gregorios Venetis,
  • Georgios Hatziantoniou,
  • Anestis Chrysostomidis,
  • Chrysanthi Sardeli and
  • Ioannis Tilaveridis

Background: Temporomandibular disorders (TMDs) encompass a group of conditions characterized by anatomical, histological, and/or functional abnormalities that affect the muscular and/or articular components of the temporomandibular joint. Prolotherap...

  • Systematic Review
  • Open Access
4,470 Views
33 Pages

Prolotherapy as a Regenerative Treatment in the Management of Chronic Low Back Pain: A Systematic Review

  • Stelian-Ilie Mociu,
  • Andreea-Dalila Nedelcu,
  • Andreea-Alexandra Lupu,
  • Andreea-Bianca Uzun,
  • Dan-Marcel Iliescu,
  • Elena-Valentina Ionescu and
  • Madalina-Gabriela Iliescu

2 September 2025

Background: Chronic low back pain markedly impairs quality of life and imposes a significant economic burden on public health. The complex pathophysiology of chronic low back pain arises from the complex anatomical configuration of the lumbar region,...

  • Case Report
  • Open Access
3 Citations
1,999 Views
16 Pages

Ultrasound-Guided Prolotherapy for Sciatica Secondary to Sacrospinous Ligament Calcification: A Potential and Previously Overlooked Etiological Factor in Deep Gluteal Syndrome—A Case Report and Literature Review

  • Yonghyun Yoon,
  • King Hei Stanley Lam,
  • Jaeyoung Lee,
  • Rowook Park,
  • Jaehyun Shim,
  • Jonghyeok Lee,
  • Daniel Chiung-Jui Su,
  • Kenneth Dean Reeves and
  • Stephen Cavallino

22 September 2025

Background: Deep gluteal syndrome (DGS) is an underdiagnosed cause of sciatica-like pain, involving the entrapment of the sciatic nerve by various structures within the subgluteal space. While cases of ossification or calcification in the context of...

  • Review
  • Open Access
1,352 Views
15 Pages

Preliminary Evidence on Intra-Articular Autologous Conditioned Serum (ACS) in Temporomandibular Joint Disorders (TMDs): A Systematic Review with a Focus on Mechanisms and Potential Application in Clinical Practice

  • Marcin Pasternak,
  • Maciej Chęciński,
  • Kamila Chęcińska,
  • Natalia Turosz,
  • Izabella Chyży,
  • Bartosz Kosiński,
  • Klaudia Kwiatkowska,
  • Kalina Romańczyk,
  • Amelia Hoppe and
  • Maciej Sikora

10 September 2025

Intra-articular injections form a substantial element of the temporomandibular joint disorder (TMD) therapy. Given the role played by IL-1β in pathology, the use of autologous conditioned serum (ACS) is well-founded. Despite years of effective u...

  • Article
  • Open Access
25 Citations
8,905 Views
24 Pages

Knee osteoarthritis (KOA) is associated with a high risk of sarcopenia. Both intra-articular injections (IAIs) and physical therapy (PT) exert benefits in KOA. This network meta-analysis (NMA) study aimed to identify comparative efficacy among the co...