Search Results (18,272)

Economic diversification is one state method used to best utilize national resources and contribute to economic and sustainable development. This paper examines the impact of governance on economic diversification in a selected number of countries (114) using both governance and economic diversification indicators from 1996 to 2023. The intended outcome of this paper is to determine whether the improvement in the quality of governance, measured by the aggregated WGI index, is positively and statistically associated with an increase in the Economic Complexity Index (ECI). A general linear mixed model (GLMM) was constructed to address the research question by evaluating fixed and random effects based on the analysis of repeated measures. However, the study has some limitations such as using an aggregate governance index rather than each indicator by itself and differences among country groups in development and institutional quality level. The findings reveal that economic diversification is linked to the quality of a country’s institutions. The result shows that (coefficient β = 0.283) with 95% CI, which means that on average, the ECI increased by 0.283 for every one-unit increase in the WGI. Moreover, the increase in ECI exceeded 0.1 for every one-unit increase in WGI 95% of the time. Countries with advanced administrative, economic, and institutional structures are better positioned to achieve their desired economic diversification goals. Thus, decision-makers and legislators, especially in countries with low-levels of institutional quality, need to balance ensuring good governance practices with supporting the country’s economic development. Full article

This mixed-methods study investigates the strategic management of digital transformation in Bulgarian schools by analysing principals’ self-reported leadership practices and styles. Using data from a nationally representative sample (N = 349) gathered through the SELFIE tool, complemented by 30 in-depth interviews, the research examines how school leaders understand and enact their roles as digital leaders within a context of fragmented policies and uneven digital capacity. Quantitative results reveal a central paradox: although 89.7% of principals claim to actively support teachers’ digital innovation, only about half report having a formalised digital strategy. This imbalance between strong operational support and weak institutionalisation reflects the dominant approach to school digitalisation in Bulgaria. Qualitative cluster analysis identifies three leadership profiles: (1) a strategic–collaborative profile, characterised by long-term planning, partnerships, and data-driven decisions; (2) a supportive–collaborative profile focused on teacher communities and context-specific professional development but lacking strategic vision; and (3) a balanced–pragmatic profile oriented toward measurable improvements and adaptive responses. Triangulation with national assessment data shows that leadership styles align with institutional contexts: high-performing schools tend to apply strategic–collaborative leadership, while lower-performing schools adopt pragmatic, adaptive approaches. The study argues that digital transformation requires context-sensitive frameworks recognising multiple developmental trajectories, highlighting the need for differentiated policies that support strategic institutionalisation of existing digital innovations while addressing structural inequalities. Full article

Efficient operation of electric vehicle (EV) charging stations is vital in the development of green transportation infrastructure. To address the challenge of balancing profitability, resource utilization, user behavior, and grid stability, this paper proposes a multi-objective dynamic pricing optimization framework based on a chaotic genetic algorithm (CGA). The model jointly maximizes operator profit and charging pile utilization while incorporating price-responsive user demand and grid load constraints. By integrating chaotic mapping into population initialization, the algorithm enhances diversity and global search capability, effectively avoiding premature convergence. Empirical results show that the proposed strategy significantly outperforms conventional methods: profits are 41% higher than with fixed pricing and 40% higher than with traditional time-of-use optimization, while charging pile utilization is 32.27% higher. These results demonstrate that the proposed CGA-based framework can efficiently balance multiple objectives, improve operational profitability, and enhance grid stability, offering a practical solution for next-generation charging station management. Full article

Salmonella spp. is a pathogenic microorganism linked to eggs and egg products. In-shell eggs are not required to be pasteurized in any country before they reach the consumer. The use of an emerging technology known as radio frequency has been successfully used to inactivate this pathogen inside in-shell eggs and claim pasteurization standards (5 - log reduction). The objective of this manuscript was to conduct the engineering cost of egg processing using a radio frequency pasteurizer and compare the processing cost to conventional thermal pasteurization for in-shell eggs. The ARS-patented radio frequency pasteurizer was used (40.68 MHz, 35 W) to pasteurize eggs in 24.5 min. The conventional thermal pasteurization (56.7 °C) required 60 min for the same level of inactivation. The techno-economic analysis (TEA) included information from stakeholders, egg processors and equipment manufacturers and was used together with energy balances and some key assumptions. Calculations for the engineering cost were made based on the required energy for each system, showing that the radio frequency required a third of the total cost of electricity to pasteurize eggs in a year compared with thermal, based on utilities costs in PA. Other utilities such as water and steam were also minor for radio frequency pasteurization. After two years of operation, the projected additional cost of processing is ~USD 0.19 per egg for the radio frequency system, compared with USD 0.22 per egg for conventional thermal treatment, largely due to volume-based amortization of capital costs and lower annual operating costs for the RF process. Radio frequency thus could be an option to pasteurize eggs in farms from PA and potentially in other states, using the system developed by our research team, while reducing energy consumption and increasing return on investment. Full article

The development of large-scale cascade hydropower complexes has improved the navigation conditions of mountainous rivers but creates unique “continuous dam zones,” presenting complex challenges for port site selection due to hydrological variability and geological risks. To address the lack of specialized evaluation tools for this specific context, this paper constructs a comprehensive evaluation indicator system tailored for mountainous reservoir areas. The proposed system explicitly integrates critical engineering and physical constraints—specifically fluctuating backwater zones, geological hazards, and dam-bypass mileage—alongside ecological and social requirements. The Analytic Hierarchy Process (AHP) and Entropy Weight Method (EWM) are integrated using a Game Theory model to determine combined weights, and the Evaluation based on Distance from Average Solution (EDAS) model is applied to rank the alternatives. An empirical analysis of the Xiluodu Reservoir area on the Jinsha River demonstrates that operational efficiency, geological safety, and environmental feasibility constitute the critical decision-making factors. The results indicate that Option C (Majiaheba site) offers the optimal solution (ASi = 0.9695), effectively balancing engineering utility with environmental protection. Sensitivity analysis further validates the consistency and stability of this ranking under different decision-making scenarios. The findings provide quantitative decision support for project implementation and offer a replicable reference for infrastructure planning in similar complex mountainous river basins. Full article

Collateral status is an important therapeutic indicator for acute ischemic stroke (AIS), yet visual collateral grading remains subjective and suffers from inter-observer variability. To address this limitation, this study automatically extracted binarized vascular morphological features from CTA images and developed a convolutional neural network (CNN) for automated collateral classification. Performance trends were systematically analyzed across diverse hyperparameter combinations to meet different clinical decision needs. A total of 157 AIS patients (median age 65 [⁵⁷,⁵⁸,⁵⁹,⁶⁰,⁶¹,⁶²,⁶³,⁶⁴,⁶⁵,⁶⁶,⁶⁷,⁶⁸,⁶⁹,⁷⁰,⁷¹,⁷²,⁷³,⁷⁴] years; 61.8% were male) were retrospectively enrolled and stratified by Menon score into good (3–5, n = 117) and poor (0–2, n = 40) collateral groups. A total of 192 architectures were established, and three representative model tendencies emerged: a sensitivity-oriented model (AUC = 0.773; sensitivity = 87.18%; specificity = 65.00%), a balanced model (AUC = 0.768; sensitivity = 72.65%; specificity = 77.50%), and a specificity-oriented model (AUC = 0.753; sensitivity = 63.25%; specificity = 85.00%). These results demonstrate that kernel size, the number of filters in the first layer, and the number of convolutional layers are key determinants of performance directionality, allowing tailored model selection depending on clinical requirements. This work highlights the feasibility of CTA-based automated collateral classification and provides a systematic framework for developing models optimized for sensitivity, specificity, or balanced decision-making. The findings may serve as a reference for clinical model deployment and have potential for integration into multi-objective AI systems for endovascular thrombectomy patient triage. Full article

Accurate model aggregation is pivotal for the efficient dispatch and control of massive distributed photovoltaic (PV) and energy storage (ES) resources. However, the lack of unified standards across equipment manufacturers results in inconsistent data formats and resolutions. Furthermore, external disturbances like noise and packet loss exacerbate the problem. The resulting data are massive, multi-source, and heterogeneous, which poses severe challenges to building effective aggregation models. To address these issues, this paper proposes a hierarchical aggregation method based on multi-source multi-scale data fusion. First, a Multi-source Multi-scale Decision Table (Ms-MsDT) model is constructed to establish a unified framework for the flexible storage and representation of heterogeneous PV-ES data. Subsequently, a two-stage fusion framework is developed, combining Information Gain (IG) for global coarse screening and Scale-based Trees (SbT) for local fine-grained selection. This approach achieves adaptive scale optimization, effectively balancing data volume reduction with high-fidelity feature preservation. Finally, a hierarchical aggregation mechanism is introduced, employing the Analytic Hierarchy Process (AHP) and a weight-guided improved K-Means algorithm to perform targeted clustering tailored to the specific control requirements of different voltage levels. Validation on an IEEE-33 node system demonstrates that the proposed method significantly improves data approximation precision and clustering compactness compared to conventional approaches. Full article

The increasing share of heavy and high-sulfur crude oils in refinery feed slates worldwide highlights the need for models of delayed coking units (DCUs) that are both physically meaningful and computationally efficient. In this study, we develop and calibrate a simplified yet dynamic one-dimensional model of an industrial coke drum intended for integration into digital twin frameworks. The model includes a three-phase representation of the drum contents, a temperature-dependent global kinetic scheme for vacuum residue cracking, and lumped descriptions of heat transfer and phase holdups. Only three physically interpretable parameters—the kinetic scaling factors for distillate and coke formation and an effective wall temperature—were calibrated using routinely measured plant data, namely the overhead vapor and drum head temperatures and the final coke bed height. The calibrated model reproduces the temporal evolution of the top head and overhead temperatures and the final bed height with mean relative errors of a few percent, while capturing the more complex bottom-head temperature dynamics qualitatively. Scenario simulations illustrate how the coking severity (represented here by the effective wall temperature) affects the coke yield, bed growth, and cycle duration. Overall, the results indicate that low-order dynamic models can provide a practical balance between physical fidelity and computational speed, making them suitable as mechanistic cores for digital twins and optimization tools in delayed coking operations. Full article

With the rapid development of Massive Open Online Courses (MOOCs), high dropout rates have become a major challenge, limiting the quality of online education and the effectiveness of targeted interventions. Although existing MOOC dropout prediction methods have incorporated deep learning and attention mechanisms to improve predictive performance to some extent, they still face limitations in modeling differences in course difficulty and learning engagement, capturing multi-scale temporal learning behaviors, and controlling model complexity. To address these issues, this paper proposes a MOOC dropout prediction model that integrates multi-scale convolution with a symmetric dual-attention mechanism, termed SDA-Net. In the feature modeling stage, the model constructs a time allocation ratio matrix (MRatio), a resource utilization ratio matrix (SRatio), and a relative group-level ranking matrix (Rank) to characterize learners’ behavioral differences in terms of time investment, resource usage structure, and relative performance, thereby mitigating the impact of course difficulty and individual effort disparities on prediction outcomes. Structurally, SDA-Net extracts learning behavior features at different temporal scales through multi-scale convolution and incorporates a symmetric dual-attention mechanism composed of spatial and channel attention to adaptively focus on information highly correlated with dropout risk, enhancing feature representation while maintaining a relatively lightweight architecture. Experimental results on the KDD Cup 2015 and XuetangX public datasets demonstrate that SDA-Net achieves more competitive performance than traditional machine learning methods, mainstream deep learning models, and attention-based approaches on major evaluation metrics; in particular, it attains an accuracy of 93.7% on the KDD Cup 2015 dataset and achieves an absolute improvement of 0.2 percentage points in Accuracy and 0.4 percentage points in F1-Score on the XuetangX dataset, confirming that the proposed model effectively balances predictive performance and model complexity. Full article

Background/Objectives: Artificial intelligence (AI) has gained substantial prominence in pediatric dentistry, offering new opportunities to enhance diagnostic precision and clinical decision-making. AI-based systems are increasingly applied in caries detection, early childhood caries (ECC) risk prediction, tooth development assessment, mesiodens identification, and other key diagnostic tasks. This systematic review and meta-analysis aimed to synthesize evidence on the diagnostic performance of AI models developed specifically for pediatric dental applications. Methods: A systematic search was conducted in PubMed, Scopus, Web of Science, and Embase following PRISMA-DTA guidelines. Studies evaluating AI-based diagnostic or predictive models in pediatric populations (≤18 years) were included. Reference screening, data extraction, and quality assessment were performed independently by two reviewers. Pooled sensitivity, specificity, and area under the receiver operating characteristic curve (AUC) were calculated using random-effects models. Sources of heterogeneity related to imaging modality, annotation strategy, and dataset characteristics were examined. Results: Thirty-two studies met the inclusion criteria for qualitative synthesis, and fifteen were eligible for quantitative analysis. For radiographic caries detection, pooled sensitivity, specificity, and AUC were 0.91, 0.97, and 0.98, respectively. Prediction models demonstrated good diagnostic performance, with pooled sensitivity of 0.86, specificity of 0.82, and AUC of 0.89. Deep learning architectures, particularly convolutional neural networks, consistently outperformed traditional machine learning approaches. Considerable heterogeneity was identified across studies, primarily driven by differences in imaging protocols, dataset balance, and annotation procedures. Beyond quantitative accuracy estimates, this review critically evaluates whether current evidence supports meaningful clinical translation and identifies pediatric domains that remain underrepresented in AI-driven diagnostic innovation. Conclusions: AI technologies exhibit strong potential to improve diagnostic accuracy in pediatric dentistry. However, limited external validation, methodological variability, and the scarcity of prospective real-world studies restrict immediate clinical implementation. Future research should prioritize the development of multicenter pediatric datasets, harmonized annotation workflows, and transparent, explainable AI (XAI) models to support safe and effective clinical translation. Full article

Oxidative stress (OS) is a critical regulator of placental development; however, its specific effects on trophoblast biology remain incompletely elucidated. This narrative review synthesizes evidence derived from studies using human placental tissues and trophoblast cell models to delineate how excessive reactive oxygen species (ROS) disrupt molecular and cellular pathways essential for normal placentation. The literature search was restricted to human-based and in vitro investigations. Across these studies, OS was consistently shown to impair mitochondrial function in trophoblasts, resulting in increased mitochondrial ROS generation, loss of mitochondrial membrane potential, and activation of apoptotic signaling cascades. These mitochondrial disturbances were associated with reduced trophoblast proliferation, migration, and invasion, as well as dysregulation of angiogenic balance. Furthermore, several studies reported alterations in mitophagy, involvement of redox-sensitive pathways such as CYP1A1 and KLF9, and the extracellular release of mitochondrial DNA, which was linked to reduced cell viability and increased necrotic cell death. Collectively, the available evidence indicates that OS interferes with key trophoblast-dependent developmental processes, providing mechanistic insight into the pathogenesis of placental dysfunction observed in pregnancy complications such as preeclampsia (PE) and intrauterine growth restriction (IUGR). Elucidation of these pathways may inform the development of targeted therapeutic strategies aimed at preserving placental function and improving adverse pregnancy outcomes. Full article

Accurate and stable mapping of crop types is fundamental to agricultural monitoring and food security. However, inter-annual phenological shifts driven by variations in air temperature, precipitation, and sowing dates introduce systematic changes in the spectral distributions associated with the same day of year (DOY). As a result, the “date–spectrum–class” mapping learned during training can become misaligned when applied to a new year, leading to increased misclassification and unstable performance. To tackle this problem, we develop TABS-Net (Temporal–Spectral Attentive Block with Space–Time Fusion Network). The core contributions of this study are summarized as follows: (1) we propose an end-to-end 3D CNN framework to jointly model spatial, temporal, and spectral information; (2) we design and embed CBAM3D modules into the backbone to emphasize informative bands and key time windows; and (3) we introduce DOY positional encoding and temporal jitter during training to explicitly align seasonal timing and simulate phenological shifts, thereby enhancing cross-year robustness. We conduct a comprehensive evaluation on a Cropland Data Layer (CDL) subset. Within a single year, TABS-Net delivers higher and more balanced overall accuracy, Macro-F1, and mIoU than strong baselines, including 2D stacking, 1D temporal convolution/LSTM, and transformer models. In cross-year experiments, we quantify temporal stability using inter-annual robustness (IAR); with both DOY encoding and temporal jitter enabled, the model attains IAR values close to one for major crop classes, effectively compensating for phenological misalignment and inter-annual variability. Ablation studies show that DOY encoding and temporal jitter are the primary contributors to improved inter-annual consistency, while CBAM3D reduces crop–crop and crop–background confusion by focusing on discriminative spectral regions such as the red-edge and near-infrared bands and on key growth stages. Overall, TABS-Net combines higher accuracy with stronger robustness across multiple years, offering a scalable and transferable solution for large-area, multi-year remote sensing crop mapping. Full article

Gut microbiota is a potential therapeutic target for type 2 diabetes (T2D), but its role remains unclear. Investigating causal associations between them could further our understanding of their biological and clinical significance. A two-sample Mendelian randomization (MR) analysis was conducted to assess the causal relationship between gut microbiota and T2D. Key genes and mechanisms were identified through the integration of Genome-Wide Association Studies (GWAS) and cis-expression quantitative trait loci (cis-eQTL) data. Network pharmacology was applied to identify potential drugs and targets. Additionally, gut microbiota community analysis and machine learning models were used to construct a diagnostic model for T2D. MR analysis identified 17 gut microbiota taxa associated with T2D, with three showing significant associations: Actinomyces (odds ratio [OR] = 1.106; 95% confidence interval [CI]: 1.06–1.15; p < 0.01; adjusted p-value [p_adj] = 0.0003), Ruminococcaceae (UCG010 group) (OR = 0.897; 95% CI: 0.85–0.95; p < 0.01; p_adj = 0.018), and Deltaproteobacteria (OR = 1.072; 95% CI: 1.03–1.12; p < 0.01; p_adj = 0.029). Ten key genes, such as EXOC4 and IGF1R, were linked to T2D risk. Network pharmacology identified INSR and ESR1 as target driver genes, with drugs like Dienestrol showing promise. Gut microbiota analysis revealed reduced α-diversity in T2D patients (p < 0.05), and β-diversity showed microbial community differences (R² = 0.012, p = 0.001). Furthermore, molecular docking confirmed the binding affinity of potential therapeutic agents to their targets. Finally, we developed a class-weight optimized Extreme Gradient Boosting (XGBoost) diagnostic model, which achieved an area under the curve (AUC) of 0.84 with balanced sensitivity (95.1%) and specificity (83.8%). Integrating machine learning predictions with MR causal inference highlighted Bacteroides as a key biomarker. Our findings elucidate the gut microbiota-T2D causal axis, identify therapeutic targets, and provide a robust tool for precision diagnosis. Full article

The integration of biomethane into the natural gas infrastructure is a critical element of energy-sector decarbonization, yet optimal infrastructure development scenarios remain insufficiently compared using unified decision frameworks. This study evaluates three biomethane market integration scenarios—direct connection to the gas system, biomethane injection points (compressed biomethane transported by trucks to the gas system), and off-grid delivery using the multi-criteria decision-making method TOPSIS. Environmental, economic, and technical dimensions are jointly assessed. Results indicate that direct connection to the system provides the most balanced overall performance, achieving the highest integrated score (Ci = 0.70), driven by superior environmental and technical characteristics. Biomethane injection points demonstrate strong economic advantages (Ci = 0.49), particularly where capital investments need to be reduced or there is limited access to the gas system, but show weaker environmental and technical performance. Off-grid solutions perform poorly in integrated assessment (Ci = 0.00), reflecting limited scalability and high logistical complexity, although niche applications may remain viable under specific conditions. Sensitivity analysis confirms the robustness of these rankings across a wide range of weighting assumptions, strengthening the reliability of the findings for policy and infrastructure planning. This study provides one of the first integrated multi-criteria assessments explicitly incorporating virtual pipeline logistics, offering a transferable decision-support framework for sustainable biomethane development in diverse regional contexts. Full article

High penetration and output volatility of island wind and photovoltaics (PV) pose challenges to energy consumption and supply–demand balance, and cost-effective energy storage configuration. A coupled dispatch model for a wind–PV–storage system is proposed, which treats multiple canal units as virtual ‘loads’ that switch between generation and pumping under constraints of power balance and available water head model. Considering the variable reservoir–irrigation feature, a multi-objective model framework is developed to minimize both economic cost and storage capacity required. An augmented Lagrangian–Nash product enhanced NSGA-II (AL-NP-NSGA-II) algorithm enforces constraints of irrigation shortfall and overflow via an augmented Lagrangian term and allocates fair benefits across canal units through a Nash product reward. Moreover, updates of Lagrange multipliers and reward weights maintain power balance and accelerate convergence. Finally, a case simulation (3.7 MW wind, 7.1 MW PV, and 24 h rural load) is performed, where 440.98 kWh storage eliminates shortfall/overflow and yields 1.5172 × 10⁴ CNY. Monte Carlo uncertainty analysis (±10% perturbations in load, wind, and PV) shows that increasing storage to 680 kWh can stabilize reliability above 98% and raise economic benefit to 1.5195 × 10⁴ CNY. The dispatch framework delivers coordination of irrigation and power balance in island microgrids, providing a systematic configuration solution. Full article