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17 pages, 2538 KiB  
Article
Influence of Abrasive Flow Rate and Feed Rate on Jet Lag During Abrasive Water Jet Cutting of Beech Plywood
by Monika Sarvašová Kvietková, Ondrej Dvořák, Chia-Feng Lin, Dennis Jones, Petr Ptáček and Roman Fojtík
Appl. Sci. 2025, 15(15), 8687; https://doi.org/10.3390/app15158687 (registering DOI) - 6 Aug 2025
Abstract
Cutting beech plywood using abrasive water jet (AWJ) technology represents a significant area of research due to increasing demands for precision, quality, and environmental sustainability in manufacturing processes within the woodworking industry. AWJ technology enables non-contact cutting of materials without causing thermal deformation [...] Read more.
Cutting beech plywood using abrasive water jet (AWJ) technology represents a significant area of research due to increasing demands for precision, quality, and environmental sustainability in manufacturing processes within the woodworking industry. AWJ technology enables non-contact cutting of materials without causing thermal deformation or mechanical damage, which is crucial for preserving the structural integrity and mechanical properties of the plywood. This article investigates cutting beech plywood using technical methods using an abrasive water jet (AWJ) at 400 MPa pressure, with Australian garnet (80 MESH) as the abrasive material. It examines how abrasive mass flow rate, traverse speed, and material thickness affect AWJ lag, which in turn influences both cutting quality and accuracy. Measurements were conducted with power abrasive mass flow rates of 250, 350, and 450 g/min and traverse speeds of 0.2, 0.4, and 0.6 m/min. Results show that increasing the abrasive mass flow rate from 250 g/min to 350 g/min slightly decreased the AWJ cut width by 0.05 mm, while further increasing to 450 g/min caused a slight increase of 0.1 mm. Changes in traverse speed significantly influenced cut width; increasing the traverse speed from 0.2 m/min to 0.4 m/min widened the AWJ by 0.21 mm, while increasing it to 0.6 m/min caused a slight increase of 0.18 mm. For practical applications, it is recommended to use an abrasive mass flow rate of around 350 g/min combined with a traverse speed between 0.2 and 0.4 m/min when cutting beech plywood with AWJ. This balance minimizes jet lag and maintains high surface quality comparable to conventional milling. For thicker plywood, reducing the traverse speed closer to 0.2 m/min and slightly increasing the abrasive flow should ensure clean cuts without compromising surface integrity. Full article
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21 pages, 5621 KiB  
Article
Establishing Rational Processing Parameters for Dry Finish-Milling of SLM Ti6Al4V over Metal Removal Rate and Tool Wear
by Sergey V. Panin, Andrey V. Filippov, Mengxu Qi, Zeru Ding, Qingrong Zhang and Zeli Han
Constr. Mater. 2025, 5(3), 53; https://doi.org/10.3390/constrmater5030053 - 5 Aug 2025
Abstract
The study is motivated by the application of dry finish milling for post-build processing of additive Ti6Al4V blanks, since the use of neither lubricant nor coolants has been attracting increasing attention due to its environmental benefits, non-toxicity, and the elimination of the need [...] Read more.
The study is motivated by the application of dry finish milling for post-build processing of additive Ti6Al4V blanks, since the use of neither lubricant nor coolants has been attracting increasing attention due to its environmental benefits, non-toxicity, and the elimination of the need for additional cleaning processes. For end mills, wear patterns were investigated upon finish milling of the SLM Ti6Al4V samples under various machining conditions (by varying the values of radial depth of cut and feed values at a constant level of axial depth of cut and cutting speed). When using all the applied milling modes, the identical tool wear mechanism was revealed. Built-up edges mainly developed on the leading surfaces, increasing the surface roughness on the SLM Ti6Al4V samples but protecting the cutting edges. However, abrasive wear was mainly characteristic of the flank surfaces that accelerated peeling of the protective coatings and increased wear of the end mills. The following milling parameters have been established as being close to rational ones: Vc = 60 m/min, Vf = 400 mm/min, ap = 4 mm, and ae = 0.4 mm. They affected the surface roughness of the SLM Ti6Al4V samples in the following way: max cutting thickness—8 μm; built-up edge at rake surface—50 ± 3 μm; max wear of flank surface—15 ± 1 μm; maximum adherence of workpiece. Mode III provided the maximum MRR value and negligible wear of the end mill, but its main disadvantage was the high average surface roughness on the SLM Ti6Al4V sample. Mode II was characterized by both the lowest average surface roughness and the lowest wear of the end mill, as well as an insufficient MRR value. Since these two modes differed only in their feed rates, their values should be optimized in the range from 200 to 400 mm/min. Full article
(This article belongs to the Special Issue Mineral and Metal Materials in Civil Engineering)
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23 pages, 3106 KiB  
Article
Preparation of a Nanomaterial–Polymer Dynamic Cross-Linked Gel Composite and Its Application in Drilling Fluids
by Fei Gao, Peng Xu, Hui Zhang, Hao Wang, Xin Zhao, Xinru Li and Jiayi Zhang
Gels 2025, 11(8), 614; https://doi.org/10.3390/gels11080614 - 5 Aug 2025
Viewed by 25
Abstract
During the process of oil and gas drilling, due to the existence of pores or micro-cracks, drilling fluid is prone to invade the formation. Under the action of hydration expansion of clay in the formation and liquid pressure, wellbore instability occurs. In order [...] Read more.
During the process of oil and gas drilling, due to the existence of pores or micro-cracks, drilling fluid is prone to invade the formation. Under the action of hydration expansion of clay in the formation and liquid pressure, wellbore instability occurs. In order to reduce the wellbore instability caused by drilling fluid intrusion into the formation, this study proposed a method of forming a dynamic hydrogen bond cross-linked network weak gel structure with modified nano-silica and P(AM-AAC). The plugging performance of the drilling fluid and the performance of inhibiting the hydration of shale were evaluated through various experimental methods. The results show that the gel composite system (GCS) effectively optimizes the plugging performance of drilling fluid. The 1% GCS can reduce the linear expansion rate of cuttings to 14.8% and increase the recovery rate of cuttings to 96.7%, and its hydration inhibition effect is better than that of KCl and polyamines. The dynamic cross-linked network structure can significantly increase the viscosity of drilling fluid. Meanwhile, by taking advantage of the liquid-phase viscosity effect and the physical blocking effect, the loss of drilling fluid can be significantly reduced. Mechanism studies conducted using zeta potential measurement, SEM analysis, contact angle measurement and capillary force assessment have shown that modified nano-silica stabilizes the wellbore by physically blocking the nano-pores of shale and changing the wettability of the shale surface from hydrophilic to hydrophobic when the contact angle exceeds 60°, thereby reducing capillary force and surface free energy. Meanwhile, the dynamic cross-linked network can reduce the seepage of free water into the formation, thereby significantly lowering the fluid loss of the drilling fluid. This research provides new insights into improving the stability of the wellbore in drilling fluids. Full article
(This article belongs to the Special Issue Advanced Gels for Oil Recovery (2nd Edition))
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15 pages, 1476 KiB  
Systematic Review
Intramedullary Nailing vs. Plate Fixation for Trochanteric Femoral Fractures: A Systematic Review and Meta-Analysis of Randomized Trials
by Ümit Mert, Maher Ghandour, Moh’d Yazan Khasawneh, Filip Milicevic, Ahmad Al Zuabi, Klemens Horst, Frank Hildebrand, Bertil Bouillon, Mohamad Agha Mahmoud and Koroush Kabir
J. Clin. Med. 2025, 14(15), 5492; https://doi.org/10.3390/jcm14155492 - 4 Aug 2025
Viewed by 213
Abstract
Background/Objectives: Trochanteric femoral fractures pose significant surgical challenges, particularly in elderly patients. Intramedullary nailing (IMN) and plate fixation (PF) are the primary operative strategies, yet their comparative efficacy and safety remain debated. This meta-analysis synthesizes randomized controlled trials (RCTs) to evaluate clinical, [...] Read more.
Background/Objectives: Trochanteric femoral fractures pose significant surgical challenges, particularly in elderly patients. Intramedullary nailing (IMN) and plate fixation (PF) are the primary operative strategies, yet their comparative efficacy and safety remain debated. This meta-analysis synthesizes randomized controlled trials (RCTs) to evaluate clinical, functional, perioperative, and biomechanical outcomes of IMN versus PF specifically in trochanteric fractures. Methods: A systematic search of six databases was conducted up to 20 May 2024, to identify RCTs comparing IMN and PF in adult patients with trochanteric femoral fractures. Data extraction followed PRISMA guidelines, and outcomes were pooled using random-effects models. Subgroup analyses examined the influence of fracture stability, implant type, and patient age. Risk of bias was assessed using the Cochrane RoB 2.0 tool. Results: Fourteen RCTs (n = 4603 patients) were included. No significant differences were found in reoperation rates, union time, implant cut-out, or mortality. IMN was associated with significantly reduced operative time (MD = −5.18 min), fluoroscopy time (MD = −32.92 s), and perioperative blood loss (MD = −111.68 mL). It also had a lower risk of deep infection. Functional outcomes and anatomical results were comparable. Subgroup analyses revealed fracture stability and nail type significantly modified operative time, and compression screws were associated with higher reoperation rates than IMN. Conclusions: For trochanteric femoral fractures, IMN and PF yield comparable results for most clinical outcomes, with IMN offering some advantages in surgical efficiency and perioperative morbidity, though functional outcomes were comparable. Implant selection and fracture stability influence outcomes, supporting individualized surgical decision making. Full article
(This article belongs to the Section Orthopedics)
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21 pages, 1488 KiB  
Article
Comparative Evaluation and Optimization of Auxin Type and Concentration on Rooting Efficiency of Photinia × fraseri Dress: Stem Cuttings Using Response Surface Methodology
by Gülcay Ercan Oğuztürk, Müberra Pulatkan, Cem Alparslan and Türker Oğuztürk
Plants 2025, 14(15), 2420; https://doi.org/10.3390/plants14152420 - 4 Aug 2025
Viewed by 187
Abstract
This study aimed to evaluate and optimize the effects of three auxin types—indole-3-butyric acid (IBA), naphthaleneacetic acid (NAA), and indole-3-acetic acid (IAA)—applied at four concentrations (1000, 3000, 5000, and 8000 ppm) on the rooting performance of Photinia × fraseri Dress. stem cuttings. The [...] Read more.
This study aimed to evaluate and optimize the effects of three auxin types—indole-3-butyric acid (IBA), naphthaleneacetic acid (NAA), and indole-3-acetic acid (IAA)—applied at four concentrations (1000, 3000, 5000, and 8000 ppm) on the rooting performance of Photinia × fraseri Dress. stem cuttings. The experiment was conducted under controlled greenhouse conditions using a sterile perlite medium. Rooting trays were placed on bottom-heated propagation benches maintained at a set temperature of 25 ± 2 °C to stimulate root formation. However, the actual rooting medium temperature—measured manually every four days from the perlite zone using a calibrated thermometer—ranged between 18 °C and 22 °C, with an overall average of approximately 20 ± 2 °C. The average values of these root-zone temperatures were used in the statistical analyses. Rooting percentage, root number, root length, callus formation, and mortality rate were recorded after 120 days. In addition to classical one-way ANOVA, response surface methodology (RSM) was employed to model and optimize the interactions between auxin type, concentration, and temperature. The results revealed that 5000 ppm IBA significantly enhanced rooting performance, yielding the highest rooting percentage (85%), average root number (5.80), and root length (6.30 cm). RSM-based regression models demonstrated strong predictive power, with the model for rooting percentage explaining up to 92.79% of the total variance. Temperature and auxin concentration were identified as the most influential linear factors, while second-order and interaction terms—particularly T·ppm—contributed substantially to root length variation. These findings validate IBA as the most effective exogenous auxin for the vegetative propagation of Photinia × fraseri Dress. and provide practical recommendations for optimizing hormone treatments. Moreover, the study offers a robust statistical modeling framework that can be applied to similar propagation systems in woody ornamental plants. Full article
(This article belongs to the Section Horticultural Science and Ornamental Plants)
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21 pages, 2228 KiB  
Article
Multi-Objective Optimization of Abrasive Cutting Process Conditions to Increase Economic Efficiency
by Irina Aleksandrova
Technologies 2025, 13(8), 337; https://doi.org/10.3390/technologies13080337 - 3 Aug 2025
Viewed by 208
Abstract
Existing studies on the abrasive cutting process have primarily focused on the influence of cutting conditions on key parameters such as temperature, cut-off wheel wear, and machined surface quality. However, the choice of working conditions is often made based on the experience of [...] Read more.
Existing studies on the abrasive cutting process have primarily focused on the influence of cutting conditions on key parameters such as temperature, cut-off wheel wear, and machined surface quality. However, the choice of working conditions is often made based on the experience of qualified personnel or using data from reference sources. The literature also provides optimal values for the cutting mode elements, but these are only valid for specific methods and cutting conditions. This article proposes a new multi-objective optimization approach for determining the conditions for the implementation of the abrasive cutting process that leads to Pareto-optimal solutions for improving economic efficiency, evaluated by production rate and manufacturing net cost parameters. To demonstrate this approach, the elastic abrasive cutting process of structural steels C45 and 42Cr4 has been selected. Theoretical–experimental models for production rate and manufacturing net cost have been developed, reflecting the complex influence of the conditions of the elastic abrasive cutting process (compression force of the cut-off wheel on the workpiece and rotational frequency of the workpiece). Multi-objective compromise optimization based on a genetic algorithm has been conducted by applying two methods—the determination of a compromise optimal area for the conditions of the elastic abrasive cutting process and the generalized utility function method. Optimal conditions for the implementation of the elastic abrasive cutting process have been determined, ensuring the best combination of high production rate and low manufacturing net cost. Full article
(This article belongs to the Section Innovations in Materials Science and Materials Processing)
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15 pages, 1745 KiB  
Article
A Prediction Method for Technically Recoverable Reserves Based on a Novel Relationship Between the Relative Permeability Ratio and Saturation
by Dongqi Wang, Jiaxing Wen, Yang Sun and Daiyin Yin
Eng 2025, 6(8), 182; https://doi.org/10.3390/eng6080182 - 2 Aug 2025
Viewed by 157
Abstract
Upon reaching stabilized production in waterflooded reservoirs, waterflood performance curves are conventionally used to predict technically recoverable reserves (TRRs). However, as reservoirs enter high water-cut stages, the relationship between the relative permeability ratio and saturation becomes nonlinear, causing deflection in waterflood performance curves. [...] Read more.
Upon reaching stabilized production in waterflooded reservoirs, waterflood performance curves are conventionally used to predict technically recoverable reserves (TRRs). However, as reservoirs enter high water-cut stages, the relationship between the relative permeability ratio and saturation becomes nonlinear, causing deflection in waterflood performance curves. This leads to systematic overestimation of both predicted TRR and ultimate recovery factors. To overcome these limitations in conventional TRR prediction methods, this study establishes a novel relative permeability ratio-saturation relationship based on characteristic relative permeability curve behaviors. The proposed model is validated for three distinct fluid-rock interaction types. We further develop a permeability-driven forecasting model for oil production rates and water cuts. Comparative analyses with a conventional waterflood curve methodology demonstrate significant accuracy improvements. The results show that while traditional methods predict TRR ranging from 78.40 to 92.29 million tons, our model yields 70.73 million tons—effectively resolving overestimation issues caused by curve deflection during high water-cut phases. This approach establishes a robust framework for determining critical development parameters, including economic field lifespan, strategy adjustments, and ultimate recovery factor. Full article
(This article belongs to the Section Chemical, Civil and Environmental Engineering)
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21 pages, 875 KiB  
Article
Comprehensive Analysis of Neural Network Inference on Embedded Systems: Response Time, Calibration, and Model Optimisation
by Patrick Huber, Ulrich Göhner, Mario Trapp, Jonathan Zender and Rabea Lichtenberg
Sensors 2025, 25(15), 4769; https://doi.org/10.3390/s25154769 - 2 Aug 2025
Viewed by 237
Abstract
The response time of Artificial Neural Network (ANN) inference is critical in embedded systems processing sensor data close to the source. This is particularly important in applications such as predictive maintenance, which rely on timely state change predictions. This study enables estimation of [...] Read more.
The response time of Artificial Neural Network (ANN) inference is critical in embedded systems processing sensor data close to the source. This is particularly important in applications such as predictive maintenance, which rely on timely state change predictions. This study enables estimation of model response times based on the underlying platform, highlighting the importance of benchmarking generic ANN applications on edge devices. We analyze the impact of network parameters, activation functions, and single- versus multi-threading on response times. Additionally, potential hardware-related influences, such as clock rate variances, are discussed. The results underline the complexity of task partitioning and scheduling strategies, stressing the need for precise parameter coordination to optimise performance across platforms. This study shows that cutting-edge frameworks do not necessarily perform the required operations automatically for all configurations, which may negatively impact performance. This paper further investigates the influence of network structure on model calibration, quantified using the Expected Calibration Error (ECE), and the limits of potential optimisation opportunities. It also examines the effects of model conversion to Tensorflow Lite (TFLite), highlighting the necessity of considering both performance and calibration when deploying models on embedded systems. Full article
(This article belongs to the Section Fault Diagnosis & Sensors)
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16 pages, 2892 KiB  
Article
Evaluation of Cutting Forces and Roughness During Machining of Spherical Surfaces with Barrel Cutters
by Martin Reznicek, Cyril Horava and Martin Ovsik
Materials 2025, 18(15), 3630; https://doi.org/10.3390/ma18153630 - 1 Aug 2025
Viewed by 181
Abstract
Barrel tools are increasingly used in high-precision machining of free-form surfaces. However, limited studies evaluate their performance specifically on spherical geometries, where tool–surface contact characteristics differ significantly. Understanding how tool geometry and process parameters influence surface quality and cutting forces in such cases [...] Read more.
Barrel tools are increasingly used in high-precision machining of free-form surfaces. However, limited studies evaluate their performance specifically on spherical geometries, where tool–surface contact characteristics differ significantly. Understanding how tool geometry and process parameters influence surface quality and cutting forces in such cases remains underexplored. This study evaluates how barrel cutter radius and varying machining parameters affect cutting forces and surface roughness when milling internal and external spherical surfaces. Machining tests were conducted on structural steel 1.1191 using two barrel cutters with different curvature radii (85 mm and 250 mm) on a 5-axis CNC machine. Feed per tooth and radial depth of cut were systematically varied. Cutting forces were measured using a dynamometer, and surface roughness was assessed using the Rz parameter, which is more sensitive to peak deviations than Ra. Novelty lies in isolating spherical surface shapes (internal vs. external) under identical path trajectories and systematically correlating tool geometry to force and surface metrics. The larger curvature tool (250 mm) consistently generated up to twice the cutting force of the smaller radius tool under equivalent conditions. External surfaces showed higher Rz values than internal ones due to less favorable contact geometry. Radial depth of the cut had a linear influence on force magnitude, while feed rate had a limited effect except at higher depths. Smaller-radius barrel tools and internal geometries are preferable for minimizing cutting forces and achieving better surface quality when machining spherical components. The aim of this paper is to determine the actual force load and surface quality when using specific cutting conditions for internal and external spherical machined surfaces. Full article
(This article belongs to the Special Issue Recent Advances in Precision Manufacturing Technology)
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15 pages, 1521 KiB  
Review
The Effect of Heterogeneous Definitions of Massive Transfusion on Using Blood Component Thresholds to Predict Futility in Severely Bleeding Trauma Patients
by Samuel J. Thomas, Vraj S. Patel, Connor P. Schmitt, Aleksey T. Zielinski, Mia N. Aboukhaled, Christopher A. Steinberg, Ernest E. Moore, Hunter B. Moore, Scott G. Thomas, Dan A. Waxman, Joseph B. Miller, Connor M. Bunch, Michael W. Aboukhaled, Emmanuel J. Thomas, Saniya K. Zackariya, Halina Oryakhail, Alexander Mehreteab, Reagan E. Ludwig, Sarah M. George, Aayan I. Siddiqi, Bilal M. Zackariya, Aadil Qasim, Mark M. Walsh and Mahmoud D. Al-Fadhladd Show full author list remove Hide full author list
J. Clin. Med. 2025, 14(15), 5426; https://doi.org/10.3390/jcm14155426 - 1 Aug 2025
Viewed by 313
Abstract
In the trauma resuscitation literature, there are inconsistent definitions of what constitutes massive transfusion and a unit of blood, complicating the use of transfusion cut-points to declare futility. This is problematic as it can lead to the inefficient use of blood products, further [...] Read more.
In the trauma resuscitation literature, there are inconsistent definitions of what constitutes massive transfusion and a unit of blood, complicating the use of transfusion cut-points to declare futility. This is problematic as it can lead to the inefficient use of blood products, further exacerbating current blood product shortages. Previous studies have used various transfusion cut-points per hour to define futility in retrospective analyses but have not accurately defined futility at the bedside due to patient survival even at large rates and volumes of blood transfused. In an attempt to use transfusion cut-points as a marker to help define futility, guidelines have been proposed to limit blood product waste in transfusions for severely bleeding trauma patients, such as Suspension of Transfusion and Other Procedures (STOP) for patients older than 15 and the Futility of Resuscitation Measure (FoRM), used to determine futility in patients older than 60. In an effort to construct effective bedside futile resuscitation criteria with 100% positive predictive value and specificity, this review proposes the use of specific blood component transfusion cut-points combined with parameters from both STOP and FoRM to allow for a comprehensive and accurate method of declaring futility in severely bleeding trauma patients. Full article
(This article belongs to the Special Issue Current Trends and Prospects of Critical Emergency Medicine)
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20 pages, 10603 KiB  
Article
A Safety-Based Approach for the Design of an Innovative Microvehicle
by Michelangelo-Santo Gulino, Susanna Papini, Giovanni Zonfrillo, Thomas Unger, Peter Miklis and Dario Vangi
Designs 2025, 9(4), 90; https://doi.org/10.3390/designs9040090 (registering DOI) - 31 Jul 2025
Viewed by 168
Abstract
The growing popularity of Personal Light Electric Vehicles (PLEVs), such as e-scooters, has revolutionized urban mobility by offering compact, cost-effective, and environmentally friendly transportation solutions. However, safety concerns, including inadequate infrastructure, poor protective measures, and high accident rates, remain critical challenges. This paper [...] Read more.
The growing popularity of Personal Light Electric Vehicles (PLEVs), such as e-scooters, has revolutionized urban mobility by offering compact, cost-effective, and environmentally friendly transportation solutions. However, safety concerns, including inadequate infrastructure, poor protective measures, and high accident rates, remain critical challenges. This paper presents the design and development of an innovative self-balancing microvehicle under the H2020 LEONARDO project, which aims to address these challenges through advanced engineering and user-centric design. The vehicle combines features of monowheels and e-scooters, integrating cutting-edge technologies to enhance safety, stability, and usability. The design adheres to European regulations, including Germany’s eKFV standards, and incorporates user preferences identified through representative online surveys of 1500 PLEV users. These preferences include improved handling on uneven surfaces, enhanced signaling capabilities, and reduced instability during maneuvers. The prototype features a lightweight composite structure reinforced with carbon fibers, a high-torque motorized front wheel, and multiple speed modes tailored to different conditions, such as travel in pedestrian areas, use by novice riders, and advanced users. Braking tests demonstrate deceleration values of up to 3.5 m/s2, comparable to PLEV market standards and exceeding regulatory minimums, while smooth acceleration ramps ensure rider stability and safety. Additional features, such as identification plates and weight-dependent motor control, enhance compliance with local traffic rules and prevent misuse. The vehicle’s design also addresses common safety concerns, such as curb navigation and signaling, by incorporating large-diameter wheels, increased ground clearance, and electrically operated direction indicators. Future upgrades include the addition of a second rear wheel for enhanced stability, skateboard-like rear axle modifications for improved maneuverability, and hybrid supercapacitors to minimize fire risks and extend battery life. With its focus on safety, regulatory compliance, and rider-friendly innovations, this microvehicle represents a significant advancement in promoting safe and sustainable urban mobility. Full article
(This article belongs to the Section Vehicle Engineering Design)
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28 pages, 3272 KiB  
Review
Research Advancements in High-Temperature Constitutive Models of Metallic Materials
by Fengjuan Ding, Tengjiao Hong, Fulong Dong and Dong Huang
Crystals 2025, 15(8), 699; https://doi.org/10.3390/cryst15080699 - 31 Jul 2025
Viewed by 1046
Abstract
The constitutive model is widely employed to characterize the rheological properties of metallic materials under high-temperature conditions. It is typically derived from a series of high-temperature tests conducted at varying deformation temperatures, strain rates, and strains, including hot stretching, hot compression, separated Hopkinson [...] Read more.
The constitutive model is widely employed to characterize the rheological properties of metallic materials under high-temperature conditions. It is typically derived from a series of high-temperature tests conducted at varying deformation temperatures, strain rates, and strains, including hot stretching, hot compression, separated Hopkinson pressure bar testing, and hot torsion. The original experimental data used for establishing the constitutive model serves as the foundation for developing phenomenological models such as Arrhenius and Johnson–Cook models, as well as physical-based models like Zerilli–Armstrong or machine learning-based constitutive models. The resulting constitutive equations are integrated into finite element analysis software such as Abaqus, Ansys, and Deform to create custom programs that predict the distributions of stress, strain rate, and temperature in materials during processes such as cutting, stamping, forging, and others. By adhering to these methodologies, we can optimize parameters related to metal processing technology; this helps to prevent forming defects while minimizing the waste of consumables and reducing costs. This study provides a comprehensive overview of commonly utilized experimental equipment and methods for developing constitutive models. It discusses various types of constitutive models along with their modifications and applications. Additionally, it reviews recent research advancements in this field while anticipating future trends concerning the development of constitutive models for high-temperature deformation processes involving metallic materials. Full article
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12 pages, 457 KiB  
Article
Clinical Outcomes of Surgical Revascularization in Patients Presenting with Critical Limb Ischemia and Aortic Valve Stenosis
by Luca Attisani, Alessandro Pucci, Matteo A. Pegorer, Luca Luzzani, Francesco Casali, Giorgio Luoni, Stefano Tanagli, Gabriele Piffaretti and Raffaello Bellosta
J. Cardiovasc. Dev. Dis. 2025, 12(8), 292; https://doi.org/10.3390/jcdd12080292 - 31 Jul 2025
Viewed by 240
Abstract
(1) Background: Comparison of clinical outcomes between patients with moderate-severe aortic valve stenosis and those with mild or no aortic valve stenosis undergoing surgical revascularization for critical limb threating ischemia (CLTI). (2) Methods: Single center retrospective analysis of consecutive patients undergoing surgical lower [...] Read more.
(1) Background: Comparison of clinical outcomes between patients with moderate-severe aortic valve stenosis and those with mild or no aortic valve stenosis undergoing surgical revascularization for critical limb threating ischemia (CLTI). (2) Methods: Single center retrospective analysis of consecutive patients undergoing surgical lower limb revascularization with femoro-distal bypass for critical ischemia between 2016 and 2022. All patients were evaluated preoperatively by echocardiographic examination and divided into two cohorts: group A with moderate-severe aortic valve stenosis (AVA-cm2 < or =1.5 cm2) and group B with mild or absent stenosis (AVA-cm2 > 1.5 cm2). Primary outcomes were major limb amputation and mortality between the two groups. The rate of major cardiovascular events (stroke, myocardial infarction, sudden cardiac death) and change in “preoperative functional status” were the secondary outcomes. Descriptive statistics for continuous variables were performed by calculating means, standard deviation (SD) medians, and interquartile range (IQR) while, for categorical variables, frequencies and percentages were performed. Intergroup comparison tests, for continuous variables, were performed by t-test or corresponding nonparametric tests (Mann-Whitney test) while, for categorical variables, Chi-square test was used. Evaluation of cut-offs for the variable AVA-fx-cm2, in terms of predictive of outcome outcomes, was calculated by ROC curves. Comparison between clinical and outcome variables was performed using logistic regression models. A total of 316 patients were analyzed and divided in two groups: 50 (16%) patients with moderate or severe aortic valve stenosis (group A) and 266 (84%) with no or mild aortic valve stenosis (AVA > 1.5 cm2). Patients in group A were significantly older than those in group B (78 years vs. 74 years, p value = 0.005); no other significant comorbidity differences were found between the two groups. The mean follow-up was 1178 days (SD 991 days; 2–3869 days). There were no statistically significant differences between group A and group B in terms of major amputation rate (20% vs. 16.5%; p = 0.895) and overall mortality (48.0% vs. 40.6%; p = 0.640). In the total cohort, the statistically significant variables associated with the major amputation were systemic perioperative complication (OR 5.83, 95% CI: 2.36, 14.57, p < 0.001), bypass-related complication within 30 days of surgery (OR 2.74, 95% CI: 1.17, 6.45, p = 0.020), surgical revascularization below the knee (OR 7.72, 95% CI: 1.53, 140.68, p = 0.049), and the presence of a previous cardiovascular event (OR 2.65, 95% CI: 1.14, 6.26, p = 0.024). In patients undergoing surgical revascularization for CLTI, no significant difference in major amputation rate and overall mortality was found between subjects with mild or no aortic valve stenosis and those with moderate/severe stenosis. As expected, overall mortality was higher in older patients with worse functional status. A significantly higher rate of limb amputation was found in those subjects undergoing subgenicular revascularization, early bypass failure, or previous cardiovascular event. Full article
(This article belongs to the Special Issue Endovascular Intervention for Peripheral Artery Disease)
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25 pages, 11507 KiB  
Article
Accurate EDM Calibration of a Digital Twin for a Seven-Axis Robotic EDM System and 3D Offline Cutting Path
by Sergio Tadeu de Almeida, John P. T. Mo, Cees Bil, Songlin Ding and Chi-Tsun Cheng
Micromachines 2025, 16(8), 892; https://doi.org/10.3390/mi16080892 (registering DOI) - 31 Jul 2025
Viewed by 217
Abstract
The increasing utilization of hard-to-cut materials in high-performance sectors such as aerospace and defense has pushed manufacturing systems to be flexible in processing large workpieces with a wide range of materials while also delivering high precision. Recent studies have highlighted the potential of [...] Read more.
The increasing utilization of hard-to-cut materials in high-performance sectors such as aerospace and defense has pushed manufacturing systems to be flexible in processing large workpieces with a wide range of materials while also delivering high precision. Recent studies have highlighted the potential of integrating industrial robots (IRs) with electric discharge machining (EDM) to create a non-contact, low-force manufacturing platform, particularly suited for the accurate machining of hard-to-cut materials into complex and large-scale monolithic components. In response to this potential, a novel robotic EDM system has been developed. However, the manual programming and control of such a convoluted system present a significant challenge, often leading to inefficiencies and increased error rates, creating a scenario where the EDM process becomes unfeasible. To enhance the industrial applicability of this robotic EDM technology, this study focuses on a novel methodology to develop and validate a digital twin (DT) of the physical robotic EDM system. The digital twin functions as a virtual experimental environment for tool motion, effectively addressing the challenges posed by collisions and kinematic singularities inherent in the physical system, yet with proven 20-micron EDM gap accuracy. Furthermore, it facilitates a CNC-like, user-friendly offline programming framework for robotic EDM cutting path generation. Full article
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15 pages, 492 KiB  
Article
Head-to-Head Comparison of Etest, MICRONAUT-AM EUCAST and Reference Broth Microdilution-Based CLSI Results for Candida kefyr Antifungal Susceptibility Testing: Implications for Detection of Reduced Susceptibility to Amphotericin B
by Mohammad Asadzadeh, Suhail Ahmad, Jacques F. Meis, Josie E. Parker and Wadha Alfouzan
J. Fungi 2025, 11(8), 570; https://doi.org/10.3390/jof11080570 - 30 Jul 2025
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Abstract
Invasive infections with rare yeasts are increasing worldwide and are associated with higher mortality rates due to their resistance to antifungal drugs. Accurate antifungal susceptibility testing (AFST) is crucial for proper management of rare yeast infections. We performed AFST of 74 Candida kefyr [...] Read more.
Invasive infections with rare yeasts are increasing worldwide and are associated with higher mortality rates due to their resistance to antifungal drugs. Accurate antifungal susceptibility testing (AFST) is crucial for proper management of rare yeast infections. We performed AFST of 74 Candida kefyr isolates by Etest, EUCAST-based MICRONAUT-AM assay (MCN-AM) and reference Clinical and Laboratory Standards Institute broth microdilution method (CLSI). Essential agreement (EA, ±1 two-fold dilution), categorical agreement (CA), major errors (MEs) and very-major errors (VmEs) were determined using epidemiological cut-off values of ≤1.0 µg/mL, ≤0.03 µg/mL, ≤0.5 µg/mL and ≤1 µg/mL, defining wild-type isolates for fluconazole, voriconazole, micafungin and amphotericin B (AMB), respectively. Results for AMB susceptibility were correlated with ERG2/ERG3 mutations and total-cell sterols. CA of ≥97% was recorded between any two methods while EA varied between 72 and 82%, 87 and 92%, and 49 and 76% for fluconazole, voriconazole and micafungin, respectively. For AMB, CAs between CLSI and Etest; CLSI and MCN-AM; MCN-AM and Etest were 95% (4 ME, 0 VmE), 96% (3 ME, 0 VmE) and 99%, respectively, while EA varied from 32% to 69%. Non-synonymous ERG2/ERG3 mutations and no ergosterol were found in seven of eight isolates of non-wild types for AMB by Etest. Our data show that Etest, CLSI and MCN-AM methods are suitable for AFST of C. kefyr for fluconazole, voriconazole and micafungin. Excellent CAs for AMB between Etest and MCN-AM with concordant sterol profiles but not with CLSI suggest that Etest is also an excellent alternative for the detection of C. kefyr isolates with reduced susceptibility to AMB. Full article
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