Search Results (863)

Hyperloop ultra-high-speed transport presents a transformative opportunity for future mobility systems in smart cities. However, assessing its socio-economic impact remains challenging due to Hyperloop’s unique technological, modal, and operational characteristics. As a novel, fifth mode of transportation—distinct from both aviation and rail—Hyperloop requires tailored evaluation tools for policymakers. This study proposes a custom-designed framework to quantify its macroeconomic effects through changes in gross domestic product (GDP) at the city level. Unlike traditional economic models, the proposed approach is specifically adapted to Hyperloop’s multimodality, infrastructure, speed profile, and digital-green footprint. A Poisson pseudo-maximum likelihood (PPML) model is developed and applied at two technology readiness levels (TRL-6 and TRL-9). Case studies of Glasgow, Berlin, and Busan are used to simulate impacts based on geo-spatial features and city-specific trade and accessibility indicators. Results indicate substantial GDP increases driven by factors such as expanded 60 min commute catchment zones, improved trade flows, and connectivity node density. For instance, under TRL-9 conditions, GDP uplift reaches over 260% in certain scenarios. The framework offers a scalable, reproducible tool for policymakers and urban planners to evaluate the economic potential of Hyperloop within the context of sustainable smart city development. Full article

Mixed-flow assembly lines are widely employed in industrial manufacturing to handle diverse production tasks. For mixed flow assembly lines that involve mold changes and greater processing difficulties, there are currently two approaches: batch production and production according to order sequence. The first approach struggles to meet the processing constraints of workpieces with higher production difficulty, while the second approach requires the development of suitable scheduling schemes to balance mold changes and continuous processing. Therefore, under the second approach, developing an excellent scheduling scheme is a challenging problem. This study addresses the mixed-flow assembly shop scheduling problem, considering continuous processing and mold-changing constraints, by developing a multi-objective optimization model to minimize additional production time and customer waiting time. As this NP-hard problem poses significant challenges in solution space exploration, the conventional NSGA-II algorithm suffers from limited local search capability. To address this, we propose an enhanced NSGA-II algorithm (RLVNS-NSGA-II) integrating deep reinforcement learning. Our approach combines multiple neighborhood search operators with deep reinforcement learning, which dynamically utilizes population diversity and objective function data to guide and strengthen local search. Simulation experiments confirm that the proposed algorithm surpasses existing methods in local search performance. Compared to VNS-NSGA-II and SVNS-NSGA-II, the RLVNS-NSGA-II algorithm achieved hypervolume improvements ranging from 19.72% to 42.88% and 12.63% to 31.19%, respectively. Full article

The aim of this work is to evaluate the effectiveness of antimicrobial photodynamic therapy (aPDT) against oral MDR (multi-drug-resistant) Candida spp. infections related to orthodontic treatment with palatal expanders through in vitro study. Methods: PDT protocol: Curcumin + H₂O₂ was used as a photosensitizer activated by a 460 nm diode LED lamp, with an 8 mm blunt tip for 2 min in each spot of interest. In vitro simulation: A palatal expander sterile device was inserted into a custom-designed orthodontic bioreactor, realized with 10 mL of Sabouraud dextrose broth plus 10% human saliva and infected with an MDR C. albicans clinical isolate CA95 strain to reproduce an oral palatal expander infection. After 48 h of incubation at 37 °C, the device was treated with the PDT protocol. Two samples before and 5 min after the PDT process were taken and used to contaminate a Petri dish with a Sabouraud field to evaluate Candida spp. CFUs (colony-forming units). Results: A nearly 99% reduction in C. albicans colonies in the palatal expander biofilm was found after PDT. Conclusion: The data showed the effectiveness of using aPDT to treat palatal infection; however, specific patient oral micro-environment reproduction (Ph values, salivary flow, mucosal adhesion of photosensitizer) must be further analyzed. Full article

Analyzing the two-phase flow behavior in bearing lubrication is crucial for understanding friction and wear mechanisms, optimizing lubrication design, and improving bearing operational efficiency and reliability. However, the complexity of oil–air two-phase flow in high-speed bearings poses significant research challenges. Currently, there is a lack of comparative studies employing different simulation strategies to address this issue, leaving a gap in evidence-based guidance for selecting appropriate simulation approaches in practical applications. This study begins with a comparative analysis between experimental and simulation results to validate the reliability of the adopted simulation approach. Subsequently, a comparative evaluation of different simulation methods is conducted to provide a scientific basis for relevant decision-making. Evaluated from three dimensions—adaptability to rotational speed conditions, research focuses (oil distribution and power loss), and computational economy—the findings reveal that FVM excels at medium-to-high speeds, accurately predicting continuous oil film distribution and power loss, while MPS, leveraging its meshless Lagrangian characteristics, demonstrates superior capability in describing physical phenomena under extreme conditions, albeit with higher computational costs. Economically, FVM, supported by mature software ecosystems and parallel computing optimization, is more suitable for industrial design applications, whereas MPS, being more reliant on high-performance hardware, is better suited for academic research and customized scenarios. The study further proposes that future research could adopt an FVM-MPS coupled approach to balance efficiency and precision, offering a new paradigm for multi-scale lubrication analysis in bearings. Full article

This paper deals with a standard cell-based analog-in-concept pW-power building block as a comparator and a wake-up oscillator. Both topologies, traditionally conceived as an analog building block made by a custom process and supply voltage-dependent design flow, are designed only by using digital gates, enabling them to be automated and fully synthesizable. This further results in supply voltage scalability and regulator-less operation, allowing direct powering by an energy harvester without additional ancillary circuit blocks (such as current and voltage sources). In particular, the circuit similarities in implementing a rail-to-rail dynamic voltage comparator and a relaxation oscillator using only digital gates are discussed. The building blocks previously reported in the literature by the author will be described, and the common root of their design will be highlighted. Full article

The use of 3D printing holds significant promise to transform the construction industry by enabling automation and customization, although key challenges remain—particularly the control of fresh-state rheology. This study presents a novel formulation that combines potassium-rich biomass fly ash (BFAK) with an air-entraining plasticizer (APA) to optimize the rheological behavior, hydration kinetics, and structural performance of mortars tailored for extrusion-based 3D printing. The results demonstrate that BFAK enhances the yield stress and thixotropy increases, contributing to improved structural stability after extrusion. In parallel, the APA adjusts the viscosity and facilitates material flow through the nozzle. Isothermal calorimetry reveals that BFAK modifies the hydration kinetics, increasing the intensity and delaying the occurrence of the main hydration peak due to the formation of secondary sulfate phases such as Aphthitalite [(K₃Na(SO₄)₂)]. This behavior leads to an extended setting time, which can be modulated by APA to ensure a controlled processing window. Flowability tests show that BFAK reduces the spread diameter, improving cohesion without causing excessive dispersion. Calibration cylinder tests confirm that the formulation with 1.5% APA and 2% BFAK achieves the maximum printable height (35 cm), reflecting superior buildability and load-bearing capacity. These findings underscore the novelty of combining BFAK and APA as a strategy to overcome current rheological limitations in digital construction. The synergistic effect between both additives provides tailored fresh-state properties and structural reliability, advancing the development of a sustainable SMC and printable cementitious materials. Full article

Addressing the growing demand for affordable housing requires innovative solutions that strike a balance between cost efficiency and user-specific needs. Mass customization (MC) presents a promising approach that enables the creation of tailored housing solutions on a scale. In this context, this study introduces a model for mass customization of affordable single-family housing units in the city of Teresina, PI, Brazil. Our approach integrates algorithmic–parametric modeling and BIM technologies, facilitating the flow of information and enabling informed decision-making throughout the design process. Since the early design stages, the work has assumed that these integrated technologies provide real-time control over design variables and associated construction data. To develop the model, the method proceeded through the following phases: (1) analysis of the context and definition of the design language; (2) definition of the design process; (3) definition of the cost calculation method and estimation of construction time; (4) definition of the computing model based on the specified technologies; and (5) quantitative and qualitative evaluation of the computational model. As a result, this research aims to contribute to the state-of-the-art by formalizing the knowledge generated through the systematic description of the processes involved in this workflow, with a special focus on the Brazilian context, where the issue of social housing is a critical challenge. Full article

We present a neural-network-based approach to solve the image-to-image translation problem in microscale droplets squeeze flow. A residual convolutional neural network is proposed to address the inverse problem: reconstructing a low-resolution (LR) droplet pattern image from a high-resolution (HR) liquid film thickness imprint. This enables the prediction of initial droplet configurations that evolve into target HR imprints after a specified spreading time. The developed neural network architecture aims at learning to tune the refinement level of its residual convolutional blocks by using function approximators that are trained to map a given film thickness to an appropriate refinement level indicator. We use multiple stacks of convolutional layers, the output of which is translated according to the refinement level indicators provided by the directly connected function approximators. Together with a non-linear activation function, the translation mechanism enables the HR imprint image to be refined sequentially in multiple steps until the target LR droplet pattern image is revealed. We believe that this work holds value for the semiconductor manufacturing and packaging industry. Specifically, it enables desired layouts to be imprinted on a surface by squeezing strategically placed droplets with a blank surface, eliminating the need for customized templates and reducing manufacturing costs. Additionally, this approach has potential applications in data compression and encryption. Full article

The inlet operating conditions of centrifugal compressors in natural gas storage reservoirs, as well as the natural gas composition, continuously vary over time, significantly impacting compressor performance. To analyze the influence of these factors on centrifugal compressors, a method for converting the performance curves of centrifugal compressors under actual operating conditions has been established. This performance conversion process is implemented through a custom-developed program, which incorporates the polytropic index and exhaust temperature calculations. Verification results show that the conversion error of this method is within 2%. Based on the proposed performance prediction method for non-similar operating conditions, the effects of varying inlet temperatures, pressures, and natural gas compositions on compressor performance are investigated. It is observed that an increase in inlet temperature results in a decrease in compressor power and pressure ratio; an increase in inlet pressure leads to higher power consumption, while the pressure ratio varies with the flow rate at the operating point; and as the average molar mass of natural gas decreases, both the pressure ratio and power exhibit a certain degree of reduction. Full article

Accurate dynamic hydrological models are often too complex and costly for the rapid, broad-scale screening necessitated for proactive land-use planning against increasing cloudburst risks. This paper demonstrates the use of GPT-4 to develop a GUI-based Python 3.13.2 application for geospatial flood risk assessments. The study used instructive prompt techniques to script a traditional stream and catchment delineation methodology, further embedding it with a custom GUI. The resulting application demonstrates high performance, processing a 29.63 km² catchment at a 1 m resolution in 30.31 s, and successfully identifying the main upstream contributing areas and flow paths for a specified area of interest. While its accuracy is limited by terrain data artifacts causing stream breaks, this study demonstrates how human–AI collaboration, with the LLM acting as a coding assistant guided by domain expertise, can empower domain experts and facilitate the development of advanced GIS-based decision-support systems. Full article

Nipah virus (NiV) and Hendra virus (HeV), which both belong to the genus henipavirus, are zoonotic pathogens that cause severe systemic, neurological, and/or respiratory disease in humans and a variety of mammals. Therefore, monitoring viral prevalence in natural reservoirs and rapidly diagnosing cases of henipavirus infection are critical to limiting the spread of these viruses. Current laboratory methods for detecting NiV and HeV include virus isolation, reverse transcription quantitative real-time PCR (RT-qPCR), and antigen detection via an enzyme-linked immunosorbent assay (ELISA), all of which require highly trained personnel and specialized equipment. Here, we describe the development of a point-of-care customized immunochromatographic lateral flow (ILF) assay that uses recombinant human ephrin B2 as a capture ligand on the test line and a NiV-specific monoclonal antibody (mAb) on the conjugate pad to detect NiV and HeV. The ILF assay detects NiV and HeV with a diagnostic specificity of 94.4% and has no cross-reactivity with other viruses. This rapid test may be suitable for field testing and in countries with limited laboratory resources. Full article

On a worldwide scale, neurodegenerative diseases, including multiple sclerosis, Parkinson’s, and Alzheimer’s, face considerable healthcare challenges demanding the development of novel approaches to early detection and efficient treatment. With its ability to provide real-time patient monitoring, customized medical care, and advanced predictive analytics, artificial intelligence (AI) is fundamentally transforming the way healthcare is provided. Through the integration of wearable physiological sensors, motion sensors, and neurological assessment tools, the NeuroPredict platform harnesses AI and smart sensor technologies to enhance the management of specific neurodegenerative diseases. Machine learning algorithms process these data flows to find patterns that point out disease evolution. This paper covers the design and architecture of the NeuroPredict platform, stressing the ethical and regulatory requirements that guide its development. Initial development of AI algorithms for disease monitoring, technical achievements, and constant enhancements driven by early user feedback are addressed in the discussion section. To ascertain the platform’s trustworthiness and data security, it also points towards risk analysis and mitigation approaches. The NeuroPredict platform’s capability for achieving AI-driven smart healthcare solutions is highlighted, even though it is currently in the development stage. Subsequent research is expected to focus on boosting data integration, expanding AI models, and providing regulatory compliance for clinical application. The current results are based on incremental laboratory tests using simulated user roles, with no clinical patient data involved so far. This study reports an experimental technology evaluation of modular components of the NeuroPredict platform, integrating multimodal sensors and machine learning pipelines in a laboratory-based setting, with future co-design and clinical validation foreseen for a later project phase. Full article

This paper focuses on the complex dynamics that concern assembly line balance in the context of mass customization within manufacturing. In fact, the increase in demand for customized products has heightened the complexities associated with achieving optimal efficiency, productivity, product quality, and customer satisfaction. The research proposes a multi-criteria analysis of statistical methods to determine the fluctuation of parameters affecting the state of balance of an assembly line. A 3D matrix model is suggested to analyze the parameters managing the assembly line. This representation is executed using the MATLAB R2024b tool, and a methodology for finding the variability of parameters affecting balance through statistical approaches is proposed. We observed that changes in parameters such as task times, worker efficiency, or material flow led to significant changes in the line’s overall balance. As a result, static balancing becomes inadequate to deal with the complexities introduced by these highly variable parameters. The novelty of this paper consists of the innovative integration of multi-criteria statistical analysis and 3D matrix modeling to detect parameter variability and optimize assembly line balancing. Conventional static approaches are often unable to capture the process-dynamic aspect of modern manufacturing. This work presents a systematic methodology capable of identifying, quantifying, and moderating the variability of key operating parameters. This methodology, carried out using MATLAB-based simulations, is based on principal component analysis (PCA) and correlation analysis to detect critical factors influencing balancing efficiency. By structuring assembly line parameters in a 3D matrix representation, this research gives a holistic, data-based method for improving decision-making in balancing procedures. The research goes beyond theoretical modeling by applying the approach to a real automotive assembly line, validating its effectiveness and demonstrating its practical applicability in industrial conditions. Full article

Small and medium-sized enterprises (SMEs) in the manufacturing sector often struggle to make effective use of production data due to fragmented systems and limited digital infrastructure. This paper presents a case study of implementing an AI-enhanced digital twin in a custom sportswear manufacturing SME developed under the AI and Robotics Estonia (AIRE) initiative. The solution integrates real-time production data collection using the Digital Manufacturing Support Application (DIMUSA); data processing and control; clustering-based data analysis; and virtual simulation for evaluating improvement scenarios. The framework was applied in a live production environment to analyze workstation-level performance, identify recurring bottlenecks, and provide interpretable visual insights for decision-makers. K-means clustering and DBSCAN were used to group operational states and detect process anomalies, while simulation was employed to model production flow and assess potential interventions. The results demonstrate how even a lightweight AI-driven system can support human-centered decision-making, improve process transparency, and serve as a scalable foundation for Industry 5.0-aligned digital transformation in SMEs. Full article

Inefficient inland repositioning of empty containers between depots remains a persistent challenge in container logistics, contributing significantly to unnecessary truck movements, elevated operational costs, and increased CO₂ emissions. Acknowledging the importance of this problem, a large amount of relevant literature has appeared. The objective of this paper is to track the empty container flow between ports, empty depots, inland terminals, and customer premises. Additionally, it aims to simulate and assess CO₂ emissions, capturing the dynamic interactions between different agents. In this study, agent-based modeling (ABM) was proposed to simulate the empty container movements with an emphasis on inland transportation. ABM is an emerging approach that is increasingly used to simulate complex economic systems and artificial market behaviours. NetLogo was used to incorporate real-world geographic data and quantify CO₂ emissions based on truckload status and to evaluate the other operational aspects. Behavior Space was also utilized to systematically conduct multiple simulation experiments, varying parameters to analyze different scenarios. The results of the study show that customer demand frequency plays a crucial role in system efficiency, affecting container availability and logistical tension. Full article