Search Results (295)

This research assesses the design efficiency of the future centralized wastewater treatment plant (WWTP) in Prishtina, which also takes into consideration rapidly expanding suburban areas, such as Fushë Kosova, Obiliq, and Graçanica. Using a combination of both ATV-DVWK-A 131E deterministic calculations and dynamic simulation with IWASP, this study focuses on the planned configurations for the future Prishtina wastewater treatment plant (WWTP) to evaluate design efficiency alongside operational feasibility. The primary goal was to determine if meeting projected loads for the year 2040 would be possible with compliance requirements for a single-stage CAS system. Simulation data suggest that reliable nitrogen removal would not be possible with a sole CAS stage (aerobic), particularly considering seasonal and peak load dynamics. Alternatively, an optimized three-reactor CAS model, including one anoxic pre-denitrification zone coupled with two alternating aerobic zones, achieved an average total nitrogen (TN) removal efficiency of about 85%, maintaining effluent TN below 10 mg/L. Additional advantages saw COD being removed at rates between 90 and 92%, along with MLSS levels stabilizing around 3500 mg/L. The flexibly scalable design also provides adaptive operation features, including expanded tertiary nutrient removal in phase II. In scenario two’s site comparative analysis, Lismir’s centralized WWTP emerges as the most economically and technically rational option due to the enhanced reactor layout optimization. These findings confirm that enhanced configurations, validated through both static and dynamic analyses, are essential for long-term treatment efficiency and regulatory compliance. Full article

The increasing incidence of osteoporotic fractures determines ongoing research on new methods and strategies for improving the difficult healing process of this type of fracture. Osteoporotic patients suffer from the intense side effects of accustomed drug treatment and its systemic distribution in the body. To overcome these drawbacks, besides searching for new drugs, 3D-printed scaffolds and drug delivery systems have started to be increasingly seen as the main strategy employed against osteoporosis. Three-dimensionally printed scaffolds can be tailored in intricate designs and make use of nanoscale topographical and biochemical cues able to enhance bone tissue regeneration. Research regarding drug delivery systems is exploring bold new ways of targeting bone tissue, making use of designs involving nanoparticles and intricate encapsulation and support methods. The local administration of treatment with the help of a scaffold-based drug delivery system looks like the best option through its use of the advantages of both structures. Biomimetic systems are considered the future norm in the field, while stimuli-responsiveness opens the door for the next level of efficiency, patient compliance, and a drastic reduction in side effects. The successful approval of these products still requires numerous challenges throughout the development and regulatory processes, but the interest and effort in this direction are high. This review explored various strategies for managing osteoporosis, emphasizing the use of scaffolds for targeted drug delivery to bone tissue. Instead of covering the whole subject, we focused on the most important aspects, with the intention to provide an up-to-date and useful introduction to the management of osteoporosis. Full article

Addressing the urgent need to decarbonise aviation and valorise agricultural waste, this paper investigates the production of Sustainable Aviation Fuel (SAF) from corn stover. A preliminary evaluation based on a literature review indicates that among various conversion technologies, fast pyrolysis (FP) emerged as the most promising option, offering the highest fuel yield (22.5%) among various pathways, a competitive potential minimum fuel selling price (MFSP) of 1.78 USD/L, and significant greenhouse gas savings of up to 76%. Leveraging Aspen Plus simulation, SAF production via FP was rigorously designed and optimised, focusing on the heat integration strategy within the process to minimise utility consumption and ultimately the total cost. Consequently, the produced fuel exceeded the American Society for Testing and Materials (ASTM) limit for the final boiling point, rendering it unsuitable as a standalone jet fuel. Nevertheless, it achieves regulatory compliance when blended at a rate of up to 10% with conventional jet fuel, marking a practical route for early adoption. Energy optimisation through pinch analysis integrated four hot–cold stream pairs, eliminating external heating, reducing cooling needs by 55%, and improving sustainability and efficiency. Economic analysis revealed that while heat integration slashed utility costs by 84%, the MFSP only decreased slightly from 2.35 USD/L to 2.29 USD/L due to unchanging material costs. Sensitivity analysis confirmed that hydrogen, catalyst, and feedstock pricing are the most influential variables, suggesting targeted reductions could push the MFSP below 2 USD/L. In summary, this work underscores the technical and economic viability of corn stover-derived SAF, providing a promising pathway for sustainable aviation and waste valorisation. While current limitations restrict fuel quality during full substitution, the results affirm the feasibility of SAF blending and present a scalable, low-carbon pathway for future development. Full article

A palm oil company based in Bangka is actively expanding its operations in the palm oil processing industry. The company specializes in producing crude palm oil (CPO) and palm kernel, with its production process encompassing five key stages: weighing, sterilization, threshing, pressing, and clarification. Oil loss, especially at the pressing station, is one of the company’s biggest problems. Nuts, fibers, empty bunches, and effluent are some of the sources of oil loss in CPO production. Since extreme losses that exceed set norms can cause serious inefficiencies and financial repercussions, it is imperative that the organization identifies and mitigates the underlying causes of oil loss. One option that the business could use is the fault tree analysis (FTA) method, which offers a methodical way to pinpoint the root causes of production inefficiencies to solve this problem. According to current assessments, empty bunches caused the largest average oil loss over a one-month period, with a loss rate of 0.11%. Oil loss at the pressing station is caused by a number of factors, such as inadequate maintenance practices, non-compliance with established work procedures, suboptimal ripeness levels of harvested palm fruit, and operator neglect in maintaining optimal machine pressure in accordance with company standards. To reduce oil loss in the production process and increase efficiency, these concerns need to be addressed. Full article

Background: Oral semaglutide, a GLP1-receptor agonist (GLP1-RA), shows promise in efficacy and compliance, especially amid the global shortage of injectable GLP-1 RAs. Its short-term effectiveness remains unexplored. Objective: This real-world observational study assessed the short-term effectiveness of oral semaglutide after three months of therapy. Methods: Patients with type 2 diabetes from four Italian diabetes centers, who received an initial prescription of oral semaglutide, were reassessed after three months. Primary outcomes included glycated hemoglobin (HbA1c) and body weight reduction; secondary outcomes involved changes in lipid parameters and cardiovascular risk. Results: Among 167 participants (mean age 66.5 years, mostly obese, baseline HbA1c 8.4% ± 1.5), 83.2% received a 7 mg dose. After three months, HbA1c significantly declined (8.4% to 7.1%, −1.3%, p < 0.001), alongside body mass index (BMI) (30.9 kg/m² to 29.6 kg/m², p < 0.0001). The target HbA1c ≤ 7% was achieved by 54.5%, and 34.7% reached ≤6.5%. Patients losing >5% of their initial weight (30.5%) saw the largest HbA1c drop (−1.9%). Those with newly diagnosed diabetes or a duration < 5 years showed superior responses (p = 0.001), while no significant differences were found based on the timing of drug administration. Oral semaglutide replaced or supplemented prior therapies, allowing discontinuation of dipeptidyl peptidase 4 inhibitors (DPP4i), sulfonylureas, glinides, and acarbose, and deprescription of thiazolidinediones. A significant reduction in cardiovascular risk was observed (p = 0.04), together with a significant reduction in lipid parameters. Conclusions: Oral semaglutide showed significant short-term efficacy, reducing HbA1c, body weight, and cardiovascular risk in three months, making it a valuable therapeutic option. Full article

Background/Objectives: Primary prevention, germline, familial, or other pre- or post-diagnostic and standard treatment-elevated progression or recurrence risk and mitigating adverse events from systemic treatment are all clinical opportunities to reduce the risk of lethal prostate cancer. This review attempted to provide a practical and realistic consensus via an international committee of experts who, in general, harbor career-long experience in this discipline. Methods: A PubMed review primarily utilizing the latest meta-analyses, systematic reviews, and methodologically robust epidemiologic recent data adjusting for multiple confounding variables was conducted. The goal of this committee was to highlight tangible options for clinicians and patients. Results: Behavioral patterns and metrics known to reduce cardiovascular morbidity, mortality, and all-cause mortality (premature death) appear to prevent numerous lethal common cancers, including prostate cancer. This practical approach allows for the greatest probability of patient success since cardiovascular disease (CVD) is the primary cause of death in men with and without prostate cancer, and a notable source of morbidity and mortality in men with advanced disease due to systemic conventional treatment as well as the inflammatory contribution of cancer itself. Heart-healthy dietary patterns, exercise, healthy weight/waist circumference, eliminating tobacco, minimizing alcohol exposure, and other behaviors to reduce the risk of CVD should be prioritized. CVD-preventive medications, including aspirin, GLP-1 agonists, metformin, statins, etc., should receive attention to improve compliance for those that already qualify for these agents and to increase the probability of enhancing the quality and quantity of life. Dietary supplements do not have favorable data currently to espouse their utilization to prevent lethal prostate cancer but may have an ancillary role in mitigating some adverse effects of treatment. Conclusions: Remarkably, heart-healthy lifestyle changes, metrics, and promising repurposed medications known to reduce cardiovascular events, promote longevity, and improve mental health could simultaneously prevent lethal prostate cancer. This serendipitous association provides clinicians and their patients a higher probability of success, regardless of their prostate cancer pathway or circumstance. Full article

Automotive air conditioning systems improve passenger comfort and safety while keeping pace with changing environmental and technological requirements. This review evaluates the historical development, technological progress, and future trends of automotive air conditioning systems, primarily focusing on passenger vehicles, where cabin comfort and individualized thermal control are essential. The analysis examines the transition from early, energy-intensive cooling systems typically operating at a coefficient of performance (COP) of around 1.5 to modern, environmentally friendly alternatives that achieve COP values of approximately 3.0 or higher, highlighting the impact of regulatory measures such as the Kigali Amendment. A particular focus is placed on comparing refrigerants, especially the transition from HFC-134a to HFO-1234yf, with a discussion of their ecological impact and compliance with regulations. Innovative technologies, including adsorption cooling, AI-enhanced climate control, and the integration of renewable energy, are being explored as potential solutions to current challenges. Initially, 121 articles were reviewed, with 84 chosen for detailed examination based on their relevance, methodological soundness, and contributions to the field. The results reveal the trade-offs among efficiency, cost, and sustainability, highlighting the need for ongoing innovation to balance energy usage and environmental stewardship. Future studies should focus on creating refrigerants with extremely low global warming potential, improving battery efficiency in electric vehicles, and utilizing AI for tailored climate control. By tackling these issues, the automotive sector can offer more sustainable and efficient air conditioning options that align with consumer expectations and environmental regulations. Full article

Background: Over the past decade, Shanghai primary and middle schools have installed and updated direct-drinking water facilities in compliance with local policies, but few studies have assessed the schools providing direct-drinking water access. Methods: A cross-sectional study was conducted with 167 public primary, middle, and high schools across Pudong New Area, Shanghai during Autumn 2024. The type, location, and working condition of all direct-drinking water facilities throughout each school were documented by trained research staff using a direct observation protocol. Information on school direct-drinking water quality was obtained from the routine monitoring program. Data were analyzed for comprehensive assessment of direct-drinking water facilities in the schools. Results: On average, each school had one faucet of direct-water facility per 41 students; 70% of the schools met the requirement for minimum direct-drinking water access, and >90% placed facilities in high-traffic areas. In addition, 83% of the schools selected water facilities with nanofiltration and a hot water system, and most only provided hot water (above 50 degrees Celsius). For school direct-drinking water quality, the concentrations of hardness, chemical oxygen demand (COD), and total dissolved solids (TDS), as well as pH values, were improved significantly, but the total bacteria count was prone to not meeting the requirement for standards in middle and high schools, which could be caused by insufficiency of chlorination in pumping stations or neglecting to clean facilities promptly. Conclusions: Wide usage of school direct-drinking water facilities could help most public schools to meet local policies for minimum student drinking water access in Shanghai, but microbial contamination was the potential threat. Water temperature is the key factor affecting students’ drinking water, providing an optional water temperature for students’ preferences and concerns. National sanitary standards of direct-drinking water quality and relevant additional regulations should be established and implemented in China. Full article

Laminated Veneer Lumber (LVL) presents an alternative material for offshore wind turbine towers and blades for an energy sector whose greenhouse gas emissions are substantial. In compliance with AS/NZS 4536, this case study facilitates a specifications’ selection framework that embraces a validated, cost–benefit determination via life cycle cost analyses (LCCA) specification comparisons. A structured consultation with three key Western Australian offshore industry experts, compliant with a standard phenomenological qualitative approach, further facilitates offshore wind turbine (OWT), LCCA cost comparisons between traditional steel and fibreglass components and LVL wooden components. LVL is found to have a higher capital cost but can generate long-term savings of AUD 30,400 per comparable unit less than Traditional OWT specifications, noting a 5% lower LVL operation and maintenance cost. Where decommissioning recycling facilities exist, OWT LVL specification components are encouraged. This work argues that LVL options uptake in Western Australia (WA) is both practicable and whole-cost effective. Full article

Highway alignment optimization is critical for developing sustainable and resilient transportation infrastructure. Traditional alignment selection methods frequently fail to comprehensively account for all of the diverse factors, including geometric compliance, traffic efficiency, land use factors, environmental impacts, and cost considerations, ultimately resulting in suboptimal project outcomes. To address these challenges, this study proposes a building information modeling (BIM)-based alignment optimization framework that integrates diverse datasets, sophisticated modeling techniques, and stakeholder collaboration. The proposed framework systematically enables the user to model terrain, design geometric features, simulate traffic, and conduct cost analysis and environmental impact assessments. A case study of the Dera Ghazi Khan Northern Bypass project in Pakistan, a critical infrastructure project designed to ease congestion and enhance regional connectivity, is presented to validate the proposed framework. Three alignment alternatives were analyzed, with the optimized solution (Alignment Option 2) demonstrating a 30% reduction in congestion, a 20% decrease in travel time, and a 6.48% reduction in construction costs compared to the other alignment alternatives. These outcomes highlight the transformative potential of BIM-driven optimization to significantly enhance sustainability, cost-efficiency, and operational performance. This framework offers a scalable and adaptable model to guide future infrastructure development initiatives toward more sustainable outcomes. Full article

This paper presents the biodegradation and cavitational erosion behavior of new zinc alloys in the ZnMgFe system. The alloys were heat-treated through homogenization at 300 °C and 400 °C, with maintenance times of 5 and 10 h each. The experimental research consisted of characterizing the structure and mechanical properties of the newly made alloys in different structural states, as well as determining their biodegradation and cavitation behavior. Biodegradability was achieved using laboratory tests in SBF, with different immersion durations (3, 7, 14, 21, or 35 days). The cavitation behavior was assessed by performing tests on a piezoceramic crystal vibrator in compliance with ASTM G32-2016, thus constructing the curves of the erosion velocity MDER(t) and the cumulative average erosion depth MDE(t). The analyses performed on the mechanical properties, microscopic images, and the cavitation parameters MDER and MDEmax (results at the end of the cavitation attack) showed the effect of the heat treatments on the structure and structural resistance to cyclic loadings of the cavitation. The double alloying of zinc with magnesium and iron may increase either the mechanical properties or the corrosion resistance to cavitation and can control the biodegradability of the resulting ZnMgFe alloy. The best heat treatment for improving these properties is homogenization at 400 °C/10 h, which may increase the cavitation erosion of zinc by up to seven times. The experimental results demonstrate that the new alloys from the ZnMgFe system are a good option for manufacturing biodegradable implants with functional in vitro properties. Full article

Complex anatomical and physiological barriers make the eye a challenging organ to treat from a drug delivery perspective. Currently available treatment methods (topical eyedrops) for anterior segment diseases pose several limitations in terms of bioavailability and patient compliance. Conventional drug delivery methods to treat posterior segment ocular diseases are primarily intravitreal injection (IVT) of solutions. IVT is highly invasive and leads to retinal toxicity, endophthalmitis, and intraocular inflammation, frequently requiring professional administration and frequent clinical visits. Advanced drug delivery treatment strategies could improve patient compliance and convenience. Long-acting drug delivery platforms (biodegradable or nonbiodegradable) provide sustained/controlled release of drugs for at least four to six months. Smart drug delivery alternatives, for instance, in situ forming implants, are injectable formulations that form semisolid-to-solid implants in response to the various stimuli of pH, light, osmolarity, and temperature. Additionally, nanoparticulate drug delivery systems, contact lenses, electrospun patches, and microneedle-based drug delivery systems provide minimally invasive treatment options for ocular disorders. This comprehensive review focuses on advanced drug delivery options for the management of ocular disorders. Full article

Universities and other institutes of higher education could be considered as key actors in the implementation of sustainability pillars, such as the adoption of sustainable practices in wastewater management. However, the adoption of such practices is still an emerging issue. This paper discusses the design and operation of the first combined Oxylag and high rate algal pond (COHRAP) constructed at the university campus in Tunisia for irrigation. Performance was evaluated based on the removal efficiencies of nutrients, chemical oxygen demand (COD), biochemical oxygen demand (BOD), heavy metals, coliforms, and biomass productivity. The potential reuse of sludge and algal biomass is discussed based on the Tunisian national standard regulation for sludge reuse in agriculture (NT 106.20) and the European regulation (EC, 2019/1009) for fertilizer products. Effluent phytotoxicity is tested on the germination and growth on Zea mays L. The results indicate that the COHRAP performance was globally satisfactory; however, biomass productivity (1.4 g m⁻²d⁻¹) was low, indicating the need for adjustments in the operational parameters. Despite the effluent limitations for TSS and Hg, no phytotoxic effect was observed. Regarding the heavy metal content in sludge and algal biomass, the results obtained were in compliance with NT 106.20 and EC, 2019/1009), respectively. The energy consumption of COHRAP is 1.05 kWh/m³ resulting in operational costs of 0.29 euros/m³. This study revealed that COHRAP could be a sustainable option to treat wastewater from university campuses with resource recovery. Such a choice can be improved by the implementation of an algae recovery step. Full article

Background/Objective: During the systemic treatment of moderate to severe psoriasis in patients of reproductive age, contraindications and therapeutic peculiarities must be taken into account. Doctor–patient communication is crucial for therapy conduct and compliance. Methods: This survey among male and female patients from the German psoriasis registry, PsoBest, aims to provide real-world evidence on communication and patient needs for those of reproductive age (18–55). Result: In total, 404 patients were eligible for the analysis (254 m, 150 f), including 39 patients currently wishing to conceive (20 m, 19 f). Patients with and without the desire to have children received similar systemic therapy. In most cases, treatment was not adapted when patients expressed a desire to have children (85.9% m, 79.5% f). Only 38.3% of men and 49.9% of women had been informed about options for conception during or before systemic therapy, mainly by dermatologists (77.4% m, 84.6% f). The majority of patients retrieved additional information about the wish to conceive and medications from the internet and other media. This survey emphasizes the importance of open communication between patients and physicians regarding family planning and therapy options. Conclusions: Physicians need to broach the topic of family planning, conception and pregnancy with patients and support with evidence-based information to enable comprehensive medical decision making and safe therapy choices. Full article

Background: Cisplatin-based chemoradiotherapy is the standard treatment for locally advanced head and neck squamous-cell carcinoma (LA-HNSCC); however, the optimal dosing regimen remains debated. This systematic review and meta-analysis aimed to compare treatment compliance, therapeutic efficacy, and toxicity profiles between weekly (30–50 mg/m²) and triweekly (100 mg/m² every three weeks) cisplatin regimens in patients receiving concurrent radiotherapy for LA-HNSCC. Methods: A systematic literature search was conducted in PubMed, Google Scholar, and ClinicalTrials.gov to identify prospective clinical trials published before 16 January 2025, comparing weekly and triweekly cisplatin regimens. Studies were included if they reported treatment compliance, efficacy, and chemotherapy-related toxicities. Single-arm studies were excluded. Data extraction was performed independently by two reviewers, and the risk of bias was assessed using the Cochrane Risk of Bias (RoB) tool. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for the primary endpoints: overall survival (OS) and chemotherapy completion rates. Heterogeneity was assessed using the I² statistic. Results: Fifteen prospective clinical trials with 1572 patients (775 weekly and 797 triweekly) were included. Treatment compliance was similar between the regimens, with 74.76% (weekly) vs. 72.29% (triweekly) completing chemotherapy (p = 0.38). The mean cumulative cisplatin dose was significantly higher in the triweekly regimen (287.52 mg/m² vs. 241.74 mg/m², p = 0.04); however, the proportion of patients receiving a cumulative dose ≥200 mg/m² did not differ significantly (p = 0.23). The therapeutic efficacy was comparable, with complete response rates of 63.18% (weekly) and 67.13% (triweekly) (p = 0.32) and OS rates at 2 years of 51.24% and 49.47% (p = 0.45). No significant differences were observed in the toxicity rates (any grade or grade ≥ 3) or mortality. The I² statistic indicated insignificant heterogeneity across the studies. Interpretation: The results do not provide definitive evidence favoring one regimen over the other. Both regimens remain viable treatment options with comparable efficacy and adherence. Treatment selection should be individualized, considering toxicity risk, patient tolerability, and clinical factors. Full article