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Design, Synthesis, and Evaluation of Braylin Derivatives as Novel PDE4 Inhibitors with Anti-Inflammatory Effects

  • Yongdan Guo,
  • Xue Wang,
  • Feng Zhang,
  • Tianshen Zheng,
  • Zhuo Chen,
  • Sen Wang,
  • Guofeng Yang,
  • Haibo Wang,
  • Wenbo Yin and
  • Deyan Wu
  • + 3 authors
Pharmaceutics2026, 18(5), 516;https://doi.org/10.3390/pharmaceutics18050516

23 April 2026

Background/Objectives: PDE4 is a key regulator of cAMP signaling and a clinically validated anti-inflammatory target; however, the use of PDE4 inhibitors is often limited by adverse effects such as nausea, vomiting, and diarrhea. The natural compound...

(This article belongs to the Section Drug Targeting and Design)
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