Search Results (122)

To address the challenges of traditional methods for monitoring rock dynamic hazards in mines, which struggle to fully characterize the spatiotemporal heterogeneity of damage evolution and the resulting lag in early warning, this paper proposes a dynamic rock damage classification and fracture early warning model driven by acoustic emission data. Based on an improved dynamic K-means algorithm, this model fuses time dependence, energy intensity, and event spatial density characteristics through exponentially decaying weights to construct a spatiotemporal-energy synergistic clustering framework. Furthermore, a nonlinear coupling model for the comprehensive risk index (RI) is established, combining the static damage variable D with dynamic parameters such as energy release rate, ring count, and spatial clustering, to create a five-level early warning threshold. Experimental results demonstrate that the improved algorithm achieves clustering silhouette coefficients exceeding 0.7 for single-source, multi-source, and complex fracture patterns, and the error between cluster regions and actual fracture distribution is less than 1 mm. The RI model accurately identifies the damage state of the test block and effectively predicts critical instability, significantly improving both timeliness and accuracy. This research overcomes the limitations of traditional static evaluation and provides high-precision technical support for real-time monitoring of hidden rock fractures and prevention and control of mine dynamic hazards. Full article

Graphene, a 2D carbon allotrope with a hexagonal atomic structure, exhibits an exceptionally low friction coefficient of approximately 0.004, making it a superior alternative to traditional lubricants. This research investigates the performance of graphene as an additive in oil-based lubricants. Experimental trials will be conducted using a block-on-ring (B-o-R) setup involving a steel rod pressed against a rotating steel ring under a fixed load. By varying the sliding velocities, the study will map the Stribeck curve across the boundary (BL), mixed (ML), and hydrodynamic (HL) lubrication regimes. Furthermore, the lubricant’s durability under extreme pressure will be assessed via Timken testing. The study identified 0.08 wt.% as the optimal concentration for PAO8, achieving a 21.25% friction reduction in the boundary regime. Furthermore, graphene as an additive mitigated wear volume by up to 90% under extreme pressure conditions (1.3 GPa), whereas epoxidized soybean oil proved to be highly effective as a base lubricant without additional nano-additives. Full article

Wear, a critical factor governing the performance and durability of mechanical systems, is typically characterized using point-contact and line-contact test configurations. However, it remains unclear whether the wear trends observed in one test configuration would be observed in the other configuration under the same nominal conditions. In this study, ball-on-disk (ASTM G99) and block-on-ring (ASTM G77) tests were conducted under an identical maximum Hertzian contact stress and sliding speed, using the same material pair and lubricating oil, to clarify which contact configuration exhibits more wear and why. The results show that, under the same Hertzian contact stress, the line-contact configuration exhibits a specific wear rate two orders of magnitude higher than the point-contact configuration, despite exhibiting a lower and more stable coefficient of friction. The disk wear is negligible and the ball shows only mild material loss, whereas the line-contact system displays wear rates several orders of magnitude higher, with the rotating ring contributing the dominant share of the total wear. White-light interferometry and scanning electron microscopy observations reveal directional, groove-dominated surface morphologies on the ball and disk, while wear on the block is confined to edge-localized regions and the worn ring surface has smooth, polished morphology. Energy-dispersive X-ray spectroscopy confirms that a Zn- and P-rich tribofilm forms exclusively on the ring surface. Finite element analysis shows stress amplification at the finite line-contact edges, explaining the observed wear severity. These results demonstrate that matching Hertzian contact stress alone is insufficient to ensure comparable wear behavior between point and line contacts. Full article

In the current situation of the Internet of Things (IoT) with its billions of interconnected devices, security in this low-resource environment is paramount. A Physical Unclonable Function (PUF) is a very useful cryptographic primitive which allows us to extract unique information from a particular device in a non-reproducible way. This allows us to use a PUF in cryptography for authentication or secret-key generation. Ring Oscillators (ROs) and Transient Effect Ring Oscillators (TEROs) are oscillating structures used in both FPGAs and ASICs to build PUFs. In this paper we present an FPGA implementation of a PUF based on what we call the “TERORO” cell (TERO + RO), which is a hybrid structure that allows us to use the different functionalities of both RO and TERO in a single building block. We assess all the possible methods of extracting bits of information from the PUF based on TERORO cells. Finally, we tested the circuit and presented experimental results in terms of its uniqueness, uniformity, and reliability. In RO-counter mode, we obtain $49.74\%$ uniqueness, $54.66\%$ uniformity, and $97.81\%$ reliability across devices, while TERO-based XOR mixing achieves $52.83\%$ uniformity, $45.79\%$ uniqueness, and $93.15\%$ reliability. The FPGA footprint is 142 LUTs, 36 registers, and 82 slices. Full article

As a critical sealing component in aero-engines, the segmented annular seal is prone to friction and wear during the running-in stage, which seriously impairs its sealing performance and service life. To address this issue, this study takes the three-petal segmented annular seal made of T482 graphite as the research object, adopting a combined method of high-speed ring-block friction and wear tests and thermal–fluid–solid coupling simulation to investigate its friction and wear mechanisms and optimize its structural design. The results show that the segmented annular seal undergoes more severe friction and wear in the low-speed running-in stage; the wear rate increases with the rise in loading force and decreases with the increase in rotational speed, and the variation trend of surface roughness is consistent with that of the friction coefficient. Frictional heat and wear-induced scratches intensify the deformation and leakage of the seal, thereby leading to the risk of seal failure. Optimizing the depth of radial dynamic pressure grooves can significantly improve the opening performance of the seal, while optimizing the width of axial grooves mainly affects the seal leakage. This research provides a theoretical basis for improving the service life and sealing performance of segmented annular seals in aero-engines. Full article

One of the best-known flavonoid chrysin was coupled at position 7 with several trisubstituted phosphine derivatives with a flexible spacer, and their in vitro anticancer activities were investigated on 60 human tumor cell lines (NCI60) and on several gynecological cancer cells. The trisubstituted phosphines contained different substituents on the aromatic ring(s), e.g., methyl and methoxy groups or fluoro atoms. The phosphorus atom was substituted not only with aromatic rings but with cyclohexyl substituents. The ionic phosphonium building block is important because it allows the therapeutic agents to transfer across the cell membrane. Therefore, the pharmacophores linked to it can exert their effects in the mitochondria. Instead of the ionic phosphonium element, a neutral moiety, namely the triphenylmethyl group, was also added to the side chain, being sterically similar but without a charge and phosphorus atom. Most of the hybrids exhibited low micromolar growth inhibition (GI₅₀) values against the majority of the tested cell lines. Notably, conjugate 3f stood out, demonstrating nanomolar antitumor activity against the K-562 leukemia cell line (GI₅₀ = 34 nM). One selected compound (3i) with promising cancer selectivity elicited cell cycle disturbances and inhibited the migration of breast cancer. The tumor-selectivity of 3a and 3f was assessed based on their effects on non-tumor Chinese hamster ovary (CHO) cells using the CellTiter-Glo Luminescent Cell Viability Assay. Given their estimated half-maximal inhibitory concentration (IC₅₀) values on non-tumor CHO cells (2.65 µM and 1.15 µM, respectively), these conjugates demonstrate promising selectivity toward several cancer cell lines. The excellent results obtained may serve as good starting points for further optimization and the design of even more effective flavonoid- and/or phosphonium-based drugs. Full article

Background/Objective: Oncogenic tyrosine kinases (TKs) such as ALK and SRC promote cancer progression, but their effects on metabolic enzymes are still not well understood. This study examines how TK signaling regulates inosine monophosphate dehydrogenase 2 (IMPDH2), a rate-limiting enzyme in purine biosynthesis, and assesses its potential as a therapeutic target. Methods: Phosphoproteomic screening and in vitro kinase assays were used to identify phosphorylation sites on IMPDH2. Lipid-binding assays explored the role of phosphatidylinositol 3-phosphate (PI3P) in IMPDH2 regulation. Structure-based virtual screening discovered small-molecule allosteric inhibitors, which were tested in lymphoma cell models, including ALK and BTK-inhibitor resistant lines. Results: Here, we identify Inosine monophosphate dehydrogenase-2 (IMPDH2), a rate-limiting enzyme in purine biosynthesis, as a novel substrate of ALK and SRC. We show that phosphorylation at the conserved Y233 residue within the allosteric domain enhances IMPDH2 activity, linking TK signaling to metabolic reprogramming in cancer cells. We further identify PI3P as a natural lipid inhibitor that binds IMPDH2 and suppresses its enzymatic function. Using structure-based virtual screening, we developed Comp-10, a first-in-class allosteric IMPDH inhibitor. Unlike classical active-site inhibitors such as mycophenolic acid (MPA), Comp-10 decreases IMPDH1/2 protein levels, blocks filament (rod/ring) formation, and inhibits the growth of ALK and BTK inhibitor-resistant lymphoma cells. Comp-10 acts post-transcriptionally and avoids compensatory IMPDH upregulation observed with MPA (rod/ring) formation, and inhibited growth in TKI-resistant lymphoma cells. Notably, Comp-10 avoided the compensatory IMPDH upregulation observed with MPA. Conclusion: These findings uncover a novel TK–IMPDH2 signaling axis and provide mechanistic and therapeutic insight into the allosteric regulation of IMPDH2. Comp-10 represents a promising therapeutic candidate for targeting metabolic vulnerabilities in tyrosine kinase driven cancers. Full article

Aromatic ring systems appear ubiquitously in active pharmaceutical substances, such as FDA-approved histone deacetylase inhibitors. However, these rings reduce the water solubility of the molecules, which is a disadvantage during application. To address this problem, azaborine rings may be substituted for conventional aromatic ring systems. These are obtained by replacing two adjacent carbon atoms with boron and nitrogen. Incorporating B–N analogs in place of aromatic rings not only enhances structural diversity but also provides a strategy to navigate around patent-protected scaffolds. We synthesized azaborines, which are isosteric to naphthalene and indole, and utilized them as capping units for HDAC inhibitors. These molecules were attached to various aliphatic and aromatic linkers with different zinc-binding units, used in established active compounds. Nearly half of the twenty-four molecules tested exhibited inhibitory activity against at least one of the enzymes HDAC1, HDAC4, or HDAC8, with three compounds displaying IC₅₀ values in the nanomolar range. We have therefore demonstrated that azaborine building blocks can be successfully incorporated into HDACis, resulting in a highly active profile. Consequently, it should be feasible to develop active substances containing azaborine rings against other targets. Full article

Internal combustion engines remain a predominant source of global energy consumption, contributing substantially to both operational costs and greenhouse gas emissions. This work evaluates a nanomaterial-based engine oil additive that reduces friction and wear and increases torque, horsepower, and fuel efficiency. This novel nano oil additive contains functionalized carbon nanotubes and hexagonal boron nitride nanosheets that are dispersed in base oil using a proprietary ultrasonication process. Block-on-ring tests performed by multiple testing facilities demonstrated up to a 17% decrease in coefficient of friction and up to a 78% decrease in wear compared to the base oil after treating with the nano oil additive. Thermal properties enhancement by the nano oil additive was evaluated and increases up to 17 °C in thermal stability were obtained. Additionally, the nano oil additive increased torque and horsepower by an average of 7% in motorcycles and 2.4% in pickup trucks. Most importantly, the nano oil additive demonstrated improvements in fuel economy in both gasoline and diesel engines, with laboratory tests reporting 3–5% increases and practical field tests on a commercial truck fleet reporting an average of a 6% increase. The improved engine efficiency leads to reduced turbo temperature in heavy diesel engines and prolonged engine life expectancy and will significantly improve global environmental sustainability. Full article

This article demonstrated that environmentally friendly lubricants—glycerol–water-based oil (GWB) and rapeseed oil-based oil (RSB)—would provide comparable conditions (wear of node components, friction resistance) in a friction node as a commercial semi-synthetic gear oil (REF). Wear tests were performed on a block-on-ring model friction node stand using GBZ12 (CuSn12), BA1032 (CuAl10Fe3Mn2), and BA1054 (CuAl10Ni5Fe4) bronze samples. Glycerol–water-based oil (GWB) significantly reduced the wear of the samples by several times, compared to semi-synthetic oil (REF) and rapeseed oil-based oil (RSB). The (GWB) oil also provided a stable friction coefficient value at the lowest level of 0.05–0.06. The main disadvantage of the (RSB) oil was the temporary fluctuation of the friction coefficient value (increase above 0.1), which indicated the lack of stability of the boundary layer. The results highlight the potential of (GWB) oil in reducing wear and stabilizing friction under extreme conditions, supporting the shift toward sustainable lubricants in industrial applications. Full article

Biodegradable composite materials enhanced with food waste for tribological applications are proposed in this article. Polymer materials used as matrices included polypropylene and polylactic acid, which, according to the manufacturers’ claims, were made entirely or partially from biodegradable raw materials. Additionally, the matrices were enhanced with three types of waste materials: powders derived from cherry and plum stones, and pomace extracted from flax seeds. The composites differed in the percentage content of filler (15 or 25 wt.%) and particle size (d < 400 µm or d > 400 µm). Thirty-minute block-on-ring friction tests were performed to determine frictional behaviour (when pairing with steel), and the wear mechanisms were analysed using optical microscopy and scanning electron microscopy, supplemented with Raman spectroscopy. A notable effect of cherry and plum stone fillers was observed as a reduction in motion resistance, as measured by the friction coefficient. This reduction was evident across all material configurations in polypropylene-based composites and was significant at the lowest concentrations and granulation in polylactic acid composites. The effect of flaxseed pomace filler was ambiguous for both composite bases. Full article

This research examines the effects of vertical jacking construction on the mechanical behavior of shield tunnels. Model tests simulating vertical jacking were performed utilizing a purpose-built apparatus to quantify the reaction forces generated by the diffusion block during the jacking operation. A systematic analysis was conducted on the mechanical responses of shield tunnel lining segments and their interconnecting joints. Utilizing Particle Flow Code (PFC) methodology, a deformation prediction model specifically tailored for vertical jacking conditions was formulated. Correlating simulation results with experimental measurements quantified the sensitivity of tunnel deformation to grouting reinforcement, enabling the identification of an optimal reinforcement zone. Key findings reveal that the jacking reaction force distribution exhibits pronounced nonlinearity: a substantial increase precedes failure, followed by rapid post-failure reduction and eventual stabilization in advanced jacking stages. Tunnel convergence deformation evolves through four distinct phases: significant growth, rapid attenuation, gradual diminution, and final stabilization. The primary zone of influence encompasses the opening ring and its two adjacent rings. Jacking induces longitudinal bending deformation, with maximum joint opening occurring at the opening ring. Abrupt longitudinal load fluctuations cause dislocation between the opening ring and neighboring rings. Internal segment stresses exhibit initial tensile and compressive increases followed by subsequent relaxation. Externally applied grouting reinforcement effectively attenuates jacking-induced tunnel deformation. An optimal reinforcement range was determined at the 60° position relative to the segment springline, substantially lowering resource consumption and construction risks compared to conventional reinforcement strategies. These outcomes furnish theoretical underpinnings and technical benchmarks for optimizing engineering design and facilitating the implementation of vertical jacking technology. Full article

In response to the performance requirements of ship conductive rings in the coupled environment of high salt spray, high humidity, and mechanical wear in the ocean, a Cu-TiC composite coating was prepared on the surface of 7075 aluminum alloy by using the high-speed laser cladding (HLC) technology. The influence laws of the scanning speed (86.4–149.7 mm/s) on the microstructure, tribological properties, and corrosion resistance of the coating were explored. The results show that the scanning speed significantly changes the phase composition and grain morphology of the coating by regulating the thermodynamic behavior of the molten pool. At a low scanning speed (86.4 mm/s), the CuAl₂ phase is dominant, and the grains are mainly columnar crystals. As the scanning speed increases to 149.7 mm/s, the accelerated cooling rate promotes an increase in the proportion of Cu₂Al₃ phase, refines the grains to a coexisting structure of equiaxed crystals and cellular crystals, and improves the uniformity of TiC particle distribution. Tribological property analysis shows that the high scanning speed (149.7 mm/s) coating has a 17.9% lower wear rate than the substrate due to grain refinement and TiC interface strengthening. The wear mechanism is mainly abrasive wear and adhesive wear, accompanied by slight oxidative wear. Electrochemical tests show that the corrosion current density of the high-speed cladding coating is as low as 7.36 × 10⁻⁷ A·cm⁻², and the polarization resistance reaches 23,813 Ω·cm². The improvement in corrosion resistance is attributed to the formation of a dense passivation film and the blocking of the Cl diffusion path. The coating with a scanning speed of 149.7 mm/s exhibits optimal wear-resistant and corrosion-resistant synergistic performance and is suitable for the surface strengthening of conductive rings in extreme marine environments. This research provides theoretical support for the process performance regulation and engineering application of copper-based composite coatings. Full article

Expanded graphite significantly improves the tribological properties of materials in friction pairs, but there is a lack of research in the literature on its cooperation with metals and the effect of water on friction and wear mechanisms. It is particularly important to understand the phenomenon of graphite layer formation on the steel surface and its effect on tribological properties. The aim of this study is to evaluate the tribological properties of an expanded graphite–alloy steel combination operating under selected loads in both dry and humid conditions. The tests were carried out on a block-on-ring tribological tester (where the blocks were made of expanded graphite and the rings were made of AISI 4130 steel) at a rotational speed of 150 rpm, with loads of 200 and 650 N. The frictional behavior was analyzed on the basis of the measured values of the friction torque and the coefficient of friction (COF) calculated from it (and the applied load). In dry conditions, the friction torque was stable, while in humid conditions it showed cyclical changes. An increase in load from 200 to 650 N caused an increase in the average friction torque by 235% in dry conditions and by 209% in humid conditions. The presence of water reduced the friction pair temperature by 12% at 200 N and by 18% at 650 N; however, it simultaneously increased graphite consumption–by 1179% at 200 N and by 100% at 650 N. The amount of graphite deposited on the steel surface depended on the load–in humid conditions, it increased by 114% at 200 N, while it decreased by 250% at 650 N. The conducted research expanded the understanding of the influence of operating conditions on the tribological properties of the expanded graphite–alloy steel pair. It also provided new data on the friction and wear mechanisms of this material combination in humid conditions, which may have significant engineering applications. Full article

Traditional disposal methods such as landfilling and land reclamation are insufficient to mitigate the environmental impact of construction spoil, making non-sintered blocks a promising approach for resource utilization. This study investigates the production and performance of steel slag soil blocks as an alternative to conventional cement-based materials for non-sintered blocks. The optimal manufacturing parameters were identified as a sodium silicate solution with 6% Na₂O, 30% steel slag content, a liquid/solid ratio of 0.18, and a forming pressure of 10 MPa, achieving a peak compressive strength of 14.46 MPa. Further, the synergistic combination of alkali activation and carbonation enhanced compressive strength to 17.4 MPa, attributed to the development of a compact microstructure characterized by a honeycomb-like C-(A)-S-H gel and well-crystallized, triangular-shaped aragonite. However, durability tests under freeze-thaw and wet-dry cycles revealed that carbonation can detrimentally affect performance. The transformation of C-(A)-S-H gel into calcium carbonate, with relatively weaker cementitious properties, led to internal cracking and surface detachment. Micro-CT analysis confirmed ring-like patterns under freeze-thaw conditions and diagonal cracks during wet-dry cycling, whereas reference blocks incorporating 30% ordinary Portland cement maintained superior compactness with no cracks. These findings suggest that although the alkali activation and carbonation process enhances early strength, further optimization is necessary to improve long-term durability before broader application can be recommended. Full article