Design, Synthesis and Biological Evaluation of Novel Small Molecules Inhibitors, 2nd Edition
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 1454
Special Issue Editor
Interests: bioactive compounds; PPAR agonists; anticancer activity; neuroprotection; antioxidants; aromatase inhibitors; NOS; small molecules; medicinal chemistry; organic synthesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
New pharmacological therapies aim to use small-molecule inhibitors to improve their inherent properties. These small compounds can cross biological barriers and modulate different organic targets. In particular, the inhibition effects of different small molecules can have many pharmacological effects. For these reasons, in recent years, small-molecule inhibitors have been developed to regulate many biological districts, and they represent an interesting instrument for the development of potential new therapeutic agents.
In this context, this Special Issue will focus our attention on the most recent studies related to the design and synthesis of small-molecule inhibitors, as well as on the discovery of naturally occurring small molecules that inhibit biological targets and are useful as potential therapeutics.
This Special Issue will accept original research papers and high-quality reviews that cover multiple aspects of small-molecule inhibitors, focusing on the following topics:
- The design, synthesis, and identification of new small-molecule inhibitors;
- The biological evaluation of small molecules endowed with biological activity as inhibitors;
- The isolation and identification of small-molecule inhibitors from natural sources;
- The evaluation of molecular mechanisms and biological targets of new small-molecule inhibitors.
This Special Issue will make an important contribution to improving our knowledge of the importance of small-molecule inhibitors in drug discovery and pharmacology.
Dr. Letizia Giampietro
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- small molecules
- inhibitors
- natural products
- drug design
- synthetic strategies
- structure–activity relationship
- docking studies
- drug delivery
- in vivo, in vitro, and ex vivo evaluation
- biological activity
- molecular mechanisms
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