Search Results (20,681)

Ototoxicity represents a clinically significant complication of anticancer therapy in pediatric patients. Cytotoxic agents used in oncology, particularly platinum-based chemotherapy, may induce damage to the auditory and vestibular systems, resulting in hearing loss, tinnitus, and balance disturbances. Even mild hearing impairment during childhood may negatively affect speech perception, language development, communication abilities, and subsequent educational and psychosocial functioning. This narrative review aims to synthesize current evidence on treatment-related ototoxicity in children, with particular focus on commonly implicated therapies, clinical consequences, diagnostic approaches, and potential preventive strategies. A focused literature search was conducted in PubMed for publications from 2019 to 2025 addressing ototoxicity associated with pediatric anticancer treatment and audiological monitoring methods. The analysis indicates that platinum-based compounds, especially cisplatin and carboplatin, remain the primary agents associated with ototoxicity, with reported incidence ranging from approximately 20–70% for cisplatin and 10–30% for carboplatin. Additional risk factors include young age, baseline hearing status, renal function, and exposure to other ototoxic agents such as aminoglycoside antibiotics. Early detection relies on comprehensive audiological monitoring combining behavioral and objective methods, including pure-tone audiometry, extended high-frequency audiometry, otoacoustic emissions, and auditory brainstem response testing. Standardized grading systems such as ASHA, Brock, Chang, and SIOP Boston criteria play a key role in identifying and classifying ototoxic changes. Emerging research focuses on improved monitoring protocols, biomarker identification, and the development of otoprotective strategies, including sodium thiosulfate and experimental molecular therapies. Implementing systematic hearing monitoring and preventive strategies is essential to reduce long-term auditory complications and improve quality of life in pediatric cancer survivors. Full article

Asphalt pavement on rigid base (cement concrete) differs significantly from traditional granular base pavement. To investigate its mechanical behavior, a viscoelastic–viscoplastic damage constitutive model for asphalt mixtures is proposed and verified. A user-material subroutine (UMAT) is developed to implement the model, and a three-dimensional finite element model is established to analyze pavement responses under various working conditions. Key numerical results include the following: the asphalt layer primarily experiences compressive–shear failure, with peak shear stress (τ₁₂) reaching 141.6 kPa under rigid base conditions; emergency braking increases τ₁₂ to approximately 270.3 kPa, a 91% increase; increasing vehicle speed from 15 m/s to 35 m/s raises τ₁₂ by 36.7%; based on stress analysis alone, the recommended asphalt layer thickness is between 0.10 m and 0.14 m, as thickness beyond 0.10 m yields diminishing stress reduction. The findings provide references for performance prediction, structural design, and material development of asphalt pavement on a rigid base. Full article

As mining operations progressively advance to greater depths to meet increasing mineral demand, there is a growing need to develop new or improved rockbolts capable of effectively dissipating energy under dynamic loading conditions. Impact laboratory tests provide valuable insights into the dynamic performance of rockbolts; however, such tests require considerable time and cost associated with specimen preparation and experimental validation. Numerical modeling represents a robust alternative which, when properly calibrated with laboratory results, can accurately simulate the deformation process and energy dissipation mechanisms of support elements. This paper presents the implementation and results of a numerical model developed to simulate the dynamic behavior of a threadbar subjected to impact loading. The model explicitly represents all components of a full-scale impact test configuration, including the impact mass, reaction frame, threadbar geometry, grout, and steel tube. The numerical model enables real-time analysis of the dynamic response and interaction among the test components (steel tube, grout, and bolt). The implemented numerical codes were calibrated and validated against published laboratory results of threadbar dynamic behavior. Subsequently, a comprehensive parametric analysis was conducted to evaluate the response of each component in terms of load, displacement, and dissipated energy. The results allowed identification of the primary factors governing the dynamic response of the rockbolt system. The proposed methodology can be extended to other reinforcement systems and provides relevant insights into the design of bolts under dynamic loading conditions. Full article

Warm-mix asphalt (WMA) technology and basalt fiber modification have been increasingly applied in road engineering. However, conventional basalt fibers often disperse unevenly and tend to agglomerate. In this study, basalt fiber powder (BFP) was incorporated into a Sasobit-based WMA system and systematically compared with matrix asphalt, Sasobit-modified WMA, conventional basalt fiber-modified WMA, and styrene butadiene styrene (SBS)-modified asphalt. Multiscale characterization—including dynamic shear rheometry (DSR), bending beam rheometry (BBR), scanning electron microscopy (SEM), and nanoindentation—was conducted to elucidate rheological behavior and interfacial micromechanical responses. The corresponding Asphalt Concrete-13 (AC-13) mixtures were further evaluated through rutting tests, low-temperature bending tests, and moisture susceptibility tests. Results demonstrate that micronized BFP achieves more homogeneous dispersion within the asphalt matrix and may promote a more effective reinforcing morphology, significantly enhancing high-temperature deformation resistance while partially mitigating the low-temperature stiffness increase induced by Sasobit. Compared with conventional basalt fiber systems, BFP shows better stress relaxation capacity and interfacial mechanical response under the tested conditions. At the mixture level, the BFP–Sasobit system showed the best overall performance, with the dynamic stability increasing by 242.2% relative to the base asphalt mixture and the residual Marshall stability reaching 92.3%, while the low-temperature flexural strain increased by 33.3%. Overall, the findings suggest that morphology-controlled micronization provides a morphology-guided enhancement strategy for Sasobit-based warm-mix asphalt by promoting coordinated improvements across the rheological, micromechanical, and mixture scales. Full article

On 6 February 2023, Türkiye was struck by two devastating earthquakes with moment magnitudes of 7.8 and 7.6, causing severe damage to numerous tall reinforced concrete buildings and emphasizing the need for improved seismic design strategies. This study investigates the seismic response of a representative high-rise reinforced concrete building by systematically varying the shear wall area-to-floor area ratio, a key parameter directly influencing lateral stiffness and overall stability. Utilizing a solid modeling approach and incorporating three-directional seismic records, this research provides detailed insights into displacement behavior beyond conventional frame-based analyses. Focusing on Adana, a major urban center with a significant concentration of tall buildings and notable seismic risk, three design scenarios with shear wall ratios of 1.14%, 1.54%, and 2.1% were examined. The results demonstrate that increasing the shear wall cross-sectional area compared to the building plan area significantly reduces lateral and vertical displacements, with the most pronounced improvement observed when moving from 1.14% to 1.54%. Further increase to 2.1% provides additional enhancement in seismic performance. This study suggests that adopting a minimum shear wall area-to-floor area ratio of at least 2% along each principal direction (resulting in a total combined ratio of approximately 4% for the building) can substantially improve seismic resilience and mitigate collapse risk in tall structures. Importantly, the shear wall ratios were considered separately for each principal direction, with the total combined ratio doubling, highlighting the need for balanced wall distribution in both directions. Full article

Due to excellent performance, polytetrafluoroethylene (PTFE), being sealing material, is widely used in chemical engineering, aerospace engineering, mechanical engineering, civil engineering, energy engineering and other sectors. However, due to obvious temperature drops in supplying or storing fluids, the mechanical behavior of PTFE under cryogenic conditions is still unclear. In this study, the creep mechanical performance of PTFE gaskets after cryogenic aging in liquid oxygen is experimentally investigated. The circular PTFE gasket samples are immersed into liquid oxygen for cryogenic aging treatment. The universal testing machine is utilized for material mechanic tests. Three different load levels, including 10 MPa, 15 MPa and 20 MPa, are designed and accounted for. It is found that the creep strain of PTFE exhibits three typical stages, namely the initial rapid increase phase, transition phase with a reducing growth rate, and stable linear growth phase. Moderate cryogenic immersion aging can effectively improve the creep resistance of PTFE, but excessive aging treatments will lead to mechanical property degradation of PTFE. The Burgers life prediction model is improved by introducing a nonlinear correction term, which can accurately predict the creep behavior of PTFE under different aging states. The present study can provide experimental evidence and a theoretical basis for a deep understanding of the mechanical response of PTFE materials under extreme cryogenic intermittent service conditions. Full article

Polypropylene (PP) biocomposites reinforced with Cornus sanguinea L. (CS) pruning-waste particles were investigated using a combined experimental mechanics and finite element (FE) validation framework to support model-based design with an under-utilized lignocellulosic feedstock. Two particle-size fractions (<100 µm, LF1; 100–250 µm, LF2) were produced by grinding and sieving and incorporated into PP at 5–20 wt% via melt compounding and compression molding. Tensile and three-point bending properties were measured in accordance with ASTM D638 and ASTM D790. PP exhibited a tensile strength of 23.63 ± 0.51 MPa and a tensile modulus of 868 ± 21 MPa. Incorporation of LF1 particles increased tensile modulus monotonically, reaching 1020 ± 137 MPa at 20 wt%, while tensile strength decreased with filler content; by contrast, the 20 wt% LF2 formulation showed a pronounced strength reduction to 16.30 ± 0.25 MPa, indicating a disadvantageous size–loading interaction. In flexure, strength was comparatively insensitive to reinforcement (PP: 39.5 ± 0.34 MPa; reductions typically ≤7%), whereas flexural modulus increased to 2152 ± 27 MPa (LF1) and 2110 ± 34 MPa (LF2). FE models calibrated using true stress–true plastic strain data accurately reproduced tensile responses across the full strain range and flexural behavior within the pre-contact-dominated regime, demonstrating the suitability of PP/CS biocomposites for stiffness-driven applications. Full article

The remarkable ecological success of fungi is supported by their capacity for rapid and often reversible molecular responses to fluctuating environments. While conventional evolutionary theory has largely emphasized mutation and selection as central drivers of adaptation, many environmentally responsive fungal traits are also shaped by molecular processes that generate reversible phenotypic variation on ecological or developmental timescales. This review synthesizes current knowledge on reversible genetic and epigenetic mechanisms underlying fungal phenotypic plasticity by integrating insights from programmed genetic rearrangements such as mating-type switching, transposable element activity, variation in tandem repeats and the behavior of accessory chromosomes, together with dynamic epigenetic processes including histone modifications, DNA methylation, chromatin remodeling and RNA mediated regulation. Together, these mechanisms form an interconnected framework that enables rapid and, in many cases, reversible phenotypic diversification, although their consequences range from transient regulatory shifts to partially or fully irreversible sequence-level changes. We highlight the molecular machinery that governs reversibility and its evolutionary implications for fungal pathogenesis, symbiosis, and biotechnology. By uniting genetic and epigenetic perspectives, this review advances a holistic framework in which reversibility is treated as a key property of fungal phenotypic plasticity, helping fungi balance stability with flexibility under environmental challenge. Understanding these mechanisms provides new insights into fungal evolution, and opens new avenues for antifungal intervention and the rational design of industrially valuable fungal strains. Full article

The COVID-19 pandemic highlighted substantial variability in public health information environments, yet the relationship between information source, perceived credibility, and behavioral response remains incompletely understood. This study evaluated how information sources influence COVID-19-related knowledge and behaviors and whether targeted educational interventions modify these relationships. We conducted a prospective survey-based study (July–December 2021) among adults recruited from outpatient clinics in Michigan (N = 209). Participants completed pre- and post-intervention surveys assessing information sources, perceived reliability, knowledge, and behaviors, and were randomized to receive either a video or infographic. Social media was the most frequently reported source (n = 95) but had lower perceived reliability (mean 2.97/5), whereas healthcare workers (HCWs) were rated most reliable (mean 4.26/5) despite lower utilization (n = 60). Use of HCWs, print media, and websites was associated with higher baseline knowledge, while television and radio were associated with lower knowledge of vaccine side effects (p = 0.011 and p = 0.003). Educational interventions improved knowledge and attitudes, with differential effects across source groups, while infographic-based interventions were more effective among social media users (p = 0.034). Information sources and perceived credibility significantly shape health knowledge and behavior, highlighting the need for communication strategies that integrate trusted messengers, high-reach platforms, and health literacy to improve public health outcomes. Full article

The proliferation of renewable energy resources has brought numerous challenges to conventional power systems, as grid integration is predominantly achieved through inverter-interfaced technologies such as photovoltaic (PV) plants and Type-IV wind turbines. Unlike synchronous generators (SGs), inverter-based resources (IBRs) exhibit fundamentally different fault behavior by limiting fault current magnitudes, typically within 1.0–1.2 per unit. Furthermore, the phase angle and sequence composition of the injected fault current are largely dictated by the inverter control strategy rather than by the network impedance. Consequently, distance protection schemes developed under assumptions of system homogeneity, a fixed source-to-impedance ratio (SIR), high fault current contribution, and large inertia may exhibit unreliable performance in inverter-dominated power networks. In this work, the influence of IBRs on key distance protection elements, such as starting elements, fault classification techniques, and impedance calculation with or without inter-feed, is reviewed and evaluated using simulations in PSCAD 5.0 software. Further, reduced grid inertia introduces operational limitations in power swing blocking (PSB) schemes, which are discussed in this paper. This work presents an overview of IBR fault responses and critically summarizes prior work on distance protection in IBR-dominated grids, highlighting key challenges, probable solutions, and the current research status to enhance understanding for further research. Full article

Inductors are critical components in power electronic systems, yet their thermal behavior is often approximated using simplified lumped models that neglect internal gradients and transient spatial effects. This paper presents a benchmarking study of analytical thermal modeling approaches for cylindrical inductors, including 0D lumped, 1D radial, and 2D radial–axial transient formulations. Starting from the general heat conduction equation in cylindrical coordinates, closed-form or semi-analytical solutions are discussed under uniform internal heat generation and convective boundary conditions. The proposed framework provides a benchmark-oriented analytical reference for selecting the appropriate thermal model complexity in reliability-oriented design of inductive components in power electronic systems. The models are applied to a representative two-layer cylindrical inductor composed of a ferrite core and a copper winding, under identical loss and cooling assumptions, considering two axial lengths in order to assess geometric influence. Steady-state temperature levels, transient responses, modal time constants, and axial gradient indicators are extracted to quantify the differences among modeling levels. The results show that the dominant thermal behavior is governed by a single slow mode with a time constant on the order of one hour. The spatially averaged temperature predicted by the 0D model deviates by less than 2.5% from the 2D solution in steady-state conditions, with the 1D model providing accurate predictions when axial gradients remain weak. Full article

In this study, Zn-doped Co₃O₄ nanorods and nanosheets with controlled Zn/Co molar ratios were synthesized via a hydrothermal strategy to clarify the respective roles of morphology and elemental doping in ethylbenzene sensing. The gas-sensing performance is strongly influenced by morphology, and the radially oriented nanorod structure significantly enhances sensing response compared with nanosheet structures. Zn doping effectively enhances the gas-sensing performance of Co₃O₄. As a result, the optimized Zn-doped nanorod sensor exhibits high sensitivity to ethylbenzene, a low detection limit, rapid response and recovery, and excellent operational stability. Density functional theory calculations reveal that the predominantly exposed facets of the nanorod structure possess stronger adsorption affinity and pronounced charge transfer toward ethylbenzene, providing theoretical support for the morphology-dominated sensing behavior. At the same time, Zn incorporation further adjusts the band structure and surface reactivity. Overall, this work elucidates a morphology-dominated and doping-assisted enhancement mechanism, offering clear design principles for high-performance Co₃O₄-based ethylbenzene sensors. Full article

Exopolysaccharides (EPSs) are emerging as sustainable polymers for biomedical hydrogels. Here, we report hydrogels from sulfated EPSs produced by Porphyridium cruentum and ionically crosslinked with Ca²⁺, Ce³⁺, or Cu²⁺ to generate tunable networks with bioactive potential. Rheological analysis showed viscoelastic behavior was primarily governed by cation nature and accessible binding site density, with diminishing gains above 2.5 wt% EPS and limited benefit beyond 10 wt% crosslinker. Ce³⁺ produced the most solid-like gel, Ca²⁺ yielded more thixotropic networks, and Cu²⁺ promoted rapid, heterogeneous crosslinking consistent with fast surface complexation. These network signatures showed distinct in vitro performances. Cation selection tuned antibacterial activity against Staphylococcus aureus and Escherichia coli, with Cu²⁺ achieving rapid bactericidal effects and Ce³⁺ enabling an 8-log reduction after 24 h. The ABTS assay showed that Ca²⁺- and Ce³⁺-crosslinked gels had antioxidant potential (≥40 µM Trolox eq.mg⁻¹); however, antioxidant capacity was assay dependent. Conditioned-medium assays showed ≥75% viability at day 3 for Ca²⁺- and Ce³⁺-crosslinked gels against human dermal fibroblasts (HDFs), while only Ce³⁺-crosslinked gels were cytocompatible against human keratinocytes (HaCaTs). Cu²⁺-crosslinked gels were highly cytotoxic across all tested conditions. Macrophage cytokine readouts (TNF-α and IL-6) indicated formulation-dependent immunobiological response. This work establishes microalgal EPSs as versatile polymers and links crosslinking chemistry to rheological modulation and multifunctional biomedical performance, while direct wound-healing efficacy remains to be demonstrated in future in vivo or wound repair functional models. Full article

The precipitation characteristics and grain-boundary structure of Al–Cu–Mg alloys strongly affect their corrosion behavior, whereas the roles of Si and Ag microalloying in low Cu/Mg ratio systems are not yet fully understood. In this work, the effects of Si and Ag additions on age-hardening response, precipitation characteristics, and corrosion performance were systematically investigated by combining transmission electron microscopy with electrochemical and corrosion measurements. Si addition significantly accelerated the age-hardening kinetics, enabling the alloy to reach a hardness of 147 HV after only 6 h of aging, whereas the base alloy required 24 h to reach a similar level. This accelerated response was accompanied by refined S-phase precipitation and a markedly narrowed precipitation-free zone along grain boundaries. Further Ag addition introduced coherent Ω precipitates and a more complex multi-phase precipitation structure, which increased microstructural heterogeneity. As a result, the Al–Cu–Mg–Si alloy exhibited the lowest corrosion current density and the shallowest corrosion depth, whereas the Al–Cu–Mg–Si–Ag alloy showed deteriorated corrosion resistance. These results indicate that Si microalloying alone can simultaneously accelerate aging and improve corrosion resistance, while further Ag addition enhances precipitation complexity and strengthening potential but increases susceptibility to localized corrosion. Full article

This work presents the numerical assessment of a civil aircraft horizontal tailplane (HTP) using a fully parametric structural model developed through the Ansys Parametric Design Language (APDL). The objective is to evaluate the structural integrity, efficiency, and dynamic behavior of the HTP under realistic operational conditions within the HERFUSE Clean Aviation framework. The study includes linear static analyses for load distribution and critical stress regions, modal analysis for dynamic response characterization, and linear buckling analyses to determine stability assessment. Safety margins are computed for representative load cases across spars, skins, and ribs. The workflow will be integrated and connected to Multidisciplinary Optimization (MDO) loops for higher-level design trade-offs. Full article