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Article

1,166 Views

14 Pages

Adverse Events After Carbon-Ion Radiotherapy (CIRT) for Hepatocellular Carcinoma and Risk Factors for Biliary Stricture After CIRT: A Retrospective Study

Keita Maki,
Hiroaki Haga,
Tomohiro Katsumi,
Kyoko Hoshikawa,
Fumiya Suzuki,
Fumi Uchiyama,
Takashi Kaneko,
Masashi Koto and
Yoshiyuki Ueno

Cancers2025, 17(15), 2542;https://doi.org/10.3390/cancers17152542

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31 July 2025

Background/Objectives: This study investigated the timing of adverse events (AEs) after carbon-ion radiotherapy (CIRT) for hepatocellular carcinoma (HCC) and identified the risk factors for biliary stricture post CIRT. Methods: This retrospective stu...

Review

2,643 Views

19 Pages

Carbon-Ion Radiotherapy for Hepatocellular Carcinoma: Current Status and Future Prospects: A Narrative Review

Reina Sasaki-Tanaka,
Hiroyuki Abe,
Tomoaki Yoshida,
Yusuke Watanabe,
Naruhiro Kimura,
Takeshi Yokoo,
Akira Sakamaki,
Hiroteru Kamimura,
Kenya Kamimura and
Shuji Terai
+ 1 author

J. Clin. Med.2025, 14(17), 6107;https://doi.org/10.3390/jcm14176107

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29 August 2025

Because hepatocellular carcinoma (HCC) is a radiosensitive cancer, radiation therapy has been used for the treatment of HCC; however, external beam therapies are currently not described in most of the guidelines for the treatment of HCC. External bea...

Article

6 Citations

4,044 Views

12 Pages

Safety and Efficacy of Carbon-Ion Radiotherapy for Elderly Patients with High-Risk Prostate Cancer

Yuichi Hiroshima,
Hitoshi Ishikawa,
Yuma Iwai,
Masaru Wakatsuki,
Takanobu Utsumi,
Hiroyoshi Suzuki,
Koichiro Akakura,
Masaoki Harada,
Hideyuki Sakurai and
Hiroshi Tsuji
+ 1 author

Cancers2022, 14(16), 4015;https://doi.org/10.3390/cancers14164015

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19 August 2022

Carbon-ion radiotherapy (CIRT) is a high-dose intensive treatment, whose safety and efficacy have been proven for prostate cancer. This study aims to evaluate the outcomes of CIRT in elderly patients with prostate cancer. Patients aged 75 years or ab...

Article

5 Citations

2,424 Views

9 Pages

Comparative Analysis of Photon Stereotactic Radiotherapy and Carbon-Ion Radiotherapy for Elderly Patients with Stage I Non-Small-Cell Lung Cancer: A Multicenter Retrospective Study

Shuri Aoki,
Hiroshi Onishi,
Masataka Karube,
Naoyoshi Yamamoto,
Hideomi Yamashita,
Yoshiyuki Shioyama,
Yasuo Matsumoto,
Yukinori Matsuo,
Akifumi Miyakawa and
Hitoshi Ishikawa
+ 1 author

Cancers2023, 15(14), 3633;https://doi.org/10.3390/cancers15143633

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15 July 2023

The emergence of an aging society and technological advances have made radiotherapy, especially stereotactic body radiotherapy (SBRT), a common alternative to surgery for elderly patients with early stage non-small-cell lung cancer (NSCLC). Carbon-io...

Article

22 Citations

3,398 Views

11 Pages

Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer

Takashi Ono,
Naoyoshi Yamamoto,
Akihiro Nomoto,
Mio Nakajima,
Yuka Isozaki,
Goro Kasuya,
Hitoshi Ishikawa,
Kenji Nemoto and
Hiroshi Tsuji

Cancers2021, 13(1), 112;https://doi.org/10.3390/cancers13010112

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31 December 2020

Background: The purpose of the present study was to evaluate the efficacy and safety of single-fraction carbon-ion radiotherapy (CIRT) in patients with non-small cell lung cancer. Methods: Patients with histologically confirmed non-small cell lung ca...

Article

1,714 Views

15 Pages

Carbon-Ion Radiotherapy for Prostate Cancer in Patients with a History of Surgery for Benign Prostatic Hyperplasia

Atsushi Okato,
Kosei Miura,
Tomoki Yamaguchi,
Mio Nakajima,
Hirokazu Makishima,
Takanobu Utsumi,
Koichiro Akakura,
Hiroyoshi Suzuki,
Masaru Wakatsuki and
Hitoshi Ishikawa
+ 2 authors

Cancers2025, 17(18), 3039;https://doi.org/10.3390/cancers17183039

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17 September 2025

Background/Objectives: Carbon-ion radiotherapy (CIRT) offers precise dose distribution and enhanced biological effectiveness in localized prostate cancer. However, the safety of CIRT in patients with a history of surgery for benign prostatic hyperpla...

Article

4 Citations

2,980 Views

9 Pages

Intensity Modulated Radiotherapy with Carbon Ion Radiotherapy Boost for Acinic Cell Carcinoma of the Salivary Glands

Maximilian P. Schmid,
Thomas Held,
Kristin Lang,
Klaus Herfarth,
Juliane Hörner-Rieber,
Semi B. Harrabi,
Julius Moratin,
Christian Freudlsperger,
Karim Zaoui and
Sebastian Adeberg
+ 1 author

Cancers2021, 13(1), 124;https://doi.org/10.3390/cancers13010124

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2 January 2021

Aim: to report clinical outcome in patients with acinic cell carcinoma of the salivary glands treated with intensity-modulated radiotherapy (IMRT) and carbon ion radiotherapy (CIRT) boost. Materials and Methods: all patients with acinic cell carcinom...

Feature Paper
Article

10 Citations

3,797 Views

12 Pages

Accelerated Hypofractionated Active Raster-Scanned Carbon Ion Radiotherapy (CIRT) for Laryngeal Malignancies: Feasibility and Safety

Sati Akbaba,
Kristin Lang,
Thomas Held,
Olcay Cem Bulut,
Matthias Mattke,
Matthias Uhl,
Alexandra Jensen,
Peter Plinkert,
Stefan Rieken and
Sebastian Adeberg
+ 2 authors

Cancers2018, 10(10), 388;https://doi.org/10.3390/cancers10100388

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18 October 2018

(1) Background: The authors present the first results of active raster-scanned carbon ion radiotherapy (CIRT) for radioresistant laryngeal malignancies regarding efficacy and toxicity. (2) Methods: 15 patients with laryngeal adenoid cystic carcinoma...

Article

6 Citations

2,750 Views

13 Pages

Evaluation of Carbon Ion Radiation-Induced Trismus in Head and Neck Tumors Using Dose-Volume Histograms

Atsushi Musha,
Hirofumi Shimada,
Nobuteru Kubo,
Hidemasa Kawamura,
Naoko Okano,
Yuhei Miyasaka,
Hiro Sato,
Katsuyuki Shirai,
Jun-ichi Saitoh and
Tatsuya Ohno
+ 2 authors

Cancers2020, 12(11), 3116;https://doi.org/10.3390/cancers12113116

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25 October 2020

Carbon ion radiotherapy (C-ion RT) provides a highly localized deposition of energy that can increase radiation doses to tumors while minimizing irradiation of adjacent normal tissues. For tumors located near the temporomandibular joint, C-ion RT-ind...

Article

10 Citations

2,918 Views

10 Pages

Feasibility and Safety of Repeated Carbon Ion Radiotherapy for Locally Advanced Unresectable Pancreatic Cancer

Masahiko Okamoto,
Shintaro Shiba,
Shohei Okazaki,
Yuhei Miyasaka,
Kei Shibuya,
Hiroki Kiyohara and
Tatsuya Ohno

Cancers2021, 13(4), 665;https://doi.org/10.3390/cancers13040665

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7 February 2021

Purpose: The feasibility and safety of re-irradiation with carbon ion beams for locally recurrent unresectable pancreatic cancer (URPC) after carbon ion radiotherapy (CIRT) was evaluated. Methods: Medical records from patients with re-irradiated URPC...

Article

26 Citations

3,630 Views

12 Pages

Impact of Carbon Ion Radiotherapy on Inoperable Bone Sarcoma

Shintaro Shiba,
Masahiko Okamoto,
Hiroki Kiyohara,
Shohei Okazaki,
Takuya Kaminuma,
Kei Shibuya,
Isaku Kohama,
Kenichi Saito,
Takashi Yanagawa and
Tatsuya Ohno
+ 2 authors

Cancers2021, 13(5), 1099;https://doi.org/10.3390/cancers13051099

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4 March 2021

Management of patients with bone sarcoma who are unsuitable for surgery is challenging. We aimed to analyze the clinical outcomes among such patients who were treated with carbon ion radiotherapy (C-ion RT). We reviewed the medical records of the pat...

Article

9 Citations

3,392 Views

10 Pages

Dose-Limiting Organs at Risk in Carbon Ion Re-Irradiation of Head and Neck Malignancies: An Individual Risk-Benefit Tradeoff

Thomas Held,
Semi B. Harrabi,
Kristin Lang,
Sati Akbaba,
Paul Windisch,
Denise Bernhardt,
Stefan Rieken,
Klaus Herfarth,
Jürgen Debus and
Sebastian Adeberg

Cancers2019, 11(12), 2016;https://doi.org/10.3390/cancers11122016

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13 December 2019

Background: Carbon ion re-irradiation (CIR) was evaluated to investigate treatment planning and the consequences of individual risk-benefit evaluations concerning dose-limiting organs at risk (OAR). Methods: A total of 115 consecutive patients with r...

Article

1 Citations

3,253 Views

13 Pages

Long-Term Outcomes of Ablative Carbon-Ion Radiotherapy for Central Non-Small Cell Lung Cancer: A Single-Center, Retrospective Study

Shuri Aoki,
Hitoshi Ishikawa,
Mio Nakajima,
Naoyoshi Yamamoto,
Shinichiro Mori,
Masaru Wakatsuki,
Noriyuki Okonogi,
Kazutoshi Murata,
Yuji Tada and
Shigeru Yamada
+ 2 authors

Cancers2024, 16(5), 933;https://doi.org/10.3390/cancers16050933

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25 February 2024

The aim of this study is to assess the efficacy and safety of ablative carbon ion radiotherapy (CIRT) for early stage central non-small cell lung cancer (NSCLC). We retrospectively reviewed 30 patients who had received CIRT at 68.4 Gy in 12 fractions...

Article

809 Views

13 Pages

Carbon Ion Radiotherapy for Retroperitoneal Sarcoma: A Single-Institution Study

Reiko Imai,
Tsukasa Yonemoto,
Nobuhito Araki,
Hirotoshi Takiyama,
Hiroaki Ikawa,
Shigeru Yamada and
Hitoshi Ishikawa

Cancers2025, 17(20), 3395;https://doi.org/10.3390/cancers17203395

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21 October 2025

Background/Objectives: Surgery remains the mainstay of treatment for retroperitoneal sarcoma (RPS); however, definitive therapeutic strategies for patients with insufficient surgical margins and unresectable disease owing to locally advanced RPS rema...

Article

4 Citations

2,226 Views

11 Pages

Particle Reirradiation of Malignant Epithelial and Neuroectodermal Sinonasal Tumors: A Case Series from CNAO

Barbara Vischioni,
Rossana Ingargiola,
Maria Bonora,
Sara Ronchi,
Anna Maria Camarda,
Stefania Russo,
Eleonora Rossi,
Giuseppe Magro,
Alfredo Mirandola and
Ester Orlandi

J. Clin. Med.2023, 12(7), 2624;https://doi.org/10.3390/jcm12072624

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31 March 2023

Sinonasal cancers (SNCs) are rare and heterogeneous in histology and biological behavior. The prognosis is generally unfavorable, especially in inoperable cases. In recent years, for some histologies, such as undifferentiated sinonasal carcinoma (SNU...