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4 Results Found

  • Communication
  • Open Access
8 Citations
3,741 Views
13 Pages

Generation of a Peptide Vaccine Candidate against Falciparum Placental Malaria Based on a Discontinuous Epitope

  • Catherine J. Mitran,
  • Lauren M. Higa,
  • Michael F. Good and
  • Stephanie K. Yanow

In pregnant women, Plasmodium falciparum-infected red blood cells adhere to the placenta via the parasite protein VAR2CSA. Two vaccine candidates based on VAR2CSA are currently in clinical trials; however, these candidates failed to elicit strain-tra...

  • Article
  • Open Access
4 Citations
2,785 Views
20 Pages

26 August 2023

Plasmodium vivax malaria affects 14 million people each year. Its invasion requires interactions between the parasitic Duffy-binding protein (PvDBP) and the N-terminal extracellular domain (ECD1) of the host’s Duffy antigen/receptor for chemoki...

  • Article
  • Open Access
2,281 Views
11 Pages

A Multimarker Model for Aberrant Cardiac Geometry after Preeclampsia

  • Zenab Mohseni-Alsalhi,
  • Sophie A. J. S. Laven,
  • Emma B. N. J. Janssen,
  • Anique L. Wagenaar,
  • Sander M. J. van Kuijk,
  • Marc E. A. Spaanderman and
  • Chahinda Ghossein-Doha

29 March 2022

One out of four women with a history of preeclampsia shows abnormal cardiac remodeling consistent with subclinical heart failure (HF) in the first decade postpartum. Since these women are susceptible for developing remote symptomatic HF, development...

  • Article
  • Open Access
1,228 Views
12 Pages

Elevated Leukocyte Glucose Index (LGI) Is Associated with Diabetic Ketoacidosis (DKA) Severity and Presence of Microvascular Complications

  • Mircea Cătălin Coșarcă,
  • Raluca Maria Tilinca,
  • Nicolae Alexandru Lazăr,
  • Suzana Vasilica Șincaru,
  • Bogdan Corneliu Bandici,
  • Cosmin Carașca,
  • Ráduly Gergő,
  • Adrian Vasile Mureșan and
  • Mariana Cornelia Tilinca

Background and Objectives: Diabetic ketoacidosis (DKA) represents the most prevalent hyperglycemic emergency and poses a significant life-threatening metabolic risk for individuals with diabetes. The present study examines the predictive role of the...