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Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport

Svenja König,
Nadine Schmidt,
Karin Bechberger,
Sarah Morris and ,
Mercedes Priego,
Hannah Zaky,
Yuyu Song,
Jan Pielage,
Silke Brunholz and
Gerardo Morfini
+ 7 authors+ 2 authors

Cells2023, 12(19), 2403;https://doi.org/10.3390/cells12192403

4 October 2023

The amyloid precursor protein (APP) is a key molecular component of Alzheimer’s disease (AD) pathogenesis. Proteolytic APP processing generates various cleavage products, including extracellular amyloid beta (Aβ) and the cytoplasmic APP in...

(This article belongs to the Collection Molecular Insights into Neurodegenerative Diseases)

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Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport