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Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport
- Svenja König,
- Nadine Schmidt,
- Karin Bechberger,
- Sarah Morris,
- Mercedes Priego,
- Hannah Zaky,
- Yuyu Song,
- Jan Pielage,
- Silke Brunholz and
- Gerardo Morfini
- + 2 authors
The amyloid precursor protein (APP) is a key molecular component of Alzheimer’s disease (AD) pathogenesis. Proteolytic APP processing generates various cleavage products, including extracellular amyloid beta (Aβ) and the cytoplasmic APP in...