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The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer
- Pierluigi Scalia,
- Stephen J. Williams,
- Antonio Suma and
- Vincenzo Carnevale
Until recently, Deltex (DTX) proteins have been considered putative E3 ligases, based on the presence of an E3 RING domain in their protein coding sequence. The human DTX family includes DTX1, DTX2, DTX3, DTX3L and DTX4. Despite the fact that our kno...