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Assessment of l-Asparaginase Pharmacodynamics in Mouse Models of Cancer

  • Thomas D. Horvath,
  • Wai Kin Chan,
  • Michael A. Pontikos,
  • Leona A. Martin and ,
  • Di Du,
  • Lin Tan,
  • Marina Konopleva,
  • John N. Weinstein and
  • Philip L. Lorenzi
  • + 4 authors+ 0 author
Metabolites2019, 9(1), 10;https://doi.org/10.3390/metabo9010010

9 January 2019

l-asparaginase (ASNase) is a metabolism-targeted anti-neoplastic agent used to treat acute lymphoblastic leukemia (ALL). ASNase’s anticancer activity results from the enzymatic depletion of asparagine (Asn) and glutamine (Gln), which are conver...

(This article belongs to the Special Issue Cancer Metabolomics 2018)
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