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Article

5 Citations

3,050 Views

16 Pages

Post Zygotic, Somatic, Deletion in KERATIN 1 V1 Domain Generates Structural Alteration of the K1/K10 Dimer, Producing a Monolateral Palmar Epidermolytic Nevus

Sabrina Caporali,
Biagio Didona,
Mauro Paradisi,
Alessandro Mauriello,
Elena Campione,
Mattia Falconi,
Federico Iacovelli,
Marilena Minieri,
Massimo Pieri and
Sergio Bernardini
+ 1 author

Int. J. Mol. Sci.2021, 22(13), 6901;https://doi.org/10.3390/ijms22136901

27 June 2021

Palmoplantar keratodermas (PPKs) are characterized by thickness of stratum corneum and epidermal hyperkeratosis localized in palms and soles. PPKs can be epidermolytic (EPPK) or non epidermolytic (NEPPK). Specific mutations of keratin 16 (K16) and ke...

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Communication

3 Citations

2,758 Views

18 Pages

A Ca²⁺-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics

Sonia Ratajczyk,
Corinne Drexler,
Reinhard Windoffer,
Rudolf E. Leube and
Peter Fuchs

Cells2022, 11(19), 3077;https://doi.org/10.3390/cells11193077

30 September 2022

Keratins exert important structural but also cytoprotective functions. They have to be adaptable to support cellular homeostasis. Epiplakin (EPPK1) has been shown to decorate keratin filaments in epithelial cells and to play a protective role under s...

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Article

16 Citations

4,084 Views

15 Pages

A Multi-Trait Association Analysis of Brain Disorders and Platelet Traits Identifies Novel Susceptibility Loci for Major Depression, Alzheimer’s and Parkinson’s Disease

Alfonsina Tirozzi,
Miriam Shasa Quiccione,
Chiara Cerletti,
Maria Benedetta Donati,
Giovanni de Gaetano,
Licia Iacoviello and
Alessandro Gialluisi

Cells2023, 12(2), 245;https://doi.org/10.3390/cells12020245

6 January 2023

Among candidate neurodegenerative/neuropsychiatric risk-predictive biomarkers, platelet count, mean platelet volume and platelet distribution width have been associated with the risk of major depressive disorder (MDD), Alzheimer’s disease (AD)...

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Article

1,628 Views

10 Pages

Genome-Wide Association Study of Insertions and Deletions Identified Novel Loci Associated with Milk Production Traits in Dairy Cattle

Lu Zhao,
Jun Teng,
Chao Ning and
Qin Zhang

Animals2024, 14(24), 3556;https://doi.org/10.3390/ani14243556

10 December 2024

Genome-wide association study (GWAS) have identified a large number of SNPs associated with milk production traits in dairy cattle. Behind SNPs, INDELs are the second most abundant genetic polymorphisms in the genome, which may exhibit an independent...

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Article

5 Citations

3,227 Views

11 Pages

Tumor Microenvironment and Genes Affecting the Prognosis of Temozolomide-Treated Glioblastoma

Yena Jang,
Wooyong Cheong,
Gyurin Park,
Yeongmin Kim,
Junbeom Ha and
Sangzin Ahn

J. Pers. Med.2023, 13(2), 188;https://doi.org/10.3390/jpm13020188

20 January 2023

Glioblastoma (GBM) is the most frequent primary brain tumor in adults and has a poor prognosis due to its resistance to Temozolomide (TMZ). However, there is limited research regarding the tumor microenvironment and genes related to the prognosis of...

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Article

3 Citations

1,391 Views

17 Pages

Insights from Tandem Mass Tag (TMT) Proteomic Analysis on Protein Network Modification in Control of Yak Hair Follicle Cycle

Shijie Li,
Yan Cui,
Sijiu Yu,
Junfeng He,
Rui Ma,
Bo Liao,
Pengfei Zhao,
Pengqiang Wei and
Niayaler Robert

Int. J. Mol. Sci.2025, 26(4), 1532;https://doi.org/10.3390/ijms26041532

12 February 2025

Highland animals have unique hair growth mechanisms to allow them to adapt to harsh living environments. Compared with other species, their hair cycle growth is affected by more environmental factors. Yaks, as highland animals, have obvious periodic...

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Article

36 Citations

5,867 Views

11 Pages

A Proteome Approach Reveals Differences between Fertile Women and Patients with Repeated Implantation Failure on Endometrial Level—Does hCG Render the Endometrium of RIF Patients?

Alexandra P. Bielfeld,
Sarah Jean Pour,
Gereon Poschmann,
Kai Stühler,
Jan-Steffen Krüssel and
Dunja M. Baston-Büst

Int. J. Mol. Sci.2019, 20(2), 425;https://doi.org/10.3390/ijms20020425

19 January 2019

Background: The molecular signature of endometrial receptivity still remains barely understood, especially when focused on the possible benefit of therapeutical interventions and implantation-related pathologies. Therefore, the protein composition of...

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7 Results Found

Post Zygotic, Somatic, Deletion in KERATIN 1 V1 Domain Generates Structural Alteration of the K1/K10 Dimer, Producing a Monolateral Palmar Epidermolytic Nevus

A Ca2+-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics

A Multi-Trait Association Analysis of Brain Disorders and Platelet Traits Identifies Novel Susceptibility Loci for Major Depression, Alzheimer’s and Parkinson’s Disease

Genome-Wide Association Study of Insertions and Deletions Identified Novel Loci Associated with Milk Production Traits in Dairy Cattle

Tumor Microenvironment and Genes Affecting the Prognosis of Temozolomide-Treated Glioblastoma

Insights from Tandem Mass Tag (TMT) Proteomic Analysis on Protein Network Modification in Control of Yak Hair Follicle Cycle

A Proteome Approach Reveals Differences between Fertile Women and Patients with Repeated Implantation Failure on Endometrial Level—Does hCG Render the Endometrium of RIF Patients?

A Ca²⁺-Mediated Switch of Epiplakin from a Diffuse to Keratin-Bound State Affects Keratin Dynamics