You are currently on the new version of our website. Access the old version .

8 Results Found

  • Article
  • Open Access
2 Citations
2,617 Views
19 Pages

CKII Control of Axonal Plasticity Is Mediated by Mitochondrial Ca2+ via Mitochondrial NCLX

  • Tomer Katoshevski,
  • Lior Bar,
  • Eliav Tikochinsky,
  • Shimon Harel,
  • Tsipi Ben-Kasus Nissim,
  • Ivan Bogeski,
  • Michal Hershfinkel,
  • Bernard Attali and
  • Israel Sekler

9 December 2022

Mitochondrial Ca2+ efflux by NCLX is a critical rate-limiting step in mitochondria signaling. We previously showed that NCLX is phosphorylated at a putative Casein Kinase 2 (CKII) site, the serine 271 (S271). Here, we asked if NCLX is regulated by CK...

  • Article
  • Open Access
19 Citations
8,300 Views
19 Pages

16 September 2015

Massive changes in the transcriptome of Arabidopsis thaliana during onset and progression of leaf senescence imply a central role for transcription factors. While many transcription factors are themselves up- or down-regulated during senescence, the...

  • Article
  • Open Access
7 Citations
2,324 Views
17 Pages

Effects of Substituting B with FR and UVA at Different Growth Stages on the Growth and Quality of Lettuce

  • Youzhi Hu,
  • Rui He,
  • Jun Ju,
  • Shuchang Zhang,
  • Xinyang He,
  • Yamin Li,
  • Xiaojuan Liu and
  • Houcheng Liu

3 October 2023

This study investigated the effects of substituting B with FR and UVA (50 μmol·m−2·s−1) at two growth stages on the growth and quality of loose-leaf lettuce (cv. Fangni). The basal light was red and blue LEDs at 250 μm...

  • Article
  • Open Access
3 Citations
2,860 Views
12 Pages

Optical Activation of TrkB (E281A) in Excitatory and Inhibitory Neurons of the Mouse Visual Cortex

  • Antonia Lilja,
  • Giuliano Didio,
  • Jongryul Hong,
  • Won Do Heo,
  • Eero Castrén and
  • Juzoh Umemori

6 September 2022

The activation of tropomyosin receptor kinase B (TrkB), the receptor of brain-derived neurotrophic factor (BDNF), plays a key role in induced juvenile-like plasticity (iPlasticity), which allows restructuring of neural networks in adulthood. Opticall...

  • Article
  • Open Access
2 Citations
1,956 Views
16 Pages

Modulating the Activity of the Human Organic Cation Transporter 2 Emerges as a Potential Strategy to Mitigate Unwanted Toxicities Associated with Cisplatin Chemotherapy

  • Anna Hucke,
  • Marta Kantauskaite,
  • Tim N. Köpp,
  • Christoph A. Wehe,
  • Uwe Karst,
  • Pavel I. Nedvetsky and
  • Giuliano Ciarimboli

Cisplatin (CDDP) stands out as an effective chemotherapeutic agent; however, its application is linked to the development of significant adverse effects, notably nephro- and ototoxicity. The human organic cation transporter 2 (hOCT2), found in abunda...

  • Article
  • Open Access
12 Citations
4,388 Views
21 Pages

Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities

  • Cinzia Tesauro,
  • Josephine Geertsen Keller,
  • Irina Gromova,
  • Pavel Gromov,
  • Rikke Frøhlich,
  • Jens Uldum Erlandsen,
  • Anni H. Andersen,
  • Magnus Stougaard and
  • Birgitta R. Knudsen

14 May 2020

The heterogeneity of tumor cells and the potential existence of rare cells with reduced chemotherapeutic response is expected to play a pivotal role in the development of drug resistant cancers. Herein, we utilized the colon cancer cell lines, Caco2...

  • Article
  • Open Access
8 Citations
3,205 Views
13 Pages

Molecular Detection and Genetic Characterization of Japanese Encephalitis Virus in Animals from 11 Provinces in China

  • Guanyu Zhao,
  • Yan Gao,
  • Ning Shi,
  • Shiheng Zhang,
  • Pengpeng Xiao,
  • Jiaqi Zhang,
  • Changzhan Xie,
  • Zhuo Ha,
  • Sheng Feng and
  • Ningyi Jin
  • + 5 authors

24 February 2023

Japanese encephalitis virus (JEV), which uses a mosquito primary vector and swine as a reservoir host, poses a significant risk to human and animal health. JEV can be detected in cattle, goats and dogs. A molecular epidemiological survey of JEV was c...

  • Article
  • Open Access
61 Citations
11,787 Views
15 Pages

10 January 2020

Ultraviolet A (UVA)-irradiation induced reactive oxygen species (ROS) production mediates excessive melanogenesis in skin cells leading to pigmentation. We demonstrated the depigmenting and anti-melanogenic effects of Ectoine, a natural bacterial osm...