Search Results (400)

Oregano (Origanum vulgare) cultivation is of great economic importance in Peru. Tacna stands out as its main producer. However, the presence of phytopathogenic fungi represents a challenge for its production. This study aimed to characterize both the morphological and molecular levels of the causal agent of crown and root rot in a crop field in the Camilaca district, Candarave, Tacna. To this end, systematic sampling was carried out using the five-gold method, collecting plants with typical symptoms. Fungi were isolated from diseased roots and characterized using macroscopic and microscopic morphological analysis as well as sequencing and multilocus phylogenetic analysis (ITS, 28S, HIS3, TEF1, TUB2). In addition, pathogenicity tests were performed on healthy plants to confirm the infectivity of the isolates. The results demonstrated that root rot was caused by a complex of phytopathogenic fungi through phylogenetic analysis of Dactylonectria torresensis, Fusarium oxysporum, F. iranicum, and F. redolens. These findings represent the first report of these species as causal agents of oregano root rot in Peru, highlighting the need for integrated management strategies that reduce the economic impact of these diseases and contribute to the sustainability of the crop in key producing regions such as Tacna. Full article

We investigate the dynamics of vector solitons in a two-component Bose–Einstein condensates governed by the system of Gross–Pitaevskii equations. Using a gauge-transformation approach, we construct a four-soliton solution and analyze their interactions, including superposition states, fission, and shape-preserving collisions. We explore the ability of time-dependent parameters, such as the intra- and intercomponent interaction coefficients and trapping potential, to control the soliton properties. In particular, we demonstrate controlled four-soliton fission, highlighting its potential applications to quantum data processing and coherent matter-wave transport. The results suggest experimental realization in BEC systems and provide insights into nonlinear wave interactions in multicomponent quantum fluids. Full article

Marine reserves are key instruments for the conservation of biodiversity; however, benthic biodiversity studies often lack comprehensive data on species distribution and richness. The Punta Coles Natural Reserve (PCNR), located on the southern coast of Peru within the Humboldt Current System, represents a highly productive marine ecosystem, but information on its biodiversity is limited. The present study examines the benthic community of the hard substrate in the area of the PCNR via censuses by semiautonomous diving “Hookah” at depths between 1 and 15 m to provide baseline information to support its ecosystem management. Using NMDS and PERMANOVAs, we confirmed significant differences in species composition among depth strata, underscoring the role of depth as a key factor driving variability and species distribution in shallow zones. The community structure varies both spatially within the reserve and as a function of depth and is determined by the presence and distribution of key habitat-structuring organisms, as well as the configuration of the seabed. Our study highlights the ecological value of the PCNR, improves regional scientific knowledge, provides a useful baseline against which future anthropogenic pressures can be evaluated, and proposes the integration of subtidal kelp forests (Lessonia trabeculata), mussel beds (Aulacomya atra) and sea squirt (Pyura chilensis) network aggregations into conservation strategies to contribute to best management practices for PCNR. Full article

Breast cancer has emerged as the leading cause of death among females worldwide. The CYPs play a crucial role in carcinogenesis. The role of the CYP enzyme family, particularly the CYP4 family, in cancer biology has attracted significant attention in recent years. Bioinformatics indicated that breast cancer is influenced by genes like CYP4B1, CYP4F12, and CYP4F3. CYP4B1 has a non-significant correlation with BRCA1 and BRCA2, but a positive correlation with ESR1 in the basal subtype. CYP4F12 has a significant positive correlation with BRCA1 in the Luminal B subtype, but not with BRCA2, and a positive correlation with ESR1 in the basal subtype. CYP4F3 has a significant positive correlation with BRCA1 in the Luminal A and Luminal B subtypes and with BRCA2 in Her2, Luminal A, and Luminal B subtypes, and a positive correlation with ESR1 in the basal subtype and Luminal B patients. This article aims to emphasize the functional importance of CYP4, highlighting the complex interplay between CYP enzymes and estrogen receptors in breast cancer, and indicating new avenues for future research and potential therapeutic interventions. In addition, their expression profiles and alterations were examined across various organs and cancer types. These findings underscore the potential relevance of these genes as predictive biomarkers and prospective therapeutic targets in specific cancer settings. Full article

The increasing demand for sustainable energy and clean water has prompted the exploration of alternative solutions to reduce reliance on fossil fuels. In this context, hydrogen production through water electrolysis powered by solar energy presents a promising pathway toward a zero-carbon footprint. This study investigates the potential of copper slag, an abundant industrial waste, as a low-cost electrocatalyst for the hydrogen evolution reaction (HER) in contact with saline water such as 0.5 M NaCl and seawater, comparing the electrochemical response when in contact with geothermal water from El Tatio (Atacama Desert). The physicochemical characterisation of copper slag was performed using XRD, Raman, and SEM-EDS to determine its surface properties. Electrochemical evaluations were conducted in 0.5 M NaCl and natural seawater using polarisation techniques to assess the corrosion behaviour and catalytic efficiency of the copper slag electrodes. The results indicate that copper slag exhibits high stability and promising HER kinetics, particularly in seawater, where its mesoporous structure facilitates efficient charge transfer processes. The key novelty of this manuscript lies in the direct revalorisation of untreated copper slag as a functional electrode for HER in real seawater and geothermal water, avoiding the use of expensive noble metals and aligning with circular economy principles. This innovative combination of recycled material and natural saline electrolyte enhances both the technical and economic viability of electrolysis, while reducing environmental impact and promoting green hydrogen production in coastal regions with high solar potential. This research contributes to the value of industrial waste, offering a viable pathway for advancing sustainable hydrogen technologies in real-world environments. Full article

Bee pollination is essential for terrestrial ecosystems and crop production. However, the species richness of wild bees and other pollinators has declined over the past 50 years, with some species experiencing dramatic decreases. A key factor in maintaining bee health is their gut microbiota, which plays an essential role in digestion, nutrient absorption, immune function, and resistance to pathogens. Disruptions to this microbiota can severely impact bee health, rendering them more susceptible to diseases and environmental stressors. Glyphosate, one of the most widely used herbicides, has been extensively studied for its effects on various organisms, with increasing evidence indicating its potential to disrupt bee microbiota. This review explores recent research on the effects of glyphosate and its formulations on the gut microbiota of honeybees and bumblebees. It examines species-specific responses, methodological approaches, and broader ecological implications. While evidence indicates that glyphosate can alter the gut microbiome in some bee species, its effects vary depending on exposure conditions, species, and the composition of microbial communities. Additionally, glyphosate formulations containing surfactants may exacerbate these effects. Given the endocrine-disrupting properties of glyphosate, further research is needed to understand the long-term consequences of exposure, especially its impact on hormonal regulation and bee resilience to environmental stressors. Full article

Cervical cancer (CC) remains a critical global health issue which disproportionately affects low- and middle-income countries. In Chile, the Arica and Parinacota region experiences high CC mortality and low Papanicolaou (Pap) test coverage, with indigenous Aymara women facing significant screening barriers. Understanding health beliefs surrounding CC prevention is essential for improving adherence, particularly in under-represented populations. This study assesses the psychometric properties of the CPC-28, an instrument measuring beliefs about CC and Pap testing, among Aymara women in Chile. A cross-sectional survey of 299 Aymara women (25–64) was conducted using stratified probabilistic sampling. Confirmatory factor analysis (CFA) confirmed the CPC-28’s six-factor latent structure, demonstrating strong model fit (CFI = 0.969, TLI = 0.965, RMSEA = 0.058). Reliability indices ranged from acceptable to excellent (α = 0.585–0.921; ω = 0.660–0.923). Moderate correlations emerged between severity, susceptibility, and perceived benefits of Pap testing, although CPC-28 results did not predict adherence. These findings support CPC-28’s validity evidence for Aymara women but highlight cultural influences on screening behaviors. Structural barriers, including language and healthcare inaccessibility, are likely to affect perceived susceptibility. Future research should explore indigenous perspectives and socio-cultural determinants of Pap testing, incorporating mixed-method approaches to identify culturally relevant interventions and improve screening adherence. Full article

This study investigates the influence of chirality on the dynamic susceptibility of concentric nanotori via micromagnetic simulations. The aim is to analyze the ferromagnetic resonance characteristics of coupled nanotori structures and compare them across various ring separation distances, thus providing an insight into how vortex configurations with identical or differing chiralities affect their dynamic properties. We analyze the energetic differences between the two vortex configurations and find them to be negligible; however, these minor differences suffice to explain the significant discrepancies in the demagnetization field observed between the nanotori. We examine the dynamic susceptibility spectrum and the spatial localization of the ferromagnetic resonance modes for different nanotori separations. Our findings demonstrate that the resonant oscillation frequencies are significantly influenced by the magnetostatic interactions between the nanotori, which can be effectively modulated by varying the distance between them. Furthermore, for smaller separations, the frequency peaks in the dynamic susceptibility markedly diverge between the two vortex configurations, demonstrating that the observed differences in the demagnetization field between the rings strongly influence the frequency response. In summary, our results indicate that both the inter-ring distance and the vortex configuration play a crucial role in determining the frequency response of the system. Full article

The Galápagos Petrel (Pterodroma phaeopygia) is a long-lived Critically Endangered seabird endemic to the Galápagos Islands and faces severe threats from invasive species, particularly rodents. Until now, evidence of rat predation on Galápagos Petrel nestlings has been largely indirect, inferred from indirect evidence and predator control outcomes. Here, we present the first photographic documentation of a presumed black rat (Rattus rattus) preying on a Galápagos Petrel nestling, captured by a camera trap on private farmland on Santa Cruz Island. The predation event occurred during a period of parental absence, when the nestling was left unattended while adults foraged at sea. Notably, the parent Petrels continued returning to the nest for 91 days following nestling loss, suggesting strong nest fidelity and highlighting potential energetic costs associated with breeding failure. Our findings reveal critical vulnerabilities during the nestling-rearing phase and emphasize the urgent need to enhance rodent control efforts and protect nesting areas, particularly on farmland outside the Galápagos National Park boundaries. We conclude by providing targeted conservation recommendations to mitigate invasive predator impacts and improve breeding success for this emblematic and imperiled seabird. Full article

Hepatocellular carcinoma (HCC) imposes a significant burden on global public health. Exposure to aflatoxins, potent mycotoxins produced by Aspergillus fungi contaminating staple foods, and chronic hepatitis B virus (HBV) infection are major etiological factors, especially where they co-exist. This review examines the critical role of the p53 tumor suppressor pathway as a primary target and convergence point for the carcinogenic actions of aflatoxins and HBV. Aflatoxin B₁ (AFB₁), a Group 1 carcinogen, exerts significant genotoxicity, characteristically inducing a specific hotspot mutation (R249S) in the TP53 gene via DNA adduct formation, thereby compromising p53’s critical tumor suppressor functions. This R249S mutation is considered a molecular fingerprint of aflatoxin exposure. Concurrently, the HBV X protein (HBx) functionally inactivates wild-type p53 through direct binding and by promoting its degradation. The synergistic disruption of the p53 pathway, driven by AFB₁-induced mutation and amplified by HBV-mediated functional inhibition, significantly enhances the risk of HCC development. This review addresses how aflatoxin exposure alters key aspects of p53 and how this damage interacts with HBV-mediated p53 suppression, providing crucial insights into hepatocarcinogenesis. The knowledge synthesized here underscores the importance of mitigating aflatoxin exposure alongside HBV control for effective HCC prevention and treatment strategies. Full article

Paleoclimate records have long documented the existence of multicentury hydroclimate anomalies in the Altiplano of South America. However, the causes and mechanisms of these extended events are still unknown. Here, we present a climate modeling experiment that explores the oceanic drivers and atmospheric mechanisms conducive to long-term precipitation variability in the southern Altiplano (18–25° S; 70–65 W; >3500 masl). We performed a series of 100-year-long idealized simulations using the Weather Research and Forecasting (WRF) model, configured to repeat annually the oceanic and atmospheric forcing leading to the exceptionally humid austral summers of 1983/1984 and 2011/2012. The aim of these cyclical experiments was to evaluate if these specific conditions can sustain a century-long pluvial event in the Altiplano. Unlike the annual forcing, long-term negative precipitation trends are observed in the simulations, suggesting that the drivers of 1983/1984 and 2011/2012 wet summers are unable to generate a century-scale pluvial event. Our results show that an intensification of the anticyclonic circulation along with cold surface air anomalies in the southwestern Atlantic progressively reinforce the lower and upper troposphere features that prevent moisture transport towards the Altiplano. Prolonged drying is also observed under persistent La Niña conditions, which contradicts the well-known relationship between precipitation and ENSO at interannual timescales. Contrasting the hydroclimate responses between the Altiplano and the tropical Andes result from a sustained northward migration of the Atlantic trade winds, providing a useful analog for explaining the divergences in the Holocene records. This experiment suggests that the drivers of century-scale hydroclimate events in the Altiplano were more diverse than previously thought and shows how climate modeling can be used to test paleoclimate hypotheses, emphasizing the necessity of combining proxy data and numerical models to improve our understanding of past climates. Full article

Pet tourism has experienced significant growth in recent years, reflecting changes in the perception of pets as family members. This research examines the factors influencing attitude, travel intention, and payment intention in pet tourism in Chile, specifically analyzing the role of emotional attachment, perceived benefits, prestige, and novelty. Using a quantitative methodology, data were collected through an online survey of pet owners in Chile. The results reveal that perceived benefits and novelty positively influence attitudes toward traveling with pets, while prestige and perceived benefits directly impact travel intention. Surprisingly, emotional attachment did not show a significant influence, which contrasts with previous studies in other cultural contexts. This research also confirms that attitude and travel intention are relevant predictors of willingness to pay more for pet-friendly tourism services. These findings contribute to the literature on pet tourism in Latin America and provide practical implications for developing tourism services tailored to the Chilean market. This study concludes that marketing strategies in the tourism sector should emphasize tangible benefits and novel elements rather than emotional aspects to attract this growing market segment. Full article

This scientific research presents the most significant aspects of the structural analysis and verification of the main steel railway bridges in Peru in accordance with the American standard. To this end, linear and finite element analyses (FEMs) were performed using calculation notes in MATHCAD and structural validation software (SAP2000, CSI Bridge, IDEA STATICA and GE05), among others, based on on-site inspections, which allowed results to be obtained to analyze, evaluate and determine the structural performance factors (RF) of the main railway bridges in Peru. For this, data obtained from several railway corridors in Peru were taken into consideration, such as the lines of the Southern Railway Train, Central Andean Railway, Huancayo–Huancavelica Railway Train and the Tacna–Arica Train; in addition to the feasibility studies on the Interoceanic Train project: Iquitos–Yurimaguas; projects administered through Public–Private Partnership PPP as well as by the Regionals Government and MTC-Peru. These data were used in order to be able to warn of certain technical aspects that would influence the recommendations for a locomotive replacement project in which new units had different load distributions between the axles, which would make it necessary to review the tracks and bridges of the same in order to determine if they would be able to withstand the new forces safely, as well as to reinforce structural elements according to the material and the structural condition, and finally, to assess the variation in the increase in train speed in some road corridors to achieve a better FRA (Federal Railway Administration) classification of Class 3, where the presence of structures dating back to the last century has been verified as well (1851–1856–1908). Likewise, the seismic criteria and geotechnical conditions of the most representative areas of the country (acceleration 0.30 g) were included in order to also be able to make technical recommendations that would allow us to ensure the useful life of the structure in service, operation and maintenance conditions. Full article

Water quality and the culture performance of juvenile rainbow trout (Oncorhynchus mykiss) were evaluated between 2014 and 2017 in a recirculating aquaculture system (RAS) in the Chilean Altiplano. Key parameters such as temperature, total ammonia nitrogen (TAN), nitrates, and dissolved oxygen were monitored, with values ranging from 7 to 21 °C, <0.1 to 0.63 mg/L, 2.0 to 135 mg/L, and 1.8 to 7.5 mg/L, respectively. Additional parameters—including alkalinity, arsenic, chlorine, true color, conductivity, hardness, phosphorus, pH, potassium, suspended solids, and salinity—were also assessed, comparing different points within the system (head tank, culture tanks, and settling tanks). The results showed that water quality remained within acceptable ranges for aquaculture, although fluctuations in pH and low alkalinity levels caused stress in the fish. Despite these challenges, the specific growth rate (SGR) was 1.49, the feed conversion ratio (FCR) was 1.52, and weight gain reached 298.7%, with a survival rate of 96.2%. This study demonstrates that aquaculture in the Altiplano is feasible and can contribute to the sustainable development of aquaculture in the region. Furthermore, it highlights the importance of comprehensive water quality monitoring to optimize RAS performance in challenging environments. Full article

This review provides an updated overview of oncolytic virotherapy as a promising therapeutic strategy for colorectal cancer (CRC), focusing on six key viral platforms: adenovirus, herpes simplex virus (HSV), reovirus, vesicular stomatitis virus (VSV), vaccinia virus (VV), and measles virus (MV). These viruses exhibit tumor-selective replication and exert their effects through mechanisms such as direct oncolysis, the delivery of immunostimulatory genes (e.g., IL-12, IL-15, GM-CSF), the activation of innate and adaptive immune responses, and the remodeling of the tumor microenvironment. Preclinical and early clinical studies suggest that oncolytic viruses can enhance the efficacy of existing treatments, particularly in immunologically “cold” tumors such as microsatellite stable CRC, when used in combination with chemotherapy or immune checkpoint inhibitors. Despite encouraging results, several challenges remain, including antiviral immune clearance, tumor heterogeneity, and limitations in systemic delivery. Current research focuses on improving viral engineering, enhancing tumor targeting, and designing combinatorial strategies to overcome resistance and maximize clinical benefits. Overall, oncolytic viruses represent a versatile and evolving therapeutic class with the potential to address unmet clinical needs in CRC. Full article