1,663 Results Found

Background: There has been no report regarding the clinicopathological features and genetic mutations regarding elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) in gastric cancer (GC). Methods: The correlation among EMA...

Peptide drugs that target protein–protein interactions have attracted mounting research efforts towards clinical developments over the past decades. Increasing reports have indicated that expression of Musashi 1 (MSI1) is tightly correlated to...

In colorectal cancer (CRC), the role of microsatellite instability (MSI) is well known. In a genome-wide scale, for the first time, we explored whether differential methylation is associated with MSI. We analyzed 250 paired samples from 125 CRC patie...

MSI is a crucial biomarker for selecting CRC patients for immunotherapy. Here, we analyze the first results from the observational prospective trial BLOOMSI (NCT06414304), which investigated the impact of MSI/dMMR testing methods and baseline tumor h...

Gastroesophageal adenocarcinoma (GEA) patients with the microsatellite instability (MSI) subtype emerged as optimal candidates for immunotherapy. To date, immunohistochemistry (IHC) is the gold standard for MSI assessment in formalin-fixed paraffin-e...

Microsatellite instability (MSI) represents an accumulation of frameshifts in short tandem repeats, microsatellites, across the genome due to defective DNA mismatch repair (dMMR). MSI has been associated with distinct clinical, histological, and mole...

The stem cell marker Musashi1 (MSI1) is highly expressed during neurogenesis and in glioblastoma (GBM). MSI1 promotes self-renewal and impairs differentiation in cancer and non-malignant progenitor cells. However, a comprehensive understanding of its...

Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes&...

The Harris Hawks Optimization algorithm (HHO) is a sophisticated metaheuristic technique that draws inspiration from the hunting process of Harris hawks, which has gained attention in recent years. However, despite its promising features, the algorit...

Sentinel-2A MSI is the Landsat-like spatial resolution (10–60 m) super-spectral instrument of the European Space Agency (ESA), aimed at additional data continuity for global land surface monitoring with Landsat and Satellite Pour l’Observation de la...

Suspended particulate matter (SPM) is one of the dominant water constituents in inland and coastal waters, and SPM concnetration (CSPM) is a key parameter describing water quality. This study, using in-situ spectral and CSPM measurements as well as S...

Matrix Assisted Laser Desorption/Ionisation-Mass Spectrometry Imaging (MALDI-MSI) is a well-established spatial omic technique which enables the untargeted mapping of various classes of biomolecules, including tryptic peptides, directly on tissue. Th...

Colorectal cancer is one of the most common cancers with a high mortality rate. The determination of microsatellite instability (MSI) status in resected cancer tissue is vital because it helps diagnose the related disease and determine the relevant t...

Both EBV+ and MSI gastric cancers (GCs) have high lymphoid infiltration which is rare in MSS/EBV− cancers. PD-L1/PD-1 interaction leads to a down-regulated immune response and it is one of the most promising targets for gastric cancer immunotherapy....

This study presents the use of matrix-assisted laser desorption and ionization mass spectrometry imaging (MALDI-MSI) directly on the tissue of two ovarian tumors that often present a diagnostic challenge, a low-grade serous borderline ovarian tumor a...

Accurate monitoring of soil salinization plays a key role in the ecological security and sustainable agricultural development of arid regions. As a branch of artificial intelligence, machine learning acquires new knowledge through self-learning and c...

The aim of this article is to choose the most appropriate method for identifying and managing land cover changes over time. These processes intensify due to human activities such as agriculture, urbanisation and deforestation. The study is based in t...

Trichophyton indotineae is an emerging pathogen which recently spread from India to Europe and that is more prone than other species of the Trichophyton mentagrophytes complex to show resistance to terbinafine, resulting in the necessity of rapid ide...

The present study applies for the first time as Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry Imaging (MSI) on real thyroid Fine Needle Aspirations (FNAs) to test its possible complementary role in routine cytology in the diag...

MSI-H/dMMR endometrial cancer (EC) is closely linked to the mismatch repair (MMR) pathway, and its pathogenesis is associated with microsatellite instability (MSI) caused by abnormalities in the core genes of the conventional MMR system. This cancer...

Equine metabolic syndrome (EMS) is a significant global health concern in veterinary medicine. There is increasing interest in utilizing molecular agents to modulate hepatocyte function for potential clinical applications. Recent studies have shown p...

Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) is increasingly used in a broad range of research due to its ability to visualize the spatial distribution of metabolites in vivo. Here, we have developed a method, nam...

Imprint Desorption Electrospray Ionization Mass Spectrometry Imaging (IDESI-MSI) has proven to be a robust and reliable tool for chemically imaging biological samples such as fungi, animal tissues, and plants, but the choice of the imprint substrate...

Adenocarcinoma of the esophagus (EAC) and gastroesophageal junction (GEJ-AC) is associated with poor prognosis, treatment resistance and limited systemic therapeutic options. To deeply understand the genomic landscape of this cancer type, and potenti...

Depending on the band position on the electromagnetic spectrum, optical and electronic characteristics, sensors collect the reflected energy by the Earth’s surface and the atmosphere. Currently, the availability of the new generation of medium...

A band-to-band mis-registration (BBMR) error often occurs in remote sensing (RS) images acquired by multi-spectral push broom spectrometers such as the Sentinel-2 Multi-spectral Instrument (MSI), leading to adverse impacts on the reliability of furth...

Research on the consistency of suspended particulate matter (SPM) concentration retrieved from multisource satellite sensors can serve as long-time monitoring of water quality. To explore the influence of the atmospheric correction (AC) algorithm and...

The distribution of pharmatically important alkaloids gelsemine, koumine, and gelsenicine in Gelsemium elegans tissues is a hot topic attracting research attention. Regretfully, the in planta visual distribution details of these alkaloids are far fro...

In this study, we developed an innovative and self-supervised pretraining approach using Sentinel-2/MSI satellite imagery specifically designed for the intelligent identification of drainage at sea discharge outlets. By integrating the geographical i...

Pumice rafts are considered to be a long-range drifting agent that promotes material exchange and the dispersal of marine species. Large ones can also interfere with vessel navigation and have a negative impact on the social economy and marine ecosys...

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with limited survival. Curative opportunities are only available for patients with resectable cancer. Palliative chemotherapy is the current standard of care for unresectable tumo...

MicroRNAs (miRNAs) could be potential biomarkers for glioblastoma multiforme (GBM) prognosis and response to therapeutic agents. We previously demonstrated that the cancer stem cell marker Musashi-1 (MSI1) is an RNA binding protein that promotes radi...

MicroRNAs (miRNAs) are critical post-transcriptional gene regulators and their involvement in sporadic colon cancer (CRC) tumorigenesis has been confirmed. In this study we investigated differences in miRNA expression in microsatellite stable (MSS/EM...

EFNA1 (ephrinA1), a highly expressed tyrosine kinase receptor-ligand in healthy cardiomyocytes, is reduced following myocardial infarction (MI). A single intramyocardial injection of chimeric EFNA1-Fc at the time of ischemia mitigates the injury in b...

In colorectal carcinoma (CRC), 5-fluorouracil (5-FU) remains the cornerstone of adjuvant systemic therapy, with folic acid (FA) serving as an essential adjunct. Expression of genes related to the metabolism and action of 5-FU and FA can be influenced...

The present study assesses the performance of state-of-the-art atmospheric correction (AC) algorithms applied to Sentinel-2-MultiSpectral Instrument (S2-MSI) and Sentinel-3-Ocean and Land Color Instrument (S3-OLCI) data recorded over moderately to hi...

Background: In microsatellite instability (MSI)/mismatch repair-deficient (dMMR) gastrointestinal cancers, the optimum therapy after the progression of immune checkpoint inhibitors (ICIs) is yet unknown. Here, we compared the efficacy of programmed d...

Inland waters, including lakes, are one of the key points of the carbon cycle. Using remote sensing data in lake monitoring has advantages in both temporal and spatial coverage over traditional in-situ methods that are time consuming and expensive. I...

Advanced high-grade serous ovarian carcinoma is a serious malignant neoplasm with a late diagnosis and high mortality rate. Even when treated with standard therapy, such as surgery followed by carboplatin and paclitaxel chemotherapy, the prognosis re...

Background: Mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) colorectal tumors constitute 5% of metastatic colorectal cancer(mCRC). Immunotherapy is a new standard, but it is difficult to provide for all patients. 5-Flurouraci...

Adenomyosis (AM) is a gynecological disease characterized by the invasion of endometrial glands and stroma within the myometrium. The etiology and pathogenesis of AM remain inadequately understood. Pale cells were identified as a novel cell type char...

Remote sensing technology is widely used to obtain information on floating green tides, and thresholding methods based on indices such as the normalized difference vegetation index (NDVI) and the floating algae index (FAI) play an important role in s...

Colored dissolved organic matter (CDOM) is a significant constituent of aquatic systems and biogeochemical cycles. Satellite CDOM retrievals are challenging in inland waters, due to overlapped absorption properties of bio-optical parameters, like Tot...

Ovarian cancer is the most lethal gynecological cancer. Up to 75% of cases are high-grade serous ovarian cancer (HGSOC) that have high chemosensitivity to first-line platinum-based therapies. However, 75% of patients will become chemoresistant follow...

The successful launch of Korea Multipurpose Satellite-3/Advanced Earth Imaging Sensor System (KOMPSAT-3/AEISS) on 18 May 2012 allowed the Republic of Korea to meet the growing demand for high-resolution satellite imagery. However, like all satellite...

Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at advanced stages. Due to pronounced intratumoral heterogeneity (ITH), reliable risk stratification and prediction of treatment response remain challenging. This study aimed to identif...

Amyotrophic lateral sclerosis (ALS) is an idiopathic, fatal neurodegenerative disease characterized by progressive loss of motor function with an average survival time of 2–5 years after diagnosis. Due to the lack of signature biomarkers and he...

Respiratory infections are a real threat for humans, and therefore the pig model is of interest for studies. As one of a case for studies, Actinobacillus pleuropneumoniae (APP) caused infections and still worries many pig breeders around the world. T...

Background/Objectives: In recent years, lipids have emerged as critical regulators of different disease processes, being involved in cancer pathogenesis, progression, and outcome. Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging...

The Sentinel-2A and Sentinel-2B satellites, with on-board Multi-Spectral Instrument (MSI), and launched on 23 June 2015 and 7 March 2017, respectively, are very useful tools for studying ocean color, even if they were designed for land and vegetation...