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55 Results Found

  • Article
  • Open Access
3 Citations
4,194 Views
16 Pages

Mapping Aspergillus niger Metabolite Biomarkers for In Situ and Early Evaluation of Table Grapes Contamination

  • Joao Raul Belinato,
  • Carina Pedrosa Costa,
  • Adelaide Almeida,
  • Silvia M. Rocha and
  • Fabio Augusto

19 November 2021

The Aspergillus niger exometabolome was recently investigated using advanced gas chromatography in tandem with multivariate analysis, which allowed a metabolite biomarker pattern to be proposed. Microbial metabolomics patterns have gained enormous re...

  • Article
  • Open Access
13 Citations
4,382 Views
13 Pages

Visceral Adipose Tissue Displays Unique Metabolomic Fingerprints in Obesity, Pre-Diabetes and Type 2 Diabetes

  • Tiago Morais,
  • Alexandre L. Seabra,
  • Bárbara G. Patrício,
  • Marta Guimarães,
  • Mário Nora,
  • Pedro F. Oliveira,
  • Marco G. Alves and
  • Mariana P. Monteiro

Visceral adipose tissue (VAT) metabolic profiling harbors the potential to disentangle molecular changes underlying obesity-related dysglycemia. In this study, the VAT exometabolome of subjects with obesity and different glycemic statuses are analyze...

  • Article
  • Open Access
6 Citations
6,355 Views
13 Pages

Metabolic Perturbations in a Bacillus subtilis clpP Mutant during Glucose Starvation

  • Daniel Schultz,
  • Rabea Schlüter,
  • Ulf Gerth and
  • Michael Lalk

24 November 2017

Proteolysis is essential for all living organisms to maintain the protein homeostasis and to adapt to changing environmental conditions. ClpP is the main protease in Bacillus subtilis, and forms complexes with different Clp ATPases. These complexes p...

  • Article
  • Open Access
1 Citations
3,666 Views
32 Pages

Glucagon and Glucose Availability Influence Metabolic Heterogeneity and Malignancy in Pancreatic Neuroendocrine Tumour (pNET) Cells: Novel Routes for Therapeutic Targeting

  • Bárbara Ferreira,
  • Isabel Lemos,
  • Cindy Mendes,
  • Beatriz Chumbinho,
  • Fernanda Silva,
  • Daniela Pereira,
  • Emanuel Vigia,
  • Luís G. Gonçalves,
  • António Figueiredo and
  • Jacinta Serpa

25 June 2025

Cancer metabolism is a hallmark of cancer. However, the impact of systemic metabolism and diet on tumour evolution is less understood. This study delves into the role of glucagon, as a component of the pancreatic microenvironment, in regulating featu...

  • Article
  • Open Access
1 Citations
3,674 Views
23 Pages

Impact of a Formulation Containing Chaga Extract, Coenzyme Q10, and Alpha-Lipoic Acid on Mitochondrial Dysfunction and Oxidative Stress: NMR Metabolomic Insights into Cellular Energy

  • Maria D’Elia,
  • Carmen Marino,
  • Rita Celano,
  • Enza Napolitano,
  • Chiara Colarusso,
  • Rosalinda Sorrentino,
  • Anna Maria D’Ursi and
  • Luca Rastrelli

Objectives: The aim of this study was to evaluate the impact of a novel antioxidant formulation (RE:PAIR, RP-25) containing CoQ10, alpha-lipoic acid, and Chaga extract on mitochondrial dysfunction and oxidative stress. To explore the activity of the...

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