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Search Results (8,754)

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Authors = Zheng Wang ORCID = 0000-0001-5956-6250

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21 pages, 8385 KiB  
Article
Hydraulic Fracture Propagation Behavior in Tight Conglomerates and Field Applications
by Zhenyu Wang, Wei Xiao, Shiming Wei, Zheng Fang and Xianping Cao
Processes 2025, 13(8), 2494; https://doi.org/10.3390/pr13082494 (registering DOI) - 7 Aug 2025
Abstract
The tight conglomerate oil reservoir in Xinjiang’s Mahu area is situated on the northwestern margin of the Junggar Basin. The reservoir comprises five stacked fan bodies, with the Triassic Baikouquan Formation serving as the primary pay zone. To delineate the study scope and [...] Read more.
The tight conglomerate oil reservoir in Xinjiang’s Mahu area is situated on the northwestern margin of the Junggar Basin. The reservoir comprises five stacked fan bodies, with the Triassic Baikouquan Formation serving as the primary pay zone. To delineate the study scope and conduct a field validation, the Ma-X well block was selected for investigation. Through triaxial compression tests and large-scale true triaxial hydraulic fracturing simulations, we analyzed the failure mechanisms of tight conglomerates and identified key factors governing hydraulic fracture propagation. The experimental results reveal several important points. (1) Gravel characteristics control failure modes: Larger gravel size and higher content increase inter-gravel stress concentration, promoting gravel crushing under confining pressure. At low-to-medium confining pressures, shear failure primarily occurs within the matrix, forming bypassing fractures around gravel particles. (2) Horizontal stress differential dominates fracture geometry: Fractures preferentially propagate as transverse fractures perpendicular to the wellbore, with stress anisotropy being the primary control factor. (3) Injection rate dictates fracture complexity: Weakly cemented interfaces in conglomerates lead to distinct fracture morphologies—low rates favor interface activation, while high rates enhance penetration through gravels. (4) Stimulation strategy impacts SRV: Multi-cluster perforations show limited effectiveness in enhancing fracture network complexity. In contrast, variable-rate fracturing significantly increases stimulated reservoir volume (SRV) compared to constant-rate methods, as evidenced by microseismic data demonstrating improved interface connectivity and broader fracture coverage. Full article
(This article belongs to the Special Issue Structure Optimization and Transport Characteristics of Porous Media)
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15 pages, 1774 KiB  
Article
Study on the Effect of pH Modulation on Lactic Acid Production by Electro-Fermentation of Food Waste
by Nuohan Wang, Jianguo Liu, Yongsheng Li, Yuanyuan Ren, Xiaona Wang, Tianlong Zheng and Qunhui Wang
Sustainability 2025, 17(15), 7160; https://doi.org/10.3390/su17157160 - 7 Aug 2025
Abstract
Lactic acid (LA) synthesis through fermentation of food waste (FW) is an emerging techniques for utilizing perishable organic wastes with high value. Using food waste collected from a cafeteria as the substrate for fermentation, the current study was conducted by applying a micro [...] Read more.
Lactic acid (LA) synthesis through fermentation of food waste (FW) is an emerging techniques for utilizing perishable organic wastes with high value. Using food waste collected from a cafeteria as the substrate for fermentation, the current study was conducted by applying a micro electric field to the conventional LA fermentation process and performing open-ended electro-fermentation (EF) without sterilization and lactobacilli inoculation. Furthermore, the effects of pH adjustment on LA production were examined. The findings demonstrated that electrical stimulation enhances the electron transfer rate within the system, accelerates REDOX reactions, and thereby intensifies the lactic acid production process. The pH-regulated group produced LA and dissolved organic materials at considerably higher rates than the control group, which did not receive any pH modification. The maximum LA concentration and organic matter dissolution in the experimental group, where the pH was set to 7 every 12 h of fermentation, were 33.9 and 38.4 g/L, respectively. These values were 208 and 203% higher than those in the control group, indicating that the pH adjustment greatly aided the solubilization and hydrolysis of macromolecules. Among the several hydrolyzing bacteria (Actinobacteriota) that were enriched, Lactobacillus predominated, but Bifidobacterium also became a major genus in the neutral-acidic environment, and its abundance grew dramatically. This study provides a scientific basis for optimizing the LA process of FW. Full article
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15 pages, 6405 KiB  
Article
Rainy Season Onset in Northeast China: Characteristic Changes and Physical Mechanisms Before and After the 2000 Climate Regime Shift
by Hanchen Zhang, Weifang Wang, Shuwen Li, Qing Cao, Quanxi Shao, Jinxia Yu, Tao Zheng and Shuci Liu
Water 2025, 17(15), 2347; https://doi.org/10.3390/w17152347 - 7 Aug 2025
Abstract
The rainy season characteristics are directly modulated by atmospheric circulation and moisture transport dynamics. Focusing on the characteristics of the rainy season onset date (RSOD), this study aims to advance the understanding and prediction of climate change impacts on agricultural production and disaster [...] Read more.
The rainy season characteristics are directly modulated by atmospheric circulation and moisture transport dynamics. Focusing on the characteristics of the rainy season onset date (RSOD), this study aims to advance the understanding and prediction of climate change impacts on agricultural production and disaster mitigation strategies. Based on rainfall data from 66 meteorological stations in northeast China (NEC) from 1961 to 2020, this study determined the patterns of the RSOD in the region and established its mechanistic linkages with atmospheric circulation and water vapor transport mechanisms. This study identifies a climatic regime shift around 2000, with the RSOD transitioning from low to high interannual variability in NEC. Further analysis reveals a strong correlation between the RSOD and atmospheric circulation characteristics: cyclonic vorticity amplifies before the RSOD and dissipates afterward. Innovatively, this study reveals a significant transition in the water vapor transport paths during the early rainy season in NEC around 2000, shifting from eastern Mongolia–Sea of Japan to the northwestern Pacific region. Moreover, the advance or delay of the RSOD directly influences the water vapor transport intensity—an early (delayed) RSOD is associated with enhanced (weakened) water vapor transport. These findings provide a new perspective for predicting the RSOD in the context of climate change while providing critical theoretical underpinnings for optimizing agricultural strategies and enhancing disaster prevention protocols. Full article
(This article belongs to the Section Water and Climate Change)
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26 pages, 1810 KiB  
Article
A Memetic and Reflective Evolution Framework for Automatic Heuristic Design Using Large Language Models
by Fubo Qi, Tianyu Wang, Ruixiang Zheng and Mian Li
Appl. Sci. 2025, 15(15), 8735; https://doi.org/10.3390/app15158735 - 7 Aug 2025
Abstract
The increasing complexity of real-world engineering problems, ranging from manufacturing scheduling to resource optimization in smart grids, has driven demand for adaptive and high-performing heuristic methods. Automatic Heuristic Design (AHD) and neural-enhanced metaheuristics have shown promise in automating strategy development, but often suffer [...] Read more.
The increasing complexity of real-world engineering problems, ranging from manufacturing scheduling to resource optimization in smart grids, has driven demand for adaptive and high-performing heuristic methods. Automatic Heuristic Design (AHD) and neural-enhanced metaheuristics have shown promise in automating strategy development, but often suffer from limited flexibility and scalability due to static operator libraries or high retraining costs. Recently, Large Language Models (LLMs) have emerged as a powerful alternative for exploring and evolving heuristics through natural language and program synthesis. This paper proposes a novel LLM-based memetic framework that synergizes LLM-driven exploration with domain-specific local refinement and memory-aware reflection, enabling a dynamic balance between heuristic creativity and effectiveness. In the experiments, the developed framework outperforms other LLM-based state-of-the-art approaches across the designed AGV-drone scheduling scenario and two benchmark combinatorial problems. The findings suggest that LLMs can serve not only as general-purpose optimizers but also as interpretable heuristic generators that adapt efficiently to complex and heterogeneous domains. Full article
(This article belongs to the Section Computing and Artificial Intelligence)
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19 pages, 8504 KiB  
Article
Fiber-Based Ultra-High-Speed Diffuse Speckle Contrast Analysis System for Deep Blood Flow Sensing Using a Large SPAD Camera
by Quan Wang, Renzhe Bi, Songhua Zheng, Ahmet T. Erdogan, Yi Qi, Chenxu Li, Yuanyuan Hua, Mingliang Pan, Yining Wang, Neil Finlayson, Malini Olivo, Robert K. Henderson and David Uei-Day Li
Biosensors 2025, 15(8), 514; https://doi.org/10.3390/bios15080514 - 7 Aug 2025
Abstract
Diffuse speckle contrast analysis (DSCA), also called speckle contrast optical spectroscopy (SCOS), has emerged as a groundbreaking optical imaging technique for tracking dynamic biological processes, including blood flow and tissue perfusion. Recent advancements in single-photon avalanche diode (SPAD) cameras have unlocked exceptional sensitivity, [...] Read more.
Diffuse speckle contrast analysis (DSCA), also called speckle contrast optical spectroscopy (SCOS), has emerged as a groundbreaking optical imaging technique for tracking dynamic biological processes, including blood flow and tissue perfusion. Recent advancements in single-photon avalanche diode (SPAD) cameras have unlocked exceptional sensitivity, time resolution, and high frame-rate imaging capabilities. Despite this, the application of large-format SPAD arrays in speckle contrast analysis is still relatively uncommon. This study introduces a pioneering use of a large-format SPAD camera for DSCA. By harnessing the camera’s high temporal resolution and photon-detection efficiency, we significantly enhance the accuracy and robustness of speckle contrast measurements. Our experimental results demonstrate the system’s remarkable ability to capture rapid temporal variations over a broad field of view, enabling detailed spatiotemporal analysis. Through simulations, phantom experiments, and in vivo studies, we validated the proposed approach’s potential for cerebral blood flow and functional tissue monitoring. This work highlights the transformative impact of large SPAD cameras on DSCA, setting the stage for breakthroughs in optical imaging. Full article
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39 pages, 825 KiB  
Article
Public Water Concern, Managerial Green Cognition, and Corporate Water Responsibility: Evidence from High-Water-Consuming Enterprises in China
by Liyuan Zheng, Wei Wang, Bo Shang and Mengjiao Wang
Sustainability 2025, 17(15), 7150; https://doi.org/10.3390/su17157150 - 7 Aug 2025
Abstract
To address water sustainability challenges, this study investigates how public water concern influences corporate water responsibility (CWR) and how managerial green cognition moderates this relationship. Drawing on institutional theory and cognitive theory, we analyze a panel of 1292 publicly listed high-water-consuming firms in [...] Read more.
To address water sustainability challenges, this study investigates how public water concern influences corporate water responsibility (CWR) and how managerial green cognition moderates this relationship. Drawing on institutional theory and cognitive theory, we analyze a panel of 1292 publicly listed high-water-consuming firms in China from 2015 to 2024. The results show that public water concern significantly improves CWR by increasing legitimacy pressure, while its effect through government water governance attention is not statistically significant. Furthermore, managerial green cognition—including both economic and moral dimensions—positively moderates this relationship. Heterogeneity analysis reveals that the moderating effect is stronger in firms with more female directors, older executives, and internationally experienced teams. These findings contribute to refining institutional theory in the context of environmental responsibility and highlight the critical role of executive cognition and demographic structure in corporate sustainability behavior. Full article
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18 pages, 19901 KiB  
Article
A Novel Polysilicon-Fill-Strengthened Etch-Through 3D Trench Electrode Detector: Fabrication Methods and Electrical Property Simulations
by Xuran Zhu, Zheng Li, Zhiyu Liu, Tao Long, Jun Zhao, Xinqing Li, Manwen Liu and Meishan Wang
Micromachines 2025, 16(8), 912; https://doi.org/10.3390/mi16080912 - 6 Aug 2025
Abstract
Three-dimensional trench electrode silicon detectors play an important role in particle physics research, nuclear radiation detection, and other fields. A novel polysilicon-fill-strengthened etch-through 3D trench electrode detector is proposed to address the shortcomings of traditional 3D trench electrode silicon detectors; for example, the [...] Read more.
Three-dimensional trench electrode silicon detectors play an important role in particle physics research, nuclear radiation detection, and other fields. A novel polysilicon-fill-strengthened etch-through 3D trench electrode detector is proposed to address the shortcomings of traditional 3D trench electrode silicon detectors; for example, the distribution of non-uniform electric fields, asymmetric electric potential, and dead zone. The physical properties of the detector have been extensively and systematically studied. This study simulated the electric field, potential, electron concentration distribution, complete depletion voltage, leakage current, capacitance, transient current induced by incident particles, and weighting field distribution of the detector. It also systematically studied and analyzed the electrical characteristics of the detector. Compared to traditional 3D trench electrode silicon detectors, this new detector adopts a manufacturing process of double-side etching technology and double-side filling technology, which results in a more sensitive detector volume and higher electric field uniformity. In addition, the size of the detector unit is 120 µm × 120 µm × 340 µm; the structure has a small fully depleted voltage, reaching a fully depleted state at around 1.4 V, with a saturation leakage current of approximately 4.8×1010A, and a geometric capacitance of about 99 fF. Full article
(This article belongs to the Special Issue Photonic and Optoelectronic Devices and Systems, Third Edition)
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15 pages, 4493 KiB  
Article
Highly Efficient Tribocatalysis of Superhard SiC for Water Purification
by Yuanfang Wang, Zheng Wu, Siqi Hong, Ziqi Zhu, Siqi Wu, Biao Chen and Yanmin Jia
Nanomaterials 2025, 15(15), 1206; https://doi.org/10.3390/nano15151206 - 6 Aug 2025
Abstract
Mechanical friction offers a frequent approach for sustainable energy harvesting, as it can be captured and transformed into electricity by means of the triboelectric phenomenon. Theoretically, this electricity may subsequently be employed to drive electrochemical water purification processes. Herein, the experimental results confirm [...] Read more.
Mechanical friction offers a frequent approach for sustainable energy harvesting, as it can be captured and transformed into electricity by means of the triboelectric phenomenon. Theoretically, this electricity may subsequently be employed to drive electrochemical water purification processes. Herein, the experimental results confirm that the SiC particles effectively trigger the tribocatalytic decomposition of Rhodamine B (RhB). During the tribocatalytic decomposition of dye, mechanical friction is generated at the contact surface between the tribocatalyst and a custom-fabricated polytetrafluoroethylene (PTFE) rotating disk, under varying conditions of stirring speed, temperature, and pH value. Hydroxyl radicals and superoxide radicals are confirmed as the dominant reactive species participating in tribocatalytic dye decomposition, as demonstrated by reactive species inhibition experiments. Furthermore, the SiC particles demonstrate remarkable reusability, even after being subjected to five consecutive recycling processes. The exceptional tribocatalytic performance of SiC particles makes them potentially applicable in water purification by harnessing environmental friction energy. Full article
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20 pages, 1414 KiB  
Article
Awareness, Preference, and Acceptance of HPV Vaccine and Related Influencing Factors Among Guardians of Adolescent Girls in China: A Health Belief Model-Based Cross-Sectional Study
by Shuhan Zheng, Xuan Deng, Li Li, Feng Luo, Hanqing He, Ying Wang, Xiaoping Xu, Shenyu Wang and Yingping Chen
Vaccines 2025, 13(8), 840; https://doi.org/10.3390/vaccines13080840 - 6 Aug 2025
Abstract
Background: Cervical cancer poses a threat to the health of women globally. Adolescent girls are the primary target population for HPV vaccination, and guardians’ attitude towards the HPV vaccine plays a significant role in determining the vaccination status among adolescent girls. Objectives: This [...] Read more.
Background: Cervical cancer poses a threat to the health of women globally. Adolescent girls are the primary target population for HPV vaccination, and guardians’ attitude towards the HPV vaccine plays a significant role in determining the vaccination status among adolescent girls. Objectives: This study aimed to explore the factors influencing guardians’ HPV vaccine acceptance for their girls and provide clues for the development of health intervention strategies. Methods: Combining the health belief model as a theoretical framework, a questionnaire-based survey was conducted. A total of 2157 adolescent girls and their guardians were recruited. The multivariable logistic model was applied to explore associated factors. Results: The guardians had a high HPV vaccine acceptance rate (86.7%) for their girls, and they demonstrated a relatively good level of awareness regarding HPV and HPV vaccines. Factors influencing guardians’ HPV vaccine acceptance for girls included guardians’ education background (OR = 0.57, 95%CI = 0.37–0.87), family income (OR = 1.94, 95%CI = 1.14–3.32), risk of HPV infection (OR = 3.15, 95%CI = 1.40–7.10) or importance of the HPV vaccine for their girls (OR = 6.70, 95%CI = 1.61–27.83), vaccination status surrounding them (OR = 2.03, 95%CI = 1.41–2.92), awareness of negative information about HPV vaccines (OR = 0.59, 95%CI = 0.43–0.82), and recommendations from medical staff (OR = 2.32, 95%CI = 1.65–3.25). Also, guardians preferred to get digital information on vaccines via government or CDC platforms, WeChat platforms, and medical knowledge platforms. Conclusions: Though HPV vaccine willingness was high among Chinese guardians, they preferred to vaccinate their daughters at the age of 17–18 years, later than WHO’s recommended optimal age period (9–14 years old), coupled with safety concerns. Future work should be conducted based on these findings to explore digital intervention effects on girls’ vaccination compliance. Full article
(This article belongs to the Special Issue Prevention of Human Papillomavirus (HPV) and Vaccination)
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18 pages, 8682 KiB  
Article
Urban Carbon Metabolism Optimization Based on a Source–Sink–Flow Framework at the Functional Zone Scale
by Cui Wang, Liuchang Xu, Xingyu Xue and Xinyu Zheng
Land 2025, 14(8), 1600; https://doi.org/10.3390/land14081600 - 6 Aug 2025
Abstract
Carbon flow tracking and spatial pattern optimization at the scale of urban functional zones are key scientific challenges in achieving carbon neutrality. However, due to the complexity of carbon metabolism processes within urban functional zones, related studies remain limited. To address these scientific [...] Read more.
Carbon flow tracking and spatial pattern optimization at the scale of urban functional zones are key scientific challenges in achieving carbon neutrality. However, due to the complexity of carbon metabolism processes within urban functional zones, related studies remain limited. To address these scientific challenges, this study, based on the “source–sink–flow” ecosystem services framework, develops an integrated analytical approach at the scale of urban functional zones. The carbon balance is quantified using the CASA model in combination with multi-source data. A network model is employed to trace carbon flow pathways, identify critical nodes and interruption points, and optimize the urban spatial pattern through a low-carbon land use structure model. The research results indicate that the overall carbon balance in Hangzhou exhibits a spatial pattern of “deficit in the center and surplus in the periphery.” The main urban area shows a significant carbon deficit and relatively poor connectivity in the carbon flow network. Carbon sequestration services primarily flow from peripheral areas (such as Fuyang and Yuhang) with green spaces and agricultural functional zones toward high-emission residential–commercial and commercial–public functional zones in the central area. However, due to the interruption of multiple carbon flow paths, the overall carbon flow transmission capacity is significantly constrained. Through spatial optimization, some carbon deficit nodes were successfully converted into carbon surplus nodes, and disrupted carbon flow edges were repaired, particularly in the main urban area, where 369 carbon flow edges were restored, resulting in a significant improvement in the overall transmission efficiency of the carbon flow network. The carbon flow visualization and spatial optimization methods proposed in this paper provide a new perspective for urban carbon metabolism analysis and offer theoretical support for low-carbon city planning practices. Full article
(This article belongs to the Special Issue The Second Edition: Urban Planning Pathways to Carbon Neutrality)
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21 pages, 3733 KiB  
Article
DNO-RL: A Reinforcement-Learning-Based Approach to Dynamic Noise Optimization for Differential Privacy
by Guixin Wang, Xiangfei Liu, Yukun Zheng, Zeyu Zhang and Zhiming Cai
Electronics 2025, 14(15), 3122; https://doi.org/10.3390/electronics14153122 - 5 Aug 2025
Abstract
With the globalized deployment of cross-border vehicle location services and the trajectory data, which contain user identity information and geographically sensitive features, the variability in privacy regulations in different jurisdictions can further exacerbate the technical and compliance challenges of data privacy protection. Traditional [...] Read more.
With the globalized deployment of cross-border vehicle location services and the trajectory data, which contain user identity information and geographically sensitive features, the variability in privacy regulations in different jurisdictions can further exacerbate the technical and compliance challenges of data privacy protection. Traditional static differential privacy mechanisms struggle to accommodate spatiotemporal heterogeneity in dynamic scenarios because of the use of a fixed privacy budget parameter, leading to wasted privacy budgets or insufficient protection of sensitive regions. This study proposes a reinforcement-learning-based dynamic noise optimization method (DNO-RL) that dynamically adjusts the Laplacian noise scale by real-time sensing of vehicle density, region sensitivity, and the remaining privacy budget via a deep Q-network (DQN), with the aim of providing context-adaptive differential privacy protection for cross-border vehicle location services. Simulation experiments of cross-border scenarios based on the T-Drive dataset showed that DNO-RL reduced the average localization error by 28.3% and saved 17.9% of the privacy budget compared with the local differential privacy under the same privacy budget. This study provides a new paradigm for the dynamic privacy–utility balancing of cross-border vehicular networking services. Full article
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14 pages, 2093 KiB  
Article
Parameter Identification Method of Grid-Forming Static Var Generator Based on Trajectory Sensitivity and Proximal Policy Optimization Algorithm
by Yufei Teng, Peng Shi, Jiayu Bai, Xi Wang, Ziyuan Shao, Tian Cao, Xianglian Guan and Zongsheng Zheng
Electronics 2025, 14(15), 3119; https://doi.org/10.3390/electronics14153119 - 5 Aug 2025
Abstract
As the penetration rate of new energy continues to increase, the active voltage support capability of the power system is decreasing. The grid-forming static var generator (GFM-SVG) features the advantages of fast dynamic response, strong reactive power support, and high overload capacity, which [...] Read more.
As the penetration rate of new energy continues to increase, the active voltage support capability of the power system is decreasing. The grid-forming static var generator (GFM-SVG) features the advantages of fast dynamic response, strong reactive power support, and high overload capacity, which play an important role in maintaining voltage stability. However, the parameters of the GFM-SVG are often unknown due to trade secret reasons. Meanwhile, the parameters may be changed during the long-term operation of the system, which brings challenges to the system stability analysis and control. Aiming at this problem, a parameter identification method based on trajectory sensitivity analysis and the proximal policy optimization (PPO) algorithm is proposed in this paper. Firstly, through trajectory sensitivity analysis, the key influential parameters on the output characteristics of the GFM-SVG can be selected, which can reduce the dimensionality of the identification parameters and improve the identification efficiency. Then, a parameter identification framework based on the PPO algorithm is constructed for GFM-SVGs, which utilizes its adaptive learning capability to achieve accurate identification of the key parameters of the system. Finally, the effectiveness of the proposed parameter identification method is verified through simulation examples. The simulation results show that the identification error of the parameters in the GFM-SVG is small. The proposed method can characterize the output response of the GFM-SVG under different operating conditions. Full article
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13 pages, 3474 KiB  
Article
Energy Dispersion Relationship and Hofstadter Butterfly of Triangle and Rectangular Moiré Patterns in Tight Binding States
by Ziheng Li, Jiangwei Liu, Xiaoxiao Zheng, Yu Sun, Nan Han, Liang Wang, Muyang Li, Lei Han, Safia Khan, S. Hassan M. Jafri, Klaus Leifer, Yafei Ning and Hu Li
Physics 2025, 7(3), 34; https://doi.org/10.3390/physics7030034 - 5 Aug 2025
Abstract
Herein, the energy dispersion relationship and the density of states of triangular and rectangular moiré patterns are investigated using a tight binding model. Their characteristics of Hofstadter butterflies under different magnetic fields are also examined. The results indicate that, by analyzing different moiré [...] Read more.
Herein, the energy dispersion relationship and the density of states of triangular and rectangular moiré patterns are investigated using a tight binding model. Their characteristics of Hofstadter butterflies under different magnetic fields are also examined. The results indicate that, by analyzing different moiré superlattices, Hofstadter butterflies arising from different moiré pattern structures are obtained, exhibiting considerable fractal characteristics and self-similarities. Moreover, it is also observed that under an alternating magnetic field, the redistribution of electronic states leads to a significant change in the density of states curve, and the Van Hove peak changes with the increase in magnetic field intensity. This study enriches the understanding of the electronic behavior of moiré systems, but it also provides multiple potential application directions for future technological development. Full article
(This article belongs to the Section Statistical Physics and Nonlinear Phenomena)
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17 pages, 3344 KiB  
Article
Connectiveness of Antimicrobial Resistance Genotype–Genotype and Genotype–Phenotype in the “Intersection” of Skin and Gut Microbes
by Ruizhao Jia, Wenya Su, Wenjia Wang, Lulu Shi, Xinrou Zheng, Youming Zhang, Hai Xu, Xueyun Geng, Ling Li, Mingyu Wang and Xiang Li
Biology 2025, 14(8), 1000; https://doi.org/10.3390/biology14081000 - 5 Aug 2025
Abstract
The perianal skin is a unique “skin–gut” boundary that serves as a critical hotspot for the exchange and evolution of antibiotic resistance genes (ARGs). However, its role in the dissemination of antimicrobial resistance (AMR) has often been underestimated. To characterize the resistance patterns [...] Read more.
The perianal skin is a unique “skin–gut” boundary that serves as a critical hotspot for the exchange and evolution of antibiotic resistance genes (ARGs). However, its role in the dissemination of antimicrobial resistance (AMR) has often been underestimated. To characterize the resistance patterns in the perianal skin environment of patients with perianal diseases and to investigate the drivers of AMR in this niche, a total of 51 bacterial isolates were selected from a historical strain bank containing isolates originally collected from patients with perianal diseases. All the isolates originated from the skin site and were subjected to antimicrobial susceptibility testing, whole-genome sequencing, and co-occurrence network analysis. The analysis revealed a highly structured resistance pattern, dominated by two distinct modules: one representing a classic Staphylococcal resistance platform centered around mecA and the bla operon, and a broad-spectrum multidrug resistance module in Gram-negative bacteria centered around tet(A) and predominantly carried by IncFIB and other IncF family plasmids. Further analysis pinpointed IncFIB-type plasmids as potent vehicles driving the efficient dissemination of the latter resistance module. Moreover, numerous unexplained resistance phenotypes were observed in a subset of isolates, indicating the potential presence of emerging and uncharacterized AMR threats. These findings establish the perianal skin as a complex reservoir of multidrug resistance genes and a hub for mobile genetic element exchange, highlighting the necessity of enhanced surveillance and targeted interventions in this clinically important ecological niche. Full article
(This article belongs to the Section Microbiology)
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23 pages, 5217 KiB  
Article
High-Performance Pd-Pt/α-MnO2 Catalysts for the Oxidation of Toluene
by Ning Dong, Wenjin Wang, Xuelong Zheng, Huan Liu, Jingjing Zhang, Qing Ye and Hongxing Dai
Catalysts 2025, 15(8), 746; https://doi.org/10.3390/catal15080746 - 5 Aug 2025
Abstract
Herein, α-MnO2-supported Pt-Pd bimetal (xPd-yPt/α-MnO2; x and y are the weight loadings (wt%) of Pd and Pt, respectively; x = 0, 0.23, 0.47, 0.93, and 0.92 wt%; and y = 0.91, 0.21, [...] Read more.
Herein, α-MnO2-supported Pt-Pd bimetal (xPd-yPt/α-MnO2; x and y are the weight loadings (wt%) of Pd and Pt, respectively; x = 0, 0.23, 0.47, 0.93, and 0.92 wt%; and y = 0.91, 0.21, 0.46, 0.89, and 0 wt%) catalysts were prepared using the polyvinyl alcohol-protected NaBH4 reduction method. The physicochemical properties of the catalysts were determined by means of various techniques and their catalytic activities for toluene oxidation were evaluated. It was found that among the xPd-yPt/α-MnO2 samples, 0.93Pd-0.89Pt/α-MnO2 showed the best catalytic performance, with the toluene oxidation rate at 156 °C (rcat) and space velocity = 60,000 mL/(g h) being 6.34 × 10−4 mol/(g s), much higher than that of 0.91Pt/α-MnO2 (1.31 × 10−4 mol/(g s)) and that of 0.92Pd/α-MnO2 (6.13 × 10−5 mol/(g s)) at the same temperature. The supported Pd-Pt bimetallic catalysts possessed higher Mn3+/Mn4+ and Oads/Olatt molar ratios, which favored the enhancement in catalytic activity of the supported Pd-Pt bimetallic catalysts. Furthermore, the 0.47Pd-0.46Pt/α-MnO2 sample showed better resistance to sulfur dioxide poisoning. The partial deactivation of 0.47Pd-0.46Pt/α-MnO2 was attributed to the formation of sulfate species on the sample surface, which covered the active site of the sample, thus decreasing its toluene oxidation activity. In addition, the in situ DRIFTS results demonstrated that benzaldehyde and benzoate were the intermediate products of toluene oxidation. Full article
(This article belongs to the Section Environmental Catalysis)
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