Gynecological Endocrinology Updates

Topic Information

Dear Colleagues,

Hormones and good health are tightly linked in our biology, especially in women. The complexity of the endocrine axes and hormonal control of the ovarian cycle is just a simple example of such an issue. This interdisciplinary Topic on gynecological endocrinology has been created to bridge the many disciplines that deal with women's well-being. The gynecological endocrinology field deals with not only gynecological issues but also cardiological, pure endocrinological, dermatological, oncological, and orthopedic areas, among many others. There are dozens of specialties where women health is at the center of scientists’ interest. This new interdisciplinary Topic on gynecological endocrinology aims to collate research that links hormones with women health; it also aims to create a specific space where “gynecology” attracts streams of new scientific research that will expand our knowledge and skills in women’s health.

Dr. Alessandro Genazzani
Dr. Stefano Luisi
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Endocrines endocrines	-	2.4	2020	26.5 Days	CHF 1000	Submit
International Journal of Molecular Sciences ijms	4.9	9.0	2000	16.8 Days	CHF 2900	Submit
Journal of Clinical Medicine jcm	2.9	5.2	2012	16 Days	CHF 2600	Submit
Women women	1.6	-	2021	17.8 Days	CHF 1000	Submit
Reproductive Medicine reprodmed	1.3	-	2020	30.8 Days	CHF 1000	Submit

Preprints.org is a multidisciplinary platform offering a preprint service designed to facilitate the early sharing of your research. It supports and empowers your research journey from the very beginning.

MDPI Topics is collaborating with Preprints.org and has established a direct connection between MDPI journals and the platform. Authors are encouraged to take advantage of this opportunity by posting their preprints at Preprints.org prior to publication:

1. Share your research immediately: disseminate your ideas prior to publication and establish priority for your work.
2. Safeguard your intellectual contribution: Protect your ideas with a time-stamped preprint that serves as proof of your research timeline.
3. Boost visibility and impact: Increase the reach and influence of your research by making it accessible to a global audience.
4. Gain early feedback: Receive valuable input and insights from peers before submitting to a journal.
5. Ensure broad indexing: Web of Science (Preprint Citation Index), Google Scholar, Crossref, SHARE, PrePubMed, Scilit and Europe PMC.

Published Papers (1 paper)

Order results

Content type Publication Date

Result details

Normal Extended Compact

Journals

All Endocrines IJMS JCM Women Reprod. Med.

Show export options expand_more Show export options expand_less

Select all

Export citation of selected articles as:

Plain Text BibTeX BibTeX (without abstracts) Endnote Endnote (without abstracts) Tab-delimited RIS

Error

Oops... you haven't selected anything for export.

Ok

clear

12 pages, 488 KiB  

Open AccessArticle

Association Between Endogenous Equol Production and the Onset of Overactive Bladder in Postmenopausal Women

by Hiroyuki Honda, Tomohiro Matsuo, Hidenori Ito, Shota Kakita, Shintaro Mori, Kyohei Araki, Kensuke Mitsunari, Kojiro Ohba, Yasushi Mochizuki and Ryoichi Imamura

J. Clin. Med. 2025, 14(12), 4183; https://doi.org/10.3390/jcm14124183 - 12 Jun 2025

Viewed by 306

Abstract

Objectives: Equol, a gut-derived metabolite of soy isoflavones with estrogenic activity, may influence bladder aging. However, the association between overactive bladder (OAB), which is closely linked to bladder aging, and the estrogenic effects of equol remains unknown. Therefore, this study investigated the [...] Read more.

Objectives: Equol, a gut-derived metabolite of soy isoflavones with estrogenic activity, may influence bladder aging. However, the association between overactive bladder (OAB), which is closely linked to bladder aging, and the estrogenic effects of equol remains unknown. Therefore, this study investigated the association between endogenous equol production and onset and severity of OAB in postmenopausal women. Methods: The study included 128 postmenopausal women, newly diagnosed with OAB, who were categorized into equol- and non-equol-producing groups based on urinary equol levels as measured by enzyme-linked immunosorbent assay. Patient clinical characteristics, OAB Symptom Score (OABSS), and urodynamic parameters were assessed. Propensity score matching was performed to minimize confounding factors related to the timing of lower urinary tract symptom (LUTS) onset. Results: Equol producers exhibited a significantly later onset of LUTS than non-producers (68.7 ± 10.9 vs. 62.7 ± 10.7 years, p = 0.002). Equol producers were more prevalent in the late-onset group (58.6% vs. 31.0%, p = 0.002), which had significantly higher urinary equol concentrations than the early-onset group (p = 0.014). No significant differences were observed in total OABSS or subscale scores between the groups, suggesting that equol did not affect symptom severity. Propensity score-matched analysis (n = 104) confirmed that equol non-production was an independent risk factor for early-onset LUTS (OR, 1.930; 95% CI, 1.248–4.049; p = 0.014). Conclusions: Endogenous equol production was significantly associated with the delayed onset of OAB in postmenopausal women. Thus, equol may serve as a protective factor and non-invasive biomarker to guide individualized prevention and early intervention strategies in urological care for women. Full article

(This article belongs to the Topic Gynecological Endocrinology Updates)

►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less

Select all

Export citation of selected articles as:

Plain Text BibTeX BibTeX (without abstracts) Endnote Endnote (without abstracts) Tab-delimited RIS

 

Error

Oops... you haven't selected anything for export.

Ok

clear

Displaying articles 1-1