Special Issue "Next Generation Sequencing: A Game Changer in the Understanding of the HIV Persistence"

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Animal Viruses".

Deadline for manuscript submissions: closed (31 August 2021).

Special Issue Editor

Dr. Francesco Andrea Procopio
E-Mail Website
Guest Editor
CHUV, Divison of Immunology and Allergy, Lausanne, Switzerland
Interests: HIV; HIV reservoir; quantification of HIV DNA and RNA; single cells analysis; HIV reactivation; HIV cure; HIV vaccines

Special Issue Information

Dear Colleagues,

Determination of the mechanisms by which HIV persists is a critical goal of HIV cure studies. Pioneering studies have revealed that one of the major mechanisms by which HIV persists is through the establishment of a latent viral reservoir, early on in the course of HIV infection. Characterization of the latent viral reservoir for the longest time has relied on the quantitative characterization of the latent reservoir, mainly using qPCR based technologies assessing HIV DNA and HIV RNA in bulk samples. However, recent technological advances allow the simultaneous single genome proviral sequencing and corresponding HIV integration site determination with MIP-seq and next generation sequencing (NGS) technologies and have unraveled the high complexity of the in vivo situation. These studies have been instrumental in demonstrating that one of the major mechanisms by which HIV persists in vivo is through the homeostatic proliferation of individual HIV infected cells.

In this Special Issue, we focus on the state-of-the art research regarding the use of NGS technology in HIV persistence studies with particular emphasis on advantages and limitation of such technologies. Finally, we want to assess their clinical relevance and how they can contribute in the development of a cure for HIV.

Dr. Francesco Andrea Procopio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HIV reservoir
  • HIV persistence
  • HIV near-near-full-genome sequencing
  • MIP-seq
  • FLIP-seq
  • Quadruplex qPCR

Published Papers

There is no accepted submissions to this special issue at this moment.
Back to TopTop