Special Issue "Feline Retroviruses"
Deadline for manuscript submissions: closed (31 July 2012).
Interests: FIV; FeLV; retroviruses; AIDS; viral immunology
In 1964, Bill Jarrett and colleagues at the University of Glasgow Veterinary Hospital reported in Nature that kittens injected with material from the mediastinal mass of an 8.5-year-old female cat developed lymphosarcoma. Examination of tissue sections under electron microscopy revealed the presence of virus-like particles that bore a striking resemblance to "the virus of murine leukaemias". These seminal studies launched the field of feline retrovirology; the virus that had been identified was subsequently named feline leukaemia virus (FeLV) and millions of cats are now vaccinated successfully against FeLV every year. Since then, cats have been shown to harbour spumaviruses (FFV, feline foamy virus), replication-competent endogenous retroviruses (RD114) and lentiviruses (feline immunodeficiency virus, FIV).
This special edition of "Viruses" aims to examine the areas of current interest in feline retrovirology. The issue will expand on our understanding of innate resistance/intrinsic immunity to retroviral infection and the host pathogen interactions that determine the outcome of retroviral diseases in felids. It will consider the prospects for the development of safe and efficacious FIV vaccines and the use of feline retrovirus-derived vectors for gene therapy and the likely benefits to both human and veterinary medicine.
Prof. Brian J. Willett
- foamy virus