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Viruses 2012, 4(2), 236-257;

Emerging Viruses in the Felidae: Shifting Paradigms

Laboratory of Genomic Diversity, National Cancer Institute-Frederick, Frederick, MD 21702, USA
SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, MD 21702, USA
Banfield Pet Hospital, 800 NE Tillamook Street, Portland, OR 97213, USA
CIMAR/CIIMAR, University of Porto, Rua dos Bragas, 177, Porto 4050-123, Portugal
Present Address: Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg University, St. Petersburg, 190000, Russia.
Author to whom correspondence should be addressed.
Received: 1 December 2011 / Revised: 21 December 2011 / Accepted: 11 January 2012 / Published: 7 February 2012
(This article belongs to the Special Issue Feline Retroviruses)
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The domestic cat is afflicted with multiple viruses that serve as powerful models for human disease including cancers, SARS and HIV/AIDS. Cat viruses that cause these diseases have been studied for decades revealing detailed insight concerning transmission, virulence, origins and pathogenesis. Here we review recent genetic advances that have questioned traditional wisdom regarding the origins of virulent Feline infectious peritonitis (FIP) diseases, the pathogenic potential of Feline Immunodeficiency Virus (FIV) in wild non-domestic Felidae species, and the restriction of Feline Leukemia Virus (FeLV) mediated immune impairment to domestic cats rather than other Felidae species. The most recent interpretations indicate important new evolutionary conclusions implicating these deadly infectious agents in domestic and non-domestic felids. View Full-Text
Keywords: FIV; FCoV; FeLV; Felidae FIV; FCoV; FeLV; Felidae

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O’Brien, S.J.; Troyer, J.L.; Brown, M.A.; Johnson, W.E.; Antunes, A.; Roelke, M.E.; Pecon-Slattery, J. Emerging Viruses in the Felidae: Shifting Paradigms. Viruses 2012, 4, 236-257.

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