Next Article in Journal
Recombination in Eukaryotic Single Stranded DNA Viruses
Next Article in Special Issue
Feline Immunodeficiency Virus (FIV) Neutralization: A Review
Previous Article in Journal
Mechanisms and Factors that Influence High Frequency Retroviral Recombination
Open AccessReview

Viral Determinants of FeLV Infection and Pathogenesis: Lessons Learned from Analysis of a Natural Cohort

by Lisa L. Bolin 1,2 and Laura S. Levy 1,2,*
1
Department of Microbiology and Immunology, School of Medicine, Tulane University, 1430 Tulane Avenue SL-38, New Orleans, LA 70112, USA
2
Tulane Cancer Center, School of Medicine, Tulane University, 1430 Tulane Avenue SL-38, New Orleans, LA 70112, USA
*
Author to whom correspondence should be addressed.
Viruses 2011, 3(9), 1681-1698; https://doi.org/10.3390/v3091681
Received: 29 July 2011 / Revised: 31 August 2011 / Accepted: 1 September 2011 / Published: 9 September 2011
(This article belongs to the Special Issue Feline Retroviruses)
Detailed analysis has been performed over many years of a geographic and temporal cohort of cats naturally infected with feline leukemia virus (FeLV). Molecular analysis of FeLV present in the diseased tissues and application of those viruses to experimental systems has revealed unique isolates with distinctive disease potential, previously uncharacterized virus-receptor interactions, information about the role of recombinant viruses in disease induction, and novel viral and cellular oncogenes implicated in pathogenesis, among other findings. The studies have contributed to an understanding of the selective forces that lead to predominance of distinctive FeLV isolates and disease outcomes in a natural population.
Keywords: feline leukemia virus; lymphoma; pathogenesis; oncogenesis; long terminal repeat; surface glycoprotein feline leukemia virus; lymphoma; pathogenesis; oncogenesis; long terminal repeat; surface glycoprotein
MDPI and ACS Style

Bolin, L.L.; Levy, L.S. Viral Determinants of FeLV Infection and Pathogenesis: Lessons Learned from Analysis of a Natural Cohort. Viruses 2011, 3, 1681-1698.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop