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Antiviral Functions of Monoclonal Antibodies against Chikungunya Virus

1,2,* and 1,2,*
1
Vitalant Research Institute, San Francisco, CA 94118, USA
2
Department of Pathology and Laboratory Medicine, University of California, San Francisco, CA 94143, USA
*
Authors to whom correspondence should be addressed.
Viruses 2019, 11(4), 305; https://doi.org/10.3390/v11040305
Received: 7 March 2019 / Revised: 25 March 2019 / Accepted: 27 March 2019 / Published: 28 March 2019
(This article belongs to the Special Issue Chikungunya Virus and (Re-) Emerging Alphaviruses)
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Abstract

Chikungunya virus (CHIKV) is the most common alphavirus infecting humans worldwide. Antibodies play pivotal roles in the immune response to infection. Increasingly, therapeutic antibodies are becoming important for protection from pathogen infection for which neither vaccine nor treatment is available, such as CHIKV infection. The new generation of ultra-potent and/or broadly cross-reactive monoclonal antibodies (mAbs) provides new opportunities for intervention. In the past decade, several potent human and mouse anti-CHIKV mAbs were isolated and demonstrated to be protective in vivo. Mechanistic studies of these mAbs suggest that mAbs exert multiple modes of action cooperatively. Better understanding of these antiviral mechanisms for mAbs will help to optimize mAb therapies. View Full-Text
Keywords: Chikungunya; antibodies; neutralization; budding; effector functions Chikungunya; antibodies; neutralization; budding; effector functions
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Jin, J.; Simmons, G. Antiviral Functions of Monoclonal Antibodies against Chikungunya Virus. Viruses 2019, 11, 305.

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