Conferences

The topic of the IRNCAS International Symposium is the retroviral nucleocapsid protein (NC) and its Gag precursor, a polyprotein responsible for the viral assembly.

This symposium represents an important opportunity in getting together the specialists and generating new collaborations and multidisciplinary studies (biophysics, biochemistry, virology, cellular biology, biomedicine and biophotonics). During the last 15 years, these collaborations have provided important progresses in the insight into the molecular and cellular mechanisms of action of the HIV-1 nucleocapsid and its Gag precursor, making them promising targets in the design of inhibitors against the AIDS epidemics.

This 10th edition should encourage the continuation of our collaborative network in order to enlighten the structural and functional properties of the NC domain of Gag during virus assembly in the host cell.
Special attention will be given to :
- RNA-NC interactions
- Gag and cell factors interactions (membrane lipids and cellular proteins)
- Gag and NC chaperone properties
- The impact of the biophysical methods, notably of the high resolution microscopy and the NMR, on the understanding of Gag assembly
- Therapeutic strategies targeting HIV-1 NC and Gag assembly.

The major topics discussed during this Symposium are focused on the HIV-1 nucleocapsid and on the retroviral Gag proteins, however other nucleocapsid of viruses causing human pathologies (HTLV, Hepatitis and Influenza) will be also considered.

http://irncas2016.sciencesconf.org/