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Article

Comparison of Two Hepatitis B Vaccination Strategies Targeting Vertical Transmission: A 10-Year Japanese Multicenter Prospective Cohort Study

1
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo 1738610, Japan
2
Department of Pediatrics, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
3
Department of Pediatrics, Kakogawa Central City Hospital, Kakogawa 6758611, Japan
4
Department of Pediatrics, Kasukabe Medical Center, Kasukabe 3448588, Japan
5
Department of Pediatrics, Numazu City Hospital, Numazu 4100302, Japan
6
Division of Neonatology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo 1708476, Japan
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Vaccines 2021, 9(1), 58; https://doi.org/10.3390/vaccines9010058
Received: 30 November 2020 / Revised: 12 January 2021 / Accepted: 14 January 2021 / Published: 17 January 2021
(This article belongs to the Special Issue Timely Administration of the Hepatitis B Birth Dose Vaccine)
In 1985, a hepatitis B (HB) vaccination strategy against vertical HB virus transmission was introduced in Japan that recommended vaccination of infants at two, three, and five months of age (delayed strategy). This schedule was revised in 2013, recommending to vaccinate at birth and at 1 and 6 months of age (non-delayed strategy). We aimed to compare the vertical HB virus transmission rates and immunogenic responses between these two vaccination strategies. This Japanese multicenter prospective cohort study included 222 infants born between 2008 and 2017 to serum hepatitis B surface (HBs) antigen (HBsAg)-positive mothers. During the study period, 136 and 86 infants received delayed and non-delayed strategies, respectively. A positive vertical HB virus transmission was defined as a positive serum HBsAg status. Seropositive immunogenic response was defined as a serum anti-HBs titer of ≥10 mIU/mL. Post-vaccination serum HBsAg positivity rates did not differ significantly between the delayed (0/136 [0.0%, 95% confidence interval, 0.0–2.7%]) and non-delayed (2/86 [2.3%, 95% confidence interval, 0.3–8.1%]) strategy groups. Seropositive immunogenic response rates were 100.0% (136/136) and 97.7% (84/86), respectively. Although this study was under-powered to detect a statistically significant result, no vertical HB virus transmission was observed in the delayed strategy. View Full-Text
Keywords: hepatitis B surface antigen; hepatitis B virus; immunogenic response; mother-to-child infection; prevention hepatitis B surface antigen; hepatitis B virus; immunogenic response; mother-to-child infection; prevention
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MDPI and ACS Style

Nishimura, K.; Yamana, K.; Fukushima, S.; Fujioka, K.; Miyabayashi, H.; Murabayashi, M.; Masunaga, K.; Okahashi, A.; Nagano, N.; Morioka, I. Comparison of Two Hepatitis B Vaccination Strategies Targeting Vertical Transmission: A 10-Year Japanese Multicenter Prospective Cohort Study. Vaccines 2021, 9, 58. https://doi.org/10.3390/vaccines9010058

AMA Style

Nishimura K, Yamana K, Fukushima S, Fujioka K, Miyabayashi H, Murabayashi M, Masunaga K, Okahashi A, Nagano N, Morioka I. Comparison of Two Hepatitis B Vaccination Strategies Targeting Vertical Transmission: A 10-Year Japanese Multicenter Prospective Cohort Study. Vaccines. 2021; 9(1):58. https://doi.org/10.3390/vaccines9010058

Chicago/Turabian Style

Nishimura, Koji, Keiji Yamana, Sachiyo Fukushima, Kazumichi Fujioka, Hiroshi Miyabayashi, Masao Murabayashi, Ken Masunaga, Aya Okahashi, Nobuhiko Nagano, and Ichiro Morioka. 2021. "Comparison of Two Hepatitis B Vaccination Strategies Targeting Vertical Transmission: A 10-Year Japanese Multicenter Prospective Cohort Study" Vaccines 9, no. 1: 58. https://doi.org/10.3390/vaccines9010058

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