Special Issue "Tuberculosis Diagnostic, Treatments and Vaccines Research"

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: 30 November 2023 | Viewed by 964

Special Issue Editor

Institut Pasteur de Lille, Centre d’Infection et d’Immunité de Lille, Université de Lille, CNRS UMR9017, INSERM U1019, CHU Lille, 59000 Lille, France
Interests: tuberculosis; pulmonary infection; drug discovery; drug delivery; nanotechnology; cell biology; macrophages; host-pathogen interaction; immune response; brucellosis
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Special Issue Information

Dear Colleagues,

Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis (TB), a human infectious lung disease that causes the death of more than 1.5 million persons each year (according to the WHO). Mtb is a successful pathogen, which, upon inhalation, is able to infect the host alveolar macrophages. The bacteria are able to prevent the acidification of its containing vacuole by blocking the phagosomal maturation. Ultimately, Mtb can escape the vacuole and reside inside the cell cytoplasm. Therefore, Mtb has developed a huge set of mechanisms to promote its survival and massively replicate during its prolonged stay in the host. Several virulence factors of Mtb have been identified with the help of genetic tools and animal models.

Although the mortality associated with tuberculosis decreased over the last 15 years, cases of resistance and multidrug resistance continue to rise in a very worrying manner (500,000 cases diagnosed each year). Current treatment is an antibiotic therapy that is characterized by a complex drug regimen that has to be taken for a long time, causing problems with toxicity and compliance. Therefore, treating TB remains a real challenge. With the difficulties encountered in recent decades to find new antimicrobial molecules, there is an urgent need to develop new strategies to improve the current treatment.

BCG (Bacillus Calmette-Guérin) remains the only effective vaccine against tuberculosis. Its discovery early in the 20th century allowed a drastic reduction in children mortalities. However, the vaccine has been shown to provide variable protection in adults against pulmonary tuberculosis. Novel and more effective strategies, including new vaccines or a different use of BCG, are now essential to reduce the prevalence of the disease and foresee its eradication.

TB diagnosis is particularly difficult in immunocompromised individuals or children. In this regard, the latest WHO report highlights improvements in TB diagnostics and shortening the time to initiate appropriate treatment as key priorities.

For this Special Issue of Vaccines, we kindly invite authors to submit an original research article or a review focusing on the recent advances to diagnose, prevent or treat TB. Potential topics could include (but are not limited to): new treatment strategy, vaccine studies or the setting up of a new diagnostic test.

Dr. Machelart Arnaud
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Mycobacterium tuberculosis
  • vaccine
  • diagnostic
  • treatment

Published Papers (1 paper)

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Morphology of Lymphoid Tissue in the Lungs of Guinea Pigs Infected with Mycobacterium bovis against the Background of Vaccine Immunity and the Action of Betulin and Its Derivatives
Vaccines 2022, 10(12), 2084; https://doi.org/10.3390/vaccines10122084 - 06 Dec 2022
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Tuberculosis caused by Mycobacterium bovis is a serious problem for animal and human health worldwide. A promising concept for the design of anti-tuberculosis drugs is the conjugation of an immunogenic fraction isolated from bacterial vaccines with a stimulating component. Taking this principle as [...] Read more.
Tuberculosis caused by Mycobacterium bovis is a serious problem for animal and human health worldwide. A promising concept for the design of anti-tuberculosis drugs is the conjugation of an immunogenic fraction isolated from bacterial vaccines with a stimulating component. Taking this principle as a basis, conjugates based on BCG antigens with betulin and its derivatives (betulonic and betulinic acids) were designed. The aim of this research was to study the morphological changes in the lymphoid tissue associated with the bronchial mucosa lungs (BALT) in guinea pigs sensitized with experimental conjugates using a model of experimental tuberculosis. The results showed a significant decrease in the BALT response, expressed by a decrease in the diameter of lymphatic follicles and a decrease in their activity when exposed to conjugates based on BCG antigens with betulin and, especially, with betulonic acid, with a visually greater number of plasma cells observed in the lung tissues of guinea pigs of these groups. The absence of tuberculous foci and low BALT activity in the lungs of animals treated with betulin and betulonic acid are probably associated with the activation of humoral immunity under the action of these conjugates. Full article
(This article belongs to the Special Issue Tuberculosis Diagnostic, Treatments and Vaccines Research)
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